William R Swindell

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
  2. ncbi In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 45:366-74. 2010
  3. ncbi Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations
    William R Swindell
    University of Michigan, Departments of Pathology and Geriatrics, Ann Arbor MI 48109, USA
    Aging (Albany NY) 1:573-7. 2009
  4. ncbi Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    William R Swindell
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 10:585. 2009
  5. ncbi Accelerated failure time models provide a useful statistical framework for aging research
    William R Swindell
    Departments of Pathology and Geriatrics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 44:190-200. 2009
  6. ncbi How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
  7. ncbi Genes regulated by caloric restriction have unique roles within transcriptional networks
    William R Swindell
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 129:580-92. 2008
  8. ncbi Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 130:393-400. 2009
  9. ncbi Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    William R Swindell
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, United States
    Mech Ageing Dev 129:138-53. 2008
  10. ncbi Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007

Collaborators

Detail Information

Publications13

  1. ncbi Indicators of "healthy aging" in older women (65-69 years of age). A data-mining approach based on prediction of long-term survival
    William R Swindell
    Department of Pathology, University of Michigan, School of Medicine, Ann Arbor, MI 48109 2200, USA
    BMC Geriatr 10:55. 2010
    ..The aims of this study were to identify predictors of long-term survival in older women and to develop a multivariable model based upon longitudinal data from the Study of Osteoporotic Fractures (SOF)...
  2. ncbi In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 45:366-74. 2010
    ....
  3. ncbi Heat shock proteins in long-lived worms and mice with insulin/insulin-like signaling mutations
    William R Swindell
    University of Michigan, Departments of Pathology and Geriatrics, Ann Arbor MI 48109, USA
    Aging (Albany NY) 1:573-7. 2009
    ..elegans daf-2 mutants. This result, in combination with other recent findings, underscores the possibility that systemic overexpression of chaperones will have dissimilar effects on longevity in vertebrate and invertebrate systems...
  4. ncbi Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    William R Swindell
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    BMC Genomics 10:585. 2009
    ..Furthermore, CR is thought to oppose age-associated gene expression patterns, but detailed statistical investigations of this hypothesis have not been carried out...
  5. ncbi Accelerated failure time models provide a useful statistical framework for aging research
    William R Swindell
    Departments of Pathology and Geriatrics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 44:190-200. 2009
    ..In addition, from the standpoint of aging research, these statistical approaches have appealing properties and provide valuable tools for the analysis of survivorship data...
  6. ncbi How long will my mouse live? Machine learning approaches for prediction of mouse life span
    William R Swindell
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 63:895-906. 2008
    ..Future work in this direction can provide tools for aging research and will shed light on associations between phenotypic traits and longevity...
  7. ncbi Genes regulated by caloric restriction have unique roles within transcriptional networks
    William R Swindell
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 129:580-92. 2008
    ..These findings contribute to a systems-level picture of how CR influences transcription within mammalian cells, and point towards a comprehensive understanding of CR in terms of its influence on biological networks...
  8. ncbi Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice
    William R Swindell
    University of Michigan, Department of Pathology and Geriatrics Center, Ann Arbor, MI 48109 2200, USA
    Mech Ageing Dev 130:393-400. 2009
    ..Contributions of chaperones to longevity in mice may be more complex than those inferred from C. elegans...
  9. ncbi Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues
    William R Swindell
    Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, United States
    Mech Ageing Dev 129:138-53. 2008
    ..These analyses shed light on the systemic transcriptional activity associated with CR diets, and also illustrate new approaches for comparative analysis of microarray datasets in the context of aging biology...
  10. ncbi Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging
    William R Swindell
    Department of Pathology, University of Michigan, 3118 BSRB, Ann Arbor, MI, USA
    BMC Genomics 8:353. 2007
    ..Points of overlap with the effects of calorie restriction (CR), CR mimetic compounds, low fat diets, gender dimorphism and aging were also examined...
  11. ncbi Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    Kevin J Pearson
    Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Cell Metab 8:157-68. 2008
    ..Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife...
  12. ncbi Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways
    William R Swindell
    Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA
    BMC Genomics 8:125. 2007
    ....
  13. ncbi Inbreeding depression and male survivorship in Drosophila: implications for senescence theory
    William R Swindell
    Department of Biological Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA
    Genetics 172:317-27. 2006
    ..These findings provide insights into the genetic basis of longevity as a quantitative trait and have implications regarding the mutation-accumulation evolutionary explanation of senescence...