Research Topics
Genomes and Genes | Yoshikazu TakadaSummaryAffiliation: University of California Country: USA Publications
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Publications
The integrinsYoshikazu Takada
Department of Dermatology, University of California Davis School of Medicine, Second Avenue, Sacramento, CA 95817, USA
Genome Biol 8:215. 2007..Here we provide a brief overview that concentrates mostly on the organization, structure and function of mammalian integrins, which have been more extensively studied than integrins in other organisms...- A T cell-binding fragment of fibrinogen can prevent autoimmunityYoshikazu Takada
Department of Dermatology, University of California Davis School of Medicine, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA
J Autoimmun 34:453-9. 2010..Our results also identify gammaC399tr as a novel therapeutic molecule... - Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent mannerJun Saegusa
Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
J Biol Chem 283:26107-15. 2008..These results suggest that integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, and that integrin-sPLA2-IIA interaction is a novel therapeutic target... - Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signalingKatsuaki Ieguchi
Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
J Biol Chem 285:31388-98. 2010..These results suggest that direct NRG1-integrin interaction mediates integrin-ErbB cross-talk and that ?6?4 plays a major role in NRG-ErbB signaling in these cancer cells... - The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signalingJun Saegusa
Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
J Biol Chem 284:24106-14. 2009.... - The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growthNobuaki Akakura
Department of Dermatology, University of California Davis Medical Center, Sacramento, CA 95817, USA
Cancer Res 66:9691-7. 2006..These results suggest that fibrinogen has a novel cryptic determinant, which can exert apoptosis-inducing activity on endothelial cells when exposed, and polypeptides containing this determinant have therapeutic potential... - Discovery of targeting ligands for breast cancer cells using the one-bead one-compound combinatorial methodNianhuan Yao
Department of Internal Medicine, Division of Hematology and Oncology, UC Davis Cancer Center, University of California, Davis, Sacramento, California 95817, USA
J Med Chem 52:126-33. 2009..Moreover, the targeting efficiency and specificity of 2 to the breast adenocarcinoma tumors in mouse xenografts were further confirmed by in vivo and ex vivo near-infrared fluorescence optical imaging... - A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonistSatoshi Yamaji
Department of Dermatology, University of California Davis School of Medicine, Sacramento, California, United States of America
PLoS ONE 5:e10273. 2010.... - Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signalingSeiji Mori
Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
J Biol Chem 283:18066-75. 2008..We propose that R50E is a useful tool to identify the role of integrins in FGF signaling... - Combinatorial chemistry identifies high-affinity peptidomimetics against alpha4beta1 integrin for in vivo tumor imagingLi Peng
Division of Hematology and Oncology, Department of Internal Medicine, UC Davis Cancer Center, University of California, Davis, 4501 X Street, Sacramento, California 95817, USA
Nat Chem Biol 2:381-9. 2006..Thus, LLP2A provides an important tool for noninvasive monitoring of alpha4beta1 expression and activity during tumor progression, and it shows great potential as an imaging and therapeutic agent for alpha4beta1-positive tumors... - The use of one-bead one-compound combinatorial library technology to discover high-affinity ?v?3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handleWenwu Xiao
Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, California 95817, USA
Mol Cancer Ther 9:2714-23. 2010..When compared with biotinylated RGD cyclopentapeptide ligands, biotinylated LXW7 showed higher tumor uptake but lower liver uptake... - Direct interaction of the kringle domain of urokinase-type plasminogen activator (uPA) and integrin alpha v beta 3 induces signal transduction and enhances plasminogen activationTakehiko Tarui
Department of Dermatology, UC Davis Medical Center, Research III, Sacramento, CA 95817, USA
Thromb Haemost 95:524-34. 2006..The uPA kringle-integrin interaction may represent a novel therapeutic target for cancer, inflammation, and vascular remodeling... - Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanismMingzhang Guo
Division of Research, Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
Arterioscler Thromb Vasc Biol 29:394-400. 2009..The purposes of this study were to characterize the direct effect of the C-terminal fragment of fibrinogen gamma chain (gammaC) on microvascular endothelial permeability and to examine its molecular mechanism of action... - Novel peptide ligands for integrin alpha 4 beta 1 overexpressed in cancer cellsMasahito Mikawa
University of California at Davis Cancer Center, 4501 X Street, Sacramento, CA 95817, USA
Mol Cancer Ther 3:1329-34. 2004..Using Chinese hamster ovary cells transfected with either wild-type or mutant integrin alpha(4), a critical binding site for these peptides was localized to the glycine residue at position 190 of integrin alpha(4)... - Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1)Mousumi Majumdar
Department of Dermatology, University of California Davis Medical Center, Sacramento, California 95817, USA
