Research Topics
| Andreas StengelSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weightAndreas Stengel
CURE Digestive Diseases Research Center and Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:357-69. 2010....- Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in ratsAndreas Stengel
Department of Medicine, Center for Ulcer Research and Education, Digestive Diseases Division, University of California Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Endocrinology 151:4224-35. 2010.... - Chronic injection of pansomatostatin agonist ODT8-SST differentially modulates food intake and decreases body weight gain in lean and diet-induced obese ratsAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Regul Pept 167:201-8. 2011..In DIO rats, ODT8-SST reduces lean mass but promotes food intake and fat mass, indicating differential responsiveness to somatostatin under obese conditions... - Activation of brain somatostatin 2 receptors stimulates feeding in mice: analysis of food intake microstructureAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Physiol Behav 101:614-22. 2010..The shortened inter-meal interval suggests an inhibitory effect of the sst(2) agonist on "satiety", whereas "satiation" is not altered as indicated by normal meal size... - Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fastingAndreas Stengel
Center for Ulcer Research and Education, Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90073, USA
Endocrinology 150:153-60. 2009..These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response... - Restraint stress activates nesfatin-1-immunoreactive brain nuclei in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA
Brain Res 1300:114-24. 2009..These data demonstrate that nesfatin-1 neurons are part of the hypothalamic and hindbrain neuronal cell groups activated by restraint suggesting a possible role of nesfatin-1 in the response to stress... - Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosaAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, University of California, Los Angeles, California, USA
Endocrinology 150:232-8. 2009..NUCB2 gene expression is significantly regulated by nutritional status, suggesting a regulatory role of peripheral nesfatin-1 in energy homeostasis... - Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptorAndreas Stengel
Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:4911-9. 2009..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect... - Lipopolysaccharide differentially decreases plasma acyl and desacyl ghrelin levels in rats: potential role of the circulating ghrelin-acylating enzyme GOATAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, Los Angeles, CA 90073, USA
Peptides 31:1689-96. 2010..These data indicate that LPS induces a long-lasting reduction of AG and DG levels that may have a bearing with the decrease in food intake. The faster drop in AG than DG within 2 h is associated with reduced circulating GOAT... - Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in ratsMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Brain Res 1351:150-64. 2010.... - Peripheral activation of corticotropin-releasing factor receptor 2 inhibits food intake and alters meal structures in miceLixin Wang
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine Digestive Diseases Division, David Geffen School of Medicine, UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Peptides 32:51-9. 2011..These data indicate that Ucns, through peripheral CRF(2) receptor-mediated induction of satiation, inhibit the eating response to a fast more potently than the physiological nocturnal feeding in mice... - Central nesfatin-1 reduces the nocturnal food intake in mice by reducing meal size and increasing inter-meal intervalsMiriam Goebel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and Veterans Affairs Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:36-43. 2011..The lack of nesfatin-1 effect when injected peripherally at a 23-times higher dose indicates a primarily central site of the anorexigenic action for nesfatin-1 in mice... - Abdominal surgery activates nesfatin-1 immunoreactive brain nuclei in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Peptides 31:263-70. 2010.... - Mice overexpressing corticotropin-releasing factor show brain atrophy and motor dysfunctionsMiriam Goebel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine, UCLA and VA GLA Healthcare System, Los Angeles, CA, USA
Neurosci Lett 473:11-5. 2010.... - Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 31:2229-35. 2010..The restoration of circulating AG levels inhibited by abdominal surgery may contribute to alleviate postoperative gastric ileus... - Ghrelin: new insight to mechanisms and treatment of postoperative gastric ileusAndreas Stengel
CURE Digestive Diseases Research Center, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Curr Pharm Des 17:1587-93. 2011.... - Nesfatin-1--role as possible new potent regulator of food intakeAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Digestive Diseases Division UCLA, Los Angeles, CA 90073, USA
