Research Topics
| Melissa A TroesterSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samplesFathi Elloumi
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
BMC Med Genomics 4:54. 2011..This "normal" tissue could represent a source of non-random error or systematic bias in genomic classification...- Activation of host wound responses in breast cancer microenvironmentMelissa A Troester
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Clin Cancer Res 15:7020-8. 2009..Despite the widespread acknowledgment of commonalities between host responses to wounds and host responses to cancer, the gene expression responses of normal tissue adjacent to cancers have not been well characterized... - Challenges in studying the etiology of breast cancer subtypesMelissa A Troester
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Breast Cancer Res 11:104. 2009.... - Prediction of toxicant-specific gene expression signatures after chemotherapeutic treatment of breast cell linesMelissa A Troester
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Environ Health Perspect 112:1607-13. 2004..These analyses also showed that toxicant-specific gene expression patterns, similar to general stress responses, vary according to cell type... - EGFR associated expression profiles vary with breast tumor subtypeKatherine A Hoadley
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Genomics 8:258. 2007..An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors... - Estrogen-regulated genes predict survival in hormone receptor-positive breast cancersDaniel S Oh
Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
J Clin Oncol 24:1656-64. 2006..CONCLUSION: This study provides new biologic information concerning differences within hormone receptor-positive breast cancers and a means of predicting long-term outcomes in tamoxifen-treated patients... - Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signaturesCheng Fan
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA
BMC Med Genomics 4:3. 2011..We evaluated whether combining the prognostic powers of standard breast cancer clinical variables with a large set of gene expression signatures could improve on our ability to predict patient outcomes... - Interactions with fibroblasts are distinct in Basal-like and luminal breast cancersJ Terese Camp
Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, 135 Dauer Ln, Chapel Hill, NC 27599, USA
Mol Cancer Res 9:3-13. 2011..The phenotypes and gene expression changes invoked by cancer cell interactions with fibroblasts support the microenvironment and cell-cell interactions as intrinsic features of breast cancer subtypes... - Race, breast cancer subtypes, and survival in the Carolina Breast Cancer StudyLisa A Carey
Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
JAMA 295:2492-502. 2006..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B... - Cell-type-specific responses to chemotherapeutics in breast cancerMelissa A Troester
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
Cancer Res 64:4218-26. 2004..Similarities between in vivo and in vitro responses help to identify important response mechanisms to chemotherapeutics... - Expression of exogenous human telomerase in cultures of endometrial stromal cells does not alter their hormone responsivenessClaire S Barbier
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA
Biol Reprod 73:106-14. 2005.... - Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor statusMontserrat Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852 7234, USA
Cancer Epidemiol Biomarkers Prev 16:2269-75. 2007..These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships... - Gene expression patterns associated with p53 status in breast cancerMelissa A Troester
Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA
BMC Cancer 6:276. 2006..The relation between p53 status and subtype can be better studied by combining data from primary tumors with data from isogenic cell line pairs (with and without p53 function)...