Research Topics
Genomes and Genes | G A ScottSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Demonstration of melanosome transfer by a shedding microvesicle mechanismGlynis Scott
Departments of Dermatology and Pathology, University of Rochester School of Medicine, Rochester, New York 14618, USA
J Invest Dermatol 132:1073-4. 2012..This model adds further complexity to the process of melanosome transfer in the skin...- Lysophosphatidylcholine mediates melanocyte dendricity through PKCzeta activationGlynis A Scott
Department of Dermatology, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Invest Dermatol 127:668-75. 2007..Downstream mediators of LPC-dependent dendricity include Rac and Rho... - Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiationGlynis Scott
Department of Dermatology, University of Rochester School of Medicine, Box 697, 601 Elmwood Avenue, Rochester, NY 14642, USA
Exp Cell Res 304:407-16. 2005..The regulation of the FP receptor and the stimulation of production of PGF2alpha in melanocytes in response to ultraviolet radiation suggest that PGF2alpha could act as an autocrine factor for melanocyte differentiation... - Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrinsGlynis A Scott
Department of Dermatology and Pathology, University of Rochester School of Medicine, Rochester, New York 14618, USA
J Invest Dermatol 128:151-61. 2008..Furthermore, we show that beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation... - Proteinase-activated receptor-2 stimulates prostaglandin production in keratinocytes: analysis of prostaglandin receptors on human melanocytes and effects of PGE2 and PGF2alpha on melanocyte dendricityGlynis Scott
Department of Dermatology, School of Medicine, University of Rochester, Rochester, New York, USA
J Invest Dermatol 122:1214-24. 2004.... - Prostaglandin E2 regulates melanocyte dendrite formation through activation of PKCzetaGlynis Scott
Department of Dermatology, University of Rochester School of Medicine, Rochester, NY 14642, USA
Exp Cell Res 313:3840-50. 2007..Our data suggest that PKCzeta activation plays a predominant role in regulation of PGE(2)-dependent melanocyte dendricity... - The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cellsGlynis Scott
Department of Dermatology, University of Rochester School of Medicine, Rochester, New York, USA
Pigment Cell Res 16:139-48. 2003..We conclude that cAMP-mediated dendrite formation in melanocytic cells is mediated through upregulation of Rac activity and downregulation of Rho activity... - sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanismGlynis A Scott
Department of Dermatology, University or Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Invest Dermatol 126:855-61. 2006..Because secretory phospholipases are released during inflammation and are regulated by UV irradiation, our data suggest an important role for sPLA2-X in cutaneous pigmentation through the release of LPC... - Plexin C1, a receptor for semaphorin 7a, inactivates cofilin and is a potential tumor suppressor for melanoma progressionGlynis A Scott
Department of Dermatology, School of Medicine, University of Rochester, Rochester, New York, USA
J Invest Dermatol 129:954-63. 2009.... - Melanocytes adhere to and synthesize laminin-5 in vitroG A Scott
Department of Dermatology, University of Rochester Medical Center, NY 14642, USA
Exp Dermatol 8:212-21. 1999..Our results suggest that laminin-5 may be a ligand for normal human melanocytes in the basement membrane, and that loss of laminin-5 production by melanoma cells may be a marker for malignant transformation... - Filopodia are conduits for melanosome transfer to keratinocytesGlynis Scott
Department of Dermatology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Cell Sci 115:1441-51. 2002.... - Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet-induced carcinogenesis, but increases tumor aggressivenessSabine Brouxhon
Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Invest Dermatol 127:439-46. 2007.... - Developmental regulation of focal contact protein expression in human melanocytesG A Scott
Department of Dermatology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
Pigment Cell Res 8:221-8. 1995..The developmentally specific changes in focal contact protein expression observed suggest that this may be an important mechanism by which focal contact assembly is controlled in human melanocytes during development... - Nodular amyloidosis: differentiation from colloid milium by electron microscopyKimberly W Lai
