Susan Smyth

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi Autotaxin and its product lysophosphatidic Acid suppress brown adipose differentiation and promote diet-induced obesity in mice
    Lorenzo Federico
    Biomedical Biological Sciences Research Building 255, 741 South Limestone Street, Lexington Kentucky 40536 0509
    Mol Endocrinol 26:786-97. 2012
  2. ncbi Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling
    Hsin Yuan Cheng
    Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 32:24-32. 2012
  3. ncbi Editorial [hot topic: anti-platelet therapy (guest editor: susan s. Smyth)]
    Susan S Smyth
    Lexington VA Medical Center, The Division of Cardiovascular Medicine, The Gill Heart Institute, BBSRB 255 741 S Limestone Lexington, KY 40536 0509, USA
    Curr Drug Targets 12:1790-1. 2011
  4. ncbi G-protein-coupled receptors as signaling targets for antiplatelet therapy
    Susan S Smyth
    Veterans Affairs Medical Center, Department of Medicine, Physiology, and Pharmacology, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 29:449-57. 2009
  5. ncbi Platelet functions beyond hemostasis
    S S Smyth
    Lexington VA Medical Center and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
    J Thromb Haemost 7:1759-66. 2009
  6. ncbi Roles of lysophosphatidic acid in cardiovascular physiology and disease
    Susan S Smyth
    Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA
    Biochim Biophys Acta 1781:563-70. 2008
  7. ncbi Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation
    Andrew J Morris
    The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Trends Cardiovasc Med 19:135-40. 2009
  8. ncbi Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling
    Manikandan Panchatcharam
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0200, United States
    Int J Biochem Cell Biol 42:965-74. 2010
  9. ncbi Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism
    Anping Dong
    VA Medical Center Lexington, Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, USA
    Thromb Res 126:e312-7. 2010
  10. ncbi Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia
    Ahmed Abdel-Latif
    Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky, 740 S Limestone Street, Lexington, KY 40536 0200, USA
    Exp Hematol 38:1131-1142.e1. 2010

Research Grants

  1. Diabetes, Inflammation and Vascular Disease
    Susan Smyth; Fiscal Year: 2004
  2. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2009
  3. Platelet Membrane Proteins in Thrombosis
    Susan Smyth; Fiscal Year: 2005
  4. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2007
  5. Lysolipid Signaling in Cardovascular Disease
    Susan Smyth; Fiscal Year: 2007
  6. Lysolipid Signaling in Cardiovascular Disease
    Susan S Smyth; Fiscal Year: 2010

