Research Topics
Genomes and Genes
Species | Christine F SkibolaSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Multi-locus HLA class I and II allele and haplotype associations with follicular lymphomaC F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Tissue Antigens 79:279-86. 2012..These results provide further insight into the critical roles of HLA alleles and SNPs in FL pathogenesis that involve multi-locus effects across the HLA region...- Genetic susceptibility to lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Haematologica 92:960-9. 2007..Numerous studies suggest that common genetic variants with low penetrance influence lymphoma risk, though replication studies will be needed to eliminate false positive associations... - A functional TNFRSF5 gene variant is associated with risk of lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Blood 111:4348-54. 2008..These results suggest that the TNFRSF5 -1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings... - Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphomaChristine F Skibola
School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
PLoS ONE 3:e2816. 2008..Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms... - Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
Nat Genet 41:873-5. 2009..7 x 10(-11)). The region of strongest association overlapped C6orf15 (STG), located near psoriasis susceptibility region 1 (PSORS1)... - Obesity, diet and risk of non-Hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 16:392-5. 2007..The accumulated scientific evidence concerning the associations between obesity, diet, and NHL suggests several identified modifiable risk factors that might be recommended to decrease lymphoma risk... - Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Br J Haematol 129:618-21. 2005..44, 95% confidence interval (CI) 1.02-2.03], particularly diffuse large B-cell lymphoma (OR = 1.76, CI 1.14-2.71). Associations of CYP17A1 polymorphisms with increased risk of NHL suggest a role for oestrogen in lymphomagenesis... - Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cellsChristine F Skibola
School of Public Health, University of California Berkeley, Berkeley, CA, USA
J Nutr 135:296-300. 2005..4, 31.8, and 40.7 micromol/L, respectively. These data show endocrine modulating effects of kelp at relevant doses and suggest that dietary kelp may contribute to the lower incidence of hormone-dependent cancers among the Japanese... - The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case reportChristine F Skibola
School of Public Health, Molecular Epidemiology and Toxicology Laboratory, University of California, Berkeley, CA 94720, USA
BMC Complement Altern Med 4:10. 2004..To test this, bladderwrack was administered to three pre-menopausal women with abnormal menstrual cycling patterns and/or menstrual-related disease histories... - Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Blood 104:2155-62. 2004..The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL... - Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 13:779-86. 2004.... - Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) polymorphisms and risk of non-Hodgkin lymphoma in the InterLymph ConsortiumChristine F Skibola
237A Hildebrand Hall, School of Public Health, University of California, Berkeley, Berkeley, CA 94720 7360, USA
Am J Epidemiol 171:267-76. 2010..04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology... - Chemokine polymorphisms and lymphoma: a pooled analysisPaige M Bracci
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94118 1944, USA
Leuk Lymphoma 51:497-506. 2010..The CCL5 -403A allele conferred reduced risks of FL and chronic lymphocytic leukemia/small lymphocytic lymphoma. Results should be interpreted conservatively. Continued investigation is warranted to confirm these findings... - Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemiaChristine F Skibola
NFCR Center for Genomics and Nutrition, School of Public Health, and the Department of Nutritional Sciences, University of California, Berkeley, CA 94720-7360, USA
Blood 99:3786-91. 2002.... - Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma riskChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Earl Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 14:2391-401. 2005..These results suggest that PRL, CYP17A1, and COMT may be relevant genetic loci for non-Hodgkin lymphoma and indicate a possible role for prolactin and estrogen in lymphoma pathogenesis... - Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphomaMatthew S Forrest
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Br J Haematol 134:180-3. 2006..8), whereas the toll-like receptor 4 1063A>G variant allele was inversely associated with diffuse large cell lymphoma (OR = 0.67, 95% CI 0.45-0.99). These results suggest that variation in innate immune genes may alter NHL susceptibility... - Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, ArgentinaCraig Steinmaus
Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Oakland, CA, USA
Toxicol Appl Pharmacol 247:138-45. 2010..These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility... - Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32Lucia Conde
