Research Topics
| A SimonyiSummaryAffiliation: University of Missouri Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
The neuroprotective effects of apocyninAgnes Simonyi
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Front Biosci (Elite Ed) 4:2183-93. 2012..In this review, we aim to give an overview of current literature on the neuroprotective effects of apocynin in the prevention and treatment of neurodegenerative disorders. Particular attention is given to in vivo studies...- Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA?-IIA expression in astrocytes and microgliaWenwen Sheng
Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
J Neuroinflammation 8:121. 2011.... - Polyphenols in cerebral ischemia: novel targets for neuroprotectionAgnes Simonyi
Department of Biochemistry and Pathology, University of Missouri Columbia, Columbia, MO, USA
Mol Neurobiol 31:135-47. 2005..This article reviews the neuroprotective effects of plant extracts and their constituents that have been used in animal models of cerebral ischemia. The use of polyphenols as therapeutic agents in stroke has been suggested... - Expression of groups I and II metabotropic glutamate receptors in the rat brain during agingAgnes Simonyi
Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
Brain Res 1043:95-106. 2005..These results demonstrate region- and subtype-specific, including splice variant specific changes in the expression of mGlu receptors in the brain with increasing age... - Metabotropic glutamate receptor subtype 5 antagonism in learning and memoryAgnes Simonyi
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Eur J Pharmacol 639:17-25. 2010.... - Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learningA Simonyi
Department of Biochemistry, University of Missouri Columbia, M743 Medical Sciences Building, Columbia, MO 65212, USA
Neurobiol Learn Mem 88:305-11. 2007..These findings indicate a selective participation of hippocampal group I mGlu receptors in memory processing in this task... - Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's diseaseJ M Walker
Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, MO 65211, USA
Behav Brain Res 222:169-75. 2011..These results demonstrate that TgCRND8 mice show significant deficits in spatial and nonspatial behavioral tasks at advanced stages of amyloid pathology... - Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampusQun Wang
Department of Biochemistry, M743 Medical Sciences Building, University of Missouri-Columbia, Columbia, MO 65212, USA
Brain Res 1090:182-9. 2006.... - Ethanol preconditioning protects against ischemia/reperfusion-induced brain damage: role of NADPH oxidase-derived ROSQun Wang
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
Free Radic Biol Med 43:1048-60. 2007..Our results further suggest the possibility that preconditioning with other pharmacological agents that induce a mild oxidative stress may have similar therapeutic value for suppressing stroke-mediated damage in brain... - Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neuronsPhullara B Shelat
Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
J Neurochem 106:45-55. 2008..This novel mechanism may contribute to the oxidative stress hypothesis and synaptic failure that underline the pathogenesis of Alzheimer's disease... - Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbilsQun Wang
Department of Biochemistry, University of Missouri, Columbia, MO, USA
Mol Nutr Food Res 49:443-51. 2005..The neuroprotective effects of GP supplement may have wide implication in the future for prevention/protection against other neurodegenerative damage... - Targeting NADPH oxidase and phospholipases A2 in Alzheimer's diseaseAgnes Simonyi
Biochemistry Department, University of Missouri, 117 Schweitzer Hall, Columbia, MO, USA
Mol Neurobiol 41:73-86. 2010..This information should provide new therapeutic approaches for prevention of this debilitating disease... - Metabotropic glutamate receptor 5 in conditioned taste aversion learningA Simonyi
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Neurobiol Learn Mem 92:460-3. 2009..These results indicate that mGlu5 receptors are involved in taste memories in a region-specific manner... - Botanical phenolics and brain healthAlbert Y Sun
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65211, USA
Neuromolecular Med 10:259-74. 2008..The main goal is to provide a better understanding of the mode of action of these compounds and assess their use as therapeutics to ameliorate age-related neurodegenerative diseases... - Resveratrol protects against neurotoxicity induced by kainic acidQun Wang
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Neurochem Res 29:2105-12. 2004..Since increased oxidative stress is a key factor for KA-induced neurotoxicity, this study demonstrated the ability of resveratrol to act as free radical scavenger to protect against neuronal damage caused by excitotoxic insults... - Functional interaction of mGlu5 and NMDA receptors in aversive learning in ratsS W Fowler
Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