Detail Information

Publications25

  1. ncbi Autotaxin and its product lysophosphatidic Acid suppress brown adipose differentiation and promote diet-induced obesity in mice
    Lorenzo Federico
    Biomedical Biological Sciences Research Building 255, 741 South Limestone Street, Lexington Kentucky 40536 0509
    Mol Endocrinol 26:786-97. 2012
    ....
  2. ncbi Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling
    Hsin Yuan Cheng
    Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 32:24-32. 2012
    ..To determine whether LPA contributes to remodeling of the pulmonary vasculature, we examined responses in mice with alterations in LPA signaling and metabolism...
  3. ncbi Editorial [hot topic: anti-platelet therapy (guest editor: susan s. Smyth)]
    Susan S Smyth
    Lexington VA Medical Center, The Division of Cardiovascular Medicine, The Gill Heart Institute, BBSRB 255 741 S Limestone Lexington, KY 40536 0509, USA
    Curr Drug Targets 12:1790-1. 2011
    ....
  4. ncbi G-protein-coupled receptors as signaling targets for antiplatelet therapy
    Susan S Smyth
    Veterans Affairs Medical Center, Department of Medicine, Physiology, and Pharmacology, University of Kentucky, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 29:449-57. 2009
    ..The identification and development of new agents directed against specific platelet signaling pathways may offer an advantage in preventing thrombotic events while minimizing bleeding risk...
  5. ncbi Platelet functions beyond hemostasis
    S S Smyth
    Lexington VA Medical Center and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
    J Thromb Haemost 7:1759-66. 2009
    ....
  6. ncbi Roles of lysophosphatidic acid in cardiovascular physiology and disease
    Susan S Smyth
    Department of Veterans Affairs Medical Center, Lexington, Kentucky 40511, USA
    Biochim Biophys Acta 1781:563-70. 2008
    ..In this review we discuss aspects of LPA signaling in the cardiovasculature focusing on recent advances and attempting to highlight presently unresolved issues and promising avenues for further investigation...
  7. ncbi Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation
    Andrew J Morris
    The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Trends Cardiovasc Med 19:135-40. 2009
    ..We review the mechanisms controlling the production, metabolism, and distribution of these lipids between vascular cells, circulating blood components, and the plasma...
  8. ncbi Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling
    Manikandan Panchatcharam
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, KY 40536 0200, United States
    Int J Biochem Cell Biol 42:965-74. 2010
    ....
  9. ncbi Enhanced platelet reactivity and thrombosis in Apoe-/- mice exposed to cigarette smoke is attenuated by P2Y12 antagonism
    Anping Dong
    VA Medical Center Lexington, Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, USA
    Thromb Res 126:e312-7. 2010
    ..Smoking increases the risk of acute arterial thrombosis, including myocardial infarction, likely due to multi-factorial effects on the vasculature. Heightened platelet reactivity may be among the adverse effects of smoke exposure...
  10. ncbi Evidence of mobilization of pluripotent stem cells into peripheral blood of patients with myocardial ischemia
    Ahmed Abdel-Latif
    Gill Heart Institute and Division of Cardiovascular Medicine, University of Kentucky, 740 S Limestone Street, Lexington, KY 40536 0200, USA
    Exp Hematol 38:1131-1142.e1. 2010
    ..However, the mobilization of primitive pluripotent stem cells (PSCs) enriched in very small embryonic-like stem cells (VSELs) in various cardiac ischemic scenarios is not well understood...
  11. ncbi Bleeding events are associated with an increase in markers of inflammation in acute coronary syndromes: an ACUITY trial substudy
    Charles L Campbell
    Gill Heart Institute, University of Kentucky, 326 Charles T Wethington Building, 900 South Limestone, Lexington, KY 40536 0293, USA
    J Thromb Thrombolysis 31:139-45. 2011
    ..3.60, P = 0.09). These data suggest that major bleeding is associated with development of a pro-inflammatory state. If confirmed, this mechanism may in part explain the poor prognosis of patients experiencing an acute hemorrhagic event...
  12. ncbi Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development
    Marlene S Williams
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
    Arterioscler Thromb Vasc Biol 30:2372-84. 2010
    ....
  13. ncbi Considerable variability in platelet activity among patients with coronary artery disease in response to an increased maintenance dose of clopidogrel
    Julie H Oestreich
    Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40536 0293, USA
    Coron Artery Dis 20:207-13. 2009
    ..Studies have shown that the mean aggregation response to clopidogrel can be changed by a higher maintenance dose. However, these studies have not focused on individual changes...
  14. ncbi Thrombosis and antithrombotic therapy in women
    Alison L Bailey
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, VA Medical Center, Lexington, KY, USA
    Arterioscler Thromb Vasc Biol 29:284-8. 2009
