Research Topics
Genomes and GenesSpecies | P F SullivanSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
The public health utility of genome-wide association study results for smoking behaviorHelena Furberg
Department of Psychiatry and Behavioral Science, Memorial Sloan Kettering Cancer Center, 641 Lexington Ave, New York, NY 10022, USA
Genome Med 2:26. 2010..The coordinated effort of multidisciplinary research teams will help reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society...- MAOA haplotypes associated with thrombocyte-MAO activityMarten Jansson
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
BMC Genet 6:46. 2005..3 - 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in a Swedish sample (N = 573 individuals)... - An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatiguePatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
BMC Microbiol 11:2. 2011..Controls were the unaffected monozygotic co-twins of cases, and serum samples were obtained at the same place and time... - Genomewide association for schizophrenia in the CATIE study: results of stage 1P F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 13:570-84. 2008.... - Schizophrenia genetics: the search for a hard leadPatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
Curr Opin Psychiatry 21:157-60. 2008.... - The genetics of schizophreniaPatrick F Sullivan
Department of Genetics, Psychiatry, and Epidemiology, University of North Carolina, Chapel Hill, USA
PLoS Med 2:e212. 2005 - Genomewide linkage survey of nicotine dependence phenotypesPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Drug Alcohol Depend 93:210-6. 2008..We sought to identify genomic regions that might contain etiologically-relevant loci using genomewide univariate and bivariate linkage analyses... - Twin analyses of chronic fatigue in a Swedish national samplePatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
Psychol Med 35:1327-36. 2005..Chronic fatigue has infrequently been studied in twins. Data from twin studies can inform clinical and research approaches to the management and etiology of human complex traits... - Chronic fatigue in a population sample: definitions and heterogeneityPatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
Psychol Med 35:1337-48. 2005..Numerous nosological decisions are made when moving from the common human symptom of unusual fatigue to the rare chronic fatigue syndrome (CFS). These decisions have infrequently been subjected to rigorous evaluation... - Spurious genetic associationsPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
Biol Psychiatry 61:1121-6. 2007..I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication... - NCAM1 and neurocognition in schizophreniaPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
Biol Psychiatry 61:902-10. 2007..Neural cell adhesion molecule 1 (NCAM1, aliases NCAM and CD56) may be a candidate gene for schizophrenia or for neurocognition in schizophrenia as supported by linkage and functional findings... - Empirical evaluation of the genetic similarity of samples from twin registries in Australia and the Netherlands using 359 STRP markersPatrick F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, United States of America
Twin Res Hum Genet 9:600-2. 2006..30% between the Australian and the Netherlands cohorts, a smaller value than between many European groups. We conclude that it is reasonable to combine the Australian and the Netherlands samples for joint genetic analyses... - Evaluation of genetic substructure in the Irish Study of High-Density Schizophrenia FamiliesPatrick F Sullivan
University of North Carolina at Chapel Hill, Department of Genetics, 27599 7264, USA
Psychiatr Genet 14:187-9. 2004..We found no evidence for the presence of genetic substructure in this sample... - Evaluating the comparability of gene expression in blood and brainPatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 141:261-8. 2006..This suggests that the cautious and thoughtful use of peripheral gene expression may be a useful surrogate for gene expression in the CNS when it has been determined that the relevant gene is expressed in both... - Multipoint and single point non-parametric linkage analysis with imperfect dataPatrick F Sullivan
Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 121:89-94. 2003..The absence of parental genotypes in the presence of 1% genotype error led to marked degradation of linkage signal, particularly for multipoint analyses... - Schizophrenia as a complex trait: evidence from a meta-analysis of twin studiesPatrick F Sullivan
Department of Genetics, University of North Carolina at Chapel Hill, 27599, USA
Arch Gen Psychiatry 60:1187-92. 2003.... - Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccoloP F Sullivan
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Mol Psychiatry 14:359-75. 2009..With the integrated replication effort, we present a specific hypothesis for further studies... - Snus use and other correlates of smoking cessation in the Swedish Twin RegistryH Furberg
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599 7264, USA
