Research Topics
| Daniel TeitelbaumSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
A decade of experience with the primary pull-through for hirschsprung disease in the newborn period: a multicenter analysis of outcomesD H Teitelbaum
Department of Surgery, Section of Pediatric Surgery, the University of Michigan Medical Center and the C S Mott Children s Hospital, Ann Arbor, Michigan 48109, USA
Ann Surg 232:372-80. 2000..To determine whether use of a primary pull-through would result in equivalent perioperative and long-term complications compared with the two-stage approach...- Primary pull-through for Hirschsprung's diseaseDaniel H Teitelbaum
Section of Pediatric Surgery, F 3970, C S Mott Children s Hospital, University of Michigan Medical School, P O Box 0245, Ann Arbor, MI 48109, USA
Semin Neonatol 8:233-41. 2003..The purpose of this review is to discuss the technique of primary pull-through, the peri-operative management and a summary of clinical results... - Epidermal growth factor/TNF-? transactivation modulates epithelial cell proliferation and apoptosis in a mouse model of parenteral nutritionYongjia Feng
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, Michigan MI 48109 5245, USA
Am J Physiol Gastrointest Liver Physiol 302:G236-49. 2012..It emphasizes the importance of both TNFR1 and TNFR2 pathways, as well as the strong interdependence on an intact EGF/ErbB1 pathway... - Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasisDaniel H Teitelbaum
Department of Surgery, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109 0245, USA
Pediatrics 115:1332-40. 2005..To determine whether cholecystokinin-octapeptide (CCK-OP) would prevent or ameliorate parenteral nutrition-associated cholestasis (PNAC) among high-risk neonates treated with total parenteral nutrition... - Prevention of parenteral nutrition-associated liver disease: lipid minimizationM Petrea Cober
Department of Pharmacy, University of Michigan Hospitals and Health Centers, and CS Mott Children s Hospital, Ann Arbor, Michigan, USA
Curr Opin Organ Transplant 15:330-3. 2010..The cause of parenteral nutrition-associated liver disease (PNALD) is unknown. Evidence over the past decade has suggested soybean oil-based intravenous emulsions are a contributing factor to the development of PNALD... - Risk stratification in gastroschisis: can prenatal evaluation or early postnatal factors predict outcome?Ryan P Davis
Section of Pediatric Surgery, Department of Surgery, University of Michigan Hospitals, Mott Children s Hospital F3970, Box 0245, Ann Arbor, MI 48109, USA
Pediatr Surg Int 25:319-25. 2009..We evaluated the prognostic value of prenatal ultrasonographic parameters and early postnatal factors in predicting clinical outcomes... - Excision of large cystic ovarian tumors: combining minimal invasive surgery techniques and cancer surgery--the best of both worldsPeter F Ehrlich
Department of Pediatric Surgery, University of Michigan Medical School, C S Mott Children s Hospital Box 0231, Ann Arbor, MI 48109, USA
J Pediatr Surg 42:890-3. 2007..Up to 57% of malignant ovarian tumors have a cystic component. We present an approach to these neoplasms that adheres to oncologic principles using minimally invasive techniques... - Parenteral nutrition-associated cholestasis in neonates: multivariate analysis of the potential protective effect of taurineAriel U Spencer
Department of Surgery, University of Michigan, and C.S. Mott Children's Hospital, Ann Arbor, MI 48109, USA
JPEN J Parenter Enteral Nutr 29:337-43; discussion 343-4. 2005..Patients with NEC or severe prematurity are most likely to benefit substantially from taurine supplementation... - Failure of cholecystokinin-octapeptide to prevent TPN-associated gallstone diseaseSusan Tsai
Section of Pediatric Surgery, CS Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Pediatr Surg 40:263-7. 2005..In addition, the use of ursodeoxycholic acid did not dissolve gallstones, once identified. Future methods will be needed to address the prevention and treatment of these stones... - Alteration of canalicular transporters in a mouse model of total parenteral nutritionYuko Tazuke
Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
J Pediatr Gastroenterol Nutr 48:193-202. 2009..The present study hypothesized that these changes would lead to functional changes in the liver, and would contribute to the development of liver dysfunction... - Hepatic P-glycoprotein changes with total parenteral nutrition administrationYuko Tazuke
