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| Donald TashkinSummaryAffiliation: University of California Country: USA Publications
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Publications
Efficacy and safety of a fixed-dose combination of mometasone furoate and formoterol fumarate in subjects with moderate to very severe COPD: results from a 52-week Phase III trialDonald P Tashkin
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Int J Chron Obstruct Pulmon Dis 7:43-55. 2012....- Efficacy and safety characteristics of mometasone furoate/formoterol fumarate fixed-dose combination in subjects with moderate to very severe COPD: findings from pooled analysis of two randomized, 52-week placebo-controlled trialsDonald P Tashkin
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Int J Chron Obstruct Pulmon Dis 7:73-86. 2012.... - Adverse health consequences in COPD patients with rapid decline in FEV1 - evidence from the UPLIFT trialSteven Kesten
Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, USA
Respir Res 12:129. 2011..The rate of decline in forced expiratory volume in 1 second (FEV1) is representative of the natural history of COPD. Sparse information exists regarding the associations between the magnitude of annualised loss of FEV1 with other endpoints... - Acute bronchodilator responsiveness and health outcomes in COPD patients in the UPLIFT trialNicola A Hanania
Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
Respir Res 12:6. 2011..Debate continues as to whether acute bronchodilator responsiveness (BDR) predicts long-term outcomes in COPD. Furthermore, there is no consensus on a threshold for BDR... - Long-term efficacy of tiotropium in relation to smoking status in the UPLIFT trialD P Tashkin
Dept of Medicine, David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
Eur Respir J 35:287-94. 2010..63 units, p = 0.0006) and the least in IS (-0.60 units, p = 0.51), [corrected] compared with control. Tiotropium provided long-term benefits irrespective of smoking status, although differences among categories were observed... - Nebulized formoterol provides added benefits to tiotropium treatment in chronic obstructive pulmonary diseaseDonald P Tashkin
David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Adv Ther 26:1024-34. 2009..This analysis pooled the results of two double-blind studies evaluating the efficacy and safety of adding nebulized formoterol fumarate inhalation solution (FFIS) to maintenance tiotropium (TIO) treatment... - Evidence implicating cocaine as a possible risk factor for HIV infectionDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
J Neuroimmunol 147:26-7. 2004..The huPBL SCID mouse and SCID-hu mouse provide potentially useful models for evaluating the impact of other drugs of abuse on HIV infection and the mechanisms mediating these effects... - The role of long-acting bronchodilators in the management of stable COPDDonald P Tashkin
Division of Pulmonary and Critical Care Medicine and the UCLA Pulmonary Function and Exercise Physiology Laboratory, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Chest 125:249-59. 2004..Based on this review, a treatment algorithm for the introduction of long-acting bronchodilators to patients with COPD is proposed, which includes the use of long-acting bronchodilators early in the treatment algorithm... - Long-acting anticholinergic use in chronic obstructive pulmonary disease: efficacy and safetyDonald P Tashkin
Division of Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, California 90095 1690, USA
Curr Opin Pulm Med 16:97-105. 2010.... - Preventing and managing exacerbations in COPD--critical appraisal of the role of tiotropiumDonald P Tashkin
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Int J Chron Obstruct Pulmon Dis 5:41-53. 2010.... - Impact of tiotropium on the course of moderate-to-very severe chronic obstructive pulmonary disease: the UPLIFT trialDonald P Tashkin
David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90272, USA
Expert Rev Respir Med 4:279-89. 2010..Adverse events were consistent with the drug's known anticholinergic pharmacology... - Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responsesDonald Tashkin
Pulmonary Division, David Geffen School of Medicine at the University of California at Los Angeles, 90095, USA
Chest 123:1441-9. 2003.... - Smoking cessation in chronic obstructive pulmonary diseaseDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095 1690, USA
