N Stella

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195 7280, USA
    Glia 58:1017-30. 2010
  2. ncbi Endocannabinoid signaling in microglial cells
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195 7280, USA
    Neuropharmacology 56:244-53. 2009
  3. ncbi Cannabinoid signaling in glial cells
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195 7280, USA
    Glia 48:267-77. 2004
  4. ncbi Receptor-dependent formation of endogenous cannabinoids in cortical neurons
    N Stella
    Department of Pharmacology, 360 Med Surge II, University of California, Irvine 92697-4625, USA
    Eur J Pharmacol 425:189-96. 2001
  5. ncbi Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice
    Anke Witting
    Department of Pharmacology, University of Washington, Seattle, WA, USA
    J Neurochem 89:1555-7. 2004
  6. ncbi Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival
    Patrick Weydt
    Department of Neurology, University of Washington, Seattle, WA 98195, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:182-4. 2005
  7. ncbi Cannabinoids and neuroinflammation
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Br J Pharmacol 141:775-85. 2004
  8. ncbi Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA
    J Neurosci 23:1398-405. 2003
  9. ncbi Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue
    Eiron Cudaback
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Neurobiol 36:36-44. 2007
  10. ncbi Cannabinoid receptors and endocannabinoids: evidence for new players
    Ken Mackie
    Department of Anesthesiology, University of Washington, 1959 Pacific Ave N, Seattle, WA 98195-7280, USA
    AAPS J 8:E298-306. 2006

Research Grants

  1. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
  2. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2010
  3. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2009
  4. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2007
  5. Novel Monoacylglycerol Lipase
    Nephi Stella; Fiscal Year: 2007
  6. Cannabinoid Signaling System in Microglial Cells
    Nephi Stella; Fiscal Year: 2007
  7. Genetics of endocannabinoid biosynthesis and inactivation
    Nephi Stella; Fiscal Year: 2007
  8. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2005
  9. Role of ABHD6 in 2-AG Signaling
    Nephi Stella; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. ncbi Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195 7280, USA
    Glia 58:1017-30. 2010
    ....
  2. ncbi Endocannabinoid signaling in microglial cells
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195 7280, USA
    Neuropharmacology 56:244-53. 2009
    ....
  3. ncbi Cannabinoid signaling in glial cells
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195 7280, USA
    Glia 48:267-77. 2004
    ....
  4. ncbi Receptor-dependent formation of endogenous cannabinoids in cortical neurons
    N Stella
    Department of Pharmacology, 360 Med Surge II, University of California, Irvine 92697-4625, USA
    Eur J Pharmacol 425:189-96. 2001
    ....
  5. ncbi Endocannabinoids accumulate in spinal cord of SOD1 G93A transgenic mice
    Anke Witting
    Department of Pharmacology, University of Washington, Seattle, WA, USA
    J Neurochem 89:1555-7. 2004
    ..Our results show that chronic neurodegeneration induced by a genetic mutation increases endocannabinoid production possibly as part of an endogenous defense mechanism...
  6. ncbi Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival
    Patrick Weydt
    Department of Neurology, University of Washington, Seattle, WA 98195, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:182-4. 2005
    ..Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS...
  7. ncbi Cannabinoids and neuroinflammation
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Br J Pharmacol 141:775-85. 2004
    ..Our aim is to identify immune functions modulated by cannabinoids that could account for their anti-inflammatory effects in these animal models...
  8. ncbi Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA
    J Neurosci 23:1398-405. 2003
    ....
  9. ncbi Targeting astrocytomas and invading immune cells with cannabinoids: a promising therapeutic avenue
    Eiron Cudaback
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Mol Neurobiol 36:36-44. 2007
    ..We further propose the continued intense investigation of cannabinoid efficacies as novel anti-cancer agents, especially in models recapitulating such properties within the unique environment of the brain...
  10. ncbi Cannabinoid receptors and endocannabinoids: evidence for new players
    Ken Mackie
    Department of Anesthesiology, University of Washington, 1959 Pacific Ave N, Seattle, WA 98195-7280, USA
    AAPS J 8:E298-306. 2006
    ....
  11. ncbi Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
    Anke Witting
    Department of Pharmacology, Anesthesiology, Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:6362-7. 2006
    ....
  12. ncbi The endocannabinoid system promotes astroglial differentiation by acting on neural progenitor cells
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Neurosci 26:1551-61. 2006
    ..These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function...
  13. ncbi Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
    ..CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas...
  14. ncbi Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    Allyn Franklin
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 23:7767-75. 2003
    ....
  15. ncbi Cannabis Sativa: getting closer to separating the medicinal properties from the drug of abuse
    Nephi Stella
    J Neuroimmunol 166:1-2. 2005
  16. ncbi Endothelin-1 increases 2-arachidonoyl glycerol (2-AG) production in astrocytes
    Lisa Walter
    Department of Pharmacology, University of Washington, Seattle, Washington, USA
    Glia 44:85-90. 2003
    ..The data suggest that endothelin-1 modulates 2-AG production in astrocytes and that this endocannabinoid may participate in paracrine signaling toward neurons and microglia...
  17. ncbi The endocannabinoid system drives neural progenitor proliferation
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    FASEB J 19:1704-6. 2005
    ..Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain...

Research Grants18

  1. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2010
    ....
  2. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2010
    ..In doing so, we will also gain a better understanding of the molecular mechanism controlling eCB signaling in the CMS. ..
  3. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2009
    ..In doing so, we will also gain a better understanding of the molecular mechanism controlling eCB signaling in the CMS. ..
  4. Novel CB Receptors
    Nephi Stella; Fiscal Year: 2007
    ....
  5. Novel Monoacylglycerol Lipase
    Nephi Stella; Fiscal Year: 2007
    ....
  6. Cannabinoid Signaling System in Microglial Cells
    Nephi Stella; Fiscal Year: 2007
    ..In doing so, we will also gain a better understanding of the molecular mechanism controlling eCB signaling in the CMS. ..
  7. Genetics of endocannabinoid biosynthesis and inactivation
    Nephi Stella; Fiscal Year: 2007
    ..Results obtained with this R21 grant will provide the basis for an RO1 aimed on understanding the genetic and molecular basis of mammalian eCB production and inactivation, a pivotal question in the field of drug of abuse research. ..
  8. Cannabinoid Signaling System in Microglial Cell
    Nephi Stella; Fiscal Year: 2005
    ..Finally, because cannabinoids are immunoactive, characterization of the cannabinoid signaling system in microglial cells might lead to new pharmaceutical targets that could specifically temper inflammation of the CNS. ..
  9. Role of ABHD6 in 2-AG Signaling
    Nephi Stella; Fiscal Year: 2010
    ....