Neurobiol Learn Mem 95:73-9. 2011.... - Oral administration of grape polyphenol extract ameliorates cerebral ischemia/reperfusion-induced neuronal damage and behavioral deficits in gerbils: comparison of pre- and post-ischemic administrationQun Wang
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
J Nutr Biochem 20:369-77. 2009..These findings indicate that oral GPE intake may confer protection against I/R injury and emphasize that early intervention may be an effective therapeutic measure for ameliorating brain injury in stroke... - The role of metabotropic glutamate receptor 5 in learning and memory processesAgnes Simonyi
Department of Biochemistry and Pathology, University of Missouri, Columbia, Missouri 65212, USA. edu
Drug News Perspect 18:353-61. 2005.... - Resveratrol protects against global cerebral ischemic injury in gerbilsQun Wang
Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri-Columbia, Columbia, MO 65212, USA
Brain Res 958:439-47. 2002..This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury... - Region-specific decline in the expression of metabotropic glutamate receptor 7 mRNA in rat brain during agingA Simonyi
Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
Brain Res Mol Brain Res 82:101-6. 2000..The difference between the young and aged groups exceeded 35%. These region-specific decreases may have important implication in some of the age-related changes in cognitive, motor and/or sensory functions... - Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficitsQun Wang
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
J Neurosci Res 82:138-48. 2005..Together, these findings attribute the neuroprotective effect of curcumin against I/R-induced neuronal damage to its antioxidant capacity in reducing oxidative stress and the signaling cascade leading to apoptotic cell death... - Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbilsQun Wang
Department of Biochemistry, University of Missouri School of Medicine, Columbia, MO 65211, USA
Brain Res 1285:188-95. 2009..The results also suggest that nanocrystals hold promise as an effective strategy for the delivery of compounds with poor solubility that would otherwise be precluded from preclinical development... - The "French Paradox" and beyond: neuroprotective effects of polyphenolsAlbert Y Sun
Department of Pharmacology, University of Missouri, Columbia, MO 65212, USA
Free Radic Biol Med 32:314-8. 2002..These studies demonstrate an urgent need to extend research beyond the "French Paradox" towards better understanding molecular mechanisms of action of polyphenolic compounds and their application to human health... - Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brainAgnes Simonyi
Department of Biochemistry, University of Missouri, M121 Medical Sciences Building, Columbia, MO 65212, USA
Alcohol Clin Exp Res 26:352-7. 2002..Dietary supplementation of GP may have a beneficial role in inhibiting certain alcohol effects... - Resveratrol as a therapeutic agent for neurodegenerative diseasesAlbert Y Sun
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
Mol Neurobiol 41:375-83. 2010..The goal here is to provide a better understanding of the mode of action of resveratrol and its possible use as a potential therapeutic agent to ameliorate stroke damage as well as other age-related neurodegenerative disorders... - MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in ratsTodd R Schachtman
Department of Psychological Sciences, University of Missouri, 210 McAlester Hall, Columbia, MO 65211, USA
Behav Brain Res 141:177-82. 2003..Similar experiments using the mGluR1 antagonist AIDA, have found no effect on CTA learning. These results suggest that the two subtypes of Group I mGluRs are differentially involved in taste aversion learning... - Phospholipases A2 and inflammatory responses in the central nervous systemGrace Y Sun
Department of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO 65211, USA
Neuromolecular Med 12:133-48. 2010.... - Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocyninQun Wang
Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
Phytomedicine 15:496-503. 2008..No diapocynin was detected in any samples. These results indicate rapid glycosylation of apocynin and its transport to blood and other organs but no apparent conversion to diapocynin in vivo... - Phospholipase A2 in the central nervous system: implications for neurodegenerative diseasesGrace Y Sun
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
J Lipid Res 45:205-13. 2004..Information from these studies has provided clear evidence for the important role of PLA2 in regulating physiological and pathological functions in the CNS... - Involvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytesMichael D Jensen
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Neurochem Int 55:362-8. 2009.... - Chronic ethanol-induced subtype- and subregion-specific decrease in the mRNA expression of metabotropic glutamate receptors in rat hippocampusAgnes Simonyi
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