Respir Med 103:963-74. 2009..We also discuss the pharmacologic therapies used to enhance the likelihood of quitting, including nicotine replacement, bupropion SR and varenicline, along with novel nicotine vaccines, which are currently undergoing clinical trials... - Comparing COPD treatment: nebulizer, metered dose inhaler, and concomitant therapyDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1690, USA
Am J Med 120:435-41. 2007..This study compared the 2 methods of delivering medication and the concomitant use of both nebulizer and inhaler, with respect to health-related quality of life, patient symptoms, and efficacy... - Formoterol and tiotropium compared with tiotropium alone for treatment of COPDDonald P Tashkin
David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
COPD 6:17-25. 2009..04) were seen at endpoint with combination FORM + TIO versus TIO monotherapy. Both treatments were well tolerated. This study demonstrated that concurrent treatment with FORM + TIO results in greater therapeutic benefits than TIO alone... - Effects of 1-year treatment with cyclophosphamide on outcomes at 2 years in scleroderma lung diseaseDonald P Tashkin
Department of Medicine, David Geffen School of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 176:1026-34. 2007..Although treatment-related benefits in pulmonary function, skin scores, and patient-centered outcomes were demonstrated after 1 year of therapy, the duration of benefit beyond 1 year was unclear... - The role of patient-centered outcomes in the course of chronic obstructive pulmonary disease: how long-term studies contribute to our understandingDonald P Tashkin
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Am J Med 119:63-72. 2006..This article examines the rationale for each of these studies and provides an overview of study methodology as well as preliminary demographic data... - Cyclophosphamide versus placebo in scleroderma lung diseaseDonald P Tashkin
University of California at Los Angeles, Los Angeles, USA
N Engl J Med 354:2655-66. 2006.... - Bronchodilator responsiveness in patients with COPDD P Tashkin
David Geffen School of Medicine, UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90024, USA
Eur Respir J 31:742-50. 2008..The majority of patients with moderate-to-very-severe chronic obstructive pulmonary disease demonstrate meaningful increases in lung function following administration of inhaled anticholinergic plus sympathomimetic bronchodilators... - Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trialDonald P Tashkin
Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, California, USA
Drugs 68:1975-2000. 2008..Budesonide/formoterol dry powder inhaler (DPI) has demonstrated efficacy and tolerability in patients with COPD... - Smoked marijuana as a cause of lung injuryD P Tashkin
Division of Pulmonaiy and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
Monaldi Arch Chest Dis 63:93-100. 2005..In view of the growing interest in medicinal marijuana, further epidemiologic studies are needed to clarify the true risks of regular marijuana smoking on respiratory health... - A 4-year trial of tiotropium in chronic obstructive pulmonary diseaseDonald P Tashkin
David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
N Engl J Med 359:1543-54. 2008..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy... - Is a long-acting inhaled bronchodilator the first agent to use in stable chronic obstructive pulmonary disease?Donald P Tashkin
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1690, USA
Curr Opin Pulm Med 11:121-8. 2005.... - Effects of arformoterol twice daily, tiotropium once daily, and their combination in patients with COPDD P Tashkin
David Geffen School of Medicine UCLA, Los Angeles, CA 90095 1690, USA
Respir Med 103:516-24. 2009..This 2-week, multi-center (34 sites), randomized, modified-blind, parallel group study evaluated the efficacy and safety of concomitant treatment with nebulized arformoterol (the formoterol(R,R)-isomer) BID and tiotropium DPI QD... - Skin manifestations of inhaled corticosteroids in COPD patients: results from Lung Health Study IIDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at UCLA, 10833 LeConte Ave, Los Angeles, CA 90095 1690, USA
Chest 126:1123-33. 2004..To explore the relationship between easy skin bruising and other systemic effects of ICS therapy, including adrenal suppression and loss of bone mineral density (BMD)... - Indacaterol maleate for the treatment of chronic obstructive pulmonary diseaseDonald P Tashkin
David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Expert Opin Pharmacother 11:2077-85. 2010..Indacaterol maleate has been developed as a new once-daily inhaled beta(2)-selective agonist... - Combined treatment with formoterol and tiotropium is more efficacious than treatment with tiotropium alone in patients with chronic obstructive pulmonary disease, regardless of smoking status, inhaled corticosteroid use, baseline severity, or genderDonald P Tashkin
