Research Topics
| Cecilia M ShikumaSummaryAffiliation: University of Hawaii Country: USA Publications
Research Grants
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Detail Information
Publications
Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)Cecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii at Manoa, Manoa Leihi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 44:540-50. 2007..To assess metabolic changes after initiation of protease inhibitor (PI)-sparing regimens in antiretroviral-naive patients...- Mitochondrial oxidative phosphorylation protein levels in peripheral blood mononuclear cells correlate with levels in subcutaneous adipose tissue within samples differing by HIV and lipoatrophy statusCecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
AIDS Res Hum Retroviruses 24:1255-62. 2008..We conclude that CI and CIV levels in PBMCs correlate to their respective levels in fat and may have utility as surrogate markers of mitochondrial dysfunction in lipoatrophy... - Insulin resistance in the HIV-infected population: the potential role of mitochondrial dysfunctionC M Shikuma
Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu 96816, USA
Curr Drug Targets Infect Disord 5:255-62. 2005..Based on current knowledge, mitochondrial dysfunction can be hypothesized to play a key role in each of these components... - HIV-associated wasting in the era of highly active antiretroviral therapy: a syndrome of residual HIV infection in monocytes and macrophages?Cecilia M Shikuma
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
Clin Infect Dis 40:1846-8. 2005..9 vs. 0.9 copies/10(6) PBMCs; P = .006)... - Changes in weight and lean body mass during highly active antiretroviral therapyC M Shikuma
Dept of Medicine, Hawaii AIDS Clinical Research Program, University of Hawaii, Manoa, Honolulu, Hawaii 96816, USA
Clin Infect Dis 39:1223-30. 2004..Few studies have prospectively evaluated the impact of highly active antiretroviral therapy (HAART) on body weight and lean body mass (LBM) or explored the impact of baseline immunologic or virological changes on these parameters... - Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individualsCecilia M Shikuma
University of Hawaii, Honolulu, Hawaii, USA
AIDS Res Hum Retroviruses 27:461-8. 2011..hsCRP levels increased significantly only in women. Randomization to abacavir had no effect on changes in hsCRP levels. Changes in hsCRP levels did not correlate with changes in fasting metabolic parameters... - Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophyC M Shikuma
Pacific Biomedical Research Center, John A Burns School of Medicine, University of Hawaii Manoa, Honolulu, Hawaii 96816, USA
AIDS 15:1801-9. 2001.... - Insulin resistance is associated with cognition among HIV-1-infected patients: the Hawaii Aging With HIV cohortVictor G Valcour
Office of Neurology and Aging Research, University of Hawaii, Leahi Hospital, 3675 Kilauea Avenue, Honolulu, HI 96816, USA
J Acquir Immune Defic Syndr 43:405-10. 2006..To determine if insulin resistance (IR) is associated with lower cognitive performance among HIV-1-infected adults and to determine if advanced age magnifies risk... - Diabetes, insulin resistance, and dementia among HIV-1-infected patientsVictor G Valcour
University of Hawaii, Neuro AIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, HI, USA
J Acquir Immune Defic Syndr 38:31-6. 2005..The objective of this study was to examine the relationship between HIV-associated dementia (HAD) and diabetes among patients with HIV-1 infection... - HIV DNA in circulating monocytes as a mechanism to dementia and other HIV complicationsVictor G Valcour
Hawaii Center for AIDS, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA
J Leukoc Biol 87:621-6. 2010..Herein, we summarize our current understanding of monocyte HIV DNA and central nervous system dysfunction in humans. We present a model to understand these relationships and suggest possible treatment approaches to be tested... - Mitochondrial DNA levels of peripheral blood mononuclear cells and subcutaneous adipose tissue from thigh, fat and abdomen of HIV-1 seropositive and negative individualsMariana Gerschenson
Hawaii AIDS Clinical Research Program, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA
Antivir Ther 10:M83-9. 2005..Thigh fat mtDNA levels were 45-55% lower than abdomen and neck. These studies help demonstrate that mtDNA levels can vary in different subcutaneous adipose depots suggesting possible metabolic differences... - Expression of monocyte markers in HIV-1 infected individuals with or without HIV associated dementia and normal controls in Bangkok ThailandSilvia Ratto-Kim
