Neal Swerdlow

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:506-15. 2006
  2. ncbi Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
  3. ncbi The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
  4. ncbi Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 190:201-11. 2007
  5. ncbi Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function
    Neal R Swerdlow
    Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 63:1325-35. 2006
  6. ncbi Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats
    Ying Qu
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 207:271-80. 2009
  7. ncbi Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats
    Neal R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:2011-21. 2006
  8. ncbi Reduced startle gating after D1 blockade: effects of concurrent D2 blockade
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 82:293-9. 2005
  9. ncbi Tourette syndrome: current controversies and the battlefield landscape
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA
    Curr Neurol Neurosci Rep 5:329-31. 2005
  10. ncbi Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function
    Neal R Swerdlow
    Department of Psychiatry, University of California School of Medicine, San Diego, La Jolla, CA 92093, USA
    Neuropsychopharmacology 31:721-9. 2006

Research Grants

  1. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
  2. CORTICO STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 1999
  3. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
  4. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 2009
  5. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
  6. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
  7. Neural basis of heritable DA-mediated gating deficits
    Neal Swerdlow; Fiscal Year: 2006
  8. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
  9. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 2007
  10. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2009

Detail Information

Publications89

  1. ncbi Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:506-15. 2006
    ..Despite similarities in drug sensitivity, these results suggest that distinct neurobiological mechanisms underlie drug-induced deficits in PPI and N40 gating...
  2. ncbi Successful multi-site measurement of antisaccade performance deficits in schizophrenia
    Allen D Radant
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
    Schizophr Res 89:320-9. 2007
    ..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies...
  3. ncbi The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration
    Monica E Calkins
    Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
    Schizophr Bull 33:33-48. 2007
    ..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment...
  4. ncbi Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits
    Kayla L Metzger
    Stanley Center for Experimental Therapeutics in Psychiatry, Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 190:201-11. 2007
    ..Non-adherence with medication remains the major correctable cause of poor outcome in schizophrenia. However, few treatments have addressed this major determinant of outcome with novel long-term delivery systems...
  5. ncbi Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of function
    Neal R Swerdlow
    Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Arch Gen Psychiatry 63:1325-35. 2006
    ..Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex...
  6. ncbi Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats
    Ying Qu
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 207:271-80. 2009
    ..These heritable strain differences in sensitivity to the PPI disruptive effects of DA agonists must ultimately reflect neural changes "downstream" from forebrain DA receptors...
  7. ncbi Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats
    Neal R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 31:2011-21. 2006
    ..In both humans and rats, normal 'low gating' appears to be an atypical antipsychotic-sensitive phenotype. PPI at short intervals may be most sensitive to pro-gating effects of these drugs...
  8. ncbi Reduced startle gating after D1 blockade: effects of concurrent D2 blockade
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 82:293-9. 2005
    ..We studied the neurochemical basis for the D1 regulation of PPI in rats...
  9. ncbi Tourette syndrome: current controversies and the battlefield landscape
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA
    Curr Neurol Neurosci Rep 5:329-31. 2005
  10. ncbi Heritable differences in the dopaminergic regulation of behavior in rats: relationship to D2-like receptor G-protein function
    Neal R Swerdlow
    Department of Psychiatry, University of California School of Medicine, San Diego, La Jolla, CA 92093, USA
    Neuropsychopharmacology 31:721-9. 2006
    ..Conceivably, genes that regulate heritable differences in forebrain D2 function may contribute to heritable differences in PPI in patients with specific neuropsychiatric disorders, including schizophrenia and Tourette Syndrome...
  11. ncbi Using animal models to develop therapeutics for Tourette Syndrome
    Neal R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Pharmacol Ther 108:281-93. 2005
    ..In addition to models that will advance the pharmacotherapy of TS, other animal models may enhance the utility of nonpharmacologic TS treatments, ranging from behavior therapy to deep brain stimulation (DBS)...
  12. ncbi Probing the molecular basis for an inherited sensitivity to the startle-gating disruptive effects of apomorphine in rats
    Neal R Swerdlow
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 216:401-10. 2011
    ..Here, we examined phosphorylation of cyclic-AMP response element-binding protein (CREB), a putative intermediary step between dopamine receptor stimulation and Fos expression, in SD and LE rats...
  13. ncbi Prepulse inhibition of perceived stimulus intensity: paradigm assessment
    Neal R Swerdlow
    Department of Psychiatry, University of California, 9500 Gilman Dr La Jolla, San Diego, CA 92039 0804, USA
    Biol Psychol 69:133-47. 2005
    ..PPIPSI is a robust, stable, parametrically sensitive and "low tech" measure of sensory gating that is relatively unaffected by a number of biological variables in normal individuals...