David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Pulm Pharmacol Ther 24:147-52. 2011..We conclude that coadministered FOR + TIO significantly improves lung function compared with TIO treatment alone in COPD patients regardless of differences in patient subgroups... - Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agentsDonald P Tashkin
David Geffen School of Medicine, Division of Pulmonary and Critical Care Medicine, UCLA, Los Angeles, California, USA
Respir Res 11:149. 2010..Once-daily LABAs used both alone and in combination with long-acting muscarinic antagonists represent a promising advance in the treatment of COPD, and are likely to further improve outcomes for patients... - Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trialD Tashkin
Division of Pulmonary and Critical Care Medicine, Department of Medicine, UCLA School of Medicine, 90095, Los Angeles CA, USA
Lancet 357:1571-5. 2001..Our aim was to investigate the effect of sustained-release bupropion (amfebutamone) (SR) in promoting abstinence from smoking in patients with COPD... - Effect of tiotropium in men and women with COPD: results of the 4-year UPLIFT trialDonald Tashkin
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1690, USA
Respir Med 104:1495-504. 2010..Gender differences may occur in many chronic diseases. We have examined the influence of gender in chronic obstructive pulmonary disease (COPD) on long-term responses to tiotropium... - Concomitant treatment with nebulized formoterol and tiotropium in subjects with COPD: a placebo-controlled trialDonald P Tashkin
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Respir Med 102:479-87. 2008..2% vs. 1.5%). Nebulized formoterol fumarate in combination with tiotropium provided statistically and clinically significant improvements in bronchodilation and symptom control over tiotropium alone and demonstrated good tolerability... - Airway effects of marijuana, cocaine, and other inhaled illicit agentsD P Tashkin
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Curr Opin Pulm Med 7:43-61. 2001..Heroin inhalation can induce severe and even fatal exacerbations of asthma. Pulmonary consequences of inhaled amyl and butyl nitrites, crystalline methamphetamine (ice), and phencyclidine have been less well documented... - Budesonide and formoterol in a single pressurized metered-dose inhaler for treatment of COPDDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Expert Rev Respir Med 4:703-14. 2010..It also has a satisfactory safety profile and has not been shown to increase the risk of pneumonia... - Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trialDonald P Tashkin
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095 1690, USA
Chest 139:591-9. 2011..To our knowledge, this is the first randomized clinical trial to compare the efficacy and safety of varenicline tartrate vs placebo in smokers with mild to moderate COPD... - Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivors of non-small cell lung cancerLinda Sarna
School of Nursing, University of California Los Angeles, 700 Tiverton Avenue, Box 9569182, Factor 4 262, Los Angeles, CA 90095 6918, USA
Chest 125:439-45. 2004..To describe respiratory symptoms and pulmonary function among long-term survivors of non-small cell lung cancer (NSCLC), and their relationship to quality of life (QOL)... - Recreational drug use and risk of Kaposi's sarcoma in HIV- and HHV-8-coinfected homosexual menChun Chao
Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
AIDS Res Hum Retroviruses 25:149-56. 2009..46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men... - Course of dermal ulcers and musculoskeletal involvement in systemic sclerosis patients in the scleroderma lung studyKaren Au
University of California, Los Angeles, Los Angeles, CA 90025, USA
Arthritis Care Res (Hoboken) 62:1772-8. 2010..Subjects were then followed off the study agent for an additional 12 months... - A 56-year-old woman with COPD and multiple pulmonary nodulesAmmar Sakkour
Division of Pulmonary and Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA
Chest 133:566-9. 2008 - Subacute lack of asthma control and acute asthma exacerbation history as predictors of subsequent acute asthma exacerbations: evidence from managed care dataRichard D O'Connor
Department of Quality Management, Sharp Rees Stealy Medical Group, San Diego, California, CA 92101, USA
J Asthma 47:422-8. 2010..Monitoring indicators of subacute lack of asthma control (SALAC) may help to reduce asthma morbidity... - Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected menChun Chao