University of Michigan Medical School, Section of Pediatric Surgery, Department of Surgery, F3970 Mott Children's Hospital, Ann Arbor, Michigan 48109-0245, USA
JPEN J Parenter Enteral Nutr 28:1-6. 2004..This suggests that alterations in mdr gene expression may be a causative factor in the development of PNALD... - Pediatric short bowel syndrome: redefining predictors of successAriel U Spencer
Departments of Surgery, University of Michigan, C. S. Mott Children's Hospital, Ann Arbor, MI 48109, USA
Ann Surg 242:403-9; discussion 409-12. 2005..Age-adjusted small bowel length and ICV are the major predictors of weaning from PN. These data permit better prediction of outcomes of pediatric SBS, which may help to direct future management of these challenging patients... - Association of gastroschisis and choledochal cystJulia Serber
Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Pediatr Surg 44:e23-6. 2009..The cases are a novel association not previously reported and should heighten the awareness that anatomical causes of a direct hyperbilirubinemia need to be ruled out in all neonates... - The Kasai portoenterostomy for biliary atresia: A review of a 27-year experience with 81 patientsBarbara E Wildhaber
Department of Surgery, Section of Pediatric Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA
J Pediatr Surg 38:1480-5. 2003..Bridging liver fibrosis at the time of the Kasai, and the increased number of postoperative cholangitic episodes were predictive of a poor PE outcome... - Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutritionXiaoyi Sun
Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 0245, USA
Am J Physiol Gastrointest Liver Physiol 294:G139-47. 2008..As the decline was partially attenuated with the administration of exogenous IL-10, our findings suggest that loss of IL-10 may be a contributing mechanism to TPN-associated epithelial barrier loss... - Imaging of total colonic Hirschsprung diseaseEnno Stranzinger
Section of Pediatric Radiology, University of Michigan Health System, Ann Arbor, MI 48109 0252, USA
Pediatr Radiol 38:1162-70. 2008..The diagnosis of total colonic HD (TCHD) based on contrast enemas is difficult in newborns because radiological findings vary... - Intestinal specific overexpression of interleukin-7 attenuates the alternation of intestinal intraepithelial lymphocytes after total parenteral nutrition administrationHua Yang
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Ann Surg 248:849-56. 2008..Previous work shows that TPN results in a loss of intestinal epithelial cell-derived interleukin-7 (IL-7), and this loss may play an important role in development of such TPN-associated IEL changes... - Pediatric short-bowel syndrome: the cost of comprehensive careAriel U Spencer
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Am J Clin Nutr 88:1552-9. 2008..Little information is available about the financial charges incurred by patients with short-bowel syndrome (SBS). This is particularly true for pediatric SBS patients who receive some of the most complex medical care... - Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophyYongjia Feng
Section of Pediatric Surgery, University of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
J Physiol 587:641-54. 2009..This potential pathway may well explain many of the findings of mucosal atrophy associated with TPN... - 2002 Harry M. Vars Research Award. Keratinocyte growth factor stimulates the recovery of epithelial structure and function in a mouse model of total parenteral nutritionHua Yang
Department of Surgery, University of Michigan Medical School, C. S. Mott Children's Hospital, Ann Arbor, USA
JPEN J Parenter Enteral Nutr 26:333-40; discussion 340-1. 2002..Additionally, KGF up-regulated epithelial KGF receptor expression. It is possible that KGF may have a therapeutic efficacy in patients who are receiving TPN... - Stooling and manometric findings after primary pull-throughs in Hirschsprung's disease: Perineal versus abdominal approachesKathleen Van Leeuwen
Section of Pediatric Surgery, Division of Gastroenterology, Department of Surgery, The University of Michigan Medical Center, Ann Arbor, MI, USA
J Pediatr Surg 37:1321-5. 2002..Evaluation of early stooling frequency shows a comparable frequency after a PA. This suggests that both methods are safe, and the PA does not appear to compromise sphincter integrity... - Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutritionHua Yang
Section of Pediatric Surgery, The University of Michigan Medical School and C. S. Mott Children's Hospital, Ann Arbor, Michigan, USA
