Research Topics
| Bruce J TrombergSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer's diseaseAlexander J Lin
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road, Irvine, CA 92612, USA
Ann Biomed Eng 39:1349-57. 2011..controls, respectively. Our results show that SFDI is capable of revealing quantitative functional contrast in an AD model and may be a useful method for studying dynamic alterations in AD neural tissue composition and physiology...- Imaging breast cancer chemotherapy response with light. Commentary on Soliman et al., p. 2605Bruce J Tromberg
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92715, USA
Clin Cancer Res 16:2486-8. 2010..Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients... - Imaging in breast cancer: diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapyBruce J Tromberg
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Breast Cancer Res 7:279-85. 2005..These results suggest a potential role for diffuse optics as a bedside monitoring tool that could aid the development of new strategies for individualized patient care... - Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor modelSean Merritt
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Appl Opt 42:2951-9. 2003..15 M/microM). Tissue hemoglobin oxygen saturation (StO2) also showed a large variation between tissue types: viable tissue had an optically measured StO2 value of 61 +/- 5%, whereas StO2 determined for necrotic tissue was 43 +/- 6%... - In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistrationDavid J Cuccia
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Appl Opt 42:2940-50. 2003..In contrast, MB behaves as a small-molecular-weight contrast agent that leaks rapidly from the vasculature into the extravascular, extracellular space, and is sensitive to blood flow and the arterial input function... - Noninvasive in vivo monitoring of cyanide toxicity and treatment using diffuse optical spectroscopy in a rabbit modelJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, 1002 Health Sciences Road East, Irvine, CA 92612 1475, USA
Mil Med 174:615-21. 2009..Therefore, DOS enables detection and monitoring of CN toxicity and treatment with NaNO2... - Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopyAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute and Medical Clinic, University of California Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
Proc Natl Acad Sci U S A 104:4014-9. 2007..44) vs. nonresponders (1.82 +/- 0.49). These results highlight DOS sensitivity to tumor cellular metabolism and biochemical composition and demonstrate its potential for predicting and monitoring an individual's response to treatment... - Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapyAlbert E Cerussi
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road, East, Irvine, CA 92612, USA
Philos Transact A Math Phys Eng Sci 369:4512-30. 2011..This approach is well suited to monitoring breast tumour response and may provide feedback for optimizing therapeutic outcomes and minimizing side-effects... - Image correlation spectroscopy of multiphoton images correlates with collagen mechanical propertiesChristopher B Raub
Department of Biomedical Engineering, University of California, Irvine, California 92697, USA
Biophys J 94:2361-73. 2008..We conclude that MPM and ICS are an effective combination to assess bulk mechanical properties of collagen hydrogels in a noninvasive, objective, and systematic fashion and may be useful for specific in vivo applications... - Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopyJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Rd. East, University of California, Irvine, CA 92612-1475, USA
J Appl Physiol 100:615-22. 2006..These techniques are expected to be useful in evaluating dynamics of drug delivery and therapeutic efficacy in blood chemistry, human, and preclinical animal models... - Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured lightSoren D Konecky
Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute, University of California Irvine, 1002 Health Sciences Road, Irvine, CA 92617, USA
Opt Express 17:14780-90. 2009..The method provides more accurate quantification of optical absorption and higher resolution than standard diffuse reflectance measurements... - The role of diffuse optical spectroscopy in the clinical management of breast cancerNatasha Shah
Laser Microbeam and Medical Program (LAMMP, Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Dis Markers 19:95-105. 2003.... - Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopyJangwoen Lee
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 13:064027. 2008.... - Quantitation and mapping of tissue optical properties using modulated imagingDavid J Cuccia
Modulated Imaging, Inc, 1002 Health Sciences Road, Irvine, California 92612, USA
J Biomed Opt 14:024012. 2009..Last, metrics of spatial resolution are assessed through both simulations and measurements of spatially heterogeneous phantoms... - Broadband diffuse optical spectroscopy assessment of hemorrhage- and hemoglobin-based blood substitute resuscitationJangwoen Lee
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:044027. 2009.... - Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case studyNatasha Shah
