Research Topics
Species | Russell TaichmanSummaryAffiliation: University of Michigan Country: USA Publications
Research Grants
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Detail Information
Publications
Creation of a scholars program in dental leadership (SPDL) for dental and dental hygiene studentsRussell S Taichman
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
J Dent Educ 73:1139-43. 2009..Our aim for the program is to create a learning environment that fosters leadership development, so that students are prepared and motivated to assume leadership positions in the profession and their communities...- Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotypeJeena Joseph
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
Mol Cancer Res 10:282-92. 2012..These studies for the first time identify HSC/HPCs as novel targets for future therapy involved in the bone abnormalities of prostate cancer... - Leadership training for oral health professionals: a call to actionRussell S Taichman
Department of Periodontics and Oral Medicine, Scholars Program in Dental Leadership, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
J Dent Educ 76:185-91. 2012.... - Program design considerations for leadership training for dental and dental hygiene studentsRussell S Taichman
Department of Periodontics and Oral Medicine, Scholars Program in Dental Leadership, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
J Dent Educ 76:192-9. 2012..The authors hope that providing an overview of leadership programs in academic dental institutions will encourage all U.S. and Canadian dental schools to begin developing a culture that promotes leadership development... - The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasisA M Havens
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, Michigan 48109 1078, USA
BMC Cancer 6:195. 2006..CD164 is known to function as a receptor that regulates stem cell localization to the bone marrow... - Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1R S Taichman
Department of Periodontics Prevention Geriatrics, University of Michigan School of Dentistry, Ann Arbor 48109 1078, USA
Bone 21:353-61. 1997..For these reasons, caution should be exercised when evaluating osteoblastic and hematopoietic cell interactions based purely on the use of osteosarcoma cell lines... - Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell nicheRussell S Taichman
Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, 1011 N University Ave, Ann Arbor, MI 48109 1078, USA
Blood 105:2631-9. 2005.... - Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivoRussell S Taichman
Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
Stem Cells Dev 19:1557-70. 2010.... - Hepatocyte growth factor is secreted by osteoblasts and cooperatively permits the survival of haematopoietic progenitorsR Taichman
Department of Periodontics, Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA
Br J Haematol 112:438-48. 2001.... - Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to boneRussell S Taichman
Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
Cancer Res 62:1832-7. 2002..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone... - Human osteoblast-like cells and osteosarcoma cell lines synthesize macrophage inhibitory protein 1alpha in response to interleukin 1beta and tumour necrosis factor alpha stimulation in vitroR S Taichman
Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
Br J Haematol 108:275-83. 2000..These findings suggest that human osteoblast-like cells may produce MIP-1alpha in vivo to support haematopoiesis at sites where osteoblasts and haematopoietic cells are closely associated... - Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cellsYan Xi Sun
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Prostate 67:61-73. 2007..Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone--but the mechanisms as to how it localizes to the marrow remains unclear... - Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivoYan Xi Sun
Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
J Bone Miner Res 20:318-29. 2005..Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis... - Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networksSuling Liu
Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
Cancer Res 71:614-24. 2011..Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population... - Detection and isolation of circulating tumor cells in urologic cancers: a reviewRobert D Loberg
Department of Urology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 0946, USA
Neoplasia 6:302-9. 2004..The purpose of this review is to present the methods for the detection and isolation of circulating tumor cells and to discuss the importance of circulating tumor cells in the biology and treatment of urologic cancers... - Mentoring of dental and dental hygiene faculty: a case studyRobert A Bagramian
School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
J Dent Educ 75:291-9. 2011..However, future targeted interventions are needed to address the identified differences between junior and senior faculty members. Recommendations for faculty mentoring efforts are discussed... - Perceptions of business skill development by graduates of the University of Michigan Dental SchoolMichael Barber