Ann Surg 236:226-34. 2002..The partial correction with IFN-gamma knockout mice suggests that an upregulation of IFN-gamma expression is one mechanism responsible for the loss of the epithelial barrier associated with TPN... - The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutritionChaojun Zhang
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C S Mott Children s Hospital, Ann Arbor, MI 48109, USA
J Nutr 139:1315-21. 2009..The results suggest that the BMP signaling pathway may be involved in the development of intestinal mucosal atrophy due to TPN administration... - Enteral versus parenteral nutrition: effect on intestinal barrier functionHua Yang
Department of Surgery, The University of Michigan Medical School, Ann Arbor, Michigan, USA
Ann N Y Acad Sci 1165:338-46. 2009..This article discusses the potential mechanisms responsible for these changes, and potential strategies to alleviate this loss in EBF... - Outcomes in pediatric patients undergoing straight vs J pouch ileoanal anastomosis: a multicenter analysisRupa Seetharamaiah
Section of Pediatric Surgery, C S Mott Children s Hospital, University of Michigan Health System, Ann Arbor, MI 48109, USA
J Pediatr Surg 44:1410-7. 2009..Our 3 centers have had extensive experience with both techniques. Thus, we had the unique opportunity to compare outcomes within the same centers... - Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via Bcl-2Barbara E Wildhaber
University of Michigan, Department of Pediatric Surgery, C S Mott Children s Hospital, Ann Arbor, MI, USA
J Pediatr Surg 38:92-6; discussion 92-6. 2003..This study aims to determine if mRNA expression of Bcl-2 proteins (major mediators of epithelial cell apoptosis) is altered with TPN, and if KGF-administration influences Bcl-2 family expression... - Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophyYongjia Feng
Section of Pediatric Surgery, Univ of Michigan, Mott Children s Hospital F3970, Ann Arbor, MI 48109 5245, USA
Am J Physiol Gastrointest Liver Physiol 298:G833-41. 2010.... - Total parenteral nutrition-associated changes in mouse intestinal intraepithelial lymphocytesIrfan Kiristioglu
Department of Surgery, University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor 48109, USA
Dig Dis Sci 47:1147-57. 2002..Functionally, the IEL showed a significant decline in proliferation. Such changes demonstrate the important role luminal nutrients have on IEL phenotype and function... - Endorectal pull-through for Hirschsprung's disease-a multicenter, long-term comparison of results: transanal vs transabdominal approachAnne C Kim
Department of Surgery, Section of Pediatric Surgery, University of Michigan, Ann Arbor, Michigan 48109 0245, USA
J Pediatr Surg 45:1213-20. 2010..To address this, we examined long-term stooling outcomes in a large, multicenter cohort of patients undergoing either TERP or TAA... - The adolescent child with short bowel syndrome: new onset of failure to thrive and need for increased nutritional supplementationEiichi A Miyasaka
Section of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0245, USA
J Pediatr Surg 45:1280-6. 2010..This study aims to identify characteristics of adolescent SBS patients to better understand their nutritional status... - No free ride? The hidden costs of delayed operative management using a spring-loaded silo for gastroschisisJennifer D Lobo
Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The C S Mott Children s Hospital, Box 0245, Ann Arbor, MI 48109, USA
J Pediatr Surg 45:1426-32. 2010..Despite the ease of silo placement, anecdotal experience shows that silos do not always offer benefit. The aim of this study was to highlight concerns regarding use of spring loaded silos and compare outcomes to primary closure... - Multiple sequential intussusceptions causing bowel obstruction in a preterm neonateKristine D Slam
Department of Surgery, University of Toledo, Health Science Campus, Toledo, Ohio, USA
J Pediatr Surg 42:1279-81. 2007..1955;47:87-94; Pediatr Surg Int. 1998;13:232-236; Ann Saudi Med. 2000; 20:310-312; Eur J Pediatr. 1999;158:830-832; J Paedatr Child Health. 2004;40:388-391; Radiology. 1977;125:463-466; J Perinat Med. 2004;32:190-194)... - Posterior myotomy/myectomy for persistent stooling problems in Hirschsprung's diseaseBarbara E Wildhaber
Section of Pediatric Surgery, C.S Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI, USA
