Reshma Singh

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Listeria monocytogenes as a vector for tumor-associated antigens for cancer immunotherapy
    Reshma Singh
    University of Pennsylvania School of Medicine, Department of Microbiology, 323 Johnson Pavilion, Philadelphia, PA 19104 6076, USA
    Expert Rev Vaccines 5:541-52. 2006
  2. ncbi In the FVB/N HER-2/neu transgenic mouse both peripheral and central tolerance limit the immune response targeting HER-2/neu induced by Listeria monocytogenes-based vaccines
    Reshma Singh
    Department of Microbiology, School of Medicine, University of Pennsylvania, 323 Johnson Pavilion, 36th St and Hamilton Walk, Philadelphia, PA 19104 6076, USA
    Cancer Immunol Immunother 56:927-38. 2007
  3. ncbi Immunoediting sculpts tumor epitopes during immunotherapy
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA, USA
    Cancer Res 67:1887-92. 2007
  4. ncbi Vaccination strategy determines the emergence and dominance of CD8+ T-cell epitopes in a FVB/N rat HER-2/neu mouse model of breast cancer
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104, USA
    Cancer Res 66:7748-57. 2006
  5. ncbi Fusion to Listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:3663-73. 2005

Collaborators

Detail Information

Publications5

  1. ncbi Listeria monocytogenes as a vector for tumor-associated antigens for cancer immunotherapy
    Reshma Singh
    University of Pennsylvania School of Medicine, Department of Microbiology, 323 Johnson Pavilion, Philadelphia, PA 19104 6076, USA
    Expert Rev Vaccines 5:541-52. 2006
    ..Safety issues and the transition of Listeria into human clinical trials will also be discussed in this review...
  2. ncbi In the FVB/N HER-2/neu transgenic mouse both peripheral and central tolerance limit the immune response targeting HER-2/neu induced by Listeria monocytogenes-based vaccines
    Reshma Singh
    Department of Microbiology, School of Medicine, University of Pennsylvania, 323 Johnson Pavilion, 36th St and Hamilton Walk, Philadelphia, PA 19104 6076, USA
    Cancer Immunol Immunother 56:927-38. 2007
    ..This study demonstrates the ability of L. monocytogenes-based vaccines to impact upon tolerance to HER-2/neu in FVB/N HER-2/neu transgenic mice and further defines some of the aspects of tolerance in these mice...
  3. ncbi Immunoediting sculpts tumor epitopes during immunotherapy
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA, USA
    Cancer Res 67:1887-92. 2007
    ..The long delay in the onset of tumors after immunotherapy targeting the kinase domain may be because this region of HER-2/neu cannot undergo extensive mutations without impairing its ability to signal cell growth...
  4. ncbi Vaccination strategy determines the emergence and dominance of CD8+ T-cell epitopes in a FVB/N rat HER-2/neu mouse model of breast cancer
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104, USA
    Cancer Res 66:7748-57. 2006
    ..In addition, HER-2/neu DNA vaccination followed by CTL analysis further showed that both of these peptides can emerge as epitopes...
  5. ncbi Fusion to Listeriolysin O and delivery by Listeria monocytogenes enhances the immunogenicity of HER-2/neu and reveals subdominant epitopes in the FVB/N mouse
    Reshma Singh
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:3663-73. 2005
    ..monocytogenes-based HER-2/neu vaccines in a murine model of breast cancer and also that the immunogenicity of self-Ags can be increased by fusion to LLO and delivery by L. monocytogenes revealing subdominant epitopes...