Psychol Med 38:1299-308. 2008..We investigated 12 variables and their interactions as correlates of smoking cessation among regular smokers in the population-based Swedish Twin Registry (STR)... - Association study of 182 candidate genes in anorexia nervosaAndrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
Am J Med Genet B Neuropsychiatr Genet 153:1070-80. 2010.... - [Genetics in eating disorders: extending the boundaries of research]Andrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599, USA
Rev Bras Psiquiatr 28:218-25. 2006..To review the recent literature relevant to genetic research in eating disorders and to discuss unique issues which are crucial for the development of a genetic research project in eating disorders in Brazil... - Cigarettes and oral snuff use in Sweden: Prevalence and transitionsHelena Furberg
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599-7264, USA
Addiction 101:1509-15. 2006..Once snus use was initiated, more men continued using snus rather than quit tobacco completely... - Simulating association studies: a data-based resampling method for candidate regions or whole genome scansFred A Wright
Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
Bioinformatics 23:2581-8. 2007..Improvements in study design and analytic techniques will require the simulation of datasets with realistic patterns of linkage disequilibrium and allele frequencies for typed SNPs... - Meta-analysis of genome-wide association studies with overlapping subjectsDan Yu Lin
Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Hum Genet 85:862-72. 2009..The advantages of the new approach are illustrated with empirical data from two sets of genome-wide association studies... - The genetics of anorexia nervosaCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, NC 27599, USA
Annu Rev Nutr 27:263-75. 2007..With these bodies of literature as a starting point, we evaluate critically the current state of research on molecular genetic studies of anorexia nervosa and provide guidance for future research... - Current developments in the genetics of autism: from phenome to genomeMolly Losh
Department of Allied Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7190, USA
J Neuropathol Exp Neurol 67:829-37. 2008.... - Gene expression in peripheral blood leukocytes in monozygotic twins discordant for chronic fatigue: no evidence of a biomarkerAndrea Byrnes
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
PLoS ONE 4:e5805. 2009..Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes... - Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neckPatricia V Basta
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
Cancer Detect Prev 32:200-8. 2008..Here we present data examining the association of genetic variation in one of the key enzymes of the PPP, Transaldolase 1 (TALDO1) with squamous cell carcinoma of the head and neck (SCCHN)... - AKT1 and neurocognition in schizophreniaAndrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, NC, USA
Aust N Z J Psychiatry 41:169-77. 2007..Therefore, the association of genetic variation in AKT1 with neurocognition was investigated in patients with schizophrenia... - The STAGE cohort: a prospective study of tobacco use among Swedish twinsHelena Furberg
Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
Nicotine Tob Res 10:1727-35. 2008..Patterns of tobacco use may be changing in Sweden; snus use appears to be increasing, while daily smoking appears to be decreasing in popularity among the younger Swedish twins... - The neuregulin 1 promoter polymorphism rs6994992 is not associated with chronic schizophrenia or neurocognitionJames J Crowley
Department of Genetics, University of North Carolina at Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 147:1298-300. 2008..We were unable to replicate previous associations of rs6994992 with schizophrenia and, moreover, did not find significant associations with age of onset, an estimate of pre-morbid IQ, or neurocognition... - Prevalence, heritability, and prospective risk factors for anorexia nervosaCynthia M Bulik
Department of Psychiatry, School of Public Health, University of North Carolina at Chapel Hill, 27599, USA
Arch Gen Psychiatry 63:305-12. 2006..Anorexia nervosa (AN) is a serious mental illness with marked morbidity and mortality... - The prevalence of self-reported chronic fatigue in a U.S. twin registryHelena Furberg
Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
J Psychosom Res 59:283-90. 2005..Given the debilitating consequences of fatiguing illnesses, the reasons for the female predominance and the earlier onset in women should receive increased research priority... - The types of regular cigarette smokers: a latent class analysisHelena Furberg
Department of Genetics, University of North Carolina at Chapel Hill, School of Medicine 27599 7264, USA
Nicotine Tob Res 7:351-60. 2005.... - Is Swedish snus associated with smoking initiation or smoking cessation?H Furberg
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599-7264, USA