J Pediatr Surg 39:920-6; discussion 920-6. 2004..Because of the unsuccessful outcome with POMM in patients with a combination of constipation and aganglionosis, one should defer to a redo-PT in this group... - The 2 STEP: an approach to repeating a serial transverse enteroplastyPeter F Ehrlich
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Pediatr Surg 42:819-22. 2007..However, postlengthening dilatation may occur, which can lead to bacterial overgrowth and malabsorption. We addressed this problem by reperforming the STEP in 2 patients... - Early experience with minimally invasive repair of congenital diaphragmatic hernias: results and lessons learnedMarjorie J Arca
Department of Surgery, University of Michigan Medical School and the C.S. Mott Children's Hospital, Ann Arbor, MI 53226, USA
J Pediatr Surg 38:1563-8. 2003..It should be considered for nonnewborns with a Bochdalek CDH. The MIS approach for a newborn with a CDH cannot be recommended because of the high failure rate and frequent rise in PCO2 levels... - Total parenteral nutrition-induced apoptosis in mouse intestinal epithelium: modulation by keratinocyte growth factorBarbara E Wildhaber
Section of Pediatric Surgery, C.S. Mott Children's Hospital, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
J Surg Res 112:144-51. 2003..47 +/- 0.19. CONCLUSIONS: TPN-induced apoptosis was associated with decreased Bcl-2 mRNA expression. rHuKGF decreased TPN-induced EC apoptosis and increased Bcl-2 expression. rHuKGF administration may have benefit in patients on TPN... - Esophagogastric separation for failed fundoplication in neurologically impaired childrenSaleem Islam
Section of Pediatric Surgery, CS Mott Children's Hospital, University of Michigan Health System, Ann Arbor, MI 48109-0245, USA
J Pediatr Surg 39:287-91; discussion 287-91. 2004..All 9 currently surviving children are tolerating bolus gastrostomy feedings, which was an advantage to the parents. CONCLUSIONS: EGS is an attractive alternative for failed fundoplication in severely neurologically impaired children... - Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouseHua Yang
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 172:4151-8. 2004..These results show that KGF from IELs is an important factor for maintenance of intestinal epithelial cell proliferation and villus growth... - Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)Yuko Tazuke
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School, F3970 Mott Children's Hospital, Ann Arbor, MI 48109-0245, USA
Pediatr Surg Int 20:224-8. 2004..05). These changes may contribute to TPN-induced hepatocyte injury (apoptosis) or suppress the ability of liver hepatocytes to regenerate... - Gene alteration of intestinal intraepithelial lymphocytes with administration of total parenteral nutritionBarbara E Wildhaber
Section of Pediatric Surgery, Department of Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA
J Pediatr Surg 38:840-3. 2003..CONCLUSIONS: The observed alterations in IEL gene expression may have an important role in the altered immune response with TPN and may relate to the increase in sepsis with TPN administration... - Lack of enteral nutrition--effects on the intestinal immune systemBarbara E Wildhaber
Section of Pediatric Surgery, C. S. Mott Children's Hospital, University of Michigan Health System, Ann Arbor, Michigan 48109-0245, USA
J Surg Res 123:8-16. 2005..CONCLUSIONS: This study demonstrates that the major factor responsible for TPN-induced BT and IEL-changes is the lack of enteral feeding and not the administration of the TPN solution itself... - Reoperative surgery for Hirschsprung's diseaseDaniel H Teitelbaum
Section of Pediatric Surgery F3970, Department of Surgery, C.S. Mott Children's Hospital, Box 0245, University of Michigan, Ann Arbor, MI 48109, USA
Semin Pediatr Surg 12:124-31. 2003..This article reviews the workup, indications, and techniques for these procedures and discusses previously published, as well as the authors' outcome, with these 2 procedures... - Total colonic Hirschsprung's disease: a 28-year experienceBarbara E Wildhaber
Section of Pediatric Surgery, CS Mott Children's Hospital, University of Michigan Medical School, Health System, Ann Arbor, MI 48109-0245, USA
J Pediatr Surg 40:203-6; discussion 206-7. 2005..04). CONCLUSIONS: Surgical treatment of TCH is associated with a number of complications including recurrent enterocolitis and anal strictures. Long-term outcome is quite favorable... - Total parenteral nutrition leads to alteration of hepatocyte cell cycle gene expression and proliferation in the mouseYuko Tazuke
