Research Topics
| Edward L TobinickSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Rapid improvement of chronic stroke deficits after perispinal etanercept: three consecutive casesEdward Tobinick
Institute for Neurological Research, a private medical group, Inc, Los Angeles, California, USA
CNS Drugs 25:145-55. 2011..Perispinal administration of etanercept, previously reported to be beneficial for the treatment of Alzheimer's disease, may facilitate delivery of etanercept into the brain...- Deciphering the physiology underlying the rapid clinical effects of perispinal etanercept in Alzheimer's diseaseEdward Tobinick
100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095, USA
Curr Alzheimer Res 9:99-109. 2012..CSF-contacting cells may constitute a therapeutic target for a diverse group of brain, psychiatric and spinal disorders... - Perispinal etanercept: a new therapeutic paradigm in neurologyEdward Tobinick
David Geffen School of Medicine at UCLA, 100 UCLA Medical Plaza, Suites 205 210, Los Angeles, CA 90095, USA
Expert Rev Neurother 10:985-1002. 2010..The scientific rationale, physiologic mechanisms, clinical effects and potential clinical indications of this therapeutic approach are the subject of this article... - Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidenceEdward Tobinick
Institute for Neurological Research, Los Angeles, California 90095, USA
CNS Drugs 23:713-25. 2009..Perispinal etanercept for AD merits further study in randomized clinical trials... - The value of drug repositioning in the current pharmaceutical marketEdward L Tobinick
Medicine at the University of California, Los Angeles, CA, USA
Drug News Perspect 22:119-25. 2009..For these reasons, repurposing should be a primary strategy in drug discovery for every broadly focused, research-based pharmaceutical company... - Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imagingEdward L Tobinick
Institute for Neurological Research, a private medical group, Inc, 100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095 USA
BMC Res Notes 2:28. 2009..Further study of the effects of etanercept and TNF at the level of the choroid plexus may yield valuable insights into the pathogenesis of Alzheimer's disease... - Perispinal etanercept for neuroinflammatory disordersEdward Tobinick
Institute for Neurological Research, a private medical group, inc 100 UCLA Medical Plaza, Suites 205 210, Los Angeles, CA 90095, United States
Drug Discov Today 14:168-77. 2009.... - Perispinal etanercept produces rapid improvement in primary progressive aphasia: identification of a novel, rapidly reversible TNF-mediated pathophysiologic mechanismEdward Tobinick
University of California Los Angeles Institute for Neurological Research, Los Angeles, California, USA
Medscape J Med 10:135. 2008..Further study of this therapeutic method is indicated... - Rapid improvement in verbal fluency and aphasia following perispinal etanercept in Alzheimer's diseaseEdward L Tobinick
Institute for Neurological Research, a private medical group, Inc, Los Angeles, USA
BMC Neurol 8:27. 2008.... - Perispinal etanercept for treatment of Alzheimer's diseaseEdward Tobinick
100 UCLA Medical Plaza, Suites 205 210, Los Angeles, California 90095, USA
Curr Alzheimer Res 4:550-2. 2007.... - Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administrationEdward L Tobinick
Department of Medicine, Institute for Neurological Research, Los Angeles, USA
J Neuroinflammation 5:2. 2008.... - TNF-alpha modulation for treatment of Alzheimer's disease: a 6-month pilot studyEdward Tobinick
University of California, Los Angeles, California, USA
MedGenMed 8:25. 2006..Current pharmacologic treatments for Alzheimer's disease (AD) do not prevent long-term clinical deterioration. Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD... - Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patientsEdward Tobinick
Institute Research Associates, A Medical Group, Inc, Los Angeles, CA, USA
Curr Med Res Opin 20:1075-85. 2004..Documentation of the clinical results obtained utilizing perispinal etanercept off-label for treatment-refractory back and neck pain in a clinical practice setting... - Targeted etanercept for treatment-refractory pain due to bone metastasis: two case reportsEdward Lewis Tobinick
Institute for Neurological Research, Los Angeles, California 90095, USA
Clin Ther 25:2279-88. 2003..Additional studies have implicated TNF-alpha in the promotion of osteoclast-mediated malignant osteolysis and the pathogenesis of neuropathic pain. TNF-alpha antagonists have the potential to interfere in both processes... - Targeted etanercept for discogenic neck pain: uncontrolled, open-label results in two adultsEdward L Tobinick
Institute Research Associates, A Medical Group, Inc, Los Angeles, California 90095, USA
Clin Ther 25:1211-8. 2003..Directed local administration of etanercept, in anatomic proximity to the site of disc and neuronal abnormality, may result in an enhanced therapeutic response... - Perispinal TNF-alpha inhibition for discogenic painEdward L Tobinick
Institute for Neurological Research, Los Angeles, California, USA
Swiss Med Wkly 133:170-7. 2003..To examine the potential of etanercept, a biological inhibitor of tumour necrosis factor-alpha (TNF), delivered by perispinal administration, for the treatment of pain associated with intervertebral disc disease...