Rheal A Towner

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi Lymphatic vessel density and function in experimental bladder cancer
    Marcia R Saban
    Department of Physiology, College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Cancer 7:219. 2007
  2. ncbi In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging
    Rheal A Towner
    Small Animal MRI Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Mol Imaging 6:18-29. 2007
  3. ncbi Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Toxicol Appl Pharmacol 207:237-44. 2005
  4. ncbi Diffusion tensor imaging and fiber tractography of C6 rat glioma
    Taketoshi Asanuma
    Small Animal MRI Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 28:566-73. 2008
  5. ncbi Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography
    Sabrina Doblas
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 32:267-75. 2010
  6. ncbi Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering
    Rheal A Towner
    1 Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
    Tissue Eng Part A 16:365-71. 2010
  7. ncbi Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging
    Philippe Garteiser
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 31:796-806. 2010
  8. ncbi Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas
    Ting He
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    J Cell Mol Med 15:837-49. 2011
  9. ncbi In vivo detection of inducible nitric oxide synthase in rodent gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 48:691-703. 2010
  10. ncbi Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography
    Taketoshi Asanuma
    Small Animal MRI Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 28:574-87. 2008

Research Grants

  1. Molecular-Specific Detection of Tumors: MRI Investigations
    Rheal Towner; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. ncbi Lymphatic vessel density and function in experimental bladder cancer
    Marcia R Saban
    Department of Physiology, College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK 73104, USA
    BMC Cancer 7:219. 2007
    ..Both cancer and inflammation are known to induce lymphangiogenesis. However, little is known about bladder lymphatic vessels and their involvement in cancer formation and progression...
  2. ncbi In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging
    Rheal A Towner
    Small Animal MRI Core Facility, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Mol Imaging 6:18-29. 2007
    ..This method has the ability to visualize in vivo the overexpression of c-MET at early developmental stages of tumor formation...
  3. ncbi Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104, USA
    Toxicol Appl Pharmacol 207:237-44. 2005
    ..The results of our study suggest that MRS-detected alterations in lipid metabolism can be correlated with the grading of liver tumor tissue at different stages during the carcinogenesis process...
  4. ncbi Diffusion tensor imaging and fiber tractography of C6 rat glioma
    Taketoshi Asanuma
    Small Animal MRI Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 28:566-73. 2008
    ....
  5. ncbi Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography
    Sabrina Doblas
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 32:267-75. 2010
    ..To evaluate the added value of non-contrast-enhanced MR angiography (MRA) to conventional MR imaging for a detailed characterization of different rodent glioma models...
  6. ncbi Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering
    Rheal A Towner
    1 Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma
    Tissue Eng Part A 16:365-71. 2010
    ..Met levels in tumor tissues were confirmed in Western blots. Based on our results, in vivo evaluation of tissue regeneration using molecular MRI is possible in tissue engineering applications...
  7. ncbi Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging
    Philippe Garteiser
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 31:796-806. 2010
    ..To demonstrate that OKN007, a disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), has anti-glioma activity in the clinically relevant C6 rat glioma model using multi-parametric magnetic resonance imaging...
  8. ncbi Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas
    Ting He
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    J Cell Mol Med 15:837-49. 2011
    ..Together these results suggest mMRI can be very useful in assessing and characterizing the expression of specific angiogenic markers in vivo and help evaluate angiogenesis associated with tumour progression...
  9. ncbi In vivo detection of inducible nitric oxide synthase in rodent gliomas
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 48:691-703. 2010
    ..In vivo assessment of iNOS levels associated with tumor development is quite feasible in heterogeneous tissues with mMRI...
  10. ncbi Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography
    Taketoshi Asanuma
    Small Animal MRI Facility, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Magn Reson Imaging 28:574-87. 2008
    ..The fiber tractography method was able to differentiate between different tumor types, such as the C6 and F98 rat glioma models...
  11. ncbi Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy
    Ting He
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 51:490-502. 2011
    ..In conclusion, (1)H MRS and conventional MRI are useful methods to assess and follow the response of varied glioma models to anti-tumor treatments...
  12. ncbi Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Tissue Eng Part A 16:357-64. 2010
    ..VEGF-R2 levels in tumor tissues were also confirmed in western blots and via immunohistochemistry. Based on our results, in vivo evaluation of tissue angiogenesis using molecular MRI is possible in tissue engineering applications...
  13. ncbi Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer
    Robert A Floyd
    Experimental Therapeutics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Res 44:108-17. 2010
    ..PBN has significant anti-cancer activity in this model of intestinal neoplasia...
  14. ncbi Translational research involving oxidative stress and diseases of aging
    Robert A Floyd
    Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 51:931-41. 2011
    ....
  15. ncbi Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats
    Yoshiko Inoue
    Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Free Radic Res 41:972-80. 2007
    ..The CD diet model is also considered as a model for non-alcoholic steatohepatitis (NASH) in humans and early expression of Fas could also be a good index of the progression of NASH...
  16. ncbi In vivo identification of aflatoxin-induced free radicals in rat bile
    Rheal A Towner
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 35:1330-40. 2003
    ..Trapped 4-POBN radical adducts were also detected in rat bile following the in vivo metabolism of aflatoxin-M1, one of the hydroxylated metabolites of AFB1...
  17. ncbi Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds
    Yasvir A Tesiram
    Small Animal MRI Core Facility, Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    NMR Biomed 21:345-56. 2008
    ....
  18. ncbi Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process
    Sandra E Gomez-Mejiba
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 46:853-65. 2009
    ....
  19. ncbi Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI)
    Xichun Yu
    Department of Medicine, University of Oklahoma Health Sciences Center and VAMC, Oklahoma City, OK 73104, USA
    Cardiovasc Diabetol 6:6. 2007
    ..In the present study we used in vivo magnetic resonance imaging (MRI) and echocardiographic techniques to examine and characterize early changes in myocardial function in a mouse model of type 1 diabetes...
  20. ncbi Nitrones as therapeutics
    Robert A Floyd
    Experimental Therapeutics Research Program, Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 45:1361-74. 2008
    ....
  21. ncbi Assessment of in vivo oxidative lipid metabolism following acute microcystin-LR-induced hepatotoxicity in rats
    Rheal A Towner
    Department of Physiology and Pharmacology, School of Biomedical Sciences, James Cook University, Townsville, Australia
    Free Radic Res 36:63-71. 2002
    ..This study strongly suggests that oxidative stress related processes are involved in in vivo microcystin-induced hepatotoxicity in mammals, and may play an integral role in MCLR-induced toxicity...
  22. ncbi Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model
    Sabrina Doblas
    Oklahoma University Bioengineering Center, Norman, OK, USA
    Free Radic Biol Med 44:63-72. 2008
    ..The MR methods that we used also proved to be particularly suitable in following the angiogenic behavior and treatment response of a potential anti-glioma agent in a rat C6 glioma model...
  23. ncbi In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry)
    Rheal A Towner
    Department of Physiology and Pharmacology, North Queensland Magnetic Resonance Centre, School of Biomedical and Molecular Sciences, James Cook University, Molecular Sciences Building, Townsville, QLD, Australia
    Chem Biol Interact 139:231-50. 2002
    ....

Research Grants2

  1. Molecular-Specific Detection of Tumors: MRI Investigations
    Rheal Towner; Fiscal Year: 2007
    ..Once we have established the optimal molecular-targeting agent in a mouse hepatocarcinogenesis model, then the groundwork is established for initiation of human cell and planning of clinical evaluations for patients with liver cancer. ..