Research Topics
| Graham S TimminsSummaryAffiliation: University of Minnesota Country: USA Publications
| Collaborators
|
Detail Information
Publications
Mechanisms of action of isoniazidGraham S Timmins
College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Mol Microbiol 62:1220-7. 2006....- Requirements for nitric oxide generation from isoniazid activation in vitro and inhibition of mycobacterial respiration in vivoGraham S Timmins
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
J Bacteriol 186:5427-31. 2004..We also provide in vivo evidence that INH-derived NO* can inhibit key mycobacterial respiratory enzymes, which may contribute to the overall antimycobacterial action of INH... - Mycobacterium tuberculosis prevents inflammasome activationSharon S Master
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Cell Host Microbe 3:224-32. 2008..Thus, we uncovered a previously masked role for IL-1beta in the control of Mtb and a mycobacterial system that prevents inflammasome and, therefore, IL-1beta activation... - Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosaSimon R Wood
College of Pharmacy, Toxicology Program, Health Sciences Center, University of New Mexico, Albuquerque, NM 87131, USA
Free Radic Res 41:208-15. 2007..Our data suggest that the lowered levels of innate-immune nitrosative mediators (such as GSNO) in the CF lung exacerbate the effects of mucoid P. aeruginosa, by failing to suppress alginate biosynthesis... - Confinement-induced quorum sensing of individual Staphylococcus aureus bacteriaEric C Carnes
Department of Chemical and Nuclear Engineering, University of New Mexico, Albuquerque, New Mexico, USA
Nat Chem Biol 6:41-5. 2010..To demonstrate the benefit of confinement-induced quorum sensing to individuals, we showed that quorum-sensing bacteria have significantly greater viability over non-QS bacteria... - Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null miceAmie K Lund
College of Pharmacy, School of Medicine, University of New Mexico, Albuquerque, New Mexico 87131, USA
Toxicol Sci 88:265-73. 2005..In addition, the ET-1-mediated increase in ROS appears to be initiated via increased NAD(P)H oxidase activity... - Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosisJens F Poschet
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Am J Physiol Lung Cell Mol Physiol 293:L712-9. 2007..Our study suggests that phosphodiesterase 5 inhibition provides an opportunity for simultaneous and concerted correction of seemingly disparate complications in CF... - Nitric oxide generated from isoniazid activation by KatG: source of nitric oxide and activity against Mycobacterium tuberculosisGraham S Timmins
College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
Antimicrob Agents Chemother 48:3006-9. 2004..In conclusion, INH-derived NO* has biological activity, which directly contributes to the antimycobacterial action of INH... - Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: new role for the NADPH oxidase in host defenseJacob M Rothfork
Research Service, Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87108, USA
Proc Natl Acad Sci U S A 101:13867-72. 2004..Thus, oxidant-mediated inactivation of an autoinducing peptide from S. aureus is a critical innate defense mechanism against infection with this pathogen... - Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activityXu Jun Qin
Program of Toxicology, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
Toxicol Appl Pharmacol 232:41-50. 2008..Together, these findings show that arsenite at low concentration exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity, which may represent an important mechanism underlying the co-carcinogenicity of arsenic... - Direct visualization of mouse brain oxygen distribution by electron paramagnetic resonance imaging: application to focal cerebral ischemiaJiangang Shen
Center of Biomedical Research Excellence, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
J Cereb Blood Flow Metab 29:1695-703. 2009..We believe that this imaging method can be used for monitoring the effects of therapeutic intervention aimed at enhancing brain O(2) supply, which is crucial in minimizing brain injury after stroke... - Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infectionBarbara H Miller
Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0620, USA
Infect Immun 72:2872-8. 2004..certain microorganisms have the ability to prevent or reduce colocalization with iNOS; and (iv). spatial exclusion of iNOS may play a role in Mycobacterium tuberculosis pathogenesis...