Research Topics
| J B SchwimmerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, and Rady Children s Hospital and Health Center, San Diego, California, USA
Semin Liver Dis 27:312-8. 2007..Moreover, these data should guide efforts to delineate the pathophysiology in children and adolescents. Our future ability to prevent and treat pediatric NAFLD is dependent upon such work...- Health-related quality of life of severely obese children and adolescentsJeffrey B Schwimmer
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, School of Medicine, University of California, San Diego 92103, USA
JAMA 289:1813-9. 2003..One in 7 US children and adolescents is obese, yet little is known about their health-related quality of life (QOL)... - Prevalence of fatty liver in children and adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
Pediatrics 118:1388-93. 2006..Fatty liver disease is diagnosed increasingly in children, but the prevalence remains unknown. We sought to determine the prevalence of pediatric fatty liver as diagnosed by histology in a population-based sample... - Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver diseaseJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
Circulation 118:277-83. 2008..The objective of this study was to determine the association between NAFLD and the presence of metabolic syndrome in overweight and obese children... - Heritability of nonalcoholic fatty liver diseaseJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California 92103, USA
Gastroenterology 136:1585-92. 2009..Therefore, a familial aggregation study was performed to test the hypothesis that NAFLD is highly heritable... - Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, University of California, 200 W Arbor Dr, San Diego, CA 92103 8450, USA
Pediatrics 115:e561-5. 2005..Obesity and insulin resistance are major established risk factors for NAFLD. The role of gender, race, and ethnicity on the prevalence of fatty liver in obese children is unknown... - A phase 2 clinical trial of metformin as a treatment