JEANNE SNYDER

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells
    Olga L Miakotina
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Respir Res 3:27. 2002
  2. ncbi Regulation of surfactant protein D in the rodent prostate
    Rebecca E Oberley
    Department of Medicine, National Jewish Medical and Research Center, Denver, USA, CO 80206, USA
    Reprod Biol Endocrinol 5:42. 2007
  3. ncbi Alveolarization in retinoic acid receptor-beta-deficient mice
    Jeanne M Snyder
    Department of Anatomy, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Pediatr Res 57:384-91. 2005
  4. ncbi TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK
    Olga L Miakotina
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA
    Am J Physiol Lung Cell Mol Physiol 283:L418-27. 2002
  5. ncbi Antisense inhibition of surfactant protein A decreases tubular myelin formation in human fetal lung in vitro
    Jonathan M Klein
    Departments of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    Am J Physiol Lung Cell Mol Physiol 282:L386-93. 2002
  6. ncbi Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin
    Caroline L S George
    Department of Pediatrics, Division of Pediatric Critical Care, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1337-44. 2003
  7. ncbi Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responses
    Caroline L S George
    Department of Pediatrics, University of Iowa, Iowa City, 52242, USA
    Am J Physiol Lung Cell Mol Physiol 291:L512-22. 2006
  8. ncbi Surfactant-associated protein A provides critical immunoprotection in neonatal mice
    Caroline L S George
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Infect Immun 76:380-90. 2008
  9. ncbi Signal transduction events involved in TPA downregulation of SP-A gene expression
    Olga L Miakotina
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 51 Newton Rd, 1 550 BSB, Iowa City, IA 52242 1109, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1210-9. 2004
  10. ncbi 11-Beta hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids
    Mark R Garbrecht
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 62:26-31. 2007

Research Grants

  1. RETINOIC ACID RECEPTORS AND ALVEOLAR FORMATION
    JEANNE SNYDER; Fiscal Year: 2002
  2. THE ROLE OF INSULIN IN HUMAN FETAL LUNG DEVELOPMENT
    JEANNE SNYDER; Fiscal Year: 2004

