Ram Pyare Singh

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Tuning immune suppression in systemic autoimmunity with self-derived peptides
    Ram Pyare Singh
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
    Inflamm Allergy Drug Targets 7:253-9. 2008
  2. ncbi Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide
    R P Singh
    Division of Rheumatology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Immun 11:294-309. 2010
  3. ncbi pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:2069-80. 2008
  4. ncbi CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 178:7649-57. 2007
  5. ncbi Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice
    Brian J Skaggs
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hum Immunol 69:790-6. 2008
  6. ncbi CD8+ Tregs in lupus, autoimmunity, and beyond
    Ravi K Dinesh
    Division of Rheumatology, Dept of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:560-8. 2010
  7. ncbi Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors
    Bevra H Hahn
    Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:7728-37. 2005
  8. ncbi PD-1, gender, and autoimmunity
    Ravi K Dinesh
    Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:583-7. 2010
  9. ncbi The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA
    Ram Pyare Singh
    Malaria Research Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India
    J Immunol 168:4674-81. 2002

Research Grants

  1. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2007
  2. Delineating the Role of Selected Genes in Lupus Induced by CD8+Ti and CD4+CD25 T
    Ram Singh; Fiscal Year: 2007

Detail Information

Publications9

  1. ncbi Tuning immune suppression in systemic autoimmunity with self-derived peptides
    Ram Pyare Singh
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32 59, Los Angeles, CA 90095 1670, USA
    Inflamm Allergy Drug Targets 7:253-9. 2008
    ....
  2. ncbi Distinct gene signature revealed in white blood cells, CD4(+) and CD8(+) T cells in (NZBx NZW) F1 lupus mice after tolerization with anti-DNA Ig peptide
    R P Singh
    Division of Rheumatology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Genes Immun 11:294-309. 2010
    ..However, silencing of Foxp3 reduced expression of Foxp3, Ifi202b and PD1-all of which are involved in the suppressive capacity of CD8(+) Treg in this model...
  3. ncbi pConsensus peptide induces tolerogenic CD8+ T cells in lupus-prone (NZB x NZW)F1 mice by differentially regulating Foxp3 and PD1 molecules
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 180:2069-80. 2008
    ..Our data suggest that tolerization with pCons activates different subsets of inhibitory/cytotoxic CD8+ T cells whose targets are both CD4+CD25- effector T cells and B cells...
  4. ncbi CD8+ T cell-mediated suppression of autoimmunity in a murine lupus model of peptide-induced immune tolerance depends on Foxp3 expression
    Ram Pyare Singh
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 1001 Veteran Avenue, Los Angeles, CA 90095, USA
    J Immunol 178:7649-57. 2007
    ....
  5. ncbi Induction of immune tolerance by activation of CD8+ T suppressor/regulatory cells in lupus-prone mice
    Brian J Skaggs
    Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Hum Immunol 69:790-6. 2008
    ..This review will discuss the similarities and differences in CD8(+) Ts subsets, the concept of tolerance as a therapy, and the current understanding of CD8(+) Ts in mouse SLE models...
  6. ncbi CD8+ Tregs in lupus, autoimmunity, and beyond
    Ravi K Dinesh
    Division of Rheumatology, Dept of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:560-8. 2010
    ..We also discuss the potential role of CD8(+) Tregs in other diseases, including chronic infection and cancer...
  7. ncbi Tolerogenic treatment of lupus mice with consensus peptide induces Foxp3-expressing, apoptosis-resistant, TGFbeta-secreting CD8+ T cell suppressors
    Bevra H Hahn
    Department of Medicine, Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 175:7728-37. 2005
    ....
  8. ncbi PD-1, gender, and autoimmunity
    Ravi K Dinesh
    Division of Rheumatology, Department of Medicine at the David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1670, USA
    Autoimmun Rev 9:583-7. 2010
    ..Exploring the effects of sex hormones on the PD-1:PD-L pathway could shed light on the gender biased nature of many autoimmune conditions as well as aide in the development of therapeutics targeting the immune system...
  9. ncbi The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA
    Ram Pyare Singh
    Malaria Research Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India
    J Immunol 168:4674-81. 2002
    ..berghei ANKA than were wild-type C57BL/6 mice. These data suggest that IL-18 plays a protective role in host defense by enhancing IFN-gamma production during blood-stage infection by murine malaria...

Research Grants4

  1. Molecular Basis of Suppression of SLE by CD8+ Ti Cells
    Ram Singh; Fiscal Year: 2007
    ..The overall purpose is to understand the molecular mechanisms by which these CD8+ inhibitory T cells suppress autoimmunity; results may identify new targets for therapies in SLE patients. ..
  2. Delineating the Role of Selected Genes in Lupus Induced by CD8+Ti and CD4+CD25 T
    Ram Singh; Fiscal Year: 2007
    ..The overall purpose is to understand the molecular mechanisms by which these CD8+ inhibitory T cells and CD4+ T regulatory cells suppress autoimmunity; results may identify new targets for therapies for SLE in patients. ..