Research Topics
| Phyllis C TienSummaryAffiliation: University of California Country: USA Publications
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Publications
Antiretroviral therapy exposure and incidence of diabetes mellitus in the Women's Interagency HIV StudyPhyllis C Tien
San Francisco Veterans Affairs Medical Center, Infectious Disease Section, Department of Medicine, University of California San Francisco, 111W 4150 Clement Street, San Francisco, CA 94121, USA
AIDS 21:1739-45. 2007..To determine the incidence of diabetes mellitus (DM) in a nationally representative cohort of HIV-infected women and a comparison group of HIV-uninfected women...- Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohortPhyllis C Tien
Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 55:316-22. 2010..To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk... - Antiretroviral therapies associated with lipoatrophy in HIV-infected womenPhyllis C Tien
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
AIDS Patient Care STDS 21:297-305. 2007..17, -0.26), and arm (-0.23 cm, 95% CI: -0.48, 0.03; p = 0.08). These prospective data suggest that fat loss continues to predominate in HIV-positive women and exposure to didanosine for at least 12 months may further worsen fat loss... - HIV, HAART, and lipoprotein particle concentrations in the Women's Interagency HIV StudyPhyllis C Tien
Department of Medicine, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, Infectious Disease Section, San Francisco, California 94121, USA
AIDS 24:2809-17. 2010..We quantified the association HIV and HAART use had with LDL-p and HDL-p... - Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and womenPhyllis C Tien
Department of Medicine, University of California San Francisco and Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 45:60-5. 2007..Coinfection with hepatitis C virus (HCV) is reported to be associated with a higher prevalence of lipodystrophy than HIV infection alone. We examine the association between HCV and adipose tissue volume in HIV-infected men and women... - Relation of stavudine discontinuation to anthropometric changes among HIV-infected womenPhyllis C Tien
Department of Medicine, University of California, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 44:43-8. 2007..To characterize changes in regional anthropometry associated with stavudine exposure and discontinuation... - Antiretroviral therapy exposure and insulin resistance in the Women's Interagency HIV studyPhyllis C Tien
Department of Medicine, University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 49:369-76. 2008.... - Association of hepatitis C virus and HIV infection with subclinical atherosclerosis in the women's interagency HIV studyPhyllis C Tien
Department of Medicine, University of California, San Francisco, CA 94121, USA
AIDS 23:1781-4. 2009..Further follow-up is needed to clarify whether HIV/hepatitis C virus coinfection may be associated with a greater risk of carotid plaque... - Regional adipose tissue and elevations in serum aminotransferases in HIV-infected individualsPhyllis C Tien
Department of Medicine, University of California, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 48:169-76. 2008..Obesity is associated with hepatic steatosis, and ALT is a marker of steatosis in the general population... - Adipose tissue and metabolic factors associated with steatosis in HIV/HCV coinfection: histology versus magnetic resonance spectroscopyAlireza Ghotb
Department of Medicine, California Pacific Medical Center, San Francisco, CA, USA
J Acquir Immune Defic Syndr 55:228-31. 2010..We compared magnetic resonance spectroscopy (MRS) measurement of steatosis to histology in HIV/HCV-coinfected patients and explored the associated adipose tissue and metabolic factors... - Association of HIV infection, demographic and cardiovascular risk factors with all-cause mortality in the recent HAART eraLeslie Cockerham
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 53:102-6. 2010..To determine the relationship of HIV infection, demographic, and cardiovascular disease (CVD) risk factors with mortality in the recent highly active antiretroviral therapy era... - Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infectionRebecca Scherzer
University of California, San Francisco, USA
AIDS 25:1405-14. 2011..Unintentional loss of weight and muscle due to aging and disease has been associated with increased mortality. Wasting and weight loss occur in HIV infection even in the modern era of effective antiretroviral therapy... - Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapyChristina M Wyatt
Department of Medicine, Division of Nephrology, Mount Sinai School of Medicine, New York, NY, USA
Antivir Ther 16:591-6. 2011..We previously reported an increased risk of all-cause and AIDS mortality among HIV-infected women with albuminuria (proteinuria or microalbuminuria) enrolled in the Women's Interagency HIV Study (WIHS) prior to the introduction of HAART... - Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophyCarl Grunfeld