Tob Control 14:422-4. 2005..Evaluation of the efficacy of snus for smoking cessation should be evaluated in randomised clinical trials... - A searchable database of genetic evidence for psychiatric disordersThomas Konneker
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 147:671-5. 2008..Findings can be save to disk or viewed via a genome browser... - TAMAL: an integrated approach to choosing SNPs for genetic studies of human complex traitsBradley M Hemminger
School of Information and Library Science, University of North Carolina at Chapel Hill, NC, USA
Bioinformatics 22:626-7. 2006..AVAILABILITY: TAMAL is a platform independent web-based application available free of charge at http://neoref.ils.unc.edu/tamal. SUPPLEMENTARY INFORMATION: http://neoref.ils.unc.edu/tamal/... - No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognitionThomas I Konneker
Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
Am J Med Genet B Neuropsychiatr Genet 153:1115-7. 2010..67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons... - Genotyping accuracy for whole-genome amplification of DNA from buccal epithelial cellsKeren Leviel
Department of Genetics, University of North Carolina at Chapel Hill, 27599-7264, USA
Twin Res 7:482-4. 2004..If used with caution, these data suggest that rolling-circle whole-genome amplification can be used to increase the DNA mass available for large-scale genotyping projects based on DNA from buccal cells... - An empirical study of the typology of bulimic symptoms in young Portuguese womenAndrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina, USA
Int J Eat Disord 41:251-8. 2008..To investigate whether clusters of bulimic symptoms exist in a community sample of young Portuguese women... - Schizophrenia genetics: where next?Yunjung Kim
Department of Genetics, University of North Carolina, Chapel Hill, NC 2Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599 7264, USA
Schizophr Bull 37:456-63. 2011.... - A candidate gene study of Tardive dyskinesia in the CATIE schizophrenia trialHuei Ting Tsai
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 153:336-40. 2010..No single marker or haplotype association reached statistical significance after adjustment for multiple comparisons. Thus, we found no support for either novel or prior associations from the literature... - The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family historyCarol A Prescott
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 29:417-29. 2005.... - Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the NetherlandsNaomi R Wray
Department of Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Australia 4029
Arch Gen Psychiatry 65:649-58. 2008..Studying this personality dimension can give insights into the etiology of these important psychiatric disorders... - Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence... - Rare chromosomal deletions and duplications increase risk of schizophreniaJennifer L Stone
Nature 455:237-41. 2008..Our results provide strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome-wide and at specific loci... - A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependenceHermine H Maes
Departments of Human Genetics and Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0003, USA
Psychol Med 34:1251-61. 2004..As the development of ND requires regular tobacco use (RTU) which in turn requires TI, a conditional approach is necessary... - Model-based gene selection shows engrailed 1 is associated with antipsychotic responseBradley Todd Webb
Center for Biomarker Research and Personalized Medicine, Department of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298, USA
Pharmacogenet Genomics 18:751-9. 2008..We sought to find genes that may influence treatment response in a less biased manner, after integrating heterogeneous data sources related to schizophrenia... - Psychiatric and medical symptoms in binge eating in the absence of compensatory behaviorsTed Reichborn-Kjennerud
Division of Epidemiology, The Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
Obes Res 12:1445-54. 2004..To explore the extent to which binge eating in the absence of compensatory behaviors (BE) is associated with psychiatric and medical symptoms in men and women and to control for the independent effects of BMI... - A genome scan of neuroticism in nicotine dependent smokersBenjamin M Neale
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 132:65-9. 2005..52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014)... - Candidate genes for nicotine dependence via linkage, epistasis, and bioinformaticsPatrick F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, VA, USA
Am J Med Genet B Neuropsychiatr Genet 126:23-36. 2004..Although the hypotheses resulting from these linkage and bioinformatic analyses are plausible and intriguing, their ultimate worth depends on replication in additional linkage samples and in future experimental studies... - Causes and recovery in anorexia nervosa: the patient's perspectiveFederica Tozzi
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0126, USA