University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Am J Dermatopathol 31:472-4. 2009..We present a case of a 45-year-old man with nodular amyloidosis, whose diagnosis was confirmed by the characteristic appearance of filaments on electron microscopy... - Cyclooxygenase-1 deletion enhances apoptosis but does not protect against ultraviolet light-induced tumorsAlice P Pentland
Departments of Dermatology, University of Rochester Medical Center, Rochester, New York 14642, USA
Cancer Res 64:5587-91. 2004..The lack of protection observed here confirms cancer mechanisms are distinct in UV- and tumor promotor-induced cancer models and indicates that chemoprevention strategies must specifically address cancer causes to be effective... - A successful challenge in a patient with vancomycin-induced linear IgA dermatosisSunil Joshi
Department of Allergy Immunology Rheumatology, University of Rochester Medical Center, Rochester, New York 14642, USA
Ann Allergy Asthma Immunol 93:101-3. 2004..In each case, complete clearance of the skin lesions occurred with discontinued use of the drug. A subsequent rechallenge reproduced the eruption within hours to days... - Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanismSabine Brouxhon
Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Cancer Res 67:7654-64. 2007..Further understanding of how UV-PGE2-EP2 down-regulates E-cadherin may lead to novel chemopreventative strategies for the treatment of skin and other epithelial cancers... - Rac and rho: the story behind melanocyte dendrite formationGlynis Scott
Department Dermatology, University of Rochester School of Medicine, Rochester, NY, USA
Pigment Cell Res 15:322-30. 2002..In this review I will summarize the progress scientists have made in understanding the structure, hormonal regulation and molecular mediators of melanocyte dendrite formation... - The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytesGlynis Scott
Department of Dermatology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14618, USA
J Invest Dermatol 121:529-41. 2003..Because phagocytosis of melanosomes is recognized as an important mechanism for melanosome transfer to keratinocytes, these results suggest that Rho is a critical signaling intermediate in melanosome uptake in keratinocytes... - Cutaneous myiasis arising in an eccrine adnexal neoplasmSherrif F Ibrahim
Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA
Dermatol Online J 14:6. 2008..We report here a case of cutaneous myiasis observed in the setting of an eccrine adnexal neoplasm in an otherwise healthy host. Entomological analysis of the isolated organisms revealed additional information of interest... - alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytesAna Luisa Kadekaro
Department of Dermatology, University of Cincinnati College of Medicine and Shriners' Burns Institute, Cincinnati, Ohio 45267-0592, USA
Cancer Res 65:4292-9. 2005..These effects are expected to reduce genomic instability and mutagenesis... - Homeobox genes and skin development: a reviewG A Scott
Department of Dermatology, University of Rochester, New York 14642
J Invest Dermatol 101:3-8. 1993..The purpose of this review is to briefly summarize what is known about HOX genes and to familiarize the reader with recent insights into how HOX genes may function in skin development... - Plexin B1 suppresses c-Met in melanoma: a role for plexin B1 as a tumor-suppressor protein through regulation of c-MetLaurel Stevens
Department of Dermatology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14618, USA
J Invest Dermatol 130:1636-45. 2010..However, because plexin B1 activates Akt, a multifunctional protein involved in tumor progression in several cancers, plexin B1 may function as a tumor promoter in melanomas not driven by c-Met activation... - Photo protection begins at the cellular level: microparasols on the jobGlynis Scott
University of Rochester Medical School, Rochester, New York, USA
J Invest Dermatol 121:viii. 2003 - Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibitionA P Pentland
Department of Dermatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Carcinogenesis 20:1939-44. 1999.... - MRI sign of nodular fasciitis: a case reportAshwani Kumar Sharma
