Ryan Tewhey

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Enrichment of sequencing targets from the human genome by solution hybridization
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, 3344 N Torrey Pines Court, La Jolla, CA 92037, USA
    Genome Biol 10:R116. 2009
  2. ncbi Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
  3. ncbi Efficient and cost effective population resequencing by pooling and in-solution hybridization
    Vikas Bansal
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS ONE 6:e18353. 2011
  4. ncbi Accurate detection and genotyping of SNPs utilizing population sequencing data
    Vikas Bansal
    Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genome Res 20:537-45. 2010
  5. ncbi The importance of phase information for human genomics
    Ryan Tewhey
    The Scripps Translational Science Institute, 3344 North Torrey Pines Road, Suite 300, La Jolla, California 92037, USA
    Nat Rev Genet 12:215-23. 2011
  6. ncbi Microdroplet-based PCR enrichment for large-scale targeted sequencing
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California, USA
    Nat Biotechnol 27:1025-31. 2009

Collaborators

Detail Information

Publications6

  1. ncbi Enrichment of sequencing targets from the human genome by solution hybridization
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, 3344 N Torrey Pines Court, La Jolla, CA 92037, USA
    Genome Biol 10:R116. 2009
    ..9 Mb of sequence target. We demonstrate that the tiling probe frequency is important for generating sequence data with high uniform coverage of targets. We obtained 93% sensitivity to detect SNPs, with a calling accuracy greater than 99%...
  2. ncbi Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates
    Bernice Meng Qi Sim
    Genome Institute of Singapore, 60 Biopolis Street, 138672 Singapore
    Genome Biol 11:R89. 2010
    ..To study B. thailandensis genomic variation, we profiled 50 isolates using a pan-genome microarray comprising genomic elements from 28 Burkholderia strains and species...
  3. ncbi Efficient and cost effective population resequencing by pooling and in-solution hybridization
    Vikas Bansal
    Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America
    PLoS ONE 6:e18353. 2011
    ..6% of variants below 5% in frequency. Finally, allele frequencies for single nucleotide variants (SNVs) estimated from the pooled data and the HapMap genotype data were tightly correlated (correlation coefficient >? =? 0.995)...
  4. ncbi Accurate detection and genotyping of SNPs utilizing population sequencing data
    Vikas Bansal
    Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA 92037, USA
    Genome Res 20:537-45. 2010
    ..Collectively, these results suggest that analysis of population sequencing data is a powerful approach for the accurate detection of SNPs and the assignment of genotypes to individual samples...
  5. ncbi The importance of phase information for human genomics
    Ryan Tewhey
    The Scripps Translational Science Institute, 3344 North Torrey Pines Road, Suite 300, La Jolla, California 92037, USA
    Nat Rev Genet 12:215-23. 2011
    ..Thus, the existing technological impediments to obtaining phase information must be overcome if human genomics is to reach its full potential...
  6. ncbi Microdroplet-based PCR enrichment for large-scale targeted sequencing
    Ryan Tewhey
    Scripps Genomic Medicine, Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, California, USA
    Nat Biotechnol 27:1025-31. 2009
    ..Our results demonstrate that microdroplet technology is well suited for processing DNA for massively parallel enrichment of specific subsets of the human genome for targeted sequencing...