Research Topics
| F R SharpSummaryAffiliation: University of Cincinnati Country: USA Publications
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Detail Information
Publications
Cerebral ischemia-hypoxia induces intravascular coagulation and autophagyFaisal Adhami
Division of Developmental Biology, Cincinnati Children's Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
Am J Pathol 169:566-83. 2006..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...- Reperfusion activates metalloproteinases that contribute to neurovascular injuryAigang Lu
Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532
Exp Neurol 210:549-59. 2008..Administering AHA 30 min before reperfusion decreased MMP-9 activation and neurovascular injury in ischemic cerebral cortex... - Hypoxic preconditioning protects against ischemic brain injuryFrank R Sharp
Department of Neurology, University of Cincinnati, Ohio 45267, USA
NeuroRx 1:26-35. 2004..Understanding the mechanisms and genes involved in hypoxic tolerance may provide new therapeutic targets to treat ischemic injury and enhance recovery... - Neurogenesis following brain ischemiaFrank R Sharp
Department of Neurology and Neuroscience Program, Vontz Center Rm 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, OH 45267 0536, USA
Brain Res Dev Brain Res 134:23-30. 2002..It is proposed that ischemia-induced neurogenesis contributes to the recovery of function, and specifically may serve to improve anterograde and retrograde recent memory function that is lost following global ischemia in animals and man... - Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?F R Sharp
Department of Neurology and Neurosciences Program, University of Cincinnati Vontz Center, 3125 Eden Avenue Rm 2327, Cincinnati, OH 45267 0536, USA
Trends Neurosci 24:330-4. 2001..Pathological activation of thalamocortical circuits might also mediate the psychosis produced by NMDA-receptor antagonists in humans, and might contribute to psychosis in schizophrenia... - HIF1 and oxygen sensing in the brainFrank R Sharp
Department of Neurology, Pediatrics and Neuroscience Program, Vontz Center for Molecular Studies, Room 2327, 3125 Eden Avenue, University of Cincinnati, Cincinnati, Ohio 45267-0536, USA
Nat Rev Neurosci 5:437-48. 2004 - Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemiaAigang Lu
Department of Neurology, University of Cincinnati, Ohio 45267-0536, USA
J Neurochem 81:355-64. 2002..The data show that geldanamycin protects brain from focal ischemia and that this may be due, at least in part, to geldanamycin stimulation of heat shock gene transcription... - Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxiaYang Tang
Department of Neurology and Neuroscience Program, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Eur J Neurosci 15:1937-52. 2002..In contrast, there was only a single gene that was down-regulated by all of the injury conditions suggesting there is not a common gene down-regulation response to injury... - Prolonged expression of zinc finger immediate-early gene mRNAs and decreased protein synthesis following kainic acid induced seizuresJ Honkaniemi
Department of Neurology, University of California at San Francisco, USA
Eur J Neurosci 11:10-7. 1999.... - Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic toleranceMyriam Bernaudin
Department of Neurology and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Biol Chem 277:39728-38. 2002..These results suggest that a number of endogenous molecular mechanisms may explain how hypoxic preconditioning protects against subsequent ischemia, and may provide novel therapeutic targets for treatment of cerebral ischemia... - Hypoxia-inducible factor in brainF R Sharp
Department of Neurology, University of Cincinnati, OH, USA
Adv Exp Med Biol 502:273-91. 2001..Thus, HIF-1 activation could contribute to protective brain preconditioning... - 17-beta-estradiol induces heat shock proteins in brain arteries and potentiates ischemic heat shock protein induction in glia and neuronsAigang Lu
Department of Neurology and Neurosciences Program, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Cereb Blood Flow Metab 22:183-95. 2002..The induction of HSPs may be an important mechanism for estrogen protection against cerebral ischemia and other types of injury... - Genomics of the periinfarction cortex after focal cerebral ischemiaAigang Lu
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Cereb Blood Flow Metab 23:786-810. 2003..Genes regulated acutely after stroke may modulate cell survival and death; also, late regulated genes may be related to tissue repair and functional recovery... - Heme and iron metabolism: role in cerebral hemorrhageKenneth R Wagner
