Research Topics
Species | Timothy D StarnerSummaryAffiliation: University of Iowa Country: USA Publications
Research Grants
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Detail Information
Publications
Expression and activity of beta-defensins and LL-37 in the developing human lungTimothy D Starner
Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
J Immunol 174:1608-15. 2005..Lower levels of HBD-2 may be one factor contributing to the increased susceptibility of premature infants to pulmonary infections...- Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilmsTimothy D Starner
Department of Pediatrics, University of Iowa, 2080H Medical Laboratories, 200 Hawkins Drive, Iowa City, IA 52242, USA
Antimicrob Agents Chemother 52:137-45. 2008..influenzae... - Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosisTimothy D Starner
The University of Iowa, Department of Pediatrics, 200 Hawkins Drive, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 174:213-20. 2006..Bacteria biofilms are increasingly recognized as contributing to bacterial persistence and disease pathogenesis in CF... - Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbationDwight C Look
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33-GH, Iowa City, 52242, USA
Proc Am Thorac Soc 3:482-3. 2006 - Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birthDavid A Stoltz
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Sci Transl Med 2:29ra31. 2010.... - The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epitheliaAlejandro A Pezzulo
Department of Internal Medicine, Univ of Iowa, Iowa City, 52242, USA
Am J Physiol Lung Cell Mol Physiol 300:L25-31. 2011..We describe a high level of similarity between cells of tracheal and bronchial origin within and between different human donors, which suggests a very robust expression profile that is specific to airway cells... - Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylationTimothy D Starner
Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
Infect Immun 70:5287-9. 2002..In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes... - CCL20 is an inducible product of human airway epithelia with innate immune propertiesTimothy D Starner
Department of Pediatrics, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 29:627-33. 2003..Thus, CCL20 is a bi-functional peptide with both innate and adaptive immune properties that is regulated by inflammatory mediators, expressed by airway epithelia, and increased in cystic fibrosis airway secretions... - Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizersCecilia L Chin
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
Am J Respir Crit Care Med 172:85-91. 2005..Airway infection with Haemophilus influenzae causes airway inflammation, and isolation of new strains of this bacteria is associated with increased risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD)... - Pathogenesis of early lung disease in cystic fibrosis: a window of opportunity to eradicate bacteriaTimothy D Starner
University of Iowa, Iowa City, Iowa 52242, USA
Ann Intern Med 143:816-22. 2005 - Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigsChristopher S Rogers
Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Science 321:1837-41. 2008..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment... - Lysozyme secretion by submucosal glands protects the airway from bacterial infectionRana Dajani
Department of Anatomy and Cell Biology, Center for Gene Therapy, Howard Hughes Medical Institute, University of Iowa, 51 Newton Road, Iowa City, IA 52242-1109, USA
Am J Respir Cell Mol Biol 32:548-52. 2005..These studies provide evidence that submucosal glands are a major source of antibacterials critical for maintaining sterile airways... - TGF-alpha regulates TLR expression and function on epidermal keratinocytesLloyd S Miller
Division of Dermatology, Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 174:6137-43. 2005..These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces... - The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureusDavid J Schibli
Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada
J Biol Chem 277:8279-89. 2002....
Research Grants
- Beta-defensins and pulmonary host defenseTimothy Starner; Fiscal Year: 2006..This environment will maximize the potential for the principal investigator to establish himself in a basic science career as an academic independent investigator. ..