    ..Here we review plausible mechanisms that may explain how sex functions as a modifier of thrombosis and summarize clinical data on the interaction between sex and response to antithrombotic therapy...
  15. ncbi Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis
    Zehra Pamuklar
    Division of Cardiovascular Medicine, The Gill Heart Institute, Lexington, Kentucky 40536 0200, USA
    J Biol Chem 284:7385-94. 2009
    ....
  16. ncbi CX3CR1 deficiency confers protection from intimal hyperplasia after arterial injury
    Peng Liu
    Department of Medicine, University of North Carolina at Chapel Hill, USA
    Arterioscler Thromb Vasc Biol 26:2056-62. 2006
    ..We investigated the mechanisms by which CX3CR1 may be involved by evaluating the inflammatory response to arterial injury in CX3CR1-deficient animals...
  17. ncbi Platelet activation and its patient-specific consequences
    Susan S Smyth
    Division of Cardiology, University of Kentucky, Lexington, USA
    Thromb Res 122:435-41. 2008
    ..These phenomena may help to explain differences in experimental arterial thrombosis observed in individuals...
  18. ncbi Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure
    Manikandan Panchatcharam
    Division of Cardiovascular Medicine, The Gill Heart Institute, Lexington, KY 40536, USA
    Circ Res 103:662-70. 2008
    ..These results identify a role for LPA1 and LPA2 in regulating SMC migratory responses in the context of vascular injury but suggest that additional LPA receptor subtypes are required for other LPA-mediated effects in the vasculature...
  19. ncbi Aspirin dose for the prevention of cardiovascular disease: a systematic review
    Charles L Campbell
    Gill Heart Institute, University of Kentucky, Lexington, USA
    JAMA 297:2018-24. 2007
    ..More than 50 million US adults take aspirin regularly for long-term prevention of cardiovascular disease, typically either 81 mg/d or 325 mg/d. Controversy remains regarding the most appropriate long-term daily dose...
  20. ncbi Individual heterogeneity in platelet response to lysophosphatidic acid: evidence for a novel inhibitory pathway
    Zehra Pamuklar
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky, Lexington, KY 40536, USA
    Arterioscler Thromb Vasc Biol 28:555-61. 2008
    ..LPA is present in blood and exposure or release of LPA after atherosclerotic plaque rupture has been proposed to trigger platelet thrombus formation...
  21. ncbi Measurement of autotaxin/lysophospholipase D activity
    Andrew J Morris
    Division of Cardiovascular Medicine, The Gill Heart Institute, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Methods Enzymol 434:89-104. 2007
    ..This chapter describes methods for determining the activity of recombinant autotaxin/lysoPLD using radiolabeled and fluorogenic substrates...
  22. ncbi Therapeutic potential of autotaxin/lysophospholipase d inhibitors
    Lorenzo Federico
    Division of Cardiovascular Medicine, The Gill Heart Institute, 900 S Limestone Street, 326 CTW Building, Lexington, KY 40536 0200, USA
    Curr Drug Targets 9:698-708. 2008
    ....
  23. ncbi Src family kinases mediate neutrophil adhesion to adherent platelets
    Virgilio Evangelista
    Laboratory of Vascular Biology and Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8 A, 66030 Santa Maria Imbaro, Italy
    Blood 109:2461-9. 2007
    ..These results definitely establish a role for SFKs in PMN recruitment by activated platelets and suggest novel targets to disrupt the pathophysiologic consequences of platelet-leukocyte interactions in vascular disease...
  24. ncbi Rap1b is required for normal platelet function and hemostasis in mice
    Magdalena Chrzanowska-Wodnicka
    Department of Medicine and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:680-7. 2005
    ..These data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target...
  25. ncbi Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity
    Susan S Smyth
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093 0668, USA
    J Biol Chem 278:43214-23. 2003
    ....

Research Grants13

  1. Diabetes, Inflammation and Vascular Disease
    Susan Smyth; Fiscal Year: 2004
    ..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
  2. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2009
    ..abstract_text> ..
  3. Platelet Membrane Proteins in Thrombosis
    Susan Smyth; Fiscal Year: 2005
    ..This work will identify a novel target for future antithrombotic strategies and challenge the assumption that the beneficial effects of P-selectin antagonists are exclusive to leukocytes. ..
  4. Integrin Signaling In Vascular Cells
    Susan Smyth; Fiscal Year: 2007
    ..abstract_text> ..
  5. Lysolipid Signaling in Cardovascular Disease
    Susan Smyth; Fiscal Year: 2007
    ..Our results will provide specific insights into the role of LPA signaling pathways in vascular physiology and pathology and may provide novels targets for the treatment and prevention of atherothrombotic disorders. ..
  6. Lysolipid Signaling in Cardiovascular Disease
    Susan S Smyth; Fiscal Year: 2010
    ..Completion of the work will provide new insights into pathways that could be targeted to prevent and treat arterial thrombosis. ..