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States
J Neuroimmunol 195:100-7. 2008..In conclusion it appears that HAD in Thai individuals has a different immunological profile then in North America cohorts... - Symptomatic distal sensory polyneuropathy in HIV after age 50M R Watters
Office of Neurology and Aging Research, Hawaii AIDS Clinical Trials Unit, University of Hawaii, Honolulu 96816, USA
Neurology 62:1378-83. 2004..SxDSPN is associated with both dementia and low nadir CD4 in HIV-positive patients aged 50 and greater... - Incident neuropathy in HIV-infected patients on HAARTBeau K Nakamoto
Hawaii Center for AIDS, Department of Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
AIDS Res Hum Retroviruses 26:759-65. 2010..However, current or prior history of d-drug treatment is not a significant risk factor for incident DSP in subjects who had previously tolerated d-drug treatment without developing a toxic DSP... - Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170)Robert J McLinden
aUniversity of Hawai i at Manoa, Honolulu, Hawaii bWalter Reed Army Medical Center, Washington, District of Columbia cUS Military HIV Research Program, Rockville dEmpiriStat, Inc, Mt Airy, Maryland eCBAR, Harvard University, Boston, Massachusetts fUniversity of North Carolina, Chapel Hill, North Carolina, USA
AIDS 26:1-9. 2012..We investigated the impact of neutralizing antibodies (NAbs) on CD4 T-cell count and viral load in a cohort of HAART recipients who underwent extended structured treatment interruption... - Cognitive impairment in older HIV-1-seropositive individuals: prevalence and potential mechanismsVictor G Valcour
University of Hawaii, NeuroAIDS Specialized Neuroscience Research Program, John A Burns School of Medicine, Honolulu, Hawaii 96816, USA
AIDS 18:S79-86. 2004.... - Validation of the human activity profile in HIV-positive individuals on HAARTRonald K Hetzler
Department of Kinesiology and Rehabilitation Science, College of Education, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA
HIV Clin Trials 10:254-60. 2009..The HAP is a 94-item questionnaire for estimating functional capacity based on estimated metabolic equivalents for activities of daily living... - HIV DNA and cognition in a Thai longitudinal HAART initiation cohort: the SEARCH 001 Cohort StudyV G Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96816, USA
Neurology 72:992-8. 2009..This study aimed to determine if immunologic and virologic factors influence cognition after first-time HAART in Thai individuals with HIV-associated dementia (HAD) and Thai individuals without HAD (non-HAD)... - Neuropsychological abnormalities in patients with dementia in CRF 01_AE HIV-1 infectionV G Valcour
Hawaii AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
Neurology 68:525-7. 2007..Neuropsychological testing abnormalities were identified in most cognitive domains among HAD vs HIV-negative participants, confirming the presence of HAD in CRF01_AE... - Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific IslandersY Lu
Retrovirology Research Laboratory, Hawaii AIDS Research Consortium, and Native Hawaiian Health Research Program, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii 96816, USA
Int J Infect Dis 3:186-91. 1999.... - High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmissionV R Nerurkar
Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii, Honolulu, USA
J Med Virol 56:123-7. 1998.... - Sterol regulatory element-binding proteins and reactive oxygen species: potential role in highly-active antiretroviral therapy (HAART)-associated lipodystrophyP V Nerurkar
Retrovirology Research Laboratory, Leahi Hospital, Honolulu, Hawaii 96816, USA
Clin Biochem 34:519-29. 2001..Second, we hypothesize that the generation of reactive oxygen species in adipocytes may be an early and critical event in HAART-associated toxicity leading to cell death, partially explaining the mechanism underlying lipoatrophy... - Assessing the needs for HIV medical care in Hawai'iLisa R Marten
Hawai i AIDS Clinical Research Program, John A Burns School of Medicine, University of Hawai i at Manoa, Honolulu, HI 96816, USA
Hawaii Med J 68:74-8. 2009..Supporting more than one provider option and linking with ancillary services may help keep HIV patients in care... - Lamivudine-associated macrocytosis in HIV-infected patientsThana Khawcharoenporn
Department of Medicine, University of Hawaii, Honolulu, Hawaii, HI 96813, USA