Department of Epidemiology and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095 1772, USA
Drug Alcohol Depend 94:165-71. 2008..These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM... - Synergistic cytotoxicity of Delta(9)-tetrahydrocannabinol and butylated hydroxyanisoleTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Rm 37 131 Center for Health Sciences, University of California, Los Angeles 90095, USA
Toxicol Lett 133:171-9. 2002..The combination was synergistic in this respect, reducing ATP levels to <15% of control. Exposure to marijuana smoke in conjunction with BHA, a common food additive, may promote deleterious health effects in the lung... - Airway inflammation in young marijuana and tobacco smokersM D Roth
Department of Medicine, and Jonsson Comprehensive Cancer Center, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Am J Respir Crit Care Med 157:928-37. 1998..We conclude that regular smoking of marijuana by young adults is associated with significant airway inflammation that is similar in frequency, type, and magnitude to that observed in the lungs of tobacco smokers... - Histopathologic and molecular alterations in bronchial epithelium in habitual smokers of marijuana, cocaine, and/or tobaccoS H Barsky
Department of Pathology, University of California, Los Angeles, USA
J Natl Cancer Inst 90:1198-205. 1998.... - Results of a multicenter study of nebulized inhalant bronchodilator solutionsD P Tashkin
Department of Medicine, University of California Los Angeles 90095 1690, USA
Am J Med 100:62S-69. 1996.... - Marijuana use and increased risk of squamous cell carcinoma of the head and neckZ F Zhang
Department of Epidemiology, University of California at Los Angeles School of Public Health, and Jonsson Comprehensive Cancer Center, 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 8:1071-8. 1999..The results need to be interpreted with some caution in drawing causal inferences because of certain methodological limitations, especially with regard to interactions... - Unpredictability of deception in compliance with physician-prescribed bronchodilator inhaler use in a clinical trialM S Simmons
UCLA School of Medicine, Los Angeles, CA 90095 1690, USA
Chest 118:290-5. 2000..To identify subject characteristics that may be predictive of intentional dumping of metered-dose inhalers (MDIs) during a clinical trial... - Environmental tobacco smoking, mutagen sensitivity, and head and neck squamous cell carcinomaZ F Zhang
Department of Epidemiology, University of California Los Angeles School of Public Health, and Jonsson Comprehensive Cancer Center, 90095 1772, USA
Cancer Epidemiol Biomarkers Prev 9:1043-9. 2000..Our results need to be interpreted with caution because of potential residual confounding effects of active tobacco smoking and other methodological limitations. Future large-scale studies are warranted to confirm our findings... - Montelukast improves regional air-trapping due to small airways obstruction in asthmaM R Zeidler
Division of Pulmonary, Critical Care Medicine and Hospitalists, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095 1690, USA
Eur Respir J 27:307-15. 2006..In conclusion, distal airways disease improves in asthmatic subjects treated with montelukast. This improvement can be detected with high-resolution computed tomography, but not with conventional physiological studies... - Marijuana smoke and Delta(9)-tetrahydrocannabinol promote necrotic cell death but inhibit Fas-mediated apoptosisT A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, UCLA School of Medicine, Room 37 131, Center for Health Sciences, Los Angeles, California 90095 1690, USA
Toxicol Appl Pharmacol 174:264-72. 2001..This shift may affect both the carcinogenic and immunologic consequences of marijuana smoke exposure... - A computer-aided diagnosis system for quantitative scoring of extent of lung fibrosis in scleroderma patientsH G Kim
Department of Radiological Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024 2926, USA
Clin Exp Rheumatol 28:S26-35. 2010.... - Smoking reduction and the rate of decline in FEV(1): results from the Lung Health StudyM S Simmons
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Eur Respir J 25:1011-7. 2005..In conclusion, compensatory changes in smoking behaviour may account for the limited and unpredictable impact of smoking reduction on lung function decline and symptom prevalence when compared with smoking cessation... - Recent developments in inhaled therapy in stable chronic obstructive pulmonary diseaseC B Cooper
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA
BMJ 330:640-4. 2005 - Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinolM D Roth
Division of Pulmonary and Critical Care Medicine, Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, California 90095 1690, USA
Am J Respir Cell Mol Biol 24:339-44. 2001..This complex regulation of CYP1A1 by marijuana smoke and the Delta(9)-THC that it contains has implications for the role of marijuana as a cancer risk factor... - Quality of life of long-term survivors of non-small-cell lung cancerLinda Sarna
School of Nursing, University of California Los Angeles, Los Angeles, CA 90095 6918, USA
J Clin Oncol 20:2920-9. 2002..To describe the quality of life (QOL) among survivors of non-small-cell lung cancer (NSCLC)... - Household smoking behavior and ETS exposure among children with asthma in low-income, minority householdsBarbara A Berman
Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, University of California at Los Angeles, A2 125 CHS, Box 956900, Los Angeles, CA 90095 6900, USA
Addict Behav 28:111-28. 2003..Over 47% of the respondents reported absolute restrictions against smoking in the home, and these restrictions were associated with lower reported levels of smoking, ETS exposure, and air nicotine and urine cotinine concentrations... - Physiologic characteristics of malignant unilateral main-stem bronchial obstruction. Diagnosis and Nd-YAG laser treatmentA F Gelb
Department of Medicine, Doctors Hospital of Lakewood, California
Am Rev Respir Dis 138:1382-5. 1988..0 +/- 0.6 to 1.8 +/- 0.5 s-1 in patients without emphysema and from 0.8 +/- 0.3 to 0.8 +/- 0.1 s-1 in patients with emphysema.(ABSTRACT TRUNCATED AT 250 WORDS).. - The importance of control in asthma management: do leukotriene receptor antagonists meet patient and physician needs?D P Tashkin
University of California, Los Angeles School of Medicine, 10833 Le Conte Avenue, Room 37-121 CHS, Los Angeles, CA 90095-1690, USA
Allergy Asthma Proc 22:311-9. 2001.... - Effects of inhaled thiazinamium chloride on histamine-induced and exercise-induced bronchoconstrictionH Gong
Department of Medicine, UCLA School of Medicine
Ann Allergy 62:230-5. 1989..We conclude that aerosolized TC is effective in attenuating histamine-induced but not exercise-induced bronchoconstriction in the doses studied. Further studies are warranted to evaluate the role of TC in asthma therapy... - Preventing chronic obstructive pulmonary disease: what is known and what needs to be done to make a difference to the patient?Robert A Wise
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Med 120:S14-22. 2007.... - Effect of occupational exposures on decline of lung function in early chronic obstructive pulmonary diseasePhilip Harber
Division of Occupational and Environmental Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90024, USA
Am J Respir Crit Care Med 176:994-1000. 2007..Several occupational exposures adversely affect lung function... - Optimizing treatment of chronic obstructive pulmonary disease: an assessment of current therapiesRobert A Wise
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Am J Med 120:S4-13. 2007..A treatment algorithm that combines both pharmacologic and nonpharmacologic interventions for the management of COPD is presented... - Pharmacologic therapy: novel approaches for chronic obstructive pulmonary diseaseWilliam C Bailey
University of Alabama Lung Health Center, University of Alabama at Birmingham, 620 South 20th Street, Suite NHB 104, Birmingham, AL 35249 7337, USA
Proc Am Thorac Soc 4:543-8. 2007..A number of new drugs are available, and more will be brought to market in the future. We have highlighted the details of this important area... - Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung diseaseCharlie Strange
Division of Pulmonary and Critical Care Medicine, MUSC, 96 Jonathan Lucas Street, 812 CSB, Charleston, SC 29425, USA
Am J Respir Crit Care Med 177:91-8. 2008..The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease... - Oral vs IV corticosteroids for in-hospital treatment of COPD exacerbationsDonald P Tashkin
Chest 132:1728-9. 2007 - Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-betaBrian Gardner
Pulmonary Immunology Laboratory, Division of Pulmonary and Critical Care Medicine, 37-131 CHS, UCLA School of Medicine, Los Angeles, California 90073, USA
Biochem Biophys Res Commun 290:91-6. 2002..We conclude that one mechanism by which THC contributes to immune suppression is by stimulating an enhanced production of lymphocyte TGF-beta... - High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung diseaseJonathan G Goldin
David Geffen School of Medicine at UCLA, Department of Radiology, Los Angeles, CA 90095 1721, USA