Regul Pept 163:18-23. 2010..Lastly, potential clinical implications of targeting NUCB2/nesfatin-1 signaling and existing gaps in knowledge to ascertain the role and mechanisms of action of nesfatin-1 are presented... - Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stageAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Digestive Diseases Division UCLA, Los Angeles, CA, USA
Curr Protein Pept Sci 12:293-304. 2011.... - Corticotropin-releasing factor signaling and visceral response to stressAndreas Stengel
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Digestive Diseases Division, David Geffen School of Medicine at University of California Los Angeles, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Exp Biol Med (Maywood) 235:1168-78. 2010.... - Lipopolysaccharide increases gastric and circulating NUCB2/nesfatin-1 concentrations in ratsAndreas Stengel
CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division, University of California Los Angeles, VA Greater Los Angeles Health Care System, CA 90073, USA
Peptides 32:1942-7. 2011..These changes are opposite to those of ghrelin in response to LPS supporting a differential gastric regulation of NUCB2/nesfatin-1 and ghrelin expression derived from the same cell by immune challenge... - Minireview: nesfatin-1--an emerging new player in the brain-gut, endocrine, and metabolic axisAndreas Stengel
Department of Medicine, CURE Digestive Diseases Research Center, University of California, Los Angeles, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 152:4033-8. 2011..However, the cellular mechanisms of nesfatin-1's action remain poorly understood, partly because the receptor through which nesfatin-1 exerts its pleiotropic actions is yet to be identified... - Localization of nesfatin-1 neurons in the mouse brain and functional implicationMiriam Goebel-Stengel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Brain Res 1396:20-34. 2011.... - Comparison of CRF-immunoreactive neurons distribution in mouse and rat brains and selective induction of Fos in rat hypothalamic CRF neurons by abdominal surgeryLixin Wang
CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, University of California Los Angeles, VAGLAHS, Los Angeles, CA 90073, USA
Brain Res 1415:34-46. 2011..Abdominal surgery activates CRF-ir neurons selectively in the PVN of rats without colchicine treatment... - Regulation of food intake: the gastric X/A-like endocrine cell in the spotlightAndreas Stengel
Center for Ulcer Research and Education, Digestive Diseases Research Center, Center for Neurobiology of Stress, Building 115, Room 117, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 11:448-54. 2009..Importantly, synergistic interactions between ghrelin and intestinal peptides seem to orchestrate food intake and body weight regulation, which may have implications for understanding mechanisms leading to the treatment of obesity... - Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nucleiMiriam Goebel
CURE Digestive Diseases Research Center, Digestive Diseases Division, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
Neurosci Lett 452:241-6. 2009..The features and distributions of nesfatin-1 IR and mRNA expression in the brain and spinal cord suggest that NUCB2/nesfatin-1 could play a wider role in autonomic regulation of visceral-endocrine functions besides food intake... - Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implicationsAndreas Stengel
CURE Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
Peptides 32:2208-17. 2011..A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress... - The RAPID method for blood processing yields new insight in plasma concentrations and molecular forms of circulating gut peptidesAndreas Stengel
University of California and CURE Digestive Disease Research Center, Building 115, Room 117, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
Endocrinology 150:5113-8. 2009..Therefore, the RAPID method represents an efficacious means to detect circulating variations in peptide concentrations and form relevant to the understanding of physiological function of endocrine peptides... - A role for corticotropin-releasing factor in functional gastrointestinal disordersYVETTE TACHE
Center for Ulcer Research and Education CURE Digestive Diseases Research Center, Building 115, Room 117, VA Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 11:270-7. 2009..Yet to be ascertained is whether CRF1 receptor antagonists hold promise as a new therapy in IBS treatment... - Neuroendocrine control of the gut during stress: corticotropin-releasing factor signaling pathways in the spotlightAndreas Stengel
Department of Medicine and CURE Digestive Diseases Research Center, Center for Neurobiology of Stress, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Annu Rev Physiol 71:219-39. 2009..Here, we review how various stressors affect the gut, with special emphasis on the central and peripheral CRF signaling systems...