Int J STD AIDS 18:39-40. 2007..We found that lamivudine was strongly associated with macrocytosis (OR = 24.6 [2.9-3223.0], P = 0.001). This association may be due to lamivudine's effect on erythrocyte synthesis... - Comparative effectiveness of initial antiretroviral therapy regimens: ACTG 5095 and 5142 clinical trials relative to ART-CC cohort studyMichael J Mugavero
Division of Infectious Disease, Department of Medicine, University of Alabama, Birmingham, AL, USA
J Acquir Immune Defic Syndr 58:253-60. 2011.... - TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integrationQigui Yu
Retrovirology Research Laboratory, Pacific Biomedical Research Center, University of Hawaii at Manoa, Honolulu, Hawaii, USA
J Med Virol 66:276-84. 2002..Our data indicate that PBMC and PBMC subsets are not the major sites of TTV replication... - A study of the immunology, virology, and safety of prednisone in HIV-1-infected subjects with CD4 cell counts of 200 to 700 mm(-3)Robert S Wallis
The University Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, USA
J Acquir Immune Defic Syndr 32:281-6. 2003..The potential role of corticosteroids as tools to examine this question will be limited by concerns regarding their toxicity; however, further studies of other agents to limit cellular activation in AIDS are warranted... - Design issues in initial HIV-treatment trials: focus on ACTG A5095Heather J Ribaudo
Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Boston, USA
Antivir Ther 11:751-60. 2006..We also hope to inform the field regarding issues in choosing composite versus virological endpoints as well as other key considerations in trial design and monitoring... - Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infectionRoy M Gulick
Weill Medical College of Cornell University, New York, USA
N Engl J Med 350:1850-61. 2004.... - Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trialRoy M Gulick
Cornell HIV Clinical Trials Unit, Division of International Medicine and Infectious Diseases, Weill Medical College of Cornell University, New York, NY, USA
JAMA 296:769-81. 2006..Three-drug antiretroviral regimens are standard of care for initial treatment of human immunodeficiency virus 1 (HIV-1) infection, but a 4-drug regimen could improve antiretroviral activity and be more effective than a 3-drug regimen... - Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppressionRoy M Gulick
Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
AIDS 21:813-23. 2007..To compare a quadruple-nucleoside with an efavirenz-containing regimen for treatment of HIV-1 infection... - Metabolic complications of HIV therapyDominic C Chow
IAPAC Mon 12:302-17. 2006 - Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesityShalender Bhasin
Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, Boston Medical Center, 670 Albany Street, Second Floor, Boston, Massachusetts 02118, USA
J Clin Endocrinol Metab 92:1049-57. 2007..Whole body and abdominal obesity are associated with increased risk of diabetes mellitus and heart disease. The effects of testosterone therapy on whole body and visceral fat mass in HIV-infected men with abdominal obesity are unknown...
Research Grants
- HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAMCecilia Shikuma; Fiscal Year: 2004..abstract_text> ..
- HIV and Global Drug Therapies: Peripheral Neuropathy Complications and MechanismsCecilia M Shikuma; Fiscal Year: 2010..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..
- Role of macrophages in HIV LipoatrophyCecilia M Shikuma; Fiscal Year: 2010..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
- Role of Oxidative Stress and Inflammation in HIV Cardiovascular RiskCecilia M Shikuma; Fiscal Year: 2010..End of Abstract) ..
- Role of Oxidative Stress and Inflammation in HIV Cardiovascular RiskCecilia Shikuma; Fiscal Year: 2009..End of Abstract) ..
- HIV and Global Drug Therapies: Peripheral Neuropathy Complications and MechanismsCecilia Shikuma; Fiscal Year: 2009..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..
- HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAMCecilia Shikuma; Fiscal Year: 2007..abstract_text> ..
- Role of macrophages in HIV LipoatrophyCecilia Shikuma; Fiscal Year: 2007..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
- Mitochondrial Function and HIV LipoatrophyCecilia Shikuma; Fiscal Year: 2005..Obtained ATP levels will be correlated with level of adipocyte apoptosis as well as with adipocyte mtDNA copies/cell by real-time PCR and SC adipose tissue expression of select oxidative phosphorylation (OXPHOS) genes. ..
- HIV and Global Drug Therapies: Peripheral Neuropathy Complications and MechanismsCecilia M Shikuma; Fiscal Year: 2010..We will also study the role of mitochondria (a source of energy for the cell) and HIV in the development of neuropathy. ..