Office of the Principal Investigator, The FRAM Study, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
AIDS 24:1717-26. 2010..controls. Therefore, we determined change in regional adipose tissue from baseline examination to 5 years later among participants in the study of Fat Redistribution and Metabolic Change in HIV Infection... - Illicit drug use and HIV treatment outcomes in a US cohortJoseph Cofrancesco
Johns Hopkins School of Medicine, Department of Medicine, Baltimore, Maryland, USA
AIDS 22:357-65. 2008..To determine the prevalence of illicit drug use and the impact on HIV treatment... - Association of low level viremia with inflammation and mortality in HIV-infected adultsAbigail Eastburn
University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e26320. 2011..Whether HIV viremia, particularly at low levels is associated with inflammation, increased coagulation, and all-cause mortality is unclear... - Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected personsANDY CHOI
University of California, San Francisco, CA, USA
Am J Kidney Dis 56:872-82. 2010..However, the clinical importance of increased cystatin C level and albuminuria in the HIV-infected population has not been studied... - Incidence of lipoatrophy and lipohypertrophy in the women's interagency HIV studyPhyllis C Tien
Department of Medicine, University of California at San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
J Acquir Immune Defic Syndr 34:461-6. 2003..To estimate the incidence of lipoatrophy and lipohypertrophy among HIV-infected and HIV-uninfected women from the Women's Interagency HIV Study... - Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infectionChristina M Wyatt
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
J Acquir Immune Defic Syndr 55:73-7. 2010..We investigated whether microalbuminuria is associated with mortality in HIV-infected women not receiving antiretroviral therapy... - The study of fat redistribution and metabolic change in HIV infection (FRAM): methods, design, and sample characteristicsPhyllis C Tien
Department of Medicine, School of Medicine, University of California San Francisco, San Francisco, CA, USA
Am J Epidemiol 163:860-9. 2006..The representativeness of the FRAM sample increases its value as a resource for studies on fat distribution, metabolic changes, and atherosclerosis in HIV infection... - Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progressionPeter Bacchetti
Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
BMC Infect Dis 7:145. 2007..We sought to examine the accuracy of such imputation and implications for modeling factors that influence progression rates... - Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women's Interagency HIV StudyAnn Khalsa
University of Southern California, Los Angeles, California, USA
AIDS 21:2539-41. 2007..0001), and body mass index greater than 30 kg/m (P < 0.0001), whereas current pregnancy was protective (P < 0.04). HIV infection, CD4 cell count, HIV-1 viral load, and antiretroviral therapy were not associated with hypertension... - Factors associated with seronegative chronic hepatitis C virus infection in HIV infectionGabriel Chamie
Department of Medicine, University of California, San Francisco, CA, USA
Clin Infect Dis 44:577-83. 2007..However, associated factors are not well established because of the small number of reported cases... - Age-related skeletal muscle decline is similar in HIV-infected and uninfected individualsKevin E Yarasheski
Department of Medicine, Washington University, St Louis, Missouri, USA
J Gerontol A Biol Sci Med Sci 66:332-40. 2011..We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls... - Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfectionAlexander Monto
Gastroenterology Section, Veterans Affairs Medical Center, University of California, 4150 Clement Street 111B, San Francisco, CA 94121, USA
Hepatology 42:310-6. 2005..In conclusion, steatosis is less common in HIV/HCV coinfected patients than similar HCV monoinfected patients, and predictors of steatosis differ between the two groups... - Association between syphilis, antibodies to herpes simplex virus type 2, and recreational drug use and hepatitis B virus infection in the Women's Interagency HIV StudyPhyllis C Tien
Department of Medicine, University of California, San Francisco, CA, USA
Clin Infect Dis 39:1363-70. 2004..Liver disease is a leading cause of death in human immunodeficiency virus (HIV)-infected women; however, risk factors for hepatitis b virus (hbv) infection in this population have not been well studied... - The impact of kidney function at highly active antiretroviral therapy initiation on mortality in HIV-infected womenMichelle M Estrella