University of California-Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92162-1475, USA
J Biomed Opt 10:051503. 2005..7% drop in mean total hemoglobin content (THC, 41.6 versus 23.4 microM). These data provide in vivo validation of the accuracy of broadband DOS and the sensitivity of optical methods to changes in tumor physiology... - In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopyAlbert Cerussi
University of California Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 11:044005. 2006..Our findings further underscore the importance of broadband measurements and patient age stratification in breast cancer DOI... - Effect of contact force on breast tissue optical property measurements using a broadband diffuse optical spectroscopy handheld probeAlbert Cerussi
Laser Medical and Microbeam Program, Beckman Laser Institute, University of California, Irvine, 1110 Health Sciences Road, East, Irvine, California 92612, USA
Appl Opt 48:4270-7. 2009..Contact force is not a significant source of variation, most likely because of a relatively wide probe surface area and the stability of the DOS method for calculating tissue optical properties... - Rotational multiphoton endoscopy with a 1 microm fiber laser systemGangjun Liu
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Opt Lett 34:2249-51. 2009..034 microm and a repetition rate of 50 MHz. Second-harmonic-generation images of rat-tail tendon and fish scale are demonstrated with the rotational probe-based multiphoton system... - Wavelength optimization for rapid chromophore mapping using spatial frequency domain imagingAmaan Mazhar
University of California, Department of Biomedical Engineering, Irvine, CA 92612, USA
J Biomed Opt 15:061716. 2010..5s compared to 50s for a full 34-wavelength acquisition. The wavelength optimization enables dynamic imaging of arterial occlusions with improved spatial resolution due to reduction of motion artifacts... - Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case studyDorota B Jakubowski
Beckman Laser Institute, Laser Microbeam and Medical Program, University of California-Irvine, 1002 Health Sciences Road East, Irvine, CA 92612, USA
J Biomed Opt 9:230-8. 2004..These data suggest that noninvasive, quantitative optical methods that characterize tumor physiology may be useful in assessing and optimizing individual response to neoadjuvant chemotherapy... - Quantitative determination of dynamical properties using coherent spatial frequency domain imagingTyler B Rice
Department of Physics, University of California, Irvine, Irvine, California 92697, USA
J Opt Soc Am A Opt Image Sci Vis 28:2108-14. 2011..7E-07 and 5.35 mm²/s, respectively. For scattering particles in water-glycerin solutions, the fit fractional changes in D(b) with changes in viscosity were all found to be within 3% of the expected value... - PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor AYi Hong Zhou
Department of Neurological Surgery, University of California, Irvine, Irvine, CA 92697, USA
J Neurooncol 96:191-200. 2010..PAX6 suppression of VEGFA appears to be blocked in LN229. In conclusion, our data showed that PAX6 can initiate in glioma cells a new signaling pathway independent of PI3K/Akt-HIF1A signaling to suppress VEGFA expression... - Effect of excitation wavelength on penetration depth in nonlinear optical microscopy of turbid mediaMihaela Balu
University of California, Irvine, Beckman Laser Institute Laser Microbeam and Medical Program, Irvine, CA 92617, USA
J Biomed Opt 14:010508. 2009..Our results establish the feasibility of 1.3-microm excitation in nonlinear optical microscopy... - Multispectral imaging of tissue absorption and scattering using spatial frequency domain imaging and a computed-tomography imaging spectrometerJessie R Weber
University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California, 92612, USA
J Biomed Opt 16:011015. 2011..The SFDI-CTIS platform was applied to a mouse model of brain injury in order to demonstrate the utility of this approach in characterizing spatially and spectrally varying tissue optical properties... - Frequent optical imaging during breast cancer neoadjuvant chemotherapy reveals dynamic tumor physiology in an individual patientAlbert E Cerussi
Beckman Laser Institute, University of California, Irvine, 92612, USA
Acad Radiol 17:1031-9. 2010..Because optical methods provide functional imaging end points, our objective is to develop a low-barrier-to-access bedside approach that can be used for frequent, functional assessment of dynamic tumor physiology in individual patients... - Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopyShwayta Kukreti
Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Radiology 254:277-84. 2010..To develop a near-infrared spectroscopic method to identify breast cancer biomarkers and to retrospectively determine if benign and malignant breast lesions could be distinguished by using this method... - Three-dimensional speckle suppression in Optical Coherence Tomography based on the curvelet transformZhongping Jian
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Opt Express 18:1024-32. 2010..We show the approach suppresses a significant amount of speckle noise, while in the mean time preserves and thus reveals many subtle features that could get attenuated in other approaches... - Spatial variations in optical and physiological properties of healthy breast tissueNatasha Shah
