Research Topics
Genomes and Genes
Species | Sadeep ShresthaSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
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Detail Information
Publications
Association test of multiallelic gene copy numbers in family triosSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
Genet Epidemiol 34:2-6. 2010..We present theoretical derivation of the statistics and results of simulation studies that show robustness of our approach and power under several genetic models...- Variations in CCL3L gene cluster sequence and non-specific gene copy numbersSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, School of Public Health, 1665 University Blvd, RPHB Room 217L, Birmingham, Alabama 35294 0022, USA
BMC Res Notes 3:74. 2010..These genes are involved in host defense and inflammatory processes. Several CNV assays have been developed for the CCL3L1 gene... - Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescentsSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 5:e13384. 2010.... - Interleukin-10 gene (IL10) polymorphisms and human papillomavirus clearance among immunosuppressed adolescentsSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, 1665 University Boulevard, RPHB Room 220A, Birmingham, AL 35294 0022, USA
Cancer Epidemiol Biomarkers Prev 16:1626-32. 2007.... - Host genetics and HIV-1 viral load set-point in African-AmericansSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
AIDS 23:673-7. 2009..We attempted to confirm this finding in African-Americans and to address whether these SNPs are in linkage disequilibrium with human leukocyte antigen (HLA) class I alleles that mediate innate and adaptive immunity... - A genome-wide association study of carotid atherosclerosis in HIV-infected menSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, AL 35294 0022, USA
AIDS 24:583-92. 2010..The role of host genetics in the development of subclinical atherosclerosis in the context of HIV-infected persons who are being treated with highly active antiretroviral therapy (HAART) is not well understood... - The influence of human leukocyte antigen class I alleles and their population frequencies on human immunodeficiency virus type 1 control among African AmericansAleksandr Lazaryan
University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
Hum Immunol 72:312-8. 2011..Certain HLA class I associations with control of HIV-1 infection cross the boundaries of race and viral subtype, whereas others appear confined within one or the other of those boundaries... - Human leukocyte antigen class I supertypes and HIV-1 control in African AmericansAleksandr Lazaryan
University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
J Virol 84:2610-7. 2010..The study demonstrated the dominant role of HLA-B supertypes in HIV-1 clade B-infected African Americans and further dissected the contributions of individual class I alleles and their population frequencies to the supertype effects... - Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in ZambiansRakhi Malhotra
Department of Epidemiology, University of Alabama at Birmingham UAB, Birmingham, AL, USA
Retrovirology 8:22. 2011.... - Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youthYufeng Li
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Hum Genet 126:685-96. 2009.... - The major histocompatibility complex conserved extended haplotype 8.1 in AIDS-related non-Hodgkin lymphomaBrahim Aissani
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Acquir Immune Defic Syndr 52:170-9. 2009..Which gene variant on this highly conserved extended haplotype (CEH 8.1) in whites most likely represents a true etiologic factor remains uncertain... - Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected menMarguerite R Irvin
aDepartment of Epidemiology bDepartment of Biostatistics, School of Public Health cDivision of infectious Diseases, School of Medicine, University of Alabama at Birmingham, Alabama dMedical Genetics Institute, Cedars Sinai Medical Center eDepartment of Pediatrics, School of Medicine, University of California Los Angeles, Los Angeles fVeterans Affairs Medical Center, School of Medicine, University of California, San Francisco, California, USA
Pharmacogenet Genomics 21:798-807. 2011..Genetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV)... - The impact of highly active antiretroviral therapy on prevalence and incidence of cervical human papillomavirus infections in HIV-positive adolescentsSadeep Shrestha
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
BMC Infect Dis 10:295. 2010..However, the impact of HAART on cervical human papillomavirus (HPV) infection, clearance, and persistence in high-risk adolescents remains controversial... - Incidence, prevalence, and epidemiology of herpes simplex virus-2 in HIV-1-positive and HIV-1-negative adolescentsStaci L Sudenga
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
Sex Transm Dis 39:300-5. 2012..The objective of this study was to determine HSV-2 prevalence and incidence and associated risk factors in a HIV-1-positive and at risk HIV-1-negative adolescent population... - Natural selection among Eurasians at genomic regions associated with HIV-1 controlYann C Klimentidis
Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
BMC Evol Biol 11:173. 2011.... - Influence of host genetic and ecological factors in complex concomitant infections - relevance to sexually transmitted infectionsSadeep Shrestha
Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294 0022, USA
J Reprod Immunol 92:27-32. 2011.... - Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcomeAnn L Truelove
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD, USA
Int J Immunogenet 35:255-64. 2008..01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis... - Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysisSadeep Shrestha
Laboratory of Genomic Diversity, National Cancer Institute, NCI-Frederick, MD 21702, USA
J Acquir Immune Defic Syndr 43:335-43. 2006..Testing of STRs represents a promising approach to examining and accessing complex behavioral data, including syringe sharing... - Behavioral risk exposure and host genetics of susceptibility to HIV-1 infectionSadeep Shrestha
Laboratory of Genomic Diversity, National Cancer Institute at Frederick, National Institutes of Health, MD 21702, USA
J Infect Dis 193:16-26. 2006..The matched case-control study design with measured risk exposures provides an avenue for discovering genes involved in susceptibility to infection... - Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African populationDesiree C Petersen
Department of Medical Virology, University of Stellenbosch, Tygerberg Medical School, South Africa
J Acquir Immune Defic Syndr 40:521-6. 2005..Comprehensive mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient population...