School of Public Health, University of California, Berkeley, Berkeley, California, USA
Nat Genet 42:661-4. 2010..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))... - Accuracy of multiplexed Illumina platform-based single-nucleotide polymorphism genotyping compared between genomic and whole genome amplified DNA collected from multiple sourcesRandi A Paynter
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Earl Warren Hall 7360, Berkeley, CA 94720 7360, USA
Cancer Epidemiol Biomarkers Prev 15:2533-6. 2006..We conclude that highly multiplexed Illumina genotyping may be done on gDNA and wgaDNA obtained from whole blood, buccal samples, dried blood spots on Guthrie cards, and possibly even urine samples, with minimal misclassification... - Association of genetic variation in cystathionine-beta-synthase and arsenic metabolismKristin E Porter
School of Public Health, 237A Hildebrand Hall, University of California, Berkeley, CA 94720 7356, USA
Environ Res 110:580-7. 2010..No other genetic associations were found. These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease... - An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesisXuefeng Ren
Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 119:11-9. 2011..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure... - Screening the human serum proteome for genotype-phenotype associations: an analysis of the IL6 -174G>C polymorphismChristine M Hegedus
School of Public Health, University of California, Berkeley, CA 94720, USA
Proteomics 7:548-57. 2007..This study illustrates that proteome analysis can enhance our understanding of genotype-phenotype relationships. Additional studies are needed to clarify the interaction between the IL6 -174G>C polymorphism and ApoC-I... - Association of HLA-DQB1 alleles with risk of follicular lymphomaNicholas K Akers
School of Public Health, University of California, Berkeley, CA, USA
Leuk Lymphoma 52:53-8. 2011..51, 95% CI 0.38-0.69; adjusted p-value?=?4.46?×?10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association... - A search for overlapping genetic susceptibility loci between non-Hodgkin lymphoma and autoimmune diseasesLucia Conde
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA
Genomics 98:9-14. 2011..These results support continued investigation to further elucidate the relationship between lymphoma and autoimmune diseases... - Benzene, the exposome and future investigations of leukemia etiologyMartyn T Smith
Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 192:155-9. 2011..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology... - Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenicChristine M Hegedus
School of Public Health, University of California, Berkeley, California 94720 7356, USA
Toxicol Sci 106:74-82. 2008..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity... - A generic coalescent-based framework for the selection of a reference panel for imputationBogdan Pasaniuc
International Computer Science Institute, Berkeley, California 94704, USA
Genet Epidemiol 34:773-82. 2010..Our method is generic and can potentially be incorporated in any of the available imputation methods as an add-on... - Issues of processing and multiple testing of SELDI-TOF MS proteomic dataMerrill D Birkner
Division of Biostatistics, School of Public Health, University of California, Berkeley, USA
Stat Appl Genet Mol Biol 5:Article11. 2006..Given no sources of unmeasured bias (such as confounding of experimental conditions with disease status), proteins found to be statistically significant using this technique have a low probability of being false positives... - Molecular biomarkers for the study of childhood leukemiaMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Toxicol Appl Pharmacol 206:237-45. 2005..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia... - Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and childrenMartyn T Smith
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720 7360, USA
Blood 100:4590-3. 2002..The inactivating NQO1 polymorphism is associated with an increased risk of de novo leukemia with MLL translocations in infants and children... - Systems biology of human benzene exposureLuoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
Chem Biol Interact 184:86-93. 2010.... - Post-GWAS functional characterization of susceptibility variants for chronic lymphocytic leukemiaFenna C M Sillé
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
PLoS ONE 7:e29632. 2012....
Research Grants
- A Genome-Wide Association Study of Non-Hodgkin LymphomaChristine Skibola; Fiscal Year: 2007..The data generated from this study will provide a framework for further investigation within the NHL consortium, InterLymph. Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
- Genetic Susceptibility to non-Hodgkin LymphomaChristine Skibola; Fiscal Year: 2009....
- A Genome-Wide Association Study of Non-Hodgkin LymphomaChristine F Skibola; Fiscal Year: 2010..Results will later be combined with that from other InterLymph case-control studies in pooled analyses. ..
- Genetic Susceptibility to non-Hodgkin LymphomaChristine F Skibola; Fiscal Year: 2010....