Research Topics
| Natalie J SerkovaSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Detail Information
Publications
Early detection of graft failure using the blood metabolic profile of a liver recipientNatalie J Serkova
Department of Anesthesiology and Radiology, Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Transplantation 83:517-21. 2007..This article reports the potential usefulness of quantitative H-NMR based metabolomics to diagnose early graft dysfunction in liver transplantation...- NMR-based metabolomics: translational application and treatment of cancerNatalie J Serkova
University of Colorado Health Sciences Center, Department of Anesthesiology and Radiology, Denver, CO 80262, USA
Curr Opin Mol Ther 9:572-85. 2007..In addition, studies on metabolic responses to novel targeted drugs, including tyrosine kinase inhibitors and metabolic modulators, are evaluated... - Biochemical mechanisms of cyclosporine neurotoxicityNatalie J Serkova
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Mol Interv 4:97-107. 2004..The marked and unparallel potential of magnetic resonance spectroscopy (MRS) as a novel quantitative approach to evaluate metabolic drug toxicity is described... - Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the bloodNatalie J Serkova
Department of Anesthesiology, Clinical Research and Development, MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver 80262, USA
Ther Drug Monit 27:733-7. 2005..Together with pharmacokinetic studies, quantitative NMR-based metabonomics represents a powerful tool for pharmacokinetic-pharmacodynamic-toxicodynamic evaluation in drug research... - Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomicsNatalie J Serkova
University of Colorado Health Sciences Center, Biomedical MRI MRS Cancer Center Core, Department of Anesthesiology, Denver, CO 80262, USA
Expert Rev Mol Diagn 6:717-31. 2006.... - Activated Akt1 accelerates MMTV-c-ErbB2 mammary tumourigenesis in mice without activation of ErbB3Christian D Young
Department of Pathology, University of Colorado Denver, Research Complex I, South Tower, Mail Stop 8104, 12801 East 17thAvenue, Aurora, CO 80045, USA
Breast Cancer Res 10:R70. 2008..ErbB2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in 20% to 30% of human breast cancer cases and forms oncogenic signalling complexes when dimerised to ErbB3 or other EGFR family members... - The metabolites citrate, myo-inositol, and spermine are potential age-independent markers of prostate cancer in human expressed prostatic secretionsNatalie J Serkova
Department of Anesthesiology and Radiology, Biomedical MRI MRS, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Prostate 68:620-8. 2008..In this study, proton nuclear magnetic resonance spectroscopy ((1)H-NMRS) is used to assess potential metabolic markers of prostate cancer (PCa) in human expressed prostatic secretions (EPS)... - Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cellsDouglas J Kominsky
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
Clin Cancer Res 15:3442-50. 2009..In summary, elevated glucose uptake and nonoxidative glycolytic metabolic phenotype can be used as sensitive markers for early detection of imatinib resistance in BCR-ABL-positive cells... - Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolismJelena Klawitter
Clinical Research and Development, Department of Anesthesiology, and University of Colorado Cancer Center, University of Colorado Denver, Aurora, Colorado 80045, USA
Chem Res Toxicol 23:608-19. 2010..However, the three models showed different metabolic responses when challenged with the study drugs. In contrast to SRL, RAD enhances ROS formation in C6 glioma cells but has only minor effects on normal rat brain tissue... - Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell cultureJelena Klawitter
Clinical Research and Development, Department of Anesthesiology, University of Colorado Denver, Aurora, CO 80045 7503, USA
Biomed Chromatogr 23:1251-8. 2009..This semi-automated method is simple with only one manual step, uses a commercially available internal standard, and has proven to be robust in larger studies... - Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cellsJelena Klawitter
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Br J Pharmacol 158:588-600. 2009..Early detection of resistance development is crucial for imatinib-based treatment in chronic myeloid leukaemia (CML) patients. We aimed to distinguish metabolic markers of cell resistance to imatinib... - Human placental metabolic adaptation to chronic hypoxia, high altitude: hypoxic preconditioningMartha C Tissot van Patot
Department of Anesthesiology, University of Colorado Denver Health Sciences Center, Aurora, Colorado, USA
Am J Physiol Regul Integr Comp Physiol 298:R166-72. 2010..We postulate that hypoxic preconditioning might occur in placentas that develop at high altitude... - Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in miceNatalie J Serkova
Department of Anesthesiology, University of Colorado Denver School of Medicine, 1775 N Aurora Ct, M20 3103, Aurora, CO 80045, USA
Radiology 255:517-26. 2010.... - The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnessesNatalie J Serkova
Department of Anesthesiology, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA
Am J Respir Crit Care Med 184:647-55. 2011..The purpose of this review is to begin to familiarize clinicians with the field of metabolomics and its application for biomarker discovery in critical illnesses such as sepsis... - Clinical applications of metabolomics in oncology: a reviewJennifer L Spratlin
Department of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA
Clin Cancer Res 15:431-40. 2009..Here, we review the current and potential applications of metabolomics, focusing on its use as a biomarker for cancer diagnosis, prognosis, and therapeutic evaluation... - Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 mMartha C Tissot van Patot
Department of Anesthesiology, University of Colorado at Denver School of Medicine, Aurora, CO 80045, USA
Free Radic Biol Med 46:1551-7. 2009..001), as were urinary 15-F(2t)-isoprostanes (p=0.037). HIF-1 DNA binding and HIF-1alpha were elevated in vivo in leukocytes of healthy human subjects exposed to 12% oxygen, in association with plasma and urinary markers of hypoxic stress... - Metabolic profiling of livers and blood from obese Zucker ratsNatalie J Serkova