Chest 134:358-67. 2008..The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized... - The partners--airflow obstruction, emphysema, and lung cancerSteven M Dubinett
Am J Respir Crit Care Med 178:665-6. 2008 - Scleroderma lung study (SLS): differences in the presentation and course of patients with limited versus diffuse systemic sclerosisPhilip J Clements
Divisions of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Ann Rheum Dis 66:1641-7. 2007..This report examines the differences at baseline and over 12 months between patients with limited versus diffuse cutaneous SSc who participated in the Scleroderma Lung Study... - Impact of oral cyclophosphamide on health-related quality of life in patients with active scleroderma lung disease: results from the scleroderma lung studyDinesh Khanna
University of Cincinnati, Cincinnati, Ohio 45267 0563, USA
Arthritis Rheum 56:1676-84. 2007..To assess the impact of cyclophosphamide (CYC) on the health-related quality of life (HRQOL) of patients with scleroderma after 12 months of treatment... - Exhaled nitric oxide in the assessment of asthmaMichelle R Zeidler
David Geffen School of Medicine at University of California, Los Angeles, USA
Curr Opin Pulm Med 10:31-6. 2004..This review examines the role of exhaled nitric oxide in assessing and directing therapy of asthmatic airways inflammation... - Cocaine modulates cytokine and enhances tumor growth through sigma receptorsBrian Gardner
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
J Neuroimmunol 147:95-8. 2004..We conclude that sigma(1) receptor ligands, including cocaine, augment tumor growth via a cytokine-dependent, receptor-mediated mechanism that involves regulation of T helper 1/T helper 2 cytokine balance... - Mechanisms for impaired effector function in alveolar macrophages from marijuana and cocaine smokersMichael D Roth
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neuroimmunol 147:82-6. 2004..These findings confirm a significant role for NO as an antibacterial effector molecule used by normal human AM and suggest that this host defense mechanism is suppressed by habitual exposure to inhaled marijuana or crack cocaine in vivo... - All-trans retinoic acid modulates the balance of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with emphysemaJenny T Mao
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Chest 124:1724-32. 2003..This study was designed to evaluate the impact of all-trans retinoic acid (ATRA) on the balance of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with emphysema... - Methanandamide increases COX-2 expression and tumor growth in murine lung cancerBrian Gardner
UCLA Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90095-1690, USA
FASEB J 17:2157-9. 2003..These results suggest that methanandamide augments tumor growth by a cannabinoid receptor-independent pathway that is associated with the up-regulation of COX-2... - The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health StudyRobert A Wise
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Chest 124:449-58. 2003..The greater the decline in FEV(1), the greater the increase in AR. Smoking cessation had a small additional benefit in AR beyond its favorable effects on FEV(1) changes... - Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthmaJonathan Corren
Allergy Research Foundation, Inc, Los Angeles, California 90023, USA
Clin Ther 25:776-98. 2003..HFA replaces the chlorofluorocarbon (CFC) propellant of the previous formulation, producing aerosols of smaller average particle size... - IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunityLi X Zhu
University of California Los Angeles Lung Cancer Research Program, Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 1690, USA
J Immunol 170:3585-91. 2003..We report that sigma(1) receptor ligands, including cocaine, augment tumor growth through an IL-10 dependent mechanism... - Impairment of antimicrobial activity and nitric oxide production in alveolar macrophages from smokers of marijuana and cocaineAngela Hanchi Shay
Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Infect Dis 187:700-4. 2003..These results confirm that NO plays a significant role as an effector molecule used by normal human AMs, but this capacity is suppressed in AMs from MS and CS because of a lack of intrinsic cytokine priming... - Delta 9-tetrahydrocannabinol disrupts mitochondrial function and cell energeticsTheodore A Sarafian
Department of Medicine, Division of Pulmonary and Critical Care, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Lung Cell Mol Physiol 284:L298-306. 2003..These results suggest that exposure of the bronchopulmonary epithelium to THC may have important health and physiological consequences... - Effects of delta-9-tetrahydrocannabinol on human immune function and host defenseMichael D Roth
