Research Topics
Genomes and GenesSpecies | Navindra P SeeramSummaryAffiliation: University of Rhode Island Country: USA Publications
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Publications
In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juiceNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Nutr Biochem 16:360-7. 2005..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...- Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and diseaseNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 56:627-9. 2008.... - Berry fruits for cancer prevention: current status and future prospectsNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 56:630-5. 2008..Potential mechanisms of anticancer action and bioavailability of berry phenolics, as well as gaps in knowledge and recommendations for future berry research, are also briefly discussed... - Recent trends and advances in berry health benefits researchNavindra P Seeram
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Agric Food Chem 58:3869-70. 2010..Together, these papers provide valuable insight into recent research trends and advances made into evaluating the various health benefits that may result from the consumption of berries and their derived products... - Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjectsNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA
J Med Food 11:390-4. 2008..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl... - Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitroNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Agric Food Chem 54:9329-39. 2006..The data provided by the current study and from other laboratories warrants further investigation into the chemopreventive and chemotherapeutic effects of berries using in vivo models... - Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivoMaryam R Sartippour
Center for Human Nutrition, Los Angeles, CA 90095 1742, USA
Int J Oncol 32:475-80. 2008..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement... - Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axisSatomi Koyama
Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, University of California, Los Angeles, USA
Growth Horm IGF Res 20:55-62. 2010..These studies revealed novel interactions between the IGF system and pomegranate-induced apoptosis... - Strawberry consumption is associated with increased antioxidant capacity in serumSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Med Food 13:116-22. 2010..In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population... - Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate glandNavindra P Seeram
Center for Human Nutrition, Greater Los Angeles VA Medical Center, Los Angeles, California, USA
J Agric Food Chem 55:7732-7. 2007..This warrants future human tissue bioavailability studies and further clinical studies in men with CaP... - Chinese red yeast rice inhibition of prostate tumor growth in SCID miceMee Young Hong
Center for Human Nutrition, 900 Veteran Ave Room 1 2 217, University of California at Los Angeles, Los Angeles, CA 90095, USA
Cancer Prev Res (Phila) 4:608-15. 2011..05). Clinical studies of RYR for prostate cancer prevention in the increasing population of men undergoing active surveillance should be considered... - Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United StatesNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 56:1415-22. 2008..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine... - Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptorMee Young Hong
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
J Nutr Biochem 19:848-55. 2008.... - Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpressionMee Young Hong
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Med Food 11:657-66. 2008..In vivo studies are needed to further establish the potential advantages of RYR over LV in prostate cancer chemoprevention and in the prevention of the emergence of androgen independence... - Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanismMatthew B Rettig
Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
Mol Cancer Ther 7:2662-71. 2008..Our study represents the first description of PE as a promising dietary agent for the prevention of the emergence of androgen independence that is driven in part by heightened NF-kappaB activity... - Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative propertiesYanjun Zhang
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 56:670-5. 2008..This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health... - Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist sizeDavid Heber
Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
J Agric Food Chem 55:10050-4. 2007..These studies demonstrate the safety of a pomegranate ellagitannin-enriched polyphenol dietary supplement in humans and provide evidence of antioxidant activity in humans... - Eugenia jambolana Lam. berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cellsLiya Li
Department of Biomedical and Pharmaceutical Sciences, Bioactive Botanical Research Laboratory, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, USA
J Agric Food Chem 57:826-31. 2009..05) and the MDA-MB-231 (p <or= 0.01) breast cancer cells, but not toward the normal MCF-10A breast cells. These studies suggest that JFE may have potential beneficial effects against breast cancer... - Effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin A, on Wnt signalingMeenakshi Sharma
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Agric Food Chem 58:3965-9. 2010..0 microg/mL; 63 microM), and UA (IC(50) = 9.0 microg/mL; 39 microM) inhibited Wnt signaling, suggesting that ET-rich foods have potential against colon carcinogenesis and that urolithins are relevant bioactive constituents in the colon... - Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste formSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Int J Food Sci Nutr 62:219-25. 2011..However, there was no significant correlation between the AC and the concentration of chemical marker compounds. In summary, processed herbs contribute significant amounts of AC to the diet... - Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hoursNavindra P Seeram