Neuroradiology Division of Department of Radiology, Strong Memorial Hospital, University of Rochester Medical Center, Rochester, NY 14620, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e53-6. 2008..A case of nodular fasciitis of buccal space is reported. This case demonstrated characteristic thickening and enhancement of the adjacent fascial plane, supporting the preoperative specific diagnosis of the lesion... - Primary cutaneous mucormycosis: guide to surgical managementJoseph E Losee
Division of Plastic Surgery, University of Rochester, Children's Hospital at Strong, Box 661, 601 Elmwood Avenue, Rochester, NY 14642, USA
Ann Plast Surg 49:385-90. 2002..In the case of delayed diagnosis and/or advanced or rapidly progressive disease, surgical debridement of all involved tissue, in addition to chemotherapy, is warranted... - Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expressionRaymond L Konger
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 406 Fesler Hall, 1120 South Drive, Indianapolis, IN 46202, USA
Am J Pathol 161:2065-78. 2002..Thus, down-regulation of EP(2) receptors represents a potential mechanism for neoplastic progression to an invasive phenotype... - Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expressionWilliam K Kaufmann
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Invest Dermatol 128:175-87. 2008..The results suggest that defects in DNA damage checkpoints may be recognized in melanomas through analysis of gene expression... - Metastasizing atypical fibroxanthoma (cutaneous malignant histiocytoma): report of five casesJennifer Z Cooper
Department of Dermatology, Division of Otolaryngology, University of Rochester Medical Center, Rochester, New York 14642, USA
Dermatol Surg 31:221-5; discussion 225. 2005..When first described, it was felt to be a reactive tumor of low malignant potential. More recently, it has been shown to be a tumor of intermediate malignant potential... - IMP-3 is a novel progression marker in malignant melanomaJennifer G Pryor
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Mod Pathol 21:431-7. 2008..Additionally, IMP-3 may have diagnostic utility in distinguishing melanoma from benign nevic cells, dysplastic nevi, and Spitz nevi... - Glioblastoma multiforme in skin: a report of 2 cases and review of the literatureMark Mentrikoski
Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642, USA
Am J Dermatopathol 30:381-4. 2008..It is important to have an accurate clinical history when evaluating scalp nodules in patients with GBM, so that a diagnosis of GBM is not overlooked... - Anetodermic pilomatricoma with perforationAnne B Fender
J Am Acad Dermatol 58:535-6. 2008 - Self-healing juvenile cutaneous mucinosisEdward W Cowen
Department of Dermatology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Am Acad Dermatol 50:S97-100. 2004..Awareness of this disease is important because, despite an ominous presentation, all reported cases have resolved spontaneously. Therefore, aggressive therapy should be avoided... - Leukemia cutis at the site of trauma in a patient with Burkitt leukemiaCarrine A Burns
Department of Dermatology, University of Rochester, New York 14642, USA
Cutis 75:54-6. 2005..Leukemia cutis is an infrequent finding in patients with acute lymphocytic leukemia (ALL). We present a patient with Burkitt ALL (L3ALL) who developed leukemia cutis at the site of trauma... - Congenital leukemia cutisAnne B Fender
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
Pediatr Dermatol 25:34-7. 2008..As leukemia cutis more typically presents as multiple infiltrative papules, nodules, or plaques, we stress the importance of including leukemia in the differential diagnosis of a solitary nodule in a neonate...
Research Grants
- Role of Prostaglandins & Phospholipase A in melanocytesGlynis Scott; Fiscal Year: 2009..We hypothesize that PG and phospholipases stimulate HM dendricity, MS transfer & pigmentation through different mechanisms that act synergistically to modulate cutaneous pigmentation following UVR. ..
- MECHANISMS OF DENDRITE FORMATION & MELANOSOME TRANSFERGlynis Scott; Fiscal Year: 2003..abstract_text> ..
- Plexin signalling in melanocyte biology and melanoma progressionGlynis A Scott; Fiscal Year: 2010..The goal of this project is to define how Semaphorins signal through Plexin receptors, and to understand the mechanisms by which loss of Plexin receptor expression contributes to melanoma metastasis. ..