Division of Pulmonary and Critical Care Medicine and Hematology Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Chem Phys Lipids 121:229-39. 2002..Macrophage function is restored by treatment with interferon-gamma, a type 1 cytokine. Habitual exposure to THC appears capable of impacting on human cell-mediated immunity and host defense... - Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cellsMichael Yuan
Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA
J Neuroimmunol 133:124-31. 2002..The CB2 receptor antagonist, SR144528, abrogated the majority of these effects. We conclude that cannabinoids have the potential to regulate the activation and balance of human Th1/Th2 cells by a CB2 receptor-dependent pathway... - Respiratory and immunologic consequences of marijuana smokingDonald P Tashkin
Deportment of Medicine, UCLA School of Medicine, 90095-1690, USA
J Clin Pharmacol 42:71S-81S. 2002..Additional well designed epidemiological and immune monitoring studies are required to determine the potential causal relationship between marijuana use and the development of respiratory infection and/or cancer... - The role of small airway inflammation in asthmaDonald P Tashkin
Division of Pulmonary and Critical Care, University of California at Los Angeles, School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Allergy Asthma Proc 23:233-42. 2002..Their potential to treat inflammation at peripheral sites may account for the significant improvements in asthma outcomes that have been reported in clinical trials of these new formulations... - Chronic and acute effects of "crack" cocaine on diffusing capacity, membrane diffusion, and pulmonary capillary blood volume in the lungEric C Kleerup
Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095-1690, USA
Chest 122:629-38. 2002..In contrast, a clear cross-sectional effect of regular tobacco smoking was demonstrated... - Evidence of chronic damage to the pulmonary microcirculation in habitual users of alkaloidal ("crack") cocaineGayle Cocita Baldwin
Division of Hematology, UCLA School of Medicine, Los Angeles, CA 90095 1678, USA
Chest 121:1231-8. 2002..To evaluate BAL cells obtained from habitual users of alkaloidal ("crack") cocaine alone or in combination with tobacco, for evidence of cocaine-associated alveolar injury... - A pilot study of all-trans-retinoic acid for the treatment of human emphysemaJenny T Mao
Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los Angeles, CA 99095-1690, USA
Am J Respir Crit Care Med 165:718-23. 2002..We conclude that ATRA is well tolerated in patients with emphysema, and trials evaluating higher doses, longer treatment, or different dosing schedules are feasible... - Loss of bone density with inhaled triamcinolone in Lung Health Study IIPaul D Scanlon
Mayo Clinic, Rochester, MN, USA
Am J Respir Crit Care Med 170:1302-9. 2004..In summary, the use of inhaled triamcinolone acetonide was associated with loss of BMD at the femoral neck and lumbar spine after 3 years of treatment... - Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: results from the Scleroderma Lung StudyDinesh Khanna
David Geffen School of Medicine, University of California, Los Angeles, USA
Arthritis Rheum 52:592-600. 2005.... - Regional differences in bronchoalveolar lavage and thoracic high-resolution computed tomography results in dyspneic patients with systemic sclerosisPhilip J Clements
Department of Medicine, University of California, Los Angeles, 90095, USA
Arthritis Rheum 50:1909-17. 2004..This study was undertaken to investigate the utility of high-resolution computed tomography (HRCT) of the chest, in comparison with bronchoalveolar lavage (BAL), in the diagnosis of alveolitis in these patients... - Menthol cigarettes and health risks in Lung Health Study dataRobert P Murray
Department of Community Health Sciences, University of Manitoba Winnipeg, MB, Canada
Nicotine Tob Res 9:101-7. 2007..We found no difference in success at smoking cessation with or without menthol. We conclude that our data contain no evidence that mentholation of cigarettes increases the hazards of smoking... - Clinical trial design considerations in assessing long-term functional impacts of tiotropium in COPD: the UPLIFT trialMarc Decramer
Respiratory Division, University Hospitals, Leuven, Belgium
COPD 1:303-12. 2004.... - Small airways response to naturalistic cat allergen exposure in subjects with asthmaMichelle R Zeidler
Division of Pulmonary, David Geffen School of Medicine and Allergy Research Foundation, University of California, Los Angeles, CA 90025, USA
