Patrick Singleton

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids
    Patrick A Singleton
    Department of Medicine, Division of Biomedical Sciences, Section of Pulmonary and Critical Medicine, University of Chicago, Ill 60637, USA
    Circ Res 104:978-86. 2009
  2. ncbi Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:34964-75. 2009
  3. ncbi Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors
    Patrick A Singleton
    Department of Medicine, University of Chicago, 5841 S, Maryland Avenue, W604, Chicago, IL, 60637, USA
    J Angiogenes Res 2:5. 2010
  4. ncbi High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness
    Patrick A Singleton
    Dept of Medicine, Univ of Chicago, MC 6076, I 503C, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 299:L639-51. 2010
  5. ncbi Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells
    Lilly Y W Bourguignon
    Department of Medicine, University of California at San Francisco and Endocrine Unit 111N, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 281:14026-40. 2006
  6. ncbi Role of hyaluronan and hyaluronan-binding proteins in lung pathobiology
    Frances E Lennon
    Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 301:L137-47. 2011

Research Grants

  1. Hyaluronan and CD44 are Novel Targets for Acute Lung injury
    Patrick A Singleton; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids
    Patrick A Singleton
    Department of Medicine, Division of Biomedical Sciences, Section of Pulmonary and Critical Medicine, University of Chicago, Ill 60637, USA
    Circ Res 104:978-86. 2009
    ..Taken together, these results suggest Akt-dependent transactivation of S1P(1) within CEMs is important for OxPAPC-mediated cortical actin rearrangement and EC barrier protection...
  2. ncbi Dynamin 2 and c-Abl are novel regulators of hyperoxia-mediated NADPH oxidase activation and reactive oxygen species production in caveolin-enriched microdomains of the endothelium
    Patrick A Singleton
    Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:34964-75. 2009
    ..These results suggest that hyperoxia induces c-Abl-mediated dynamin 2 phosphorylation required for recruitment of p47(phox) to CEMs and subsequent ROS production in lung endothelium...
  3. ncbi Methylnaltrexone Potentiates the Anti-Angiogenic Effects of mTOR Inhibitors
    Patrick A Singleton
    Department of Medicine, University of Chicago, 5841 S, Maryland Avenue, W604, Chicago, IL, 60637, USA
    J Angiogenes Res 2:5. 2010
    ..Therefore, addition of MNTX could potentially lower the dose of mTOR inhibitors which could improve therapeutic index...
  4. ncbi High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness
    Patrick A Singleton
    Dept of Medicine, Univ of Chicago, MC 6076, I 503C, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 299:L639-51. 2010
    ..These data suggest that HMW-HA, via CD44-mediated CEM signaling events, represents a potentially useful therapeutic agent for syndromes of increased vascular permeability...
  5. ncbi Hyaluronan-CD44 interaction with leukemia-associated RhoGEF and epidermal growth factor receptor promotes Rho/Ras co-activation, phospholipase C epsilon-Ca2+ signaling, and cytoskeleton modification in head and neck squamous cell carcinoma cells
    Lilly Y W Bourguignon
    Department of Medicine, University of California at San Francisco and Endocrine Unit 111N, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 281:14026-40. 2006
    ....
  6. ncbi Role of hyaluronan and hyaluronan-binding proteins in lung pathobiology
    Frances E Lennon
    Section of Pulmonary and Critical Care, Department of Medicine, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Lung Cell Mol Physiol 301:L137-47. 2011
    ..This review focuses on the regulatory role of HA and HA-binding proteins in lung pathology and discusses the capacity of HA to augment and inhibit various lung diseases...

Research Grants2

  1. Hyaluronan and CD44 are Novel Targets for Acute Lung injury
    Patrick A Singleton; Fiscal Year: 2010
    ..Our studies will yield novel mechanistic insights into HMW-HA's protection from ALI-associated disease processes as well as provide novel treatment modalities to reduce ALI-mediated lung injury. ..