Int J Eat Disord 33:143-54. 2003..The results underscore the importance of interpersonal factors in recovery from anorexia nervosa and suggest that attention to this area in treatment may be beneficial... - The relation between eating disorders and components of perfectionismCynthia M Bulik
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, USA
Am J Psychiatry 160:366-8. 2003..The authors' goal was to explore the relation between perfectionism and psychopathology, including eating disorders... - Evaluation of analyses of univariate discrete twin dataPatrick F Sullivan
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University Richmond, 23298 0126, USA
Behav Genet 32:221-7. 2002..These results suggest that the use of AIC to guide twin modeling for univariate discrete traits should either be abandoned or used with great caution... - A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutationsEdwin J C G van den Oord
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
Hum Hered 56:188-99. 2003..To develop a method for designing studies to find disease mutations that can achieve a set of goals with respect to proportions of false and true discoveries with the minimum amount of genotyping... - Mania in the Swedish Twin Registry: criterion validity and prevalenceFederico Soldani
Department of Psychiatry, Harvard University, Boston, MA, USA
Aust N Z J Psychiatry 39:235-43. 2005..Assessment of a lifetime manic episode based on lay interviewer screening may yield misleading data... - Association of RGS2 and RGS5 variants with schizophrenia symptom severityDaniel B Campbell
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Schizophr Res 101:67-75. 2008..3-1q31. Due to overlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute to schizophrenia severity and treatment responsiveness... - The Swedish Twin Registry in the third millennium: an updatePaul Lichtenstein
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Twin Res Hum Genet 9:875-82. 2006..In particular, we describe recent efforts to screen all twins born between 1959 and 1985, and young twin pairs when they turn 9 and 12 years of age. For these studies, we present initial frequencies of common conditions and exposures... - Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depressionA Leo Beem
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Behav Genet 36:127-36. 2006..However, the association occurred in the absence of evidence for linkage in this region on chromosome 2... - A joint genomewide linkage analysis of symptoms of alcohol dependence and conduct disorderKenneth S Kendler
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA
Alcohol Clin Exp Res 30:1972-7. 2006..Are the susceptibility genes underlying this peak specific for AD or do they increase risk for externalizing disorders more generally? Can we, in the IASPSAD, replicate prior evidence for linkage to conduct disorder (CD)?.. - Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblingsChristel M Middeldorp
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Twin Res Hum Genet 8:609-15. 2005..Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found... - Identification of susceptibility loci for alcohol-related traits in the Irish Affected Sib Pair Study of Alcohol DependencePo Hsiu Kuo
Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA
Alcohol Clin Exp Res 30:1807-16. 2006..The goal of this study was to identify genomic regions containing susceptibility loci for alcohol-related traits... - Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophreniaXiangning Chen
Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richimond, VA 23298, USA
Hum Mol Genet 15:3329-42. 2006..However, due to the extended high LD in this region, we were unable to distinguish whether the association signals came from one or more of these genes... - Genetic, developmental and personality correlates of self-mutilation in depressed patientsPeter R Joyce
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, New Zealand
Aust N Z J Psychiatry 40:225-9. 2006..To examine whether the T allele of G protein beta3 (GNbeta3) is associated with self-mutilation in depressed patients... - Recurrence risks for schizophrenia in a Swedish national cohortPaul Lichtenstein
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
Psychol Med 36:1417-25. 2006..These data may be valuable for planning and interpreting genetic studies of schizophrenia... - Anxiety and comorbid measures associated with PLXNA2Naomi R Wray
Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia
Arch Gen Psychiatry 64:318-26. 2007..Common genetic liabilities have been reported between psychiatric and psychological measures, but few examples exist of common genetic variants... - Epidemiology of cancer-related fatigue in the Swedish twin registryMichael J Forlenza
Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
Cancer 104:2022-31. 2005..CONCLUSIONS: A greater proportion of individuals who were listed in a national cancer registry reported experiencing fatigue compared with individuals in the general population... - Comment on a simple and improved correction for population stratificationSeunggeun Lee