Biomedical MRI/NMR, Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, CO, USA
J Hepatol 44:956-62. 2006..CONCLUSIONS: In conclusion, NMR analysis on blood and liver tissue from obese Zucker rats reveals specific metabolic abnormalities in mitochondrial function and methionine metabolism, which result in a decreased hepatic energy state... - Oncologic imaging end-points for the assessment of therapy responseNatalie J Serkova
Department of Anesthesiology, University of Colorado Cancer Center, Aurora, CO 80045, USA
Recent Pat Anticancer Drug Discov 4:36-53. 2009..The aim of this article is to represent the available patents on imaging response assessment in oncology... - Use of the 1-mm micro-probe for metabolic analysis on small volume biological samplesNatalie J Serkova
Biomedical MRI MRS Cancer Center Core, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Cell Mol Med 13:1933-41. 2009..In this study, the use of the Bruker 1-mm micro-probe provides a convenient way to measure and quantify endogenous metabolic profiles of samples with a very low volume/weight/cell count... - Translational imaging endpoints to predict treatment response to novel targeted anticancer agentsNatalie J Serkova
Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Center, Aurora, CO 80045, USA
Drug Resist Updat 14:224-35. 2011..Finally, novel molecular imaging techniques of protein and gene expression have been developed in animal models followed by a successful human application for gene therapy-based protocols... - Magnetic resonance spectroscopy of living tissuesNatalie J Serkova
Department of Anesthesiology and Radiology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
Methods Mol Biol 520:315-27. 2009..This review focuses on applications and protocol development for in vivo (1)H- and (31)P-MRS on small animal models as well as on larger animals in cancer research, diagnosis, and treatment... - Quantitative analysis of liver metabolites in three stages of the circannual hibernation cycle in 13-lined ground squirrels by NMRNatalie J Serkova
Department of Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado 80238, USA
Physiol Genomics 31:15-24. 2007..The torpor-arousal switch is characterized by the accumulation of metabolites of nitrogen (glutamine) and phospholipid (betaine) catabolism in LT with the capacity to act as protective osmolytes... - Metabolomics of cancerNatalie J Serkova
Department of Anesthesiology and Radiology, University of Colorado at Denver and Health Sciences Center, Aurora, CO, USA
Methods Mol Biol 520:273-95. 2009.... - Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expressionZhi Yong Peng
Department of Anesthesiology, University of Colorado Health Sciences Center, Denver, 80262, USA
JPEN J Parenter Enteral Nutr 30:373-8; discussion 379. 2006..Thus, GLN's beneficial effect on cellular metabolic dysfunction and cell survival appears to be dependent on HSF-1 expression... - Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer modelsM Pia Morelli
Division of Medical Oncology, Department of Anesthesiology and Radiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA
Clin Cancer Res 18:1051-62. 2012..In this study, we focused on the preclinical assessment of a rationally based combination against KRAS-mutated CRC by testing the combination of the MEK inhibitor, selumetinib, and vorinostat, a histone deacetylase (HDAC) inhibitor... - Metabolic markers of hypoxia: systems biology application in biomedicineNatalie J Serkova
Associate Professor, Cancer Center MRI MRS Core, Department of Anesthesiology and Radiology, University of Colorado Health Sciences Center, Denver, CO
Toxicol Mech Methods 18:81-95. 2008..Drugs that promote and antagonize hypoxia are discussed and important points to consider during tissue collection in hypoxia 'omic studies are then reviewed... - Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injuryNatalie J Serkova
Department of Anesthesiology, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
Am J Physiol Lung Cell Mol Physiol 295:L152-61. 2008..Integration of these clinically available techniques into experimental models of lung injury could improve the translation of basic science knowledge and information to the clinic... - Toxicity of MRI and CT contrast agentsKendra M Hasebroock
University of Colorado, Anschutz Medical Center, Cancer Center Animal MRI PET CT Core, Department of Anesthesiology and Radiology, Aurora, CO 80045, USA
Expert Opin Drug Metab Toxicol 5:403-16. 2009..The nonionic linear Gd-chelates are associated with the highest risk of NSF. This review summarizes the incidence, symptoms, safety profile of various CT and MRI contrast agents based on their physiochemical properties... - Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolismKristine Glunde
The Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, 212 Traylor Building Baltimore, MD 21205, USA
Pharmacogenomics 7:1109-23. 2006.... - Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cellsSven Gottschalk
Department of Biology/Chemistry, University of Bremen, Bremen, Germany
Clin Cancer Res 10:6661-8. 2004.... - Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusionClaus U Niemann
Anesthesia and Perioperative Care, Division of Liver Transplantation, University of California San Francisco, San Francisco, CA 94143 0648, USA
Surgery 140:404-12. 2006.... - Biochemical mechanisms of nephrotoxicity: application for metabolomicsClaus U Niemann
University of California San Francisco, Division of Transplantation, Department of Anesthesia and Perioperative Care, San Francisco, California, USA
Expert Opin Drug Metab Toxicol 3:527-44. 2007..Each of these pathways can be monitored by specific surrogate markers in urine and blood using modern metabolomics technologies... - Ischemia-reperfusion injury is more severe in older versus young rat liversYeonho Park
Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea
J Surg Res 137:96-102. 2007..The objective of this study was to investigate whether age influences the degree of warm ischemia-reperfusion injury in rat livers...
Research Grants
- In-Vivo Spectroscopy/Imaging System PharmaScan 47/16Natalie Serkova; Fiscal Year: 2005..This is a much needed instrumentation and will provide an important regional facility for in vivo research in Colorado and the surrounding Rocky Mountain region. ..
- Metabolic Signature of Imatinib ResistanceNatalie Serkova; Fiscal Year: 2006..abstract_text> ..