  14. ncbi Startle modulation in Caucasian-Americans and Asian-Americans: a prelude to genetic/endophenotypic studies across the 'Pacific Rim'
    Neal R Swerdlow
    Department of Psychiatry, UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatr Genet 15:61-5. 2005
    ....
  15. ncbi Neurochemical analysis of rat strain differences in the startle gating-disruptive effects of dopamine agonists
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 80:203-11. 2005
    ..These findings suggest that inherited differences in the dopaminergic regulation of sensorimotor gating do not likely reflect differences in presynaptic forebrain dopaminergic or serotonergic processes...
  16. ncbi Intact visual latent inhibition in schizophrenia patients in a within-subject paradigm
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Schizophr Res 72:169-83. 2005
    ..LI deficits in schizophrenia may be paradigm-specific and are not detected by a paradigm that we previously reported to be sensitive to disruption by dopamine agonists...
  17. ncbi Heritable differences in the dopaminergic regulation of sensorimotor gating. II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 174:452-62. 2004
    ....
  18. ncbi Heritable differences in the dopaminergic regulation of sensorimotor gating. I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 174:441-51. 2004
    ..The association between pigmentation and PPI apomorphine sensitivity may provide an important clue to specific biochemical and genetic substrates responsible for population differences in the regulation of sensorimotor gating...
  19. ncbi Prepulse-elicited motor reactions do not differ between schizophrenia patients and control subjects
    Neal R Swerdlow
    Department of PsychiatryUniversity of California, San Diego School of Medicine, La Jolla, CA 92093 0804, USA
    Behav Neurosci 120:224-7. 2006
    ..Thus, differential sensitivity to the motor-activating effects of prepulses should not contribute to reduced prepulse inhibition in schizophrenia patients versus control subjects...
  20. ncbi Separable noradrenergic and dopaminergic regulation of prepulse inhibition in rats: implications for predictive validity and Tourette Syndrome
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 2093 0804, USA
    Psychopharmacology (Berl) 186:246-54. 2006
    ....
  21. ncbi Integrative circuit models and their implications for the pathophysiologies and treatments of the schizophrenias
    Neal R Swerdlow
    School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Curr Top Behav Neurosci 4:555-83. 2010
    ....
  22. ncbi Are we studying and treating schizophrenia correctly?
    Neal R Swerdlow
    School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, United States
    Schizophr Res 130:1-10. 2011
    ..The use of targeted cognitive rehabilitative psychotherapy plus synergistic medication has both common sense and time-tested efficacy with numerous other neuropsychiatric disorders...
  23. ncbi Pramipexole effects on startle gating in rats and normal men
    Neal R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 205:689-98. 2009
    ..In this study, we tested the effects of the D3-preferential agonist, pramipexole, on PPI in normal men and Sprague-Dawley rats...
  24. ncbi Effects of the first prepulse on the blink response to a startling noise
    Neal R Swerdlow
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92093 0804, USA
    Behav Neurosci 123:607-13. 2009
    ..Startle magnitude was significantly lower on pp+P than on PA trials in Order 2 but not Order 1 (F<1). Prepulses inhibit startle on the first pairing with a startling pulse, an effect that cannot be explained by learning...
  25. ncbi The effects of memantine on prepulse inhibition
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropsychopharmacology 34:1854-64. 2009
    ..These findings are discussed as they relate to consistencies across other studies in humans, as well as apparent inconsistencies in the NMDA regulation of PPI across species...
  26. ncbi Realistic expectations of prepulse inhibition in translational models for schizophrenia research
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, 92093 0804, USA
    Psychopharmacology (Berl) 199:331-88. 2008
    ..This rapid expansion and broad application of PPI as a tool for understanding schizophrenia has, at times, outpaced critical thinking and falsifiable hypotheses about the relative strengths vs. limitations of this measure...
  27. ncbi A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating
    Neal R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 88:280-90. 2008
    ..To further understand the heritability of PPI and its sensitivity to dopamine agonists, we assessed PPI and apomorphine sensitivity in SD, BN and F1 (SD x BN) rats...
  28. ncbi Strain differences in the disruption of prepulse inhibition of startle after systemic and intra-accumbens amphetamine administration
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 87:1-10. 2007
    ..Inherited differences in the ability of elevated DA activity to disrupt PPI may be useful for understanding the neural basis for PPI deficits in schizophrenia and other neuropsychiatric disorders...
