Research Topics
Genomes and Genes | Gail M SeigelSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Evidence of apoptotic cell death in keratoconusRoger M Kaldawy
Department of Ophthalmology, Trygve Gundersen Eye Center, Boston University School of Medicine, 720 Harrison Ave, 10th Floor, Boston, MA, USA
Cornea 21:206-9. 2002..To determine the potential role of apoptosis in the noninflammatory degeneration characteristic of keratoconus...- Neuronal gene expression and function in the growth-stimulated R28 retinal precursor cell lineGail M Seigel
Department of Ophthalmology, University at Buffalo, SUNY, NY 14214, USA
Curr Eye Res 28:257-69. 2004..In this study, we tested the hypothesis that the proliferative R28 retinal cell line contains subpopulations of cells that express neuronal mRNAs and proteins characteristic of CNS neurons... - High-throughput microtiter assay for Hoechst 33342 dye uptakeGail M Seigel
Ross Eye Institute, Department of Ophthalmology, University at Buffalo, 14214, NY, USA
Cytotechnology 45:155-60. 2004..Useful applications for this assay will be the rapid screening of clonal stem cell populations and tumor cells for Hoechst dye uptake... - Retinal pathology and function in a Cln3 knockout mouse model of juvenile Neuronal Ceroid Lipofuscinosis (batten disease)Gail M Seigel
Department of Ophthalmology, University of Rochester School of Medicine, New York, USA
Mol Cell Neurosci 19:515-27. 2002.... - Cancer stem cell characteristics in retinoblastomaGail M Seigel
Ross Eye Institute, Department of Ophthalmology, University of Buffalo, Buffalo, NY 14214, USA
Mol Vis 11:729-37. 2005..In this study, we tested the hypothesis that retinoblastomas contain subpopulations of cells that exhibit cancer stem cell properties... - Human corneal stem cells display functional neuronal propertiesGail M Seigel
Department of Ophthalmology, University at Buffalo, Buffalo, NY 14214, USA
Mol Vis 9:159-63. 2003..In this study, we tested the hypothesis that human corneal stem cells, derived from neural ectoderm, can exhibit functional neuronal properties... - Differentiation potential of human retinoblastoma cellsGail M Seigel
Center for Hearing and Deafness, University at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
Curr Pharm Biotechnol 12:213-6. 2011..Further study of differentiation programs may lead to new approaches in the design of strategies to combat the initiation and progression of RB in vivo... - Progression of early postnatal retinal pathology in a mouse model of neuronal ceroid lipofuscinosisG M Seigel
Department of Ophthalmology, Ross Eye Institute, Physiology and Biophysics, University at Buffalo SUNY, Buffalo, NY 14214, USA
Eye (Lond) 19:1306-12. 2005.... - Human embryonic and neuronal stem cell markers in retinoblastomaGail M Seigel
Ross Eye Institute, University of Buffalo, Buffalo, NY 14214, USA
Mol Vis 13:823-32. 2007..The early onset of RB, coupled with our previous findings of cancer stem cell characteristics in RB, led us to hypothesize that subpopulations of RB tumors harbor markers and behaviors characteristic of embryonic and neuronal origin... - Toxicity of indocyanine green (ICG) in combination with light on retinal pigment epithelial cells and neurosensory retinal cellsRaja Narayanan
Department of Ophthalmology, University of California-Irvine, 118 Med Surge I, Irvine, CA 92697-4375, USA
Curr Eye Res 30:471-8. 2005..ICG needs to be used with caution as it decreases the mitochondrial dehydrogenase activity and increases the DNA synthesis in retinal cells, markers for cell toxicity and dysfunction... - Toxicity of triamcinolone acetonide on retinal neurosensory and pigment epithelial cellsRaja Narayanan
Department of Ophthalmology, School of Medicine, University of California, Irvine, California 92697, USA
Invest Ophthalmol Vis Sci 47:722-8. 2006..The results of this in vitro study cannot be directly extrapolated to clinical practice, but, based on these data, further studies may be warranted... - Effects of benzo(e)pyrene on the retinal neurosensory cells and human microvascular endothelial cells in vitroA Jayaprakash Patil
Department of Ophthalmology, Gavin S Herbert Eye Institute, University of California, Irvine, California, USA
Curr Eye Res 34:672-82. 2009..To study the effects of benzo(e)pyrene (B(e)P), a toxic component of cigarette smoke, on retinal neurosensory (R28) cells and human microvascular endothelial cells (HMVEC)... - Evaluation of in vitro effects of bevacizumab (Avastin) on retinal pigment epithelial, neurosensory retinal, and microvascular endothelial cellsSaurabh Luthra
Department of Ophthalmology, University of California, Irvine, 92697, USA
Retina 26:512-8. 2006..This report is consistent with the recent report of lack of toxicity of intravitreal bevacizumab in rabbits as well as the lack of apparent toxicity in clinical use... - Retinal precursor cells express functional ionotropic glutamate and GABA receptorsWei Sun
Department of Ophthalmology, Physiology and Biophysics, SUNY University at Buffalo, Buffalo, NY 14214, USA
Neuroreport 13:2421-4. 2002..These results indicate that R28 progenitor cells express glutamatergic and GABAergic receptors capable of influencing their fate and function when grafted into retina or elsewhere in the nervous system... - Systemic IGF-I treatment inhibits cell death in diabetic rat retinaGail M Seigel
Department of Ophthalmology, University at Buffalo, Buffalo, NY 14214, USA
J Diabetes Complications 20:196-204. 2006..The eye is a special sensory organ, and these data show that cell loss in the nervous system, even in uncontrolled diabetes, can be prevented by IGF-I administration... - The effects of commercially available preservative-free FDA-approved triamcinolone (Triesence®) on retinal cells in cultureLeandro Cabral Zacharias
Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, CA 92697, USA
J Ocul Pharmacol Ther 27:143-50. 2011..S. Food and Drug Administration (FDA) for intraocular use, on human retina pigment epithelial (ARPE-19) and rat neurosensory (R28) cells in culture... - Cisplatin ototoxicity in rat cochlear organotypic culturesDalian Ding
Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
Hear Res 282:196-203. 2011.... - Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cellsXin Li
Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260 1200, USA
Biochem Pharmacol 81:783-92. 2011..Our data suggest that miR-519c and -328 have greater impact on ABCG2 expression than miR-520h in MCF-7 human breast cancer cells, and the presence of proximal miR-519c MRE explains the action of miR-519c on shortened ABCG2 3'UTR... - Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cellsRaja Narayanan
Department of Ophthalmology, University of California, Irvine, California 92697-4375, USA
Invest Ophthalmol Vis Sci 46:304-9. 2005..Clinical studies must be conducted to determine the safety and efficacy of staining of the inner limiting membrane with trypan blue... - Des(1-3)IGF-1 treatment normalizes type 1 IGF receptor and phospho-Akt (Thr 308) immunoreactivity in predegenerative retina of diabetic ratsA Kummer
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Int J Exp Diabesity Res 4:45-57. 2003..These data show that an IGF-1 analog can prevent early retinal biochemical abnormalities implicated in the progression of diabetic retinopathy, despite ongoing hyperglycemia... - Multiple RIBEYE-RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbonsVenkat Giri Magupalli
Department of Neuroanatomy, Institute for Anatomy and Cell Biology, Saarland University, Medical School Homburg Saar, 66421 Homburg Saar, Germany
J Neurosci 28:7954-67. 2008..Based on the identified multiple RIBEYE-RIBEYE interactions, we provide a molecular mechanism for the dynamic assembly of synaptic ribbons from individual RIBEYE subunits... - Latanoprost rescues retinal neuro-glial cells from apoptosis by inhibiting caspase-3, which is mediated by p44/p42 mitogen-activated protein kinaseYoriko Nakanishi
Division of Ophthalmology, Department of Organs Therapeutics, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
Exp Eye Res 83:1108-17. 2006..05), but not of Akt. Taken together, the present findings suggest that latanoprost rescues retinal neurons and/or glial cells from apoptosis, which is probably mediated by p44/p42 MAPK through caspase-3 inhibition... - Oxysterol-induced toxicity in R28 and ARPE-19 cellsJohn M Ong
Molecular Eye Research Laboratory, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Neurochem Res 28:883-91. 2003..These in vitro findings provide evidence that cholesterol oxides can directly damage cultured retinal and RPE cells. The oxysterol-induced oxidative stress in these cells may be a factor in the pathology of retinal degenerative diseases... - Evolutionarily conserved ELOVL4 gene expression in the vertebrate retinaPamela S Lagali
Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
Invest Ophthalmol Vis Sci 44:2841-50. 2003..In this study, the extent of evolutionary conservation and the existence and localization of retinal expression of this gene was investigated across a wide variety of species... - Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpressionIrina G Obrosova
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
Int J Mol Med 14:55-64. 2004..The results justify studies of PARP inhibitors in models of retinopathy of prematurity and diabetic retinopathy... - RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapsesKannan Alpadi
Department of Neuroanatomy, Institute for Anatomy and Cell Biology, Saarland University, Medical School Homburg Saar, 66421 Homburg Saar, Germany
J Biol Chem 283:26461-7. 2008..We show that Munc119 can be recruited to synaptic ribbons via its interaction with RIBEYE. Our data suggest that the RIBEYE-Munc119 interaction is essential for synaptic transmission at the photoreceptor ribbon synapse... - An investigation of the neuroprotective effects of tetracycline derivatives in experimental models of retinal cell deathDarryl C Baptiste
Retina and Optic Nerve Research Laboratory, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H7
Mol Pharmacol 66:1113-22. 2004..In addition, the survival-promoting actions of minocycline may arise via actions on both neuronal and non-neuronal cell targets... - cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cellsAzusa Nagai Kusuhara
Department of Organs Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Exp Eye Res 84:152-62. 2007..These results indicate that CREB at least in part mediates the cGMP/PKG-dependent anti-apoptotic signal induced by NO in R28 cells...