Beckman Laser Institute, University of California-Irvine, 1002 Health Sciences Road, Irvine, CA 92612, USA
J Biomed Opt 9:534-40. 2004.... - Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detectionAnais Leproux
University of California, Irvine, Beckman Laser Institute, Irvine, California 92612, USA
J Biomed Opt 16:116019. 2011..This also indicates that bilateral measurements are not required for lesion identification using the STC method... - Linking optics and mechanics in an in vivo model of airway fibrosis and epithelial injuryChristopher B Raub
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 2730, USA
J Biomed Opt 15:015004. 2010..SHG depth decay is sensitive to changes in extracellular matrix content and correlates with bulk Young's modulus... - Use of an oxygen-carrying blood substitute to improve intravascular optical coherence tomography imagingKhiet C Hoang
University of California, Irvine, Department of Medicine, Division of Cardiology, 101 The City Drive, Building 53, Room 100, Route 81, Orange, California 92868, USA
J Biomed Opt 14:034028. 2009..From this proof-of-concept study, we demonstrate that endovascular flushing with an oxygen-carrying blood substitute (PFD) is optically superior to saline flushing for intravascular imaging... - In situ multiphoton optical tomography of hair follicles in miceJulia G Lyubovitsky
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92612, USA
J Biomed Opt 12:044003. 2007..The combination of TPF with SHG is sensitive to structural changes in cells and extracellular matrix brought on by normal hair follicle physiology and specific gene alterations... - EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartmentYuanjie Hu
Department of Biological Chemistry, University of California Irvine, 5171 California Ave, Suite 150, Irvine, CA 92697, USA
Mol Cancer 10:123. 2011..There are conflicting reports regarding the function of EFEMP1 in different cancer types. In this study, we sought to evaluate the role of EFEMP1 in malignant glioma biology... - Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imagingRyan S Lim
Department of Physiology and Biophysics, University of California, Irvine, CA, USA
J Lipid Res 52:2177-86. 2011.... - Non-invasive in vivo diffuse optical spectroscopy monitoring of cyanide poisoning in a rabbit modelJangwoen Lee
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA 92612 1475, USA
Physiol Meas 28:1057-66. 2007..Changes in tissue scattering properties in all six animals were detected during these events, confirming the need for DOS-based methods over traditional NIR spectroscopy to obtain accurate results... - Fiber delivered probe for efficient CARS imaging of tissuesMihaela Balu
Laser Microbeam and Medical Program LAMMP, Beckman Institute and Medical Clinic, 1002 Health Sciences Road East, University of California, Irvine, 92612, USA
Opt Express 18:2380-8. 2010..Different biological tissues were imaged ex vivo in order to assess the performance of our fiber-delivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues... - Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient miceRyan S Lim
Laser Microbeam and Medical Program LAMMP, Beckman Laser Institute and Medical Clinic, Department of Physiology and Biophysics, University of California, Irvine, CA, USA
J Lipid Res 51:1729-37. 2010.... - Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasisH Garrett R Thompson
Department of Biomedical Engineering, University of California, Irvine, Irvine, California 92697 2715, USA
Am J Physiol Lung Cell Mol Physiol 291:L1277-85. 2006..We conclude that epithelial-derived TGF-beta2 is secreted in response to injury, significantly alters the bulk optical properties of the extracellular matrix, and its tight regulation may be required for normal collagen homeostasis... - Assessing the future of diffuse optical imaging technologies for breast cancer managementBruce J Tromberg
Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA
Med Phys 35:2443-51. 2008.... - Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domainDavid J Cuccia
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, 1002 Health Sciences Road, Irvine, California 92612, USA
Opt Lett 30:1354-6. 2005..Experiments performed on turbid phantoms demonstrate that spatially modulated illumination facilitates quantitative wide-field optical property mapping and tomographic imaging in turbid media... - Assessing the spatial extent of breast tumor intrinsic optical contrast using ultrasound and diffuse optical spectroscopyAng Li
University of California, Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program, Irvine, California 92612, USA
J Biomed Opt 13:030504. 2008..Analysis indicates that invasive breast tumors with anatomical dimensions of 1 cm may still be detectable at depths of 30 mm or more (the center of the lesion to the surface of tissue) using DOS in a reflectance geometry... - Hemoglobin measurement patterns during noninvasive diffuse optical spectroscopy monitoring of hypovolemic shock and fluid replacementJangwoen Lee
University of California, Irvine, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92612 1475, USA