Am J Hum Genet 82:524-6; author reply 526-8. 2008 - The subtypes of major depression in a twin registryPatrick F Sullivan
Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, P O Box 980126, Richmond VA 23298 0126, USA
J Affect Disord 68:273-84. 2002..The subtypes of major depression (MD) remain incompletely understood. While there is consensus about the existence of MD with 'typical' vegetative features, further data are required to evaluate the existence of MD with atypical features... - Twin analyses of fatigueEllen Schur
1 Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Twin Res Hum Genet 10:729-33. 2007..About half the variance for both prolonged and chronic fatigue in males was due to genetic effects, and half due to individual-specific environmental effects. For females, most variance was due to individual environmental effects... - Genetic and phenotypic stability of measures of neuroticism over 22 yearsNaomi R Wray
Genetic Epidermology, Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 10:695-702. 2007..33 for a single measure to .43 for mean score because of the reduction in the estimate of the environmental variance, and this will increase power in genetic linkage or association studies of neuroticism... - Irritable bowel syndrome: a co-twin control analysisMary K Wojczynski
Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA
Am J Gastroenterol 102:2220-9. 2007..Therefore, we aimed to examine if there is a genetic component to the co-occurrence of MDD and IBS in participants from the population-based Swedish Twin Registry... - Premorbid predictors of chronic fatigueKenji Kato
Department of Medical Epidemiology and Biostatistics, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden
Arch Gen Psychiatry 63:1267-72. 2006..These findings suggest plausible mechanisms for chronic fatiguing illness... - Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophreniaDaniel B Campbell
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA
Biol Psychiatry 63:32-41. 2008..The central role of RGS4 in regulating signaling via Gi/o coupled neurotransmitter receptors led us to hypothesize that there may be RGS4 genotypes predictive of specific disease phenotypes and antipsychotic treatment responses... - A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patientsPeter R Joyce
Department of Psychological Medicine, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
Psychol Med 36:807-13. 2006..We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD... - Genetic and environmental contributions to obesity and binge eatingCynthia M Bulik
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, PO Box 980126, Richmond, VA 23298 0126, USA
Int J Eat Disord 33:293-8. 2003..The purpose of this article was to determine the extent of overlap between genetic and environmental factors that contribute to the liability to obesity and binge eating... - False discoveries and models for gene discoveryEdwin J C G van den Oord
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Trends Genet 19:537-42. 2003..This raises the question of whether current models for gene discovery are shaped excessively by a fear of false discoveries...
Research Grants
- Replication of Schizophrenia Associations in CATIEPatrick Sullivan; Fiscal Year: 2007..We believe that the results of our study will be highly informative and are essential to the field at this critical juncture in the hunt for genes mediating liability to schizophrenia. ..
- A Large-Scale Schizophrenia Association Study in SwedenPatrick Sullivan; Fiscal Year: 2007..For the long-term, establishment of this sample will provide an accessible resource for the psychiatric research community. Future projects could include whole genome association and nested case-control studies. ..
- Major Depression: Stage 1 Genomewide Association in Population-Based SamplesPatrick Sullivan; Fiscal Year: 2007..This is arguably the best and most comprehensive sample collection for MDD in the world. ..
- A Large-Scale Schizophrenia Association Study in SwedenPatrick Sullivan; Fiscal Year: 2009..For the long-term, establishment of this sample will provide an accessible resource for the psychiatric research community. Future projects could include whole genome association and nested case-control studies. ..
- 2/2 A genome-wide association study to detect genetic variation for schizophreniaPatrick F Sullivan; Fiscal Year: 2010..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..
- GENETIC & ENVIRONMENT DETERMINANTS OF SMOKING CESSATIONPatrick Sullivan; Fiscal Year: 2006....
- DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSIONPatrick Sullivan; Fiscal Year: 2002..abstract_text> ..
- Microarrays & Proteomics in MZ Twins Discordant for CFSPatrick Sullivan; Fiscal Year: 2006..If successful, this work could lead to profound changes in the understanding of CFS and resolution of some attendant controversies. ..
- 2/2 A genome-wide association study to detect genetic variation for schizophreniaPatrick F Sullivan; Fiscal Year: 2010..Case-finding efforts could be greatly improved and we could learn far more about how this devastating disease develops. ..