  29. ncbi Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of Schizophrenia
    Neal R Swerdlow
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    Schizophr Res 92:237-51. 2007
    ..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies...
  30. ncbi Effects of prepulse intensity, duration, and bandwidth on perceived intensity of startling acoustic stimuli
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Biol Psychol 74:389-95. 2007
    ..PPIPSI is a robust, parametrically sensitive and "low tech" measure of sensory gating that may become a valuable tool for understanding the biology of certain mental disorders...
  31. ncbi Forebrain D1 function and sensorimotor gating in rats: effects of D1 blockade, frontal lesions and dopamine denervation
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, United States
    Neurosci Lett 402:40-5. 2006
    ..The effects of systemic SCH23390 were not opposed by NAC DA depletion. D1 receptors regulate PPI in rats, but this effect does not appear to be mediated either by the MPFC or by increased mesolimbic DA activity...
  32. ncbi Sensitivity to drug effects on prepulse inhibition in inbred and outbred rat strains
    Neal R Swerdlow
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92039 0804, USA
    Pharmacol Biochem Behav 77:291-302. 2004
    ..These findings identify strains suitable for comparisons of PPI neural circuitry and others for whom such comparisons would be complex and perhaps less informative...
  33. ncbi The ventral hippocampal regulation of prepulse inhibition and its disruption by apomorphine in rats are not mediated via the fornix
    N R Swerdlow
    UCSD Department of Psychiatry, 9500 Gilman Drive, 92037 0804, La Jolla, CA, USA
    Neuroscience 123:675-85. 2004
    ..The enhanced sensitivity to the PPI-disruptive effects of apomorphine after VH lesions is not dependent on excitotoxin-induced changes in the VH or its downstream projections...
  34. ncbi Latent inhibition in schizophrenia
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Schizophr Res 20:91-103. 1996
    ....
  35. ncbi Sensitivity to the dopaminergic regulation of prepulse inhibition in rats: evidence for genetic, but not environmental determinants
    N R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 70:219-26. 2001
    ..This finding is consistent with published reports in other strains. Pharmacogenetic studies of PPI in rats may identify a genetic basis for a model of deficient sensorimotor gating in schizophrenia...
  36. ncbi Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges
    N R Swerdlow
    Department of Psychiatry, UCSD Schools of Medicine, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 156:194-215. 2001
    ....
  37. ncbi Effects of caffeine on sensorimotor gating of the startle reflex in normal control subjects: impact of caffeine intake and withdrawal
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 151:368-78. 2000
    ..This study was designed to assess caffeine effects on PPI in normal humans, as part of an effort to understand cross-species differences and similarities in the neurochemical regulation of PPI...
  38. ncbi Lesion size and amphetamine hyperlocomotion after neonatal ventral hippocampal lesions: more is less
    N R Swerdlow
    Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA 92093 0804, USA
    Brain Res Bull 55:71-7. 2001
    ..It is possible that the behavioral abnormalities in the "neonatal hippocampal lesion model" reflect, at least in part, aberrant function within spared elements of the hippocampal complex...
  39. ncbi Obsessive-compulsive disorder and tic syndromes
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Med Clin North Am 85:735-55. 2001
    ..As clinicians strive to integrate clinical and scientific findings into coherent models for the pathophysiology of OCD and TS, it is useful to identify practical and effective strategies for therapeutic interventions...
  40. ncbi Regulation of sensorimotor gating in rats by hippocampal NMDA: anatomical localization
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Brain Res 898:195-203. 2001
    ..These findings demonstrate the importance of the ventral, but not the dorsal HPC, in the glutamatergic regulation of PPI...
  41. ncbi Matching strategies for drug studies of prepulse inhibition in humans
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, USA
    Behav Pharmacol 12:45-52. 2001
    ..For studies using repeated testing to assess drug time course, the predictive value of pre-testing is greatest in early test sessions...
  42. ncbi Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Behav Pharmacol 11:185-204. 2000
    ..Some of these issues--ranging from the cross-species methods for quantifying specific variables to the relevance of genetic drift to animal and human studies of PPI--and their implications for future studies are the focus of this review...
  43. ncbi Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    J Neurosci 20:4325-36. 2000
    ..These findings demonstrate robust, innate, neurochemically specific, and apparently heritable phenotypic differences in an animal model of sensorimotor gating deficits in human neuropsychiatric disorders...