J Biomed Opt 12:024001. 2007..Further studies are needed to confirm potential clinical utility and accuracy under more complex clinical conditions in animal models and patients... - Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illuminationDavid Abookasis
University of California Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 14:024033. 2009..This potentially provides a powerful approach for quantitative monitoring and imaging of neurophysiology and metabolism with high spatiotemporal resolution... - Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue modelAlvin T Yeh
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 9:248-53. 2004..This study illustrates the complementary features of linear and nonlinear light-tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues... - Multiphoton imaging of actin filament formation and mitochondrial energetics of human ACBT gliomasYu Jer Hwang
Cell Molecular and Developmental Biology Program, University of California, Riverside, Riverside, CA, USA
Photochem Photobiol 87:408-17. 2011..The MPM imaging, which probes cells directly within the 3D cancer models, could potentially aid in working out a link between the functional performance of mitochondria, actin distribution and cancer invasiveness... - Modeling aberrant wound healing using tissue-engineered skin constructs and multiphoton microscopyBehrooz A Torkian
Department of Otolaryngology- Head and Neck Surgery, University of California, Irvine Medical Center, Irvine, CA 92612, USA
Arch Facial Plast Surg 6:180-7. 2004..Furthermore, it demonstrates the biologic activity of RAFT artificial tissue constructs... - Quantitative spectroscopy of superficial turbid mediaSheng Hao Tseng
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine 92617, USA
Opt Lett 30:3165-7. 2005..The average interrogation depth of the probe design investigated here is estimated to be less than 1 mm... - Speckle attenuation in optical coherence tomography by curvelet shrinkageZhongping Jian
Beckman Laser Institute, University of California, Irvine, California 92612, USA
Opt Lett 34:1516-8. 2009..The speckle attenuation is controlled by a single parameter that determines the threshold in the curvelet domain. Applying the algorithm to OCT images shows significant improvement of image quality... - Modulated imaging in layered mediaJessie R Weber
Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA 92692, USA
Conf Proc IEEE Eng Med Biol Soc . 2006..This technique is used to provide quantitative, depth-resolved functional physiologic information with applications in layered tissues including cortex, retina and skin... - Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopyChristopher B Raub
Department of Biomedical Engineering, University of California Irvine, Irvine, California 92697 2715, USA
Biophys J 92:2212-22. 2007..Thus, optical imaging may be a useful noninvasive tool to assess tissue mechanics... - Reversible dissociation of collagen in tissuesAlvin T Yeh
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, California, USA
J Invest Dermatol 121:1332-5. 2003..These results reveal the assembly process of high-order collagen structures and propose a molecular mechanism for the increase in tissue transparency observed after glycerol application... - Imaging scattering orientation with spatial frequency domain imagingSoren D Konecky
University of California, Irvine, Beckman Laser Institute and Medical Clinic, Laser Microbeam and Medical Program LAMMP, 1002 Health Sciences Road, Irvine, California 92612, USA
J Biomed Opt 16:126001. 2011..We determine the orientation of subsurface microscopic scattering structures located up to 600 ?m beneath highly scattering (?(') (s) = 1.5 mm(-1)) material... - Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopyTuan H Pham
University of California, Beckman Laser Institute and Medical Clinic, Irvine, California, USA
J Biomed Opt 7:34-44. 2002..These results suggest that FDPM spectroscopy may be used in clinical settings to noninvasively monitor central hemodynamic parameters and to directly assess oxygenation of tissues... - Immunophototherapy using PDT combined with rapid intratumoral dendritic cell injectionBrandon W Sur
Division of Hematology Oncology, Department of Medicine, School of Medicine, University of California, Irvine, CA, USA
Photochem Photobiol 84:1257-64. 2008..These data indicate that DCs rapidly administered into the site of PDT retain their viability and functional status, supporting the further evaluation of immunophototherapy strategies... - Imaging coronary artery microstructure using second-harmonic and two-photon fluorescence microscopyAikaterini Zoumi
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, California, USA
Biophys J 87:2778-86. 2004..Overall, these data suggest that multiphoton microscopy is a highly sensitive and promising technique for studying the morphometric properties of the microstructure of the blood vessel wall... - Farnesyltransferase inhibition: a novel method of immunomodulationMing-Sing Si
Department of Surgery, UCI College of Medicine, University of California, Irvine, CA 92868, USA