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 55:217-20. 2010..We re-examined this association in the later HAART period to determine whether chronic kidney disease remains a predictor of death after HAART initiation... - Association of hepatitis C virus seropositivity with inflammatory markers and heart failure in persons with coronary heart disease: data from the Heart and Soul studyJudith I Tsui
Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine Boston Medical Center, Boston, MA 02118, USA
J Card Fail 15:451-6. 2009..How hepatitis C virus (HCV) affects coronary heart disease (CHD) risk factors and outcomes is largely unknown... - Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM studyCarl Grunfeld
Medical Service, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
AIDS 23:1841-9. 2009..However, it is controversial whether HIV infection contributes to accelerated atherosclerosis independent of traditional CVD risk factors... - Regional adipose tissue and lipid and lipoprotein levels in HIV-infected womenJudith Currier
Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
J Acquir Immune Defic Syndr 48:35-43. 2008..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described... - Vitamin D deficiency in HIV-infected and HIV-uninfected women in the United StatesOluwatoyin M Adeyemi
Department of Medicine, CORE Center, Cook County Hospital, Chicago, IL, USA
J Acquir Immune Defic Syndr 57:197-204. 2011.... - Assessing mortality in women with hepatitis C virus and HIV using indirect markers of fibrosisKiran Bambha
University of California San Francisco, San Francisco, California 94143 0538, USA
AIDS 26:599-607. 2012.... - Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniquesMamak Eatesam
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143 0628, USA
J Magn Reson Imaging 35:103-9. 2012..To compare liver ADC obtained with breathhold and free-breathing diffusion weighted imaging (DWI) in healthy volunteers and patients with liver disease... - What is HIV-associated lipodystrophy? Defining fat distribution changes in HIV infectionPhyllis C Tien
Department of Medicine, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
Curr Opin Infect Dis 17:27-32. 2004.... - Prevalence and long-term effects of occult hepatitis B virus infection in HIV-infected womenJudith I Tsui
Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Clin Infect Dis 45:736-40. 2007..CD4 cell counts of <200 cells/mm3 were more common among occult HBV-infected women than among those without occult HBV infection. Aminotransferase levels did not appear to be associated with being positive for HBV DNA... - Self-perception of body fat changes and HAART adherence in the Women's Interagency HIV StudyMichael Plankey
Department of Medicine, Division of Infectious Diseases, Georgetown University Medical Center, 2233 Wisconsin Avenue, NW Suite 214, Washington, DC, 20007, USA
AIDS Behav 13:53-9. 2009.... - Liver steatosis: investigation of opposed-phase T1-weighted liver MR signal intensity loss and visceral fat measurement as biomarkersManisha Bahl
Department of Radiology, University of California, San Francisco, Box 0628, L 307, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
Radiology 249:160-6. 2008.... - Respiratory motion-corrected proton magnetic resonance spectroscopy of the liverSusan M Noworolski
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
Magn Reson Imaging 27:570-6. 2009..To develop a post-processing, respiratory-motion correction algorithm for magnetic resonance spectroscopy (MRS) of the liver and to determine the incidence and impact of respiratory motion in liver MRS... - Conceptual framework for understanding the bidirectional links between food insecurity and HIV/AIDSSheri D Weiser
Division of HIV AIDS and the Center for AIDS Prevention Studies, University of California, San Francisco, San Francisco, CA Robert Wood Johnson Health and Society Scholars Program, Harvard University, Cambridge, MA
Am J Clin Nutr 94:1729S-39S. 2011..More research on the relative importance of each of these pathways is warranted because effective interventions to reduce food insecurity and HIV depend on a rigorous understanding of these multifaceted relationships... - Short-term bone loss in HIV-infected premenopausal womenMichael T Yin
Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA
J Acquir Immune Defic Syndr 53:202-8. 2010..Low bone mineral density (BMD) has been reported in HIV+ women, but less is known about the longitudinal evolution of BMD and fracture incidence... - Clinical presentation and course of acute hepatitis C infection in HIV-infected patientsAnnie Luetkemeyer
HIV AIDS Division, San Francisco General Hospital, University of California at San Francisco, CA 94110, USA
J Acquir Immune Defic Syndr 41:31-6. 2006..Unexplained transaminase elevations in HIV-infected patients, including men who have sex with men, should trigger an evaluation for acute HCV infection... - Regional anthropometry changes in antiretroviral-naïve persons initiating a Zidovudine-containing regimen in Mbarara, UgandaVanessa Thompson
