Research Topics
| Ashok K SinghSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Analysis of recombinant human erythropoietin and darbepoietin in spiked plasmaAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
Proteomics Clin Appl 1:626-39. 2007..SDS-PAGE improved the quality of the MALDI-TOF results. Minimum detection limits for digested fragments were lower than those for intact proteins...- How does peripheral lipopolysaccharide induce gene expression in the brain of rats?A K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
Toxicology 201:197-207. 2004.... - Effects of chronic ethanol drinking on the blood brain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injectionAshok K Singh
Department of Population Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota Twin Cities Campus, 1333 Gortner Avenue, St Paul, MN 55108, USA
Alcohol Alcohol 42:385-99. 2007..Although alcohol drinking impairs the blood-brain barrier (BBB), the underlying mechanism is not fully understood. Thus, the effects of chronic ethanol drinking on the BBB were studied in vivo... - Differential activation of NF kappa B/RelA-p50 and NF kappa B/p50-p50 in control and alcohol-drinking rats subjected to carrageenin-induced pleurisyAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN 55108, USA
Mediators Inflamm 13:255-62. 2004..Therefore, the aim of this investigation was to study the effects of ethanol intake on CAR-IP and NFkappaB activation in pleural fluid neutrophils in P rats... - Red blood cell erythropoietin, not plasma erythropoietin, concentrations correlate with changes in hematological indices in horses receiving a single dose of recombinant human erythropoietin by subcutaneous injectionA K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St Paul, MN 55108, USA
J Vet Pharmacol Ther 30:175-8. 2007 - Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure waterAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Twin Cities Campus, St Paul, MN 55108, USA
J Med Food 10:526-42. 2007..Therefore, a mixture consisting of PU and either SPCh or CU may provide alternative therapy for alcohol-related disorders... - Effects of chronic alcohol drinking on receptor-binding, internalization, and degradation of human immunodeficiency virus 1 envelope protein gp120 in hepatocytesAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Avenue, St Paul, Minnesota 55108, USA
Alcohol 41:591-606. 2007..The present observation also suggests that a number of CCR5 or ubiquitin-based therapeutic drugs may not be effective in suppressing HIV infection in alcohol-drinking subjects... - Oxidative stress and protein oxidation in the brain of water drinking and alcohol drinking rats administered the HIV envelope protein, gp120Ashok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Minnesota 55108, USA
J Neurochem 104:1478-93. 2008..In conclusion, chronic alcohol drinking, by carbonylating and hyperoxidizing free radical neutralization proteins, augmented the gp120-induced oxidative stress that may be associated with an increase in severity of the brain neuropathy... - In vitro neurogenesis from neural progenitor cells isolated from the hippocampus region of the brain of adult rats exposed to ethanol during early development through their alcohol-drinking mothersAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Twin Cities Campus, St Paul, MN 55108, USA
Alcohol Alcohol 44:185-98. 2009..This study was aimed to determine whether ethanol exposure during early development altered neurogenesis in the brain of adult rats... - Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcoholElhabib Benlhabib
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Avenue, St. Paul, MN 55108, USA
J Med Food 7:168-79. 2004..Thus, KdR isoflavones suppressed alcohol drinking and withdrawal symptoms without entering the brain... - Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcoholElhabib Benlhabib
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Avenue, St. Paul, MN 55108, USA
J Med Food 7:180-6. 2004..The absence of PU in plasma and brain indicates the possibility that some nonspecific mechanism may be involved in the anti-alcoholism effects of PU in P rats... - Quantitative analysis of phytoestrogens in kudzu-root, soy and spiked serum samples by high-pressure liquid chromatographyElhabib Benlhabib
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, 1333 Gortner Ave, St Paul, MN 55108, USA
Biomed Chromatogr 18:367-80. 2004..UV and MS detectors were suitable for phytoestrogen analysis in plant and serum samples, while the diode-array detector was suitable for generating the UV absorbance curve for phytoestrogens... - Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparationsElhabib Benlhabib
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul Campus, 1333 Gortner Avenue, St. Paul, MN 55108, USA
J Med Food 5:109-23. 2002..The differential composition of phytoestrogens in kudzu-root and soy may account for the differences in their therapeutic activities... - Enzyme-linked immunosorbent assay for ultratrace determination of antibiotics in aqueous samplesKuldip Kumar
Department of Soil, Water, and Climate, University of Minnesota, St Paul, MN 55108, USA
J Environ Qual 33:250-6. 2004..Furthermore, both ELISA procedures are rapid, portable, and easily adaptable for testing of multiple samples simultaneously... - Lipopolysaccharide (LPS) induced activation of the immune system in control rats and rats chronically exposed to a low level of the organothiophosphate insecticide, acephateA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN, USA