Alcohol Clin Exp Res 28:1419-23. 2004..This study was aimed to determine whether chronic ethanol treatment could change the messenger RNA (mRNA) expression of mGlu receptors in the hippocampus... - Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversionCarla Bills
Department of Psychological Sciences, University of Missouri, Columbia, MO 65211, USA
Behav Brain Res 157:71-8. 2005..The results found that MPEP attenuates latent inhibition suggesting that the mGlu5 receptor exerts an influence on the processes that underlie the effects of taste pre-exposure on conditioning... - Phospholipase A2 in astrocytes: responses to oxidative stress, inflammation, and G protein-coupled receptor agonistsGrace Y Sun
Department of Biochemistry, University of Missouri Columbia, Columbia, MO, USA
Mol Neurobiol 31:27-41. 2005..This review focuses on describing the effects of oxidative stress, inflammation, and activation of G protein-coupled receptors on PLA2 activation, arachidonic acid (AA) release, and production of prostanoids in astrocytes... - Prostaglandin E2 production in astrocytes: regulation by cytokines, extracellular ATP, and oxidative agentsJ Xu
Department of Biochemistry, University of Missouri, Columbia, MO 65212, USA
Prostaglandins Leukot Essent Fatty Acids 69:437-48. 2003..These results suggest that ATP release during neuronal excitation or injury can enhance the inflammatory effects of cytokines on PGE2 production and may contribute to chronic inflammation seen in Alzheimer's disease... - Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytesJianfeng Xu
Department of Biochemistry, University of Missouri-Columbia, Columbia, Missouri, USA
J Neurochem 83:259-70. 2002..Together, our results provided evidence for an important role of PKC in mediating cPLA2 phosphorylation and AA release in astrocytes through both ERK1/2-dependent and ERK1/2-independent pathways... - Extracellular signal-regulated kinase 2 mRNA expression in the rat brain during agingAgnes Simonyi
Department of Biochemistry, University of Missouri, Columbia, Missouri 65212, USA
Neurochem Res 28:1375-8. 2003..These results suggest that the impairment in ERK1/2 activity observed during aging is probably not regulated at the gene expression level... - Chronic ethanol on mRNA levels of IP3R1, IP3 3-kinase and mGluR1 in mouse Purkinje neuronsA Simonyi
Department of Biochemistry, University of Missouri, Columbia 65212, USA
Neuroreport 7:2115-8. 1996..The decrease in mRNA levels of mGluR1 and IP3R1 may be an important underlying mechanism towards explaining the alcohol-induced degenerative changes in the cerebellar Purkinje neurons... - Kainic acid-mediated excitotoxicity as a model for neurodegenerationQun Wang
Department of Medical Pharmacology, University of Missouri School of Medicine, Columbia, MO, USA
Mol Neurobiol 31:3-16. 2005..The focus of this review is to summarize studies demonstrating KA-induced excitotoxicity in the central nervous system and possible intervention by anti-oxidants... - Ischemia-induced increase in RGS7 mRNA expression in gerbil hippocampusPhullara B Shelat
Department of Biochemistry, M743 Medical Sciences Bldg, University of Missouri-Columbia, 65212, USA
Neurosci Lett 403:157-61. 2006..Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus... - Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptorQiongman Kong
Interdisciplinary Neuroscience Program, University of Missouri, Columbia, Missouri, USA
J Neurochem 109:1300-10. 2009..These results demonstrate that elevated levels of pro-inflammatory cytokines associated with neurodegenerative diseases, such as IL-1beta, can enhance non-amyloidogenic APP processing through up-regulation of the P2Y(2)R in neurons... - Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brainTeng Nan Lin
Neuroscience Program, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
J Neurochem 90:637-45. 2004..Taken together, these results demonstrate for the first time an up-regulation of the inflammatory sPLA2-IIA in reactive astrocytes in response to cerebral ischemia-reperfusion... - MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in ratsGert R J Christoffersen
Department of Biology, August Krogh Building, University of Copenhagen, DK 2100 Copenhagen, Denmark
Behav Brain Res 191:235-45. 2008..However, the fact that prelimbic administration of MPEP inhibited retention without reducing exploration shows that memory formation was also impacted directly by prelimbic mGlu5 in both spatial and non-spatial learning... - Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticityLinda A Kotilinek
Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA
Brain 131:651-64. 2008..The results lead us to propose a third possible mechanism by which NSAIDs may protect against Alzheimer's disease, involving the blockade of a COX-2-mediated PGE2 response at synapses...
Research Grants
- Involvement of mGluR5 in inhibitory avoidance and agingAgnes Simonyi; Fiscal Year: 2004..This information may also be useful for therapeutic research investigating the potential use of mGluR ligands in age-related neurodegenerative disorders, such as Alzheimer's disease. ..