Research Topics
| H TangSummaryAffiliation: University of California Country: USA Publications
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Publications
Lentivirus replication and regulationH Tang
Department of Medicine and Biology, University of California, San Diego 92093 0665, USA
Annu Rev Genet 33:133-70. 1999..Although our understanding of the biology of HIV-1 is far from complete, the knowledge gained thus far has already led to novel strategies for both virus intervention and exploiting the lentiviruses for therapeutic applications...- Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNAT R Reddy
Department of Medicine, University of California, San Diego, La Jolla 92093 0665, USA
Oncogene 19:3570-5. 2000..it is likely that this constitutive export pathway is also used by cellular mRNA, but at a different interface with the splicing process... - Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retrovirusesJ P Yang
Department of Biology, University of California, San Diego, La Jolla, California 92093 0665, USA
J Biol Chem 276:30694-700. 2001..Taken together, these data support the proposal that HAP95 specifically facilitates CTE-mediated gene expression by directly binding to RHA... - Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirusH Tang
Departments of Biology and Medicine, University of California, San Diego, La Jolla, California 92093 0665, USA
J Biol Chem 275:32694-700. 2000..The nuclear transport domain of RHA also interfered with Tap-mediated transactivation of the CTE function in quail cells, in which the function of CTE is dependent on the expression of a functional human Tap cDNA... - A cellular cofactor for the constitutive transport element of type D retrovirusH Tang
Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
Science 276:1412-5. 1997..In vivo colocalization of helicase A and CTE was observed in experiments that combined in situ hybridization and immunostaining. These results suggest that helicase A plays a role in the nuclear export of CTE-containing RNA... - A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport elementC Westberg
Departments of Biology and Medicine, University of California, San Diego, La Jolla, California 92093 0665, USA
J Biol Chem 275:21396-401. 2000..Overexpression of HAP95 significantly increases CTE-dependent gene expression but has no effect on general gene expression or that mediated by the Rev/Rev response element of human immunodeficiency virus type 1... - Identification and purification of cellular proteins that specifically interact with the RNA constitutive transport elements from retrovirus DH Tang
Department of Biology, University of California, San Diego, La Jolla 92093 0665, USA
Virology 228:333-9. 1997..Both proteins have been partially purified. The nature of these proteins and their roles in RNA intracellular trafficking are currently under investigation... - The carboxyl terminus of RNA helicase A contains a bidirectional nuclear transport domainH Tang
Department of Biology and Department of Medicine, University of California, San Diego, CA, USA
Mol Cell Biol 19:3540-50. 1999..The nuclear export pathway accessed by NTD is insensitive to leptomycin B and thus is distinct from the leucine-rich nuclear export signal pathway mediated by CRM1... - A role for RNA helicase A in post-transcriptional regulation of HIV type 1J Li
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 96:709-14. 1999..Exogenous RHA cDNA, but not the mutant RHA, rescued this inhibition. We propose that RHA is required to release both CTE- and RRE-containing mRNA from spliceosomes before completion of splicing, thus freeing them for nuclear export... - An Eulerian path approach to DNA fragment assemblyP A Pevzner
Department of Computer Science and Engineering, University of California, San Diego, La Jolla, USA
Proc Natl Acad Sci U S A 98:9748-53. 2001..euler, in contrast to the celera assembler, does not mask such repeats but uses them instead as a powerful fragment assembly tool...