Research Topics
Genomes and Genes
| M R StallcupSummaryAffiliation: University of Southern California Country: USA Publications
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Detail Information
Publications
Co-operation between protein-acetylating and protein-methylating co-activators in transcriptional activationM R Stallcup
Department of Pathology, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
Biochem Soc Trans 28:415-8. 2000..We propose that the synergy of co-activator function between p300, CARM1 and PRMT1 is due to their different but complementary protein modification activities...
Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteinsH Ma
Departments of Pathology, University of Southern California, Los Angeles, California 90033, USA
Mol Cell Biol 19:6164-73. 1999....
Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activitiesS S Koh
Department of Pathology, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 276:1089-98. 2001..Because multiple coactivators are presumably required to mediate transcriptional activation of native genes in vivo, the low-NR conditions may provide a more physiologically relevant assay for coactivator function...
Regulation of transcription by a protein methyltransferaseD Chen
Department of Pathology HMR 301, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
Science 284:2174-7. 1999..Thus, coactivator-mediated methylation of proteins in the transcription machinery may contribute to transcriptional regulation...
Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1S M Huang
Department of Pathology, University of Southern California, Los Angeles, California, CA 90089, USA
Oncogene 20:2134-43. 2001....
Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoterH Ma
Department of Pathology, HMR 301, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90089, USA
Curr Biol 11:1981-5. 2001..Thus, arginine-specific histone methylation by CARM1 is an important part of the transcriptional activation process...
Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3H Hong
Department of Pathology, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 274:22618-26. 1999..Although ERR3 is much more closely related to ERR2 than to ERR1, the expression pattern for ERR3 was similar to that of ERR1 and distinct from that for ERR2, suggesting a unique role for ERR3 in development...
The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locusJ Kim
Department of Molecular Microbiology and Immunology, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
J Mol Endocrinol 34:107-18. 2005..These results demonstrate an intriguing interplay between a signal transduction pathway, coactivator overexpression and AR signaling as a possible combined mechanism of progression to androgen-independent prostate cancer...
Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrixL Yang
Department of Pathology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
Mol Biol Cell 11:2007-18. 2000....
Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptorsS M Huang
Departments of Pathology and of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
Mol Cell Biol 20:1855-67. 2000..Thus, mZac1b can interact with nuclear receptors and their coactivators and play both positive and negative roles in regulating nuclear receptor function...
Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine lengthR A Irvine
Department of Urology, University of Southern California Norris Cancer Center, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
Hum Mol Genet 9:267-74. 2000..This molecular mechanism thus might explain, at least in part, the observed phenotypic effects of the AR CAG size polymorphism...
Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificitiesX F Ding
Department of Pathology, University of Southern California, Los Angeles 90033, USA
Mol Endocrinol 12:302-13. 1998..In summary, GRIP1 and SRC-1 have overlapping NR-binding preferences, but specific NRs display both coactivator and NR Box preferences that may contribute to the specificity of hormonal responses...
An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptorsH Hong
Department of Pathology, University of Southern California, Los Angeles, California 90033, USA
J Biol Chem 274:3496-502. 1999..SRC-1 lacks an NIDaux activity equivalent to that in GRIP1...
Role of protein methylation in chromatin remodeling and transcriptional regulationM R Stallcup
Department of Pathology, and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, CA 90089, USA
Oncogene 20:3014-20. 2001....
Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysisC L Welch
Department of Medicine, University of California, Los Angeles, California 90095, USA
Mamm Genome 8:620-1. 1997
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptorsH Hong
Department of Pathology, University of Southern California, Los Angeles 90033, USA
Mol Cell Biol 17:2735-44. 1997..These results demonstrate directly that AF-1 and AF-2 domains accomplish their transactivation activities through different mechanisms: AF-2 requires GRIP1 as a coactivator, but AF-1 does not...
GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptorsH Hong
Department of Pathology, University of Southern California, Los Angeles, 90033, USA
Proc Natl Acad Sci U S A 93:4948-52. 1996..Thus, in yeast, GRIP1 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, possibly by acting as a bridge between HBDs of the receptors and the basal transcription machinery...