Departments of Biomathematics and Human Genetics, University of California, Los Angeles, CA, USA
J Nutr 136:2481-5. 2006..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established... - Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cellsMee Young Hong
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Nutr Biochem 19:448-58. 2008..These results suggest that the matrix effects of RYR beyond MK alone may be active in inhibiting colon cancer growth. RYR with or without MK may be a botanical approach to colon cancer chemoprevention worthy of further investigation... - Identification and bioactivities of resveratrol oligomers and flavonoids from Carex folliculata seedsLiya Li
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA
J Agric Food Chem 57:7282-7. 2009..folliculata, this forage may provide a source of bioactive compounds useful for nutraceutical purposes. Also, this is the first reported phytochemical investigation of C. folliculata... - Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacitiesNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 54:7036-40. 2006..The destruction of bioactive phenolics in pistachio skins may negatively impact the potential health benefits arising from pistachio consumption... - Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacityNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 54:1599-603. 2006..Reliable labeling information and standardized manufacturing practices, based on both chemical standardization and biological assays, are recommended for the quality control of botanical dietary supplements... - Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2Naoko Kobayashi
Department of Urology, Division of Clinical Nutrition and Hematology-Oncology, University of California, Los Angeles School of Medicine, 90095-1738, USA
Clin Cancer Res 12:4662-70. 2006.... - Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrestAntonio Gonzalez-Sarrias
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
J Agric Food Chem 59:8632-8. 2011..Furthermore, Carex species should be investigated for their nutraceutical potential given that they produce biologically active stilbenoids such as ?-viniferin... - Cranberry does not affect prothrombin time in male subjects on warfarinZhaoping Li
Division of Clinical Nutrition, UCLA Center for Human Nutrition, Geffen School of Medicine at UCLA, 900 Veteran Ave, Room 12 217, Los Angeles, CA 90095 1742, USA
J Am Diet Assoc 106:2057-61. 2006..When counseling patients on dietary changes necessary during warfarin treatment, it does not seem necessary to eliminate daily cranberry juice consumption at amounts of 250 mL, but the INR should be followed up closely... - Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compoundsLiya Li
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
J Agric Food Chem 58:11673-9. 2010..Also, this is the first report of 16 of these 23 phenolics, that is, compounds 1, 2, 4-14, 18, 20, and 22, in maple syrup... - Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cellsLynn S Adams
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 54:980-5. 2006..Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells... - Phenolic Glycosides from Sugar Maple (Acer saccharum) BarkTao Yuan
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, United States
J Nat Prod 74:2472-6. 2011..All compounds isolated were evaluated for cytotoxicity effects against human colon tumorigenic (HCT-116 and Caco-2) and nontumorigenic (CCD-18Co) cell lines... - Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell linesNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 52:2512-7. 2004.... - Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicalsLiya Li
Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI 02881, USA
J Agric Food Chem 59:7708-16. 2011..The current study advances scientific knowledge of maple syrup constituents and suggests that these diverse phytochemicals may impart potential health benefits to this natural sweetener... - Maplexins, new ?-glucosidase inhibitors from red maple (Acer rubrum) stemsChunpeng Wan
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China
Bioorg Med Chem Lett 22:597-600. 2012..Structure-activity related studies suggested that both number and position of galloyls attached to 1,5-anhydro-d-glucitol were important for ?-glucosidase inhibition... - Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juiceNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Clin Chim Acta 348:63-8. 2004..We conducted in vivo studies whereby a human subject consumed pomegranate juice (PJ) (180 ml) containing EA (25 mg) and ETs (318 mg, as punicalagins, the major fruit ellagitannin)... - The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cellsKun Gao
Center for Human Nutrition, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
J Nutr Biochem 17:89-95. 2006.... - Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteersZhaoping Li
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA90095 1742, USA
J Altern Complement Med 11:1031-8. 2005..The current study compared the pharmacokinetics of CRYR with lovastatin at the same bioeffective dose for lowering cholesterol... - Structure of anthocyanins from Eugenia jambolana fruitLiya Li
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Science College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA
Nat Prod Commun 4:217-9. 2009..This is the first report to use a combination of spectrometric and spectroscopic methods to identify unequivocally the structures of E. jambolana fruit anthocyanins... - Rabdosia rubescens inhibits breast cancer growth and angiogenesisMaryam R Sartippour
Department of Surgery, University of California, Los Angeles, CA, USA