Departments of Neurology, Pediatrics and Neuroscience Programl, Unviersity of Cincinnati College of Medicine, Cincinnati, Ohio 45220, USA
J Cereb Blood Flow Metab 23:629-52. 2003..The present review will examine the uptake and metabolism of heme and iron in the brain and will relate these processes to blood removal and to the potential mechanisms underlying brain injury following cerebral hemorrhage... - Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signalingRuiqiong Ran
Department of Neurology, University of Cincinnati, Cincinnati, Ohio 45267, USA
Genes Dev 18:1466-81. 2004..These results provide significant novel insights into the molecular mechanism for the pro-apoptotic behavior of Hsp70 in death-receptor-mediated cell death... - Bilirubin oxidation products (BOXes) and their role in cerebral vasospasm after subarachnoid hemorrhageJoseph F Clark
Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
J Cereb Blood Flow Metab 26:1223-33. 2006.... - Repeated cocaine administration induces gene expression changes through the dopamine D1 receptorsDongsheng Zhang
Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0521, USA
Neuropsychopharmacology 30:1443-54. 2005.... - Hsp70 mutant proteins modulate additional apoptotic pathways and improve cell survivalRuiqiong Ran
Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
Cell Stress Chaperones 9:229-42. 2004..Hsp70 mutants represent a possible approach to antiapoptotic biotherapeutics. Similar rational designs could be used to engineer inhibitors of additional caspase family members... - Blood genomic expression profile for neuronal injuryYang Tang
Department of Neurology, Neuroscience Program, University of Cincinnati, Vontz Center for Molecular Studies Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267 0536, USA
J Cereb Blood Flow Metab 23:310-9. 2003.... - Oxidation of bilirubin produces compounds that cause prolonged vasospasm of rat cerebral vessels: a contributor to subarachnoid hemorrhage-induced vasospasmJoseph F Clark
Department of Neurology and Neuroscience Program, University of Cincinnati, Cincinnati, Ohio 45267 0536, USA
J Cereb Blood Flow Metab 22:472-8. 2002.... - Down-regulation of interleukin 7 mRNA by hypoxia is calcium dependentAigang Lu
Vontz Center for Molecular Studies, Department of Neurology, University of Cincinnati, Cincinnati, OH 45267 0532, USA
Neurol Res 31:545-9. 2009..Hypoxia affects neurological disease states in part by modulating expression of many early and late response genes. The present work used cultured PC12 cells to investigate the effect of hypoxia on IL-7 expression... - Mechanical reperfusion is associated with post-ischemic hemorrhage in rat brainAigang Lu
Department of Neurology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267 0532, USA
Exp Neurol 216:407-12. 2009..Whether pharmacological treatments prior to reperfusion attenuate post-ischemic HT requires further study... - Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brainJ Liu
Department of Neurology, University of California at San Francisco, San Francisco, California, USA
J Cereb Blood Flow Metab 21:361-73. 2001..Because there is no apparent neuronal death, it is postulated that the microglia/macrophage proliferation occurs in response to an unknown nonlethal injury to neurons or glia and may be beneficial... - Corticosteroid effects on blood gene expression in Duchenne muscular dystrophyL Lit
Department of Neurology, MIND Institute, University of California at Davis, Sacramento, CA 95817, USA
Pharmacogenomics J 9:411-8. 2009..These genes and pathways help explain mechanisms of efficacy and side effects of corticosteroids, and could provide new treatment targets for DMD and other neuromuscular disorders... - Blood gene expression profiling of neurologic diseases: a pilot microarray studyYang Tang
Department of Neurology and Neuroscience Program, University of Cincinnati, OH, USA
Arch Neurol 62:210-5. 2005..In 1 cluster, 6 genes-all associated with immune cell function-were overexpressed. CONCLUSION: Blood gene expression profiling can provide surrogate markers for neurologic diseases without obvious blood phenotypes... - Atypical antipsychotics and a Src kinase inhibitor (PP1) prevent cortical injury produced by the psychomimetic, noncompetitive NMDA receptor antagonist MK-801Jon Dickerson
Neurosciences Graduate Program, University of Cincinnati, Cincinnati, OH, USA
