Ya Xiong Tao

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs
    Zhen Chuan Fan
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5519, USA
    Domest Anim Endocrinol 34:383-90. 2008
  2. ncbi Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity
    Ya Xiong Tao
    Department of Physiology and Biophysics, 5 471 Bowen Science Building, The University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 144:4544-51. 2003
  3. ncbi Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 89:3936-42. 2004
  4. ncbi Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor
    Ya Xiong Tao
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:5904-14. 2004
  5. ncbi Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female
    Patricia A Donohoue
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 88:5841-5. 2003
  6. ncbi Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City 52242, USA
    J Clin Endocrinol Metab 90:5632-8. 2005
  7. ncbi Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Endocrinol 16:1881-92. 2002
  8. ncbi Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations
    Meilin Zhang
    Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 282:25527-39. 2007
  9. ncbi Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
    Rong Rong
    Department of Medicine, Li Ka Shing Medical Faculty, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Endocrinol (Oxf) 65:198-205. 2006
  10. ncbi Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects
    Ya Xiong Tao
    Department of Anatomy, Physiology and Pharmacology, 213 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Biochim Biophys Acta 1772:1167-74. 2007

Collaborators

Detail Information

Publications15

  1. ncbi Pharmacological analyses of two naturally occurring porcine melanocortin-4 receptor mutations in domestic pigs
    Zhen Chuan Fan
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849 5519, USA
    Domest Anim Endocrinol 34:383-90. 2008
    ..In summary, pMC4R mutants D298N and R236H do not have any overt functional defects; therefore we suggest caution using these mutations as selection markers in breeding programs...
  2. ncbi Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity
    Ya Xiong Tao
    Department of Physiology and Biophysics, 5 471 Bowen Science Building, The University of Iowa, Iowa City, Iowa 52242, USA
    Endocrinology 144:4544-51. 2003
    ..Our data, therefore, stress the importance of characterizing the properties of MC4R variants associated with early-onset severe obesity. We further propose a classification scheme for mutant MC4Rs based upon their properties...
  3. ncbi Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for G protein-coupled receptor activation
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 89:3936-42. 2004
    ..The corresponding residue is also important for agonist-induced human melanocortin-4 receptor and lutropin receptor activation. In summary, we identify a residue that is critical for activation of G protein-coupled receptors...
  4. ncbi Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor
    Ya Xiong Tao
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:5904-14. 2004
    ..In addition to documenting the self-association of cell surface hLHR, our results underscore the importance of the cellular distribution of recombinant GPCR as it relates to the nature of the GPCR dimerization and oligomerization...
  5. ncbi Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female
    Patricia A Donohoue
    Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 88:5841-5. 2003
    ..We conclude that this novel mutation is the cause of obesity of this patient...
  6. ncbi Functional analyses of melanocortin-4 receptor mutations identified from patients with binge eating disorder and nonobese or obese subjects
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa Carver College of Medicine, Iowa City 52242, USA
    J Clin Endocrinol Metab 90:5632-8. 2005
    ..Whether mutations in the melanocortin-4 receptor (MC4R) are the cause of binge eating disorder was controversial. In addition, the penetrance of mutations in the MC4R in causing obesity was debated...
  7. ncbi Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7
    Ya Xiong Tao
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    Mol Endocrinol 16:1881-92. 2002
    ....
  8. ncbi Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations
    Meilin Zhang
    Department of Molecular Physiology and Biophysics, The University of Iowa Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 282:25527-39. 2007
    ....
  9. ncbi Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
    Rong Rong
    Department of Medicine, Li Ka Shing Medical Faculty, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Endocrinol (Oxf) 65:198-205. 2006
    ..We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequences of the novel variants identified...
  10. ncbi Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects
    Ya Xiong Tao
    Department of Anatomy, Physiology and Pharmacology, 213 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Biochim Biophys Acta 1772:1167-74. 2007
    ..Additional mutations at I335 showed that I335, part of the highly conserved N/DPxxY motif, was critical for multiple aspects of the MC3R function, including cell surface expression, ligand binding, and signaling...
  11. ncbi Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity
    Ya Xiong Tao
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, USA
    Mol Cell Endocrinol 239:1-14. 2005
    ..Functional analysis of the only inactivating MC3R mutation is also summarized. Insights from the analyses of the naturally occurring mutations in the MC3R and MC4R on the structure and function of these receptors are highlighted...
  12. ncbi Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor
    Hiromitsu Shinozaki
    Department of Physiology and Biophysics, The University of Iowa, Iowa City, Iowa 52242, USA
    J Clin Endocrinol Metab 88:1194-204. 2003
    ....
  13. ncbi Inactivating mutations of G protein-coupled receptors and diseases: structure-function insights and therapeutic implications
    Ya Xiong Tao
    Department of Anatomy, Physiology and Pharmacology, 213 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Pharmacol Ther 111:949-73. 2006
    ..Since intracellular retention emerges as the most common defect, recent progresses aimed at correcting this defect through membrane permeable pharmacological chaperones are highlighted...
  14. ncbi Molecular cloning and pharmacological characterization of porcine melanocortin-3 receptor
    Zhen Chuan Fan
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama 36849 5519, USA
    J Endocrinol 196:139-48. 2008
    ..This ranking was the same as that of hMC3R. The availability of pMC3R and its pharmacological characteristics will facilitate the investigation of pMC3R in regulating food intake and fat storage...
  15. ncbi Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation
    Shu Xiu Wang
    Department of Anatomy, Physiology and Pharmacology, 213 Greene Hall, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
    Biochem Pharmacol 76:520-30. 2008
    ..In summary, we showed that acidic residues in TMs 1 and 3 are important for ligand binding whereas the acidic residues in TMs 2 and 7 are important for both ligand binding and signaling...