Research Topics
| J K TobacmanSummaryAffiliation: University of Iowa Country: USA Publications
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Publications
Consumption of carrageenan and other water-soluble polymers used as food additives and incidence of mammary carcinomaJ K Tobacman
College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1081, USA
Med Hypotheses 56:589-98. 2001..This analysis demonstrated that increasing consumption of several gums correlates positively with increased incidence of breast carcinoma...- Review of harmful gastrointestinal effects of carrageenan in animal experimentsJ K Tobacman
College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
Environ Health Perspect 109:983-94. 2001.... - Comparison of appropriateness ratings for cataract surgery between convened and mail-only multidisciplinary panelsJ K Tobacman
College of Medicine, University of Iowa, Iowa City, 52242 1081, USA
Med Decis Making 21:490-7. 2001..In this article, the authors determine the reproducibility of appropriateness ratings for cataract surgery between a multidisciplinary physician panel that convened and a multidisciplinary physician panel that completed ratings by mail... - Steroid sulfatase activity and expression in mammary myoepithelial cellsJoanne K Tobacman
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
J Steroid Biochem Mol Biol 81:65-8. 2002..This investigation examined mRNA expression and enzymatic activity of steroid sulfatase (STS) in human mammary myoepithelial cells (MMECs) and MCF-7 cells and assessed the effects of 17-beta estradiol on the activity of STS... - Implementation of personal health records by case managers in a VAMC general medicine clinicJoanne K Tobacman
College of Medicine, University of Iowa Health Care, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
Patient Educ Couns 54:27-33. 2004..At follow-up, significant differences occurred between the cohort with PHRs and the cohort without in their documentation of immunizations, allergies, medications, and operations... - Visual acuity following cataract surgeries in relation to preoperative appropriateness ratingsJoanne K Tobacman
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
Med Decis Making 23:122-30. 2003..0001, Fisher's exact test). These results provide evidence supporting the validity of the RAND-UCLA method to assess the appropriateness of surgery... - Does deficiency of arylsulfatase B have a role in cystic fibrosis?Joanne K Tobacman
Department of Internal Medicine, University of Iowa Health Care, Iowa City, IA 52242, USA
Chest 123:2130-9. 2003.... - Carrageenan-induced inclusions in mammary myoepithelial cellsJ K Tobacman
Department of Internal Medicine, University of Iowa, Iowa City 52242-1081, USA
Cancer Detect Prev 25:520-6. 2001..The observed changes appeared to lead to destruction of the MMEC by release of proteolytic enzymes from the distorted lysosomes, similar to the process observed in lysosomal storage diseases... - Utilization of a personal health record in a general medicine clinicJ K Tobacman
Department of Internal Medicine, University of Iowa, Iowa City 52242-1081, USA
J Gen Intern Med 11:370-2. 1996..065, 0.54). The baseline use of personal medical records was poor, but it was improved following introduction of the PHR, and most patients continued using the record 14 months later... - Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfatesSumit Bhattacharyya
Department of Medicine, University of Illinois, Chicago, IL 60612, USA
J Biol Chem 283:9523-30. 2008..These findings demonstrate that modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs... - Steroid sulfatase, arylsulfatases A and B, galactose-6-sulfatase, and iduronate sulfatase in mammary cells and effects of sulfated and non-sulfated estrogens on sulfatase activitySumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States Jesse Brown VAMC, Chicago, IL, United States
J Steroid Biochem Mol Biol 103:20-34. 2007..The study findings demonstrated marked variation in sulfatase activity and in effects of exogenous estrogens on sulfatase activity among the different mammary cell types... - Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cellsAlip Borthakur
Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois 60612, USA
Am J Physiol Gastrointest Liver Physiol 292:G829-38. 2007..Because of the high use of carrageenan as a food additive in the diet, the findings may have clinical significance... - Increased arylsulfatase B activity in cystic fibrosis cells following correction of CFTRSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago and Jesse Brown VAMC, Chicago, IL 60612, USA
Clin Chim Acta 380:122-7. 2007.... - Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytesSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago and Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA
Dig Dis Sci 52:2766-74. 2007..CGN may influence development of intestinal polyps in vivo by these mechanisms... - Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cellsSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Am J Physiol Gastrointest Liver Physiol 293:G429-37. 2007..Identification of Bcl10 as a mediator of LPS-induced activation of NF-kappaB and IL-8 in normal human IEC provides new insight into mechanisms of epithelial inflammation and new opportunities for therapeutic intervention... - Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cellsSumit Bhattacharyya
Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 283:10550-8. 2008..Because CGN is a commonly used food additive in the Western diet, clarification of its effects and mechanisms of action are vital to issues of food safety... - Carrageenan induces cell cycle arrest in human intestinal epithelial cells in vitroSumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA
J Nutr 138:469-75. 2008..These data document for the first time, to our knowledge, marked adverse effects of low concentrations of CGN on survival of normal human IEC and suggest that CGN exposure may have a role in development of human intestinal pathology... - Carrageenan-induced NFkappaB activation depends on distinct pathways mediated by reactive oxygen species and Hsp27 or by Bcl10Sumit Bhattacharyya
Department of Medicine, University of Illinois at Chicago, 840 SouthWood Street, M C 718 CSN 440, Chicago, IL 60612, USA
Biochim Biophys Acta 1780:973-82. 2008..Hence, the CGN-activated inflammatory cascades related to innate immunity and to generation of ROS may be integrated at the level of the IKK signalosome...