Collaborators

Detail Information

Publications20

  1. ncbi Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells
    Olga L Miakotina
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Respir Res 3:27. 2002
    ..In the present study, we investigated the signal transduction pathways involved in insulin inhibition of SP-A gene expression...
  2. ncbi Regulation of surfactant protein D in the rodent prostate
    Rebecca E Oberley
    Department of Medicine, National Jewish Medical and Research Center, Denver, USA, CO 80206, USA
    Reprod Biol Endocrinol 5:42. 2007
    ..In the present study, we characterized the regulation of SP-D expression in the mouse and rat prostate...
  3. ncbi Alveolarization in retinoic acid receptor-beta-deficient mice
    Jeanne M Snyder
    Department of Anatomy, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Pediatr Res 57:384-91. 2005
    ..Thus, deletion of the RARbeta gene impairs the formation of the distal airspaces during the postnatal phase of lung maturation in mice via a pathway that may involve PDGF-A...
  4. ncbi TNF-alpha inhibits SP-A gene expression in lung epithelial cells via p38 MAPK
    Olga L Miakotina
    Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA
    Am J Physiol Lung Cell Mol Physiol 283:L418-27. 2002
    ..We conclude that TNF-alpha downregulates SP-A gene expression in lung epithelial cells via the p38 MAPK signal transduction pathway...
  5. ncbi Antisense inhibition of surfactant protein A decreases tubular myelin formation in human fetal lung in vitro
    Jonathan M Klein
    Departments of Pediatrics, University of Iowa, Iowa City, Iowa 52242 1083, USA
    Am J Physiol Lung Cell Mol Physiol 282:L386-93. 2002
    ..We speculate that SP-A is critical to the formation of tubular myelin during human lung development and that the regulation of SP-B gene expression is independent of SP-A gene expression...
  6. ncbi Altered surfactant protein A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin
    Caroline L S George
    Department of Pediatrics, Division of Pediatric Critical Care, University of Iowa, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1337-44. 2003
    ..Furthermore, these alterations in SP-A gene activity and protein metabolism are dependent on an intact endotoxin signaling system...
  7. ncbi Early exposure to a nonhygienic environment alters pulmonary immunity and allergic responses
    Caroline L S George
    Department of Pediatrics, University of Iowa, Iowa City, 52242, USA
    Am J Physiol Lung Cell Mol Physiol 291:L512-22. 2006
    ..In conclusion, exposure to a nonhygienic environment did not induce significant airway neutrophilia, yet altered the population of immunologically active cells in the lung and reduced subsequent allergic inflammation...
  8. ncbi Surfactant-associated protein A provides critical immunoprotection in neonatal mice
    Caroline L S George
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Infect Immun 76:380-90. 2008
    ....
  9. ncbi Signal transduction events involved in TPA downregulation of SP-A gene expression
    Olga L Miakotina
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, 51 Newton Rd, 1 550 BSB, Iowa City, IA 52242 1109, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1210-9. 2004
    ..We conclude that TPA inhibits SP-A gene expression via novel isoforms of PKC, the p44/42 MAPK pathway, and the activator protein-1 complex...
  10. ncbi 11-Beta hydroxysteroid dehydrogenase type 2 in human adult and fetal lung and its regulation by sex steroids
    Mark R Garbrecht
    Department of Anatomy and Cell Biology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Pediatr Res 62:26-31. 2007
    ....
  11. ncbi 11Beta-hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites
    Mark R Garbrecht
    Department of Anatomy, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA
    Am J Physiol Endocrinol Metab 290:E653-60. 2006
    ..Together, these data suggest that differences exist in the biological activities of the metabolites of cortisol and Dex...
  12. ncbi Glucocorticoid metabolism in the human fetal lung: implications for lung development and the pulmonary surfactant system
    Mark R Garbrecht
    Department of Anatomy and Cell Biology, University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Iowa City, 52242, USA
    Biol Neonate 89:109-19. 2006
    ....
  13. ncbi Differential gene expression in human conducting airway surface epithelia and submucosal glands
    Anthony J Fischer
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 40:189-99. 2009
    ..This study illustrates the power of LCM in defining the roles of specific anatomic features in airway biology and may be useful in examining how disease states alter transcriptional programs in the conducting airways...
  14. ncbi Galectin-1 in secondary alveolar septae of neonatal mouse lung
    Jennifer J Foster
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1142-9. 2006
    ..The increased expression of galectin-1 at the site and time of ongoing alveolarization in the newborn mouse is suggestive that galectin-1 may play an important role in this critical aspect of lung development...
  15. ncbi A role for surfactant protein D in innate immunity of the human prostate
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Prostate 65:241-51. 2005
    ..SP-D protein levels are increased at sites of inflammation in the prostate, suggesting SP-D may also contribute more generally to inflammatory regulation in the prostate...
  16. ncbi Surfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Lung Cell Mol Physiol 287:L296-306. 2004
    ..In addition, the chlamydial pathogens internalized in the presence of collectins are able to grow and replicate in the THP-1 cells after phagocytosis...
  17. ncbi Surfactant protein D is expressed and modulates inflammatory responses in human coronary artery smooth muscle cells
    Gary D Snyder
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Physiol Heart Circ Physiol 294:H2053-9. 2008
    ..In conclusion, SP-D is expressed in human coronary arteries and functions as an anti-inflammatory protein in HCASMCs. SP-D may also participate in the host defense against pathogens that invade the vascular wall...
  18. ncbi Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor
    Su Jin Cho
    Department of Pediatrics, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 33:622-8. 2005
    ..These results suggest that the maintenance or growth of the endothelial cell population of the distal lung plays a major role in postnatal alveolar development...
  19. ncbi Recombinant human SP-A1 and SP-A2 proteins have different carbohydrate-binding characteristics
    Rebecca E Oberley
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 284:L871-81. 2003
    ..SP-A2 binds with a higher affinity to a wider variety of sugars than SP-A1 at either 1 or 5 mM Ca(2+). These findings are suggestive that SP-A2 may interact with a greater variety of pathogens than native SP-A...
  20. ncbi Regulation of surfactant protein D in the mouse female reproductive tract in vivo
    Rebecca E Oberley
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Hum Reprod 13:863-8. 2007
    ..These data are suggestive that SP-D may play a role in innate immunity in the female reproductive tract in vivo...

Research Grants12

  1. RETINOIC ACID RECEPTORS AND ALVEOLAR FORMATION
    JEANNE SNYDER; Fiscal Year: 2002
    ..This knowledge will form the foundation for the rational development of agents that promote alveolar growth and repair in humans. ..
  2. THE ROLE OF INSULIN IN HUMAN FETAL LUNG DEVELOPMENT
    JEANNE SNYDER; Fiscal Year: 2004
    ....