Department of Medicine, University of California, San Francisco, 94121, USA
AIDS Res Hum Retroviruses 27:785-91. 2011..Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery... - The fatty liver in AIDSPhyllis C Tien
Metabolism Section, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Semin Gastrointest Dis 13:47-54. 2002..The conditions under which some patients rapidly progress to hepatic failure and/or cirrhosis need to be defined. This is a US government work. There are no restrictions on its use... - Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US womenAudrey L French
CORE Center Stroger Cook County Hospital, Rush Medical College, Chicago, IL 60612, USA
J Infect Dis 195:1437-42. 2007..Anti-HBs levels were lower among anti-HCV-positive women. Isolated anti-HBc was rarely explained by occult HBV in this cohort but may be explained by the influence of viral coinfections on anti-HBs level or durability... - Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and menRobert C Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
AIDS 22:1615-24. 2008..To assess the association of HIV infection, HIV disease parameters (including CD4+ T-cell counts, HIV viral load, and AIDS) and antiretroviral medication use with subclinical carotid artery atherosclerosis... - Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimensKathryn Anastos
Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA
J Acquir Immune Defic Syndr 45:34-42. 2007..The effects of HIV infection, highly active antiretroviral therapy (HAART), and specific antiretroviral agents on lipoproteins in women are not well described... - Antiretroviral drugs and the risk of myocardial infarctionRobert C Kaplan
N Engl J Med 357:715; author reply 716-7. 2007 - Ten-year predicted coronary heart disease risk in HIV-infected men and womenRobert C Kaplan
Department of Epidemiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Clin Infect Dis 45:1074-81. 2007..Highly active antiretroviral therapy (HAART), in addition to traditional vascular risk factors, may affect coronary heart disease (CHD) risk in individuals with human immunodeficiency virus (HIV) infection... - The association of bone mineral density with HIV infection and antiretroviral treatment in womenKathryn Anastos
Montefiore Medical Centre, Bronx, NY, USA
Antivir Ther 12:1049-58. 2007..Low bone mineral density (BMD) has been reported in HIV-infected women and men... - Resolution of hepatitis C virus-induced steatosis improves tolerability of antiretroviral drugs associated with hepatotoxicity in an HIV-infected individualTina Shah
J Infect Dis 197:932-3. 2008 - Longitudinal anthropometric patterns among HIV-infected and HIV-uninfected womenJessica E Justman
Department of Epidemiology, Columbia University, New York, NY 10032, USA
J Acquir Immune Defic Syndr 47:312-9. 2008..Previous studies suggest that indicators of central adiposity such as waist-to-hip ratio (WHR) and waist circumference may be altered by HIV infection, antiretroviral treatment, or both... - Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected womenEva A Operskalski
Maternal Child and Adolescent Center for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
J Clin Virol 41:255-63. 2008..Co-infection with hepatitis C virus (HCV) is common among HIV-infected women... - Obesity and immune cell counts in womenJulie Womack
Yale University School of Nursing, New Haven, CT 06536 0740, USA
Metabolism 56:998-1004. 2007..Increasing body weight is associated with higher CD4, CD8, total lymphocyte, and WBC counts in women. Investigation into the impact of obesity on immune function and long-term adverse outcomes is needed... - Prevalence and predictors of Toxoplasma seropositivity in women with and at risk for human immunodeficiency virus infectionOluwatoyin Falusi
Cook County Hospital and Rush Medical College, Chicago, IL 60612, USA
Clin Infect Dis 35:1414-7. 2002..HIV-infected women aged > or =50 years and those born outside of the United States were more likely to have latent Toxoplasma infection, with prevalences of 32% and 41%, respectively... - Hormonal contraception and HIV-positive women: metabolic concerns and management strategiesJulie Womack
Yale University School of Nursing, 100 Church St South, PO Box 9740, New Haven, CT 06536 0740, USA
J Midwifery Womens Health 53:362-75. 2008..Suggestions for management strategies for women living with HIV who choose to use hormonal contraception are presented. These strategies should be viewed as suggestions for management until substantitive research becomes available...
Research Grants
- Gender Effects of HIV and HCV on lipodystrophy, glucose disorders, and steatosisPhyllis Tien; Fiscal Year: 2007..abstract_text> ..
- Visceral Adiposity, HIV, and HCV: Biologic Mediators of Hepatic SteatosisPhyllis C Tien; Fiscal Year: 2010..abstract_text> ..