Research Topics
Species | Susmit SuvasSummaryAffiliation: University of Tennessee Country: USA Publications
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Detail Information
Publications
Qa-1b and CD94-NKG2a interaction regulate cytolytic activity of herpes simplex virus-specific memory CD8+ T cells in the latently infected trigeminal gangliaSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 176:1703-11. 2006..Our results demonstrate the operation of a regulatory system in vivo that serves to protect irreplaceable neurons from destruction by the immune system...- In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathologySusmit Suvas
Department of Microbiology, M409, Walters Life Sciences Building, University of Tennessee, Knoxville, TN 37996 0845, USA
J Virol 79:11935-42. 2005..Our results are the first observations to determine in vivo kinetics of GITR and GITR-L expression after virus infection, and they emphasize the role of GITR-GITR-L interaction to regulate virus-induced immuno-inflammatory lesions... - In vitro-generated antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells control the severity of herpes simplex virus-induced ocular immunoinflammatory lesionsSharvan Sehrawat
Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996 0845, USA
J Virol 82:6838-51. 2008..The suppression effect in vivo appeared to be polyspecific. The protocol we have developed could provide a useful additional approach to control virus-induced inflammatory disease... - Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effectsBumseok Kim
Department of Microbiology and Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 177:4122-31. 2006..These results indicate a role for CD8+ T cells in the antiangiogenic effects. Our results may also imply that the anti-VEGFR-2 vaccination approach might prove useful to control pathological ocular angiogenesis and its consequences... - CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesionsSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 172:4123-32. 2004..Our results decipher the in vivo role of T(reg) in a virus-induced immunopathology and imply that manipulation of regulatory cell function represents a useful approach to control viral-induced immunoinflammatory disease... - Rescue of memory CD8+ T cell reactivity in peptide/TLR9 ligand immunization by codelivery of cytokines or CD40 ligationFelix N Toka
Department of Microbiology, M-409 Walter's Life Sciences Building, University of Tennessee, Knoxville, TN 37996-0845, USA
Virology 331:151-8. 2005..Our results indicate that good memory CD8(+) T cell response to peptide immunization can be achieved by using costimulatory procedures at the time of priming or recall immunization... - Blocking mouse MMP-9 production in tumor cells and mouse cornea by short hairpin (sh) RNA encoding plasmidsAhmet Kursat Azkur
Department of Microbiology, University of Tennessee, Knoxville, 37996, USA
Oligonucleotides 15:72-84. 2005..However, interferon-alpha (IFN-alpha) and IFN- beta induced by pshRNA might also contribute to inhibition of herpetic simplex keratitis (HSK) in the cornea... - Heat-shock protein 70 acts as an effective adjuvant in neonatal mice and confers protection against challenge with herpes simplex virusChristopher D Pack
Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA
Vaccine 23:3526-34. 2005.... - Concomitant helper response rescues otherwise low avidity CD8+ memory CTLs to become efficient effectors in vivoUdayasankar Kumaraguru
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 172:3719-24. 2004..Our results emphasize that peptide immunization remains a viable approach to induce long-term CD8+ T cell function, providing steps are taken to assure appropriate stimulation of Th cell responses... - Application of plasmid DNA encoding IL-18 diminishes development of herpetic stromal keratitis by antiangiogenic effectsBumseok Kim
Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 175:509-16. 2005..Our results could mean that IL-18 administration may represent a useful approach to manage unwanted angiogenesis... - CD4+ CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1Felix N Toka
Department of Microbiology, University of Tennessee, Walter's Life Science Bldg. M409, 1414 Cumberland Ave, Knoxville, TN 37996, USA
J Virol 78:13082-9. 2004..However, it remains to be seen if all types of vaccines against HSV are similarly affected by CD25(+) T(reg) cells and if it is possible to devise means of limiting T(reg) cell activity to enhance vaccine efficacy... - IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathologyPranita P Sarangi
Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
J Immunol 180:6297-306. 2008..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically... - CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responsesSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA
J Exp Med 198:889-901. 2003..Thus, controlling suppressor effects at the time of vaccination could result in more effective immunity... - Regulatory cells and infectious agents: detentes cordiale and contraireBarry T Rouse
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 173:2211-5. 2004..Finally, emerging approaches are discussed that either blunt or activate Treg and that could be used practically to manage host-pathogen interaction... - Regulatory T cells in virus infectionsBarry T Rouse
Department of Microbiology, The University of Tennessee, Knoxville, TN 37996, USA
Immunol Rev 212:272-86. 2006..This review also discusses how virus infections become recognized by nTreg responses and how such responses might be manipulated to increase immunity or to limit virus-induced immunopathology... - Regulation of microbial immunity: the suppressor cell renaissanceSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0854, USA
Viral Immunol 18:411-8. 2005..The mechanisms by which Treg are induced, recognize microbes, and exert their function is also discussed. Finally, we examine approaches that might prove useful to manipulate regulatory cell response against infections... - Regulatory T cells and immunity to pathogensBarry T Rouse
University of Tennessee, College of Veterinary Medicine, Department of Pathobiology, Knoxville, TN 37996 0845, USA
Expert Opin Biol Ther 7:1301-9. 2007..Treg responses to pathogens may also act to hamper the efficacy of immune control. This review discusses these issues as well as the likely mechanisms by which various pathogens can signal the participation of Treg during infection... - Treg control of antimicrobial T cell responsesSusmit Suvas
Department of Microbiology, University of Tennessee, Knoxville, TN 37996-0845, USA
Curr Opin Immunol 18:344-8. 2006..Recently, several unresolved questions about the role of Treg in microbial infections have been raised and discussed. Learning how to successfully manipulate Treg responses could result in more effective vaccines and immunomodulators... - Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphomaSusmit Suvas
Immunology Laboratory, Institute of Microbial Technology, Postgraduate Institute of Medical Education and Research, Chandigarh 160036, India
J Biol Chem 277:7766-75. 2002..Finally, the significance of the finding is that CD80 provided negative signal for the proliferation and IgG secretion of normal B cells and B cell lymphomas. In contrast, CD86 encouraged the activity of B cells...