Toxicol Ind Health 19:93-108. 2003..Thus, chronic low-level Ace exposure may impair the lineage commitment in lymphocytes, possibly by altering cytokine signaling in the brain... - Acute effects of acephate and methamidophos and interleukin-1 on corticotropin-releasing factor (CRF) synthesis in and release from the hypothalamus in vitroA K Singh
Department of Veterinary Diagnostic Medicine, Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, 1333 Gorter Avenue, St Paul, MN 55108, USA
Comp Biochem Physiol C Toxicol Pharmacol 132:9-24. 2002..The insecticides, but not IL-1, disrupt feedback regulation of CRF synthesis in and release from the hypothalamus... - Development of quantitative structure-activity relationship (QSAR) models for predicting risk of exposure from carcinogens in animalsA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, 1333 Gortner Ave, University of Minnesota, St Paul Campus, St Paul, Minnesota 55418, USA
Cancer Invest 19:611-20. 2001..However, the molecule's lipophilicity, length, and width may play important roles in the carcinogenic effects of chlorinated compounds... - Immunotoxicity of acute acephate exposure in control or IL-1-challenged rats: correlation between the immune cell composition and corticosteroid concentration in bloodAshok K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, St Paul, MN 55180, USA
J Appl Toxicol 22:279-91. 2002.... - Effects of bacterial toxins on endothelial tight junction in vitro: a mechanism-based investigationAshok K Singh
Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, Twin Cities Campus, St Paul, MN
Toxicol Mech Methods 17:331-47. 2007..Since the toxins did not cross the endothelial barrier, induction of inflammation in neurons was due to a release of proinflammatory cytokines in the abluminal fluid... - QSAR for the organophosphate-induced inhibition and 'aging' of the enzyme neuropathy target esterase (NTE)A K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St Paul Campus, 1333 Gortner Ave, St Paul, MN 55108, USA
SAR QSAR Environ Res 12:275-95. 2001..The only exception is Eq. (3) that did not accurately predict the acephate-induced inhibition of AChE, possibly because acephate and other OPs inhibit the enzyme by distinct mechanisms... - Development of QSAR models to predict estrogenic, carcinogenic, and cancer protective effects of phytoestrogensA K Singh
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, St. Paul, Minnesota, USA
Cancer Invest 19:201-16. 2001..Thus molecular shape and molecular connectivity of PEs play a key role in modulating estrogen-induced transactivation activity and DNA synthesis in BC cells... - QSAR for acetylcholinesterase inhibition and toxicity of two classes of phosphoramidothioatesD P Spassova
Department of Veterinary Diagnostic Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Ave, St. Paul, MN 55108, USA
SAR QSAR Environ Res 11:453-71. 2001..The insecticidal activity of Ace analogs may be due to direct interaction with the active center of the AChE. The mammalian toxicity of Ace analogs may be due to interaction with an 'allosteric' reaction center in the AChE... - Xylopyrine-F, a new cyclopeptide alkaloid from Zizyphus xylopyraManoj B Pandey
Department of Chemistry, S G R Post Graduate College, Purvanchal University, Jaunpur, India
J Asian Nat Prod Res 10:735-8. 2008.... - Three new cyclopeptide alkaloids from Zizyphus speciesManoj B Pandey
Department of Chemistry, S G R Post Graduate College, Purvanchal University, Jaunpur, India
J Asian Nat Prod Res 10:719-23. 2008..Two new cyclopeptide alkaloids, xylopyrine-D and xylopyrine-E, from Zizyphus xylopyra and a new alkaloid, jubanine-E, from Zizyphus jujuba have been isolated and their structures were established by chemical and spectral evidences... - Determination of carbamylated hemoglobin by an enzyme immunoassay (ELISA) based on a novel antibodyAshok K Singh
Clin Chim Acta 391:112-4. 2008 - Stromal cells cultured from omentum express pluripotent markers, produce high amounts of VEGF, and engraft to injured sitesAshok K Singh
The Division of Nephrology, John Stroger Jr Hospital of Cook County, Chicago, IL, USA
Cell Tissue Res 332:81-8. 2008..Thus, our experiments show that omental stromal cells can be cultured from activated omentum, and that these cells exhibit stem cell properties enabling them to be used for repair and possibly for the regeneration of damaged tissues... - Impaired integration of endothelial progenitor cells in capillaries of diabetic wounds is reversible with vascular endothelial growth factor infusionAshok K Singh
Division of Nephrology, Cook County Hospital, Chicago, IL 60612, USA
Transl Res 149:282-91. 2007..It was concluded that diabetes causes reduction of VEGF in the wound, resulting in loss of blood vessels by apoptosis and possible failure of CD-34 cells to integrate into the vessel structure... - Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragmentsKrishnamurthy P Gudehithlu
Division of Nephrology, Cook County Hospital, Section of Nephrology, University of Illinois at Chicago, and VAMC, West Side Division, USA
Kidney Int 65:2113-22. 2004..These findings are in sharp contrast with the established view that degraded albumin is completely reabsorbed into the blood stream...