  44. ncbi Hippocampal lesions enhance startle gating-disruptive effects of apomorphine in rats: a parametric assessment
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla CA 92093 0804, USA
    Neuroscience 96:523-36. 2000
    ..This may be an important paradigm for understanding the contribution of ventral hippocampus dysfunction to the neurobiology of impaired sensorimotor gating in neuropsychiatric populations...
  45. ncbi Preliminary findings with a new Vietnamese Stroop test
    Q T Doan
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla 92093 0804, USA
    Percept Mot Skills 89:173-82. 1999
    ....
  46. ncbi Sex differences in sensorimotor gating of the human startle reflex: all smoke?
    N R Swerdlow
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 146:228-32. 1999
    ..A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers...
  47. ncbi Cross-species studies of sensorimotor gating of the startle reflex
    N R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
    Ann N Y Acad Sci 877:202-16. 1999
    ..In this manner, PPI can be used to probe the sensitivity of DAergic systems, and perhaps other CSPP elements, across normal and neuropsychiatric-disordered populations...
  48. ncbi Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla 92093 0804, USA
    Behav Pharmacol 9:389-96. 1998
    ....
  49. ncbi Effects of pergolide on sensorimotor gating of the startle reflex in rats
    N R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 158:230-40. 2001
    ..This study was designed to assess the effects of the D2-family agonist pergolide in rats, in anticipation of human studies of the dopaminergic regulation of PPI...
  50. ncbi Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 161:189-201. 2002
    ..25, 2.5 mg; pergolide: 0.025, 0.1 mg) and indirect DA agonists (amphetamine: 20 mg; amantadine: 200 mg) ( n=6-10/dose)...
  51. ncbi Sensitivity to sensorimotor gating-disruptive effects of apomorphine in two outbred parental rat strains and their F1 and N2 progeny
    Neal R Swerdlow
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 2093 0804, USA
    Neuropsychopharmacology 28:226-34. 2003
    ..The nature of this gradient of APO sensitivity suggests relatively simple additive effects of multiple genes on the phenotype of PPI sensitivity...
  52. ncbi Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross-species comparisons
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 164:82-92. 2002
    ....
  53. ncbi Amphetamine effects on prepulse inhibition across-species: replication and parametric extension
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Neuropsychopharmacology 28:640-50. 2003
    ....
  54. ncbi Startle gating in rats is disrupted by chemical inactivation but not D2 stimulation of the dorsomedial thalamus
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Brain Res 953:246-54. 2002
    ..5 mg/kg). The MD regulation of PPI in rats is not mediated via D2 receptors, but is clearly manifested via PPI deficits after reversible MD inactivation via TTX...
  55. ncbi Dopamine agonists disrupt visual latent inhibition in normal males using a within-subject paradigm
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Psychopharmacology (Berl) 169:314-20. 2003
    ..The apparent advantages and limitations of this paradigm are discussed with regard to its future use in understanding the neural basis of reported LI deficits in schizophrenia...
  56. ncbi Genetic differences in startle gating-disruptive effects of apomorphine: evidence for central mediation
    Neal R Swerdlow
    Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093 0804, USA
    Behav Neurosci 116:682-90. 2002
    ..SD > LE PPI-disruptive effects of apomorphine were also independent of peripheral versus central route of administration. This model for PPI genetics is sensitive to differences in central rather than peripheral substrates...
  57. ncbi Prestimulus effects on startle magnitude: sensory or motor?
    Neal R Swerdlow
    Department of Psychiatry, University of California at San Diego School of Medicine, La Jolla 92093 0804, USA
    Behav Neurosci 116:672-81. 2002
    ..Despite apparent differences in the inhibitory processes mediating PPI and paired pulse inhibition, both are independent of the motoric response to the prestimulus...
  58. ncbi Prestimulus modification of the startle reflex: relationship to personality and physiological markers of dopamine function
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Biol Psychol 62:17-26. 2003
    ..In normal male humans, PPI is inversely related to a physiological marker of resting DA tone (blink rate), but not to a putatively DA-linked personality trait (high NS)...
  59. ncbi Heritable differences in the effects of amphetamine but not DOI on startle gating in albino and hooded outbred rat strains
    Neal R Swerdlow
    Department of Psychiatry, 0804, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 75:191-7. 2003
    ..These findings demonstrate that the heritable phenotype in this model is not specific to a particular compound (APO), and reflects physiological differences in the DAergic, but not serotonergic, regulation of PPI...