Section of Pediatric Surgery, C S Mott Children s Hospital, Department of Surgery, University of Michigan Medical School, F3970 Mott Children s Hospital, Box 0245, Ann Arbor, MI 48109, USA
Dig Dis Sci 52:920-30. 2007..This study demonstrates significant alterations in cell cycle gene expression with TPN. The findings correlate with a loss of hepatocyte proliferation and may give insight into the potential mechanism of TPN-induced hepatocyte injury... - Intestinal epithelial cell-derived interleukin-7: A mechanism for the alteration of intraepithelial lymphocytes in a mouse model of total parenteral nutritionHua Yang
Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and The C S Mott Children s Hospital, Ann Arbor, Michigan, USA
Am J Physiol Gastrointest Liver Physiol 292:G84-91. 2007..These findings suggest that a decrease in EC-derived IL-7 expression may be a contributing mechanism to account for the observed TPN-associated IEL changes... - Are the long-term results of the transanal pull-through equal to those of the transabdominal pull-through? A comparison of the 2 approaches for Hirschsprung diseaseMohamed I El Sawaf
Section of Pediatric Surgery, The C S Mott s Children s Hospital, University of Michigan, Ann Arbor, MI 48109 0245, USA
J Pediatr Surg 42:41-7; discussion 47. 2007..This study examined the long-term outcome of TERPT versus conventional transabdominal (ABD) pull-through for HD... - Impact of caloric intake on parenteral nutrition-associated intestinal morphology and mucosal barrier functionXiaoyi Sun
Department of Surgery, Section of Pediatric Surgery, University of Michigan, Mott Children's Hospital, Ann Arbor, Michigan 48109, USA
JPEN J Parenter Enteral Nutr 30:474-9. 2006..The study also allows the investigators to better optimize a mouse model of PN delivery... - Intraepithelial lymphocyte-derived interferon-gamma evokes enterocyte apoptosis with parenteral nutrition in miceHua Yang
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C. S. Mott Children's Hospital, Ann Arbor, Michigan 48109, USA
Am J Physiol Gastrointest Liver Physiol 284:G629-37. 2003..This may well be one of the mediators of increased EC apoptosis observed with TPN administration... - MUC-2 mucin production in Hirschsprung's disease: possible association with enterocolitis developmentAladdein F Mattar
Section of Pediatric Surgery, Department of Surgery, The University of Michigan Medical School and C.S. Mott Children's Hospital, Ann Arbor, Michigan 48109, USA
J Pediatr Surg 38:417-21; discussion 417-21. 2003..This decline in protein expression may result in a decrease in epithelial barrier function and be a predisposing factor in the development of HAEC... - Alteration in epithelial permeability and ion transport in a mouse model of total parenteral nutritionHua Yang
Section of Pediatric Surgery, University of Michigan Hospitals, Mott F3970, Box 0245, Ann Arbor, MI 48109, USA
Crit Care Med 31:1118-25. 2003..Interferon-gamma appears to play an important role in the loss of the epithelial barrier function that is associated with total parenteral nutrition... - Glutamine prevents total parenteral nutrition-associated changes to intraepithelial lymphocyte phenotype and function: a potential mechanism for the preservation of epithelial barrier functionKeisuke Nose
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and the C S Mott Children s Hospital, Ann Arbor, Michigan 48109 0245, USA
J Interferon Cytokine Res 30:67-80. 2010..Glutamine-supplemented TPN leads to a specific IEL-derived cytokine profile, which may account for the preservation of EBF; and such action may be due to a direct action of glutamine on the IEL... - One-stage transanal Soave pullthrough for Hirschsprung disease: a multicenter experience with 141 childrenJacob C Langer
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Ann Surg 238:569-83; discussion 583-5. 2003..We reviewed the early results of the transanal Soave pullthrough from 6 of the original centers to use it...
Research Grants
- TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTESDaniel Teitelbaum; Fiscal Year: 2007..This may lead to methods to prevent such problems. ..
- Enterogenesis with the Use of an Implanted Mechanotransduction DeviceDaniel Teitelbaum; Fiscal Year: 2007..Knowledge gained from this project could greatly improve the care of patients who suffer from short bowel syndrome. ..
- TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTESDaniel H Teitelbaum; Fiscal Year: 2010....