Int Immunopharmacol 3:475-83. 2003..Our results suggest that FTIs may represent a new class of clinically useful immunomodulatory agents. A-228839 has potent in vitro immunomodulatory properties that warrant in vivo evaluation as an antirejection agent... - Congruent MRI and near-infrared spectroscopy for functional and structural imaging of tumorsGultekin Gulsen
John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, Irvine, California 92697, USA
Technol Cancer Res Treat 1:497-505. 2002.... - Imaging cells and extracellular matrix in vivo by using second-harmonic generation and two-photon excited fluorescenceAikaterini Zoumi
Laser Microbeam and Medical Program (LAMMP, Beckman Laser Institute, University of California, Irvine, CA 92612, USA
Proc Natl Acad Sci U S A 99:11014-9. 2002..The use of SHG and TPEF in combination provides complementary information that allows noninvasive, spatially localized in vivo characterization of cell-ECM interactions in unstained thick tissues... - Imaging corneal pathology in a transgenic mouse model using nonlinear microscopyJulia G Lyubovitsky
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92612, USA
J Biomed Opt 11:014013. 2006.... - Spectroscopic approach for monitoring two-photon excited fluorescence resonance energy transfer from homodimers at the subcellular levelVickie J Lamorte
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, Irvine, California 92612, USA
J Biomed Opt 8:357-61. 2003..To illustrate the applicability of this technique to the detection of homodimer formation, we demonstrated the in vivo association of promyleocyte (PML) homodimers within their corresponding nuclear body... - Miniaturized probe based on a microelectromechanical system mirror for multiphoton microscopyWoonggyu Jung
Beckman Laser Institute, University of California, Irvine, CA 92697, USA
Opt Lett 33:1324-6. 2008..The completed probe was 1 cm in outer diameter and 14 cm in length. The developed probe was integrated into an MPM system and used to image fluorescent beads, paper, and biological specimens... - Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapyChao Zhou
University of Pennsylvania, Department of Physics and Astronomy, Philadelphia, Pennsylvania 19104, USA
J Biomed Opt 12:051903. 2007..The hybrid approach also enables construction of indices reflecting tissue metabolic rate of oxygen, which may provide new insights about therapy mechanisms... - Optical scanning and breast cancerBruce J Tromberg
Acad Radiol 12:923-4. 2005 - Effect of pulse duration on two-photon excited fluorescence and second harmonic generation in nonlinear optical microscopyShuo Tang
J Biomed Opt 11:020501. 2006..Because of improved signal-to-noise ratio, sub-20-fs pulses were used to enhance MPM imaging depth by approximately 160%, compared to 120-fs pulses, in human skin... - Imaging subcellular scattering contrast by using combined optical coherence and multiphoton microscopyShuo Tang
Department of Electrical and Computer Engineering, University of British Columbia, Vancouver V6T 1Z4, Canada
Opt Lett 32:503-5. 2007..There is little contribution to scattering from regions inside the nuclear core. These results confirm that light scattering signals from specific subcellular structures can be visualized by using coherent reflectance geometry... - Combined multiphoton microscopy and optical coherence tomography using a 12-fs broadband sourceShuo Tang
J Biomed Opt 11:020502. 2006..The combined MPM/OCT microscope is capable of providing simultaneous functional and structural information from cells and extracellular matrix and is potentially a powerful tool for studying biological processes in thick tissues... - Multicell tumor spheroids in photodynamic therapySteen J Madsen
Department of Health Physics, University of Nevada, Las Vegas, Nevada 89154-3037, USA
Lasers Surg Med 38:555-64. 2006..Such in silico models have made a number of counterintuitive predictions that have been verified in vitro and, as such, could guide the development of improved therapeutics... - Nonlinear optical microscopy of articular cartilageAlvin T Yeh
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Osteoarthritis Cartilage 13:345-52. 2005..NLOM was sensitive to macromolecular composition and pathologic changes in articular cartilage matrix. Advances in instrumentation may lead to the application of NLOM to study articular cartilage in vivo...
Research Grants
- A LASER MICROBEAM BIOTECHNOLOGY RESOURCEBruce Tromberg; Fiscal Year: 2007..Our long-term goal is to advance these technologies so they become widely-available, enabling methods for solving fundamentally important problems in biology and medicine. ..
- Breast Cancer Multi-dimensional Diffuse Optical ImagingBruce Tromberg; Fiscal Year: 2007..g. hormone replacement therapy (HRT) and neoadjuvant chemotherapy). ..
- A LASER MICROBEAM BIOTECHNOLOGY RESOURCEBruce Tromberg; Fiscal Year: 2007..Our long-term goal is to advance these technologies so they become widely-available, enabling methods for solving fundamentally important problems in biology and medicine. ..
- Developing DOSI Technology for Monitoring Response To Breast Cancer ChemotherapyBruce J Tromberg; Fiscal Year: 2010..The technology, Diffuse Optical Spectroscopic Imaging (DOSI), will be evaluated in a multi-site study designed to validate optical endpoints of clinical response. ..