Neuropsychopharmacology 31:1420-30. 2006.... - Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1Yang Tang
Department of Neurology, University of Cincinnati, Vontz Center, Room 2327, 3125 Eden Avenue, Cincinnati, OH 45267-0536, USA
Brain Res Mol Brain Res 132:155-67. 2004.... - Gene expression in blood of subjects with Duchenne muscular dystrophyBrenda Wong
Department of Pediatric Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Neurogenetics 10:117-25. 2009..The regulated genes might be used to monitor therapy or provide novel targets for immune-directed therapy for DMD... - Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to noveltyLaurel M Pritchard
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Brain Res Bull 70:296-303. 2006..Additionally, these findings are consistent with the hypothesis that alternative splicing may contribute to regulation of D3 dopamine receptor function... - Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of diseaseY Tang
Department of Neurology, University of Cincinnati, OH 45267-0536, USA
Ann Neurol 50:699-707. 2001..Blood genomic response patterns were different for each condition. These results demonstrate the potential of blood gene expression profiling for diagnostic, mechanistic, and therapeutic assessment of a wide variety of disease states... - Acute phencyclidine neurotoxicity in rat forebrain: induction of haem oxygenase-1 and attenuation by the antioxidant dimethylthioureaS Rajdev
Department of Neurology, University of California, San Francisco 94143, USA
Eur J Neurosci 10:3840-52. 1998..This suggests that the neurotoxicity of N-methyl-D-aspartate antagonists is due in part to the oxidative stress and may be amenable to therapeutic interventions... - Developmental expression of heme oxygenase-1 (HSP32) in rat brain: an immunocytochemical studyM Bergeron
Department of Neurology, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain Res Dev Brain Res 105:181-94. 1998..These results show that HO-1 protein expression is regulated in different cell types of specific regions of the rat brain during development... - Translational stroke research in the developing brainZinaida S Vexler
Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
Pediatr Neurol 34:459-63. 2006..These issues need to be carefully addressed in designing future clinical trials... - Hypoxia preconditioning in the brainRuiqiong Ran
Department of Neurology, M.I.N.D. Institute, University of California at Davis, Davis, CA 95817, USA
Dev Neurosci 27:87-92. 2005..This hypoxia preconditioning has potential clinical usefulness in protecting high-risk newborns or to provide protection prior to surgery... - Genomic profiles of stroke in bloodFrank R Sharp
Department of Neurology, University of California at Davis, Davis, CA, USA
Stroke 38:691-3. 2007..These studies show that gene expression changes in most patients by 2 to 3 hours after ischemic stroke, and in all patients studied by 24 hours... - The impact of excitotoxic blockade on the evolution of injury following combined mechanical and hypoxic insults in primary rat neuronal cultureTodd F Glass
Division of Pediatric Emergency Medicine, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Neurobiol Dis 17:378-84. 2004..We conclude that excitotoxic processes are more prominent after combined than isolated injuries in neurons and that increased cell death is mediated by both NMDA and AMPA receptor activation following combined injuries... - Glutamate receptor blockade attenuates glucose hypermetabolism in perihematomal brain after experimental intracerebral hemorrhage in ratTimothy D Ardizzone
Department of Neurology, University of Cincinnati College of Medicine, Ohio, USA
Stroke 35:2587-91. 2004..This may provide a possible target for the treatment of intracerebral hemorrhage... - Blood-brain barrier breakdown and repair by Src after thrombin-induced injuryDa Zhi Liu
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
Ann Neurol 67:526-33. 2010..Thrombin mediates the life-threatening cerebral edema that occurs after intracerebral hemorrhage. Therefore, we examined the mechanisms of thrombin-induced injury to the blood-brain barrier (BBB) and subsequent mechanisms of BBB repair... - Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brainChia Yi Kuan
Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Neurosci 24:10763-72. 2004..Manipulating the aberrant apoptosis-associated DNA synthesis that occurs with hypoxia-ischemia and perhaps neurodegenerative diseases could promote neuronal survival and neurogenesis... - Heat shock proteins and neuromuscular diseaseRobert N Nishimura
