Research Topics
| FRANK ALBERT SIMMENSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesisRijin Xiao
Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, AR 72202, USA
Mol Cancer 4:1. 2005..To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet), soy protein isolate (SPI), and whey protein hydrolysate (WPH) diets were determined...- The planetary biology of cytochrome P450 aromatasesEric A Gaucher
Foundation for Applied Molecular Evolution, 1115 NW 4th Street, Gainesville FL 32601 4256, USA
BMC Biol 2:19. 2004..This strategy expands systems biology to a planetary context, necessary for a notion of fitness to underlie (as it must) any discussion of function within a biomolecular system... - The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic?Frank A Simmen
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
Eur J Cancer Prev 20:539-48. 2011.... - Orchestrating the menstrual cycle: discerning the music from the noiseFrank A Simmen
Arkansas Children's Nutrition Center, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
Endocrinology 147:1094-6. 2006 - Dysregulation of intestinal crypt cell proliferation and villus cell migration in mice lacking Kruppel-like factor 9Frank A Simmen
Arkansas Children s Nutrition Center, 1120 Marshall St, Little Rock, AR 72202, USA
Am J Physiol Gastrointest Liver Physiol 292:G1757-69. 2007..Results suggest that Klf9 controls the elaboration, from intestine smooth muscle, of molecular mediator(s) of crypt cell proliferation and lineage determination and of villus cell migration... - The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expressionFrank A Simmen
Department of Physiology and Biophysics, and the Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Reprod Biol Endocrinol 6:41. 2008..This cell line provides a unique model for identifying KLF9 downstream gene targets and signaling pathways... - Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colonFrank A Simmen
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
BMC Gastroenterol 9:67. 2009..Previous work indicated an inhibitory effect of consumed blueberry (BB) on formation of aberrant crypt foci (ACF) in colons of male Fisher F344 rats (inbred strain). However, effects of BB on colon tumors and in both genders are unknown... - Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male ratFrank A Simmen
Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
J Nutr Biochem 21:1106-13. 2010..Identification of the regulation, by genistein and soy protein, of iodothyronine deiodinase synthesis has potential applications for treatment and prevention of fatty liver disease and obesity... - Null mutation of Kruppel-like factor9/basic transcription element binding protein-1 alters peri-implantation uterine development in miceMichael C Velarde
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock AR 72202, USA
Biol Reprod 73:472-81. 2005.... - Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cellsMichael C Velarde
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Mol Endocrinol 21:2988-3001. 2007..Our data identify KLF9 as a transcriptional repressor of ERalpha signaling and suggest that it may function at the node of PR and ER genomic pathways to influence cell proliferation... - Progesterone receptor transactivation of the secretory leukocyte protease inhibitor gene in Ishikawa endometrial epithelial cells involves recruitment of Krüppel-like factor 9/basic transcription element binding protein-1Michael C Velarde
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, 72202, USA
Endocrinology 147:1969-78. 2006..Our findings define a novel pathway for BTEB1/PR cross-talk to facilitate P-dependent gene transcription in endometrial epithelial cells... - Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosteroneRijin Xiao
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
J Endocrinol 195:79-87. 2007..Results indicate an effect of dietary protein type during pregnancy on colon tumor multiplicity and colon tissue gene expression, and serum IGF-I and testosterone in progeny rats as later adults... - Uterine phenotype of young adult rats exposed to dietary soy or genistein during developmentRenea R Eason
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Nutr Biochem 16:625-32. 2005..Given its limited influence on uterine phenotype of young adult females, GEN, when taken as part of soy foods or as supplement, should be favorably considered for other potential health benefits... - Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthaseRijin Xiao
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Am J Physiol Gastrointest Liver Physiol 294:G868-76. 2008.... - Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumorsYing Su
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
Physiol Genomics 30:8-16. 2007..Identification of distinct Gen and SPI responsive genes in mammary epithelial cells may define early events contributing to tumor protection by diet relevant to the prevention of breast and other types of cancer... - Soy protein isolate and protection against cancerThomas M Badger
Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Am Coll Nutr 24:146S-149S. 2005..The purpose of this presentation was to evaluate the potential of soy protein to prevent occurrence of prostate, breast and colon cancer... - Progesterone receptors and Sp/Krüppel-like family members in the uterine endometrium Rosalia C M Simmen
Arkansas Children s Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
Front Biosci 7:d1556-65. 2002.... - Dietary whey protein lowers serum C-peptide concentration and duodenal SREBP-1c mRNA abundance, and reduces occurrence of duodenal tumors and colon aberrant crypt foci in azoxymethane-treated male ratsRijin Xiao
Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
J Nutr Biochem 17:626-34. 2006..Results indicate potential physiological linkages of dietary protein type with circulating C-peptide (and by inference insulin), local expression of SREBP-1c gene and propensity for small intestine tumorigenesis... - Subfertility, uterine hypoplasia, and partial progesterone resistance in mice lacking the Kruppel-like factor 9/basic transcription element-binding protein-1 (Bteb1) geneRosalia C M Simmen
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
J Biol Chem 279:29286-94. 2004..These results identify Bteb1 as a functionally relevant PR-interacting protein and suggest its selective modulation of cellular processes that are regulated by PR-A in the uterine stroma... - Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liverLing He
Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
J Biol Chem 279:28113-21. 2004..We conclude that SREBP-1 is a negative regulator of the ADH gene and may work in concert with the CCAAT/enhancer-binding proteins to mediate ethanol induction of ADH in vivo... - Delayed parturition and altered myometrial progesterone receptor isoform A expression in mice null for Krüppel-like factor 9Zhaoyang Zeng
Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
Biol Reprod 78:1029-37. 2008..The present study highlights the potential utility of Klf9 null mice to investigate the pathophysiology of parturition defects involving PGR signaling... - Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesisRenea R Eason
Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, AR 72202, USA
Nutr Cancer 55:171-7. 2006.... - Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activationLing He
Arkansas Children s Nutrition Center and the Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
J Biol Chem 281:11126-34. 2006..Ethanol inhibition of insulin signaling reduces nuclear SREBP accumulation and results in disinhibition of Class 1 ADH transcription... - Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13John Mark P Pabona
Department of Physiology and Biophysics, and Arkansas Children s Nutrition Center, 15 Children s Way, Little Rock, AR 72202, USA
Endocrinology 151:3396-406. 2010.... - Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicityKartik Shankar
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Exp Biol Med (Maywood) 231:1379-97. 2006..Our data suggest that undernutrition potentiates the fetal toxicity of EtOH in part by disrupting maternal GH-IGF-1, signaling thereby decreasing maternal uterine capacity and placental growth...
Research Grants
- Dietary Factors in Colon Cancer PreventionFRANK ALBERT SIMMEN; Fiscal Year: 2010....
- Dietary Factors in Colon Cancer PreventionFRANK ALBERT SIMMEN; Fiscal Year: 2011..These studies have strong translational significance for improving the health and quality of life of the overweight/obese population at risk for or afflicted with colo-rectal cancer. ..