Frederico G S Toledo

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, 807N Montefiore Hospital, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 91:3224-7. 2006
  2. ncbi Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Diabetes Care 29:1845-50. 2006
  3. ncbi Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 56:2142-7. 2007
  4. ncbi Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
    Frederico G S Toledo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 57:987-94. 2008
  5. ncbi Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
    Vladimir B Ritov
    Univ of Pittsburgh, School of Medicine, Div of Endocrinology and Metabolism, 810N MUH, 3459 5th Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 298:E49-58. 2010
  6. ncbi Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility
    Peter Chomentowski
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:494-503. 2011
  7. ncbi Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
    Francesca Amati
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2588-97. 2011
  8. ncbi Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
    Paul M Coen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 59:80-8. 2010
  9. ncbi Physical inactivity and obesity underlie the insulin resistance of aging
    Francesca Amati
    Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:1547-9. 2009
  10. ncbi Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults
    Peter Chomentowski
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 64:575-80. 2009

Collaborators

Detail Information

Publications19

  1. ncbi Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, 807N Montefiore Hospital, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 91:3224-7. 2006
    ..In obesity, skeletal muscle insulin resistance may be associated with smaller mitochondria...
  2. ncbi Influence of hepatic steatosis (fatty liver) on severity and composition of dyslipidemia in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Diabetes Care 29:1845-50. 2006
    ....
  3. ncbi Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    Frederico G S Toledo
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 56:2142-7. 2007
    ....
  4. ncbi Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
    Frederico G S Toledo
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes 57:987-94. 2008
    ..Both are known to improve insulin resistance, and we tested the hypothesis that physical activity, rather than improved insulin resistance, is required to increase mitochondrial capacity of muscle...
  5. ncbi Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
    Vladimir B Ritov
    Univ of Pittsburgh, School of Medicine, Div of Endocrinology and Metabolism, 810N MUH, 3459 5th Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 298:E49-58. 2010
    ..The specific activity of NADH oxidase (per mg cardiolipin) and NADH oxidase/citrate synthase and NADH oxidase/beta-HAD ratios are reduced two- to threefold in both T2DM and obesity...
  6. ncbi Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility
    Peter Chomentowski
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:494-503. 2011
    ..Insulin resistance is accompanied by lower lipid oxidation during fasting and metabolic inflexibility. Whether these abnormalities correlate with mitochondrial content in skeletal muscle is unknown...
  7. ncbi Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
    Francesca Amati
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2588-97. 2011
    ..We also hypothesized that the expression of key skeletal muscle proteins involved in lipid droplet hydrolysis, DAG formation, and fatty-acid partitioning and oxidation would be associated with the lipotoxic phenotype...
  8. ncbi Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
    Paul M Coen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 59:80-8. 2010
    ....
  9. ncbi Physical inactivity and obesity underlie the insulin resistance of aging
    Francesca Amati
    Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:1547-9. 2009
    ..CONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity...
  10. ncbi Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults
    Peter Chomentowski
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 64:575-80. 2009
    ..Aging is associated with a loss of muscle mass and increased body fat. The effects of diet-induced weight loss on muscle mass in older adults are not clear...
  11. ncbi Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 288:E818-25. 2005
    ..We conclude that improved skeletal muscle ETC activity following moderate WL and improved aerobic capacity contributes to associated alleviation of insulin resistance...
  12. ncbi Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
    John J Dube
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Endocrinol Metab 294:E882-8. 2008
    ..Therefore, several key deleterious effects of aging and/or obesity on the metabolic profile of skeletal muscle can be reversed with only moderate increases in physical activity...
  13. ncbi Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity
    Stephanie J Mihalik
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 18:1695-700. 2010
    ..Plasma long-chain AcylCN species are increased in obesity and T2DM, suggesting that more fatty acids can enter mitochondria. In T2DM, many shorter species accumulate, suggesting that they have a generalized complex oxidation defect...
  14. ncbi Lower thigh subcutaneous and higher visceral abdominal adipose tissue content both contribute to insulin resistance
    Francesca Amati
    1 Department of Physiology, University of Lausanne, Lausanne, Switzerland 2 Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 20:1115-7. 2012
    ..This strongly suggests that these two distinct fat distribution phenotypes should both be considered in IR as important determinants of cardiometabolic risk...
  15. ncbi Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
    Koichiro Azuma
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 93:459-64. 2008
    ..We undertook a double-blinded, randomized-order, crossover study to examine the vildagliptin mechanisms of action on islet function and glucose utilization. Research..
  16. ncbi Hydroxychloroquine and glycemia in women with rheumatoid arthritis and systemic lupus erythematosus
    Sara Kaprove Penn
    Department of Medicine, Division of Rheumatology, University of Pittsburgh, School of Nursing, 440 Victoria Street, Room 453B, Pittsburgh, PA 15261, USA
    J Rheumatol 37:1136-42. 2010
    ....
  17. ncbi A role of apolipoprotein D in triglyceride metabolism
    German Perdomo
    Rangos Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    J Lipid Res 51:1298-311. 2010
    ..These data provide important clues to clinical observations that genetic variants of apoD are associated with abnormal lipid metabolism and increased risk of metabolic syndrome...
  18. ncbi Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial
    Mary T Korytkowski
    Department of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:594-6. 2009
    ..To compare two subcutaneous insulin strategies for glycemic management of hyperglycemia in non-critically ill hospitalized patients with diabetes during enteral nutrition therapy (ENT)...
  19. ncbi Alternative site testing at the earlobe tip: reliability of glucose measurements and pain perception
    Frederico G S Toledo
    Diabetes Care 27:616-7. 2004