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Ave, Ann Arbor, MI 48109 1078, USA
J Dent Educ 75:505-17. 2011..The majority of alumni believed there is a need to improve the curriculum focused on these aspects of dental practice... - New trends in the treatment of bone metastasisEvan T Keller
Department of Urology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Cell Biochem 102:1095-102. 2007..Additionally, gains in promising clinical strategies to target bone metastases have been developed. In this prospectus, we will discuss some of these advances... - Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesisJianhua Wang
Department of Periodontics, Prevention and Geriatrics, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109-1078, United States
Cell Signal 17:1578-92. 2005..Taken together, our results provide new information regarding expression of functional CXCR4 receptor-an essential role and potential mechanism of angiogenesis upon SDF-1 stimulation... - Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivoYan Xi Sun
Department of Periodontics, Prevention, Geriatrics, University of Michigan School of Dentistry, 1011 North University Ave, Ann Arbor, Michigan 48109 1078, USA
J Cell Biochem 89:462-73. 2003..These investigations provide important new information pertaining to the molecular basis of how tumors may 'home' to bone, and the mechanisms that may account for their growth in selected end organs... - Stromal factors involved in prostate carcinoma metastasis to boneCarlton R Cooper
Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109-0946, USA
Cancer 97:739-47. 2003..CONCLUSIONS: Soluble and insoluble elements of the stroma are involved in multiple steps of PC metastasis to bone. The authors hypothesize that PAR1 may play a central role in prostate tumorigenesis... - Microfluidic system for formation of PC-3 prostate cancer co-culture spheroidsAmy Y Hsiao
Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA
Biomaterials 30:3020-7. 2009.... - Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancerYusuke Shiozawa
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan 48109 1078, USA
J Cell Biochem 105:370-80. 2008..These data strongly suggest that annexin II and its receptor axis plays a central role in prostate cancer metastasis, and that prostate cancer utilize the hematopoietic stem cell homing mechanisms to gain access to the niche... - CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12Yan Xi Sun
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Room 3307, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
Clin Exp Metastasis 25:765-76. 2008..Together, these data suggest that the degradation of CXCL12 by CD26/DPPIV may be involved in the metastatic cascades of PCa, and suggests that inhibition of CD26/DPPIV may be a trigger of PCa metastasis... - A glycolytic mechanism regulating an angiogenic switch in prostate cancerJianhua Wang
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109, USA
Cancer Res 67:149-59. 2007..These data suggest that PGK1 is a critical downstream target of the chemokine axis and an important regulator of an "angiogenic switch" that is essential for tumor and metastatic growth... - Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantationYounghun Jung
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Blood 110:82-90. 2007..Collectively, these findings reveal that Anxa2 regulates HSC homing and binding to the bone marrow microenvironment and suggest that Anxa2 is crucial for determining the bone marrow niche of HSCs... - An in vivo mouse model for human prostate cancer metastasisAaron M Havens
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA
Neoplasia 10:371-80. 2008..We propose that this new model may be particularly useful in exploring the molecular events in early metastasis, identifying the metastatic niche, and studying issues pertaining to dormancy... - The pivotal role of CXCL12 (SDF-1)/CXCR4 axis in bone metastasisJianhua Wang
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, MI 48109-1078, USA
Cancer Metastasis Rev 25:573-87. 2006.... - Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal diseaseAaron M Havens
Department of Periodontics and Oral Medicine, University of Michigan Dental School, 1011 N University Avenue, Ann Arbor, MI 48109, USA
J Periodontol 79:845-53. 2008..The purpose of this study was to determine whether SDF-1alpha secreted by host cells plays a role in recruiting inflammatory cells into the periodontia during local inflammation... - Vascular endothelial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic proteinJinlu Dai
Department of Pathology, School of Medicine, University Michigan, Ann Arbor, Michigan, USA
Cancer Res 64:994-9. 2004..These results suggest a novel function for VEGF in skeletal metastases. Specifically, VEGF promotes osteoblastic lesion formation at prostate cancer bone metastatic sites... - Erythropoietin couples hematopoiesis with bone formationYusuke Shiozawa
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, United States of America