  60. ncbi Strain differences in the gating-disruptive effects of apomorphine: relationship to gene expression in nucleus accumbens signaling pathways
    Paul D Shilling
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093, USA
    Biol Psychiatry 63:748-58. 2008
    ....
  61. ncbi Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans rats
    Michelle R Breier
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, CA 92093 0804, USA
    Behav Brain Res 208:560-5. 2010
    ..Here, we investigated whether SD and LE rats differ in sensitivity to APO effects on N40 gating or amplitude...
  62. ncbi Amphetamine effects on startle gating in normal women and female rats
    Jo A Talledo
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    Psychopharmacology (Berl) 204:165-75. 2009
    ..We reported that PPI was disrupted by D: -amphetamine in men, but only among those with high basal PPI levels. Here, amphetamine effects on PPI were tested in normal women and female rats...
  63. ncbi Earliest functional declines in Huntington disease
    Leigh J Beglinger
    Department of Psychiatry, The University of Iowa, Iowa City, IA, USA
    Psychiatry Res 178:414-8. 2010
    ..These are also important areas for clinical monitoring and treatment planning as up to 65% experienced loss in at least one area prior to diagnosis...
  64. ncbi The effects of apomorphine and D-amphetamine on striatal c-Fos expression in Sprague-Dawley and Long Evans rats and their F1 progeny
    Richard L Saint Marie
    Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA 92103-0804, USA
    Brain Res 1119:203-14. 2006
    ....
  65. ncbi Heritable strain differences in sensitivity to the startle gating-disruptive effects of D2 but not D3 receptor stimulation
    Martin Weber
    Department of Psychiatry, UCSD School of Medicine, La Jolla, California 92093 0804, USA
    Behav Pharmacol 19:786-95. 2008
    ..We conclude that the heritable pattern of greater PPI 'disruptability' by DA agonists in SD versus LE rats reflects differences in D2 but not D3 receptor-associated mechanisms...
  66. ncbi Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia
    Ann Olincy
    Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
    Schizophr Res 119:175-82. 2010
    ....
  67. ncbi Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands
    Bruce I Turetsky
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biol Psychiatry 64:1051-9. 2008
    ..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes...
  68. ncbi Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures
    Bruce I Turetsky
    Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Schizophr Bull 33:69-94. 2007
    ..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates...
  69. ncbi Using prepulse inhibition to detect functional D3 receptor antagonism: effects of WC10 and WC44
    Martin Weber
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92037 0804, USA
    Pharmacol Biochem Behav 93:141-7. 2009
    ..This assay may be valuable for detecting predominantly D3 vs. D2 receptor-linked mechanisms of action in vivo...
  70. ncbi Quetiapine produces a prolonged reversal of the sensorimotor gating-disruptive effects of basolateral amygdala lesions in rats
    Jody M Shoemaker
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla 92093-0804, USA
    Behav Neurosci 117:136-43. 2003
    ..PPI deficits after BLA lesions are reversed by quetiapine, in a manner that is sustained beyond its acute pharmacological effects and which may be mediated downstream from the BLA...
  71. ncbi Parametric approaches towards understanding the effects of the preferential D3 receptor agonist pramipexole on prepulse inhibition in rats
    Wei Li Chang
    Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 95:473-8. 2010
    ..Recommendations are made regarding "optimal" experimental conditions for studying the neurobiology of PRA-induced changes in PPI in rats...
  72. ncbi Electroencephalography (EEG) and event-related potentials (ERPs) with human participants
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Curr Protoc Neurosci . 2010
    ..These paradigms can be used to assess the integrity of early sensory processing in normal individuals and clinical populations, such as individuals with schizophrenia...
  73. ncbi Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    J Cogn Neurosci 19:1624-32. 2007
    ....
  74. ncbi Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients
    Gregory A Light
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
    Biol Psychiatry 60:1231-40. 2006
    ....
  75. ncbi Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patients
    David L Braff
    Department of Psychiatry, School of Medicine, University of California, San Diego, California 92093 0804, USA
    Biol Psychiatry 61:1204-7. 2007
    ..The relationship between PPI and P50 suppression in schizophrenia patients has remained unclear...
  76. ncbi Female schizophrenia patients have prepulse inhibition deficits
    David L Braff
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
    Biol Psychiatry 57:817-20. 2005
    ..This study was designed to determine whether female schizophrenia patients have lower levels of PPI than normal females...
  77. ncbi Comorbidities of obsessive and compulsive symptoms in Huntington's disease
    Karen E Anderson
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    J Nerv Ment Dis 198:334-8. 2010
    ..Clinicians should be aware that patients with HD and O/Cs might have a somewhat different clinical picture from those without, and may require a specialized treatment plan...