Department of Neurology, Veterans Affairs Greater Los Angeles Healthcare System, 16111 Plummer Street, Sepulveda, California 91343, USA
Muscle Nerve 32:693-709. 2005..The goal of this review is to summarize the evidence linking heat shock proteins with neuromuscular disease and to provide some insight into the roles or functions of these proteins in disease states... - Genomic abnormalities in patients with migraine and chronic migraine: preliminary blood gene expression suggests platelet abnormalitiesAndrew D Hershey
Children's Hospital Medical Center, Department of Neurology, Cincinnati, OH, USA
Headache 44:994-1004. 2004..Further genomic profiling studies will help define these relationships and provide further insights into headache pathogenesis... - Modeling both the mechanical and hypoxic features of traumatic brain injury in vitro in ratsTodd F Glass
Department of Pediatric Emergency Medicine Location C 2008, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Neurosci Lett 328:133-6. 2002..05) on both assays. Stretch+Hypoxia (4 or 6 h) resulted in significantly greater injury as compared with controls (P<0.05), and as compared with either isolated Stretch or Hypoxia (1, 2, 4 or 6 h) alone (P<0.05)... - Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischeYasuaki Kokubo
Department of Neurological Surgery, University of California at San Francisco, 94143, USA
J Neurosurg 96:1084-93. 2002..A greater reduction in striatal CPS further supports the conclusion that the striatum is more susceptible to temporary MCA occlusion than the cortex... - Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injuryEdward F Chang
Department of Neurosurgery, University of California, San Francisco, San Francisco, California 94143 0520, USA
J Neurosci 23:3689-96. 2003..These findings demonstrate that HO-2 expression protects neurons against TBI by reducing lipid peroxidation via the catabolism of free heme... - Gene expression changes in children with autismJeffrey P Gregg
Department of Pathology, University of California at Davis Medical Center, Sacramento, CA 95817, USA University of California at Davis, Davis, CA 95616, USA
Genomics 91:22-9. 2008..05). We conclude that the gene expression data support emerging evidence for abnormalities in peripheral blood leukocytes in autism that could represent a genetic and/or environmental predisposition to the disorder... - A novel 165-kDa Golgin protein induced by brain ischemia and phosphorylated by Akt protects against apoptosisRuiqiong Ran
M I N D Institute and Department of Neurology, University of California at Davis Medical Center, University of California at Davis, Sacramento, CA 95817, USA
Mol Cell Neurosci 36:392-407. 2007..These data show that Akt phosphorylation of IIGP165 protects against apoptotic cell death, and add to evidence that the Golgi apparatus also plays a role in regulating apoptosis... - Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndromeXinli Du
MIND Institute, University of California at Davis, 2805 50th Street, Sacramento, CA 95817, USA
Genomics 87:693-703. 2006..These specific gene expression, cell-type-related profiles will need to be confirmed in larger data sets and could be used to study these and many other neurological diseases... - Methods to detect hypoxia-induced ischemic tolerance in the brainMyriam Bernaudin
UMR-CNRS 6551, Cyceron, BD Henri-Becquerel, France
Methods Enzymol 381:399-416. 2004 - Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray studyYang Tang
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 26:1089-102. 2006..These data provide insights into the inflammatory responses after stroke in humans, and should be helpful in diagnosis, understanding etiology and pathogenesis, and guiding acute treatment and development of new treatments for stroke... - Molecular identification of the ischemic penumbraPhilip R Weinstein
Department of Neurological Surgery, San Francisco Veterans Affairs Medical Center and University of California, San Francisco, 505 Parnassus Avenue, M 779, San Francisco, CA 94143, USA
Stroke 35:2666-70. 2004..Future studies may define endogenous cytotoxic and cytoprotective molecular penumbras that can be exploited to improve outcome after temporary focal ischemia... - Brain genomics of intracerebral hemorrhageAigang Lu
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 26:230-52. 2006..These genomic responses to ICH potentially provide new therapeutic targets for treatment... - Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitisPatricia Murphy