PLoS ONE 5:e10853. 2010..This suggests that HSCs participate in bone formation where the molecular basis for this activity is the production of BMP2 and BMP6 by HSCs. Yet, what stimulates HSCs to produce BMPs is unclear... - GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow nicheYusuke Shiozawa
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Exp Hematol 38:132-40. 2010..Despite improvements in current combinational chemotherapy regimens, the prognosis of the (1;19)(q23;p13) translocation (E2A/PBX1)-positive B-cell precursor acute lymphoblastic leukemia (ALL) is poor in pediatric leukemia patients... - Expression of PGK1 by prostate cancer cells induces bone formationYounghun Jung
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Mol Cancer Res 7:1595-604. 2009..Together, these data suggest that PGK1 secreted by PCa regulates bone formation at the metastatic site by increasing osteoblastic activity, decreasing osteoclastic function, and expressing an osteoblastic phenotype by PCa cells... - The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancerJianhua Wang
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor 48109, USA
J Biol Chem 283:4283-94. 2008..Finally, we found that signaling by CXCR7/RDC1 activates AKT pathways. Together, these data demonstrate a role for CXCR7/RDC1 in PCa metastasis and progression and suggest potential targets for therapeutic intervention... - Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell nicheYounghun Jung
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 North University Avenue, Ann Arbor, Michigan 48109 1078, USA
Stem Cells 26:2042-51. 2008..Instead, they directly participate in bone formation and niche activities. Disclosure of potential conflicts of interest is found at the end of this article... - Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in boneAmy J Koh
Department of Periodontics and Oral Medicine, School of Dentistry, Room 3343, University of Michigan, 1011 North University Avenue, Ann Arbor, Michigan 48109 1078, USA
Endocrinology 146:4584-96. 2005..These results indicate that c-fos in osteoblasts is not critical for PTH action but that cells of the osteoclast lineage are intermediate targets for the anabolic action of PTH... - GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow nicheYusuke Shiozawa
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
Neoplasia 12:116-27. 2010..Our results suggest that the activation of GAS6 receptors on PCa in the bone marrow environment may play a critical role as a molecular switch, establishing metastatic tumor cell dormancy... - Ability of dental students to deliver oxygen in a medical emergencyThao T Le
Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, 1011 North University Avenue, Ann Arbor, MI 48109 1078, USA
J Dent Educ 73:499-508. 2009..Incorporation of periodic simulation exercises, in addition to classroom education, is likely to improve the ability of dental students to manage medical emergencies... - An in vivo model to study and manipulate the hematopoietic stem cell nicheJunhui Song
Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI, USA
Blood 115:2592-600. 2010..These findings suggest the residence of HSCs in heterotopic bone marrow and support the future use of this ossicle model in elucidating the composition and regulation of the HSC niche... - Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4Zhongxing Liang
Department of Hematology/Oncology, Winship Cancer Institute, Atlanta, Georgia 30322, USA
Cancer Res 64:4302-8. 2004.... - CXCL16 functions as a novel chemotactic factor for prostate cancer cells in vitroYi Lu
Department of Medicine, Pittsburgh VA Healthcare System, Research and Development, University of Pittsburgh, Pittsburgh, PA 15240, USA
Mol Cancer Res 6:546-54. 2008..CXCL16 was found to promote prostate cancer cell migration and invasion in vitro. Therefore, we concluded that CXCL16 functions, through CXCR6, as a novel chemotactic factor for prostate cancer cells... - Cancer cells homing to bone: the significance of chemotaxis and cell adhesionCarlton R Cooper
Department of Biological Sciences, University of Delaware, Newark DE 19716, USA
Cancer Treat Res 118:291-309. 2004 - G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4Isabelle Petit
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Nat Immunol 3:687-94. 2002..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation... - Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cellsJiang Zhu
Department of Medicine, Division of Hematology Oncology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
Blood 109:3706-12. 2007..Taken together, these results demonstrate that osteoblasts are both necessary and sufficient for murine B-cell commitment and maturation, and thereby constitute the cellular homolog of the avian bursa of Fabricius...
Research Grants
- The Role of Chemokines in Metastatic Prostate CancerRussell Taichman; Fiscal Year: 2003..abstract_text> ..
- Bone and the Hematopoietic SystemRussell Taichman; Fiscal Year: 2004..These investigations will ultimately lead to new strategies for the treatment of hematopoietic and osseous disorders. ..