J Biol Chem 279:37528-34. 2004..These results suggest that plasmin induces migration by kringle-mediated binding to alpha(9)beta(1) and simultaneous proteolytic activation of PAR-1... - Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 familyPo Long Wu
Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30043, Taiwan
J Biol Chem 281:7937-45. 2006..These results identify CTX A5 as a non-RGD integrin-binding protein with therapeutic potential as an integrin antagonist... - Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactionsKoji Eto
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 277:17804-10. 2002..As alpha(9)beta(1) is a receptor for many ADAM disintegrins and alpha(9)beta(1) and ADAMs are widely expressed, alpha(9)beta(1)-ADAM interaction may be of a broad biological importance... - Model of the alphaLbeta2 integrin I-domain/ICAM-1 DI interface suggests that subtle changes in loop orientation determine ligand specificityGlen B Legge
Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 5001, USA
Proteins 48:151-60. 2002.... - A novel monoclonal antibody recognizing a cation-dependent epitope within the regulatory loop of human beta(1) integrin (CD29)Jean Pierre Levesque
The Peter MacCallum Cancer Institute, Stem Cell Biology Laboratory, East Melbourne, Australia
Hybrid Hybridomics 21:253-60. 2002..9H9 binding. Our data therefore suggest that the regulatory epitope of the human beta(1) integrin chain is flexible with multiple conformations according to the cationic environment... - Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chainYoshinobu Kariya
Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, 641 12 Maioka cho, Totsuka ku, Japan
J Cell Biochem 88:506-20. 2003..However, the structural change of the G3 domain appeared not to change integrin specificity. The present study demonstrates that the G3 domain in laminin-5 plays a central role to produce different biological effects on cells... - Critical role of integrin alpha 5 beta 1 in urokinase (uPA)/urokinase receptor (uPAR, CD87) signalingTakehiko Tarui
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 278:29863-72. 2003..uPAR complex to alpha 5 beta 1 via uPAR, and (c) signal transduction through alpha 5 beta 1... - Monkey rotavirus binding to alpha2beta1 integrin requires the alpha2 I domain and is facilitated by the homologous beta1 subunitSarah L Londrigan
Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia
J Virol 77:9486-501. 2003..Rotavirus-alpha2beta1 binding led to increased virus infection and RRV growth. SA11 and RRV require the alpha2 I domain for binding to alpha2beta1, and their binding to this integrin is distinguishable from that of collagen... - Adhesion of gastric carcinoma cells to peritoneum mediated by alpha3beta1 integrin (VLA-3)Hironori Takatsuki
Department of Microbiology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan
Cancer Res 64:6065-70. 2004..These results strongly suggest that alpha3beta1 integrin plays an essential role in mediating the initial attachment of cancer cells to the peritoneum, leading to the formation of peritoneal metastasis... - alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factorHisako Muramatsu
Department of Biochemistry and Division of Disease Models, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
J Cell Sci 117:5405-15. 2004..alpha4beta1- and alpha6beta1-Integrins are expected to co-operate with other midkine receptors, possibly in a multimolecular complex that contains other midkine receptors... - Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequencesKate L Graham
Department of Microbiology and Immunology, Gate 11, Royal Parade, The University of Melbourne, Melbourne, Victoria 3010, Australia
J Virol 78:11786-97. 2004..As polymerization can improve peptide inhibition of virus-receptor interactions, this approach could be useful in the development of inhibitors of receptor recognition by other viruses... - Rotaviruses interact with alpha4beta7 and alpha4beta1 integrins by binding the same integrin domains as natural ligandsKate L Graham
Department of Microbiology and Immunology, The University of Melbourne, Victoria 3010, Australia
J Gen Virol 86:3397-408. 2005..Several rotaviruses are able to use alpha4beta7 and alpha4beta1 for cell binding or entry, through the recognition of the same alpha4-subunit domains as natural alpha4 ligands... - Fibulin-5/DANCE is essential for elastogenesis in vivoTomoyuki Nakamura
UCSD Salk Program in Molecular Medicine and the UCSD Institute of Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA
Nature 415:171-5. 2002..Thus, fibulin-5 may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibres in the skin, lung and vasculature...
Research Grants
- LIGAND BINDING FUNCTION OF BETA INTEGRINSYoshikazu Takada; Fiscal Year: 1999..g., for preventing metastasis, thrombosis, rejection on organ transplantation). ..
- I-DOMAIN CONTAINING INTEGRIN/LIGAND INTERACTIONSYoshikazu Takada; Fiscal Year: 2002..These studies could potentially lead to the design of inhibitors or activators that could be useful for preventing cancer metastasis, rejection of a transplanted organ, or other medical conditions. ..
- Integrins and the proinflammatory phospholipase A2Yoshikazu Takada; Fiscal Year: 2007....
- Potential of a dominant-negative FGF mutant as a therapeutic in cancerYoshikazu Takada; Fiscal Year: 2009....
- FUNCTION OF LYMPHOCYTE B1 INTEGRINSYoshikazu Takada; Fiscal Year: 1993..Peptides which modify these interactions might modulate the targeting and function of lymphocytes, monocytes and other cells involved in the pathogenesis of the immunologic diseases...
- Potential of a dominant-negative FGF mutant as a therapeutic in cancerYoshikazu Takada; Fiscal Year: 2010....