Department of Anesthesiology, University of Illinois, 1819 West Polk Street, Chicago, IL 60612, USA
J Neurosci Res 67:461-70. 2002..These results indicate that ansamycins can exert potent anti-inflammatory effects on brain glial cells which may provide therapeutic benefit in neuroinflammatory diseases... - Blood expression profiles for tuberous sclerosis complex 2, neurofibromatosis type 1, and Down's syndromeYang Tang
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, CA, USA
Ann Neurol 56:808-14. 2004..These findings suggest that blood gene expression profiling on a broader basis might be useful for genetic disease screening/diagnosis and might help elucidate mechanisms and pathways that lead to genotype-phenotype differences... - In Vivo Delivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal ApoptosisGuodong Cao
Department of Neurology and Pittsburgh Institute for Neurodegenerative Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 22:5423-31. 2002.... - Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patientsWynn L Walker
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California, USA
BMC Genomics 9:494. 2008..Existing methods can correct for batch effects only when samples from all biological groups are represented in every batch... - Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic strokeHuichun Xu
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 28:1320-8. 2008..These results have wide ranging implications for similar disorders... - Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in ratsAnthony Mancuso
Department of Radiology 6069, University of Pennsylvania, Molecular Imaging Laboratory, B6 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6069, USA
Brain Res 961:121-30. 2003..The results suggest that cox-2 mRNA expression during acute MCA occlusion is caused by either or both spreading depression and transient ischemic depolarization... - Hemin induces heme oxygenase-1 in spinal cord vasculature and attenuates barrier disruption and neutrophil infiltration in the injured murine spinal cordToshihiro Yamauchi
Department of Neurological Surgery, University of California at San Francisco, San Francisco, California, USA
J Neurotrauma 21:1017-30. 2004.... - SRC kinase inhibition improves acute outcomes after experimental intracerebral hemorrhageTimothy D Ardizzone
Medical Investigation of Neurodevelopmental Diseases Institute and Department of Neurology, University of California at Davis Medical Center, Sacramento, CA 95817, USA
Stroke 38:1621-5. 2007..In this study, we begin to test the hypothesis that intracerebral hemorrhage activates Src kinases that phosphorylate other molecules to produce cell injury and behavioral deficits after intracerebral hemorrhage (ICH)... - Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitisYoung S Kim
Division of Infectious Diseases, Drexel University College of Medicine, Philadelphia, PA, USA
Brain Res Mol Brain Res 128:95-102. 2004..Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression... - The future of genomic profiling of neurological diseases using bloodFrank R Sharp
Department of Neurology and Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, CA 95817, USA
Arch Neurol 63:1529-36. 2006..Although all of these studies are still preliminary basic scientific endeavors, they suggest that this approach will have clinical applications to neurological diseases in humans... - Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemiaYasuaki Kokubo
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
Neurosurgery 53:186-90; discussion 190-1. 2003.... - Cloning and expression of short interspersed elements B1 and B2 in ischemic brainJuha-Pekka Kalkkila
Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, Finn-Medi 3, , 33014 Tampereen yliopisto, Finland
Eur J Neurosci 19:1199-206. 2004..Together with the previous data demonstrating the inducibility of the SINE transcripts using in vitro stress models, the present study shows that SINE transcripts are stress-inducible factors in the central nervous system... - Genomics of brain and blood: progress and pitfallsFrank R Sharp
Department of Neurology and the M I N D Institute, University of California at Davis, Sacramento, California 95817, USA
Epilepsia 47:1603-7. 2006..Gene expression profiles in brain and blood of animals and humans can be useful for diagnosis, prognosis, and treatment of epilepsy. This article reviews recent progress and prospects for the future...