J Allergy Clin Immunol 118:1075-81. 2006..It is currently unclear whether the small airways (diameter <2 microm) contribute significantly to late asthmatic reactions to inhaled allergen... - Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?Maureen P M H Rutten-van Mölken
Erasmus MC, Institute for Medical Technology Assessment iMTA, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Chest 130:1117-28. 2006..To assess the discriminative properties of the EuroQol five-dimension questionnaire (EQ-5D) with respect to COPD severity according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria in a large multinational study... - The role of patient-centered outcomes in defining the clinical course of chronic obstructive pulmonary disease. IntroductionDonald P Tashkin
Am J Med 119:1-3. 2006 - Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance useMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
Am J Addict 15:297-302. 2006..These findings suggest areas for further research on spontaneous recovery from marijuana use... - Single-factor scoring validation for the Health Assessment Questionnaire-Disability Index (HAQ-DI) in patients with systemic sclerosis and comparison with early rheumatoid arthritis patientsJason C Cole
Consulting Measurement Group, Huntington Beach, CA 91403, USA
Qual Life Res 15:1383-94. 2006..The goal of the current study was to examine the structural validity of the HAQ-DI in patients with systemic sclerosis (SSc, scleroderma) and to compare its performance with that in patients with RA... - Control of airway inflammation maintained at a lower steroid dose with 100/50 microg of fluticasone propionate/salmeterolNizar N Jarjour
Pulmonary and Critical Care Medicine Section, University of Wisconsin School of Medicine, Madison, WI, USA
J Allergy Clin Immunol 118:44-52. 2006..CLINICAL IMPLICATIONS: A lower-dose ICS with a LABA is effective in controlling inflammation and providing clinical asthma control, confirming current guideline recommendations... - Cannabis withdrawal among non-treatment-seeking adult cannabis usersMarc L Copersino
Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224-6823, USA
Am J Addict 15:8-14. 2006.... - Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouseMichael D Roth
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, Los Angeles, CA 90095, USA
Life Sci 77:1711-22. 2005..These results suggest that exposure to THC in vivo can suppress immune function, increase HIV coreceptor expression, and act as a cofactor to significantly enhance HIV replication... - Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinolTheodore Sarafian
Division of Pulmonary and Critical Care, Department of Medicine, 14 184 Warren Hall, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Toxicol Lett 158:95-107. 2005..THC, delivered as a component of marijuana smoke, may induce a profile of gene expression that contributes to the pulmonary pathology associated with marijuana use... - Epidemiologic review of marijuana use and cancer riskMia Hashibe
International Agency for Research on Cancer, 69008 Lyon, France
Alcohol 35:265-75. 2005..Despite the challenges, elucidation of the association between marijuana use and cancer risk is important in weighing the benefits and risks of medical marijuana use and to clarify the impact of marijuana use on public health...
Research Grants
- SCLERODERMA LUNG STUDYDonald Tashkin; Fiscal Year: 2003..abstract_text> ..
- COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSEDonald Tashkin; Fiscal Year: 2002..findings which relate to susceptibility to opportunistic infections in HIV-infected cocaine smokers. ..
- COCAINE SMOKING EFFECTS ON LUNG IMMUNITY & HOST DEFENSEDonald Tashkin; Fiscal Year: 2004..abstract_text> ..
- Distal Lung Inflammation Effect on Asthma ExacerbationsDonald Tashkin; Fiscal Year: 2007..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
- MOCSLID-CCCDonald Tashkin; Fiscal Year: 2009..End of Abstract) ..
- COCAINE SMOKING EFFECTS ON LUNG PHYSIOLOGY, HOST DEFENSEDonald Tashkin; Fiscal Year: 1993..aureus and E. coli; and c) pulmonary interstitial lymphocytes, epithelial cells and components of alveolar epithelial lining fluid that are important in the lung's defense against infection...
- LUNG HEALTH STUDY--LONG TERM FOLLOW UPDonald Tashkin; Fiscal Year: 2002..All ten of the original LHS clinical centers plan to participate in this study. To minimize bias, all surviving participants of the LHS will be invited to participate, giving a potential sample size of 5600. ..
- MOCSLID-CCCDonald P Tashkin; Fiscal Year: 2010..End of Abstract) ..