  78. ncbi Weak prepulses inhibit but do not elicit startle in rats and humans
    Neal R Swerdlow
    Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla 92093-0804, California, USA
    Biol Psychiatry 55:1195-8. 2004
    ..CONCLUSIONS: In humans and rats, PPES is not a necessary condition for either the elicitation or the disruption of PPI...
  79. ncbi Preclinical models relevant to Tourette syndrome
    Neal R Swerdlow
    Department of Psychiatry, UCSD School of Medicine, La Jolla, California, USA
    Adv Neurol 99:69-88. 2006
    ..Ultimately, the utility of these "deficient gating" models will be judged by their ability to bring us closer to identifying the causes and effective treatments of this disorder...
  80. ncbi The effects of the dopamine D2 agonist sumanirole on prepulse inhibition in rats
    Martin Weber
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Eur Neuropsychopharmacol 20:421-5. 2010
    ..PPI deficits were antagonized by low doses of the preferential D2 antagonist L741626, supporting a D2 mechanism of action. Sumanirole is a valuable tool for parsing the role of dopamine receptor subtypes in the regulation of PPI...
  81. ncbi Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies
    Ying Qu
    Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
    Pharmacol Biochem Behav 90:686-90. 2008
    ..003 (p < 0.05) and 0.01 mg/kg doses (p < 0.015). Differences in time course and dose sensitivity of quinelorane effects on VP GABA efflux and PPI are discussed...
  82. ncbi Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia
    Tiffany A Greenwood
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Gen Psychiatry 64:1242-50. 2007
    ..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia...
  83. ncbi The effects of pramipexole on prepulse inhibition and locomotor activity in C57BL/6J mice
    Wei Li Chang
    Department of Psychiatry, School of Medicine, University of California, California 92093 0804, USA
    Behav Pharmacol 21:135-43. 2010
    ..Distinct from findings in rats and humans, it seems that either: (i) PRA does not activate D3Rs in C57BL/6J mice, or (ii) D3R agonists are not sufficient to alter PPI in this mouse strain...
  84. ncbi Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation
    Susan B Powell
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive -0804, La Jolla, CA 92093, USA
    Physiol Behav 77:55-64. 2002
    ..Isolation rearing significantly disrupts PPI and locomotor habituation independent of any effects of water deprivation...
  85. ncbi Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation
    Michael K Harte
    Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom
    Biol Psychiatry 56:296-9. 2004
    ..Magnetic resonance spectroscopy studies have shown reductions of cortical and hippocampal NAA in schizophrenia, and a recent postmortem study has demonstrated a regionally selective temporal cortex deficit...
  86. ncbi Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
    William P Horan
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
    Schizophr Res 103:218-28. 2008
    ....
  87. ncbi Effects of background and prepulse characteristics on prepulse inhibition and facilitation: implications for neuropsychiatric research
    Ming H Hsieh
    Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
    Biol Psychiatry 59:555-9. 2006
    ....
  88. ncbi Much ado about (almost) nothing: response to 'prepulse lost and regained'
    Neal R Swerdlow
    Psychopharmacology (Berl) 179:893-4. 2005

Research Grants38

  1. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  2. CORTICO STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 1999
    ..In total, these studies will systematically characterize cortico-striatal circuitry regulating critical inhibitory functions that are deficient in schizophrenia. ..
  3. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  4. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 2009
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  5. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  6. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    This K02 proposal is for renewed career development support for Dr. Neal Swerdlow, to extend a period of intensive focus on his longstanding research goal: to increase our understanding of the substrates of specific mental disorders by ..
  7. Neural basis of heritable DA-mediated gating deficits
    Neal Swerdlow; Fiscal Year: 2006
    ..This new information will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  8. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ....
  9. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 2007
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  10. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2009
    ..More generally, these studies will leverage findings from MH 59803 years 1-5, to extend the important process of examining the neurochemistry of sensorimotor gating processes that fundamentally shape behavior and cognition in humans. ..
  11. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2003
    ..More generally, these studies will begin the important process of examining the neuro-chemistry of sensorimotor gating processes that fundamentally shape behavior and cognition in humans. ..
  12. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal Swerdlow; Fiscal Year: 2005
    ....
  13. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal R Swerdlow; Fiscal Year: 2011
    ..The findings will inform studies searching for the genes associated with dopamine-linked disorders of impaired sensorimotor gating in humans. ..