J Tower

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi Aging mechanisms in fruit files
    J Tower
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Bioessays 18:799-807. 1996
  2. ncbi Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification
    L Lu
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Genes Dev 15:134-46. 2001
  3. ncbi Aging-specific expression of Drosophila hsp22
    V King
    Department of Biological Sciences, University of Southern California, University Park, Los Angeles, California, 90089 1340, USA
    Dev Biol 207:107-18. 1999
  4. ncbi The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 1340, USA
    Development 126:4281-93. 1999
  5. ncbi Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity
    R Kurapati
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    J Gerontol A Biol Sci Med Sci 55:B552-9. 2000
  6. ncbi High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Genetics 158:1167-76. 2001
  7. ncbi Doxycycline-induced transgene expression during Drosophila development and aging
    E T Bieschke
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Mol Gen Genet 258:571-9. 1998
  8. ncbi FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
    J Sun
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Mol Cell Biol 19:216-28. 1999
  9. ncbi Transgenic methods for increasing Drosophila life span
    J Tower
    Department of Biological Sciences, SHS172, University of Southern California, Los Angeles, CA 90089 1340, USA
    Mech Ageing Dev 118:1-14. 2000
  10. ncbi Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress
    J C Wheeler
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Proc Natl Acad Sci U S A 92:10408-12. 1995

Collaborators

Detail Information

Publications15

  1. ncbi Aging mechanisms in fruit files
    J Tower
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Bioessays 18:799-807. 1996
    ..Transgenic files are being used to analyze the mechanisms of such aging-related gene expression, and to test the effects of specific genes on aging and aging-related deterioration...
  2. ncbi Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification
    L Lu
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Genes Dev 15:134-46. 2001
    ..The results suggest that ACE3 acts as a replicator and support and extend the replicator model for the organization of metazoan chromosomal replicons...
  3. ncbi Aging-specific expression of Drosophila hsp22
    V King
    Department of Biological Sciences, University of Southern California, University Park, Los Angeles, California, 90089 1340, USA
    Dev Biol 207:107-18. 1999
    ..Aging-specific induction of hsp22 is discussed with regard to current evolutionary theories of aging...
  4. ncbi The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 1340, USA
    Development 126:4281-93. 1999
    ..The data suggest a family of eukaryotic proteins related to Dbf4 and involved in initiation of DNA replication...
  5. ncbi Increased hsp22 RNA levels in Drosophila lines genetically selected for increased longevity
    R Kurapati
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    J Gerontol A Biol Sci Med Sci 55:B552-9. 2000
    ..Thus increased hsp22 and hsp23 RNA levels correlate with the increased life span and increased stress resistance of the genetically selected O lines...
  6. ncbi High-frequency generation of conditional mutations affecting Drosophila melanogaster development and life span
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Genetics 158:1167-76. 2001
    ..The PdL system should facilitate testing of a large fraction of Drosophila genes for overexpression and misexpression phenotypes at specific developmental and life cycle stages...
  7. ncbi Doxycycline-induced transgene expression during Drosophila development and aging
    E T Bieschke
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Mol Gen Genet 258:571-9. 1998
    ..Induction of beta-gal in adults had no detectable effect on life span. These results suggest the potential usefulness of this system for testing specific genes for effects on Drosophila development and aging...
  8. ncbi FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies
    J Sun
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Mol Cell Biol 19:216-28. 1999
    ..Finally, experimental manipulation of the genetic background demonstrated that the life span is affected by epistatic interactions between the transgene and allele(s) at other loci...
  9. ncbi Transgenic methods for increasing Drosophila life span
    J Tower
    Department of Biological Sciences, SHS172, University of Southern California, Los Angeles, CA 90089 1340, USA
    Mech Ageing Dev 118:1-14. 2000
    ..Using these techniques, over-expression of the hsp70, Cu/ZnSOD and MnSOD genes has each been demonstrated to increase Drosophila life span...
  10. ncbi Muscle-specific expression of Drosophila hsp70 in response to aging and oxidative stress
    J C Wheeler
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Proc Natl Acad Sci U S A 92:10408-12. 1995
    ..15.1.1). Taken together, the results suggest that aging-specific hsp70 expression may be a result of oxidative damage...
  11. ncbi A transcriptional insulator element, the su(Hw) binding site, protects a chromosomal DNA replication origin from position effects
    L Lu
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Mol Cell Biol 17:2202-6. 1997
    ..Inclusion of only a single su(Hw)BS in the construct did not detectably protect the chorion gene DNA replication origin from position effects...
  12. ncbi DNA mismatch repair catalyzed by extracts of mitotic, postmitotic, and senescent Drosophila tissues and involvement of mei-9 gene function for full activity
    A Bhui-Kaur
    Department of Biological Sciences and Hedco Molecular Biology Laboratories, University of Southern California, Los Angeles 90089 1340, USA
    Mol Cell Biol 18:1436-43. 1998
    ..mei-9 has been shown to be required in vivo for certain types of DNA mismatch repair, nucleotide excision repair (NER), and meiotic crossing over and is the Drosophila homolog of the yeast NER gene rad1...
  13. ncbi The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2
    G Landis
    Department of Biological Sciences, University of Southern California, Los Angeles 90089 1340, USA
    Proc Natl Acad Sci U S A 94:3888-92. 1997
    ..These results suggest an evolutionarily conserved role for Orc2p in eukaryotic chromosomal DNA replication...
  14. ncbi Preferential transposition of a Drosophila P element to the corresponding region of the homologous chromosome
    J Tower
    Department of Biological Sciences, School of Gerontology, University of Southern California, Los Angeles 90089 1340
    Mol Gen Genet 244:484-90. 1994
    ....
  15. ncbi Genetics of 51D-52A, a region containing several maternal-effect genes and two maternal-specific transcripts in Drosophila
    E M Underwood
    Department of Biological Sciences, Bowling Green State University, Ohio 43403
    Genetics 126:639-50. 1990
    ..Thus it appears that this is a "developmentally important" region, possibly representing a clustering of genes involved in either DNA replication or nuclear division...