Int J Oncol 26:121-7. 2005..We conclude that Rabdosia rubescens may potentially be used to treat or prevent breast cancer, and that the extract from this herbal source deserves further studies... - Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumptionSusanne M Henning
Department of Pathology, VA West Los Angeles, CA 90073, USA
J Nutr 136:1839-43. 2006..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer... - Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injuryDavid J Loren
Division of Neonatology, University of Washington, Seattle, WA 98195, USA
Pediatr Res 57:858-64. 2005..These results demonstrate that maternal dietary supplementation with pomegranate juice is neuroprotective for the neonatal brain... - Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compoundsYanjun Zhang
Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, Michigan 48824, USA
J Agric Food Chem 52:228-33. 2004..This is the first report of beta-sitosterol-6'-linolenoyl-3-O-beta-D-glucopyranoside (1) from grape skin and insulin secretion activities of compounds 4 and 5... - Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studiesBharat B Aggarwal
Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
Anticancer Res 24:2783-840. 2004..Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer... - Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechinsNavindra P Seeram
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, Michigan 48824, USA
J Agric Food Chem 50:5308-12. 2002.... - Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cellsClaudia I Muller
Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Leuk Res 30:841-8. 2006..These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies... - Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activityKun Gao
State Key Laboratory of Biocontrol, Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Sciences, Sun Yatsen (Zhongshan) University, Guangzhou, China
J Nutr 136:52-7. 2006..In summary, fermentation by intestinal microbes of GT, BT, C+R, and S flavonoids resulted in the conversion to the same major phenolic acids... - Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreanaBolleddula Jayaprakasam
Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, MI 48824, USA
Cancer Lett 189:11-6. 2003..Vioxx showed specific COX-2 inhibition by 71%. Also, cucurbitacins 1 and 4 inhibited lipid peroxidation by 59 and 23%, respectively, at 100 microg/ml... - Characterization, quantification, and bioactivities of anthocyanins in Cornus speciesNavindra P Seeram
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety, Michigan State University, East Lansing, MI 48824, USA
J Agric Food Chem 50:2519-23. 2002..At 10 microM concentration, commercial synthetic antioxidants tert-butylhydroquinone, butylated hydroxytoluene, butylated hydroxyanisole, and vitamin E gave 83.2, 79.7, 82.1, and 10.2% of antioxidant activity, respectively... - Acylphloroglucinol derivatives from Hypericum prolificumGeneive E Henry
Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, Pennsylvania 17870, USA
J Nat Prod 69:1645-8. 2006..Prolificin A showed growth inhibition of all cell lines with IC50 values ranging from 23 to 36 microM. Prolifenones A and B were inactive at the concentrations tested... - Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindacGerd Bobe
Department of Food Science and Human Nutrition, Bioactive Natural Products and Phytoceuticals, Department of Horticulture, and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 44824, USA
J Agric Food Chem 54:9322-8. 2006..These results suggest that a dietary combination of tart cherry anthocyanins and sulindac is more protective against colon cancer than sulindac alone... - Tart cherry anthocyanins inhibit tumor development in Apc(Min) mice and reduce proliferation of human colon cancer cellsSoo-Young Kang
Department of Food Science and Human Nutrition, Michigan State University, 139 G M Trout Building, East Lansing, MI 48824-1224, USA
Cancer Lett 194:13-9. 2003..These results suggest that tart cherry anthocyanins and cyanidin may reduce the risk of colon cancer... - Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechinsNavindra P Seeram
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Nutr Cancer 46:101-6. 2003..Overall, only the galloyl derivatives of catechins 11-16 inhibited the proliferation of the cancer cell lines... - Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leavesBolleddula Jayaprakasam
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Life Sci 74:125-32. 2003..9 +/- 2.9 and 17.3 +/- 3.9 microg/ml. However, Physagulin D type withanolides showed either weak or no activity at 30 microg/mL. Therefore, incorporation of withanolides in the diet may prevent or decrease the growth of tumors in human... - Inhibition of human tumor cell proliferation by novel anthraquinones from dayliliesRobert H Cichewicz
Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
Life Sci 74:1791-9. 2004..In contrast, vitamins C and E potentiated the cytotoxic effects of the anthraquinones against the colon cancer cells. None of the anthraquinones inhibited the activity of topoisomerase... - Biochemical composition and immunological comparison of select pecan [Carya illinoinensis (Wangenh.) K. Koch] cultivarsMahesh Venkatachalam
Department of Nutrition, Food, and Exercise Sciences, College of Human Sciences, Florida State University, Tallahassee, Florida 32306, USA
J Agric Food Chem 55:9899-907. 2007..89 +/- 0.20; n = 27) with the USDA "Desirable" cultivar as the reference standard (immunoreactivity designated as 1.0)... - Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruitsNavindra P Seeram
Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, Michigan 48824, USA
J Agric Food Chem 51:1948-51. 2003..2% activities, respectively. The cyanogenic glycoside, amygdalin (4), and its hydrolysis products, mandelonitrile (5) and benzaldehyde (6), were not active in the antioxidant or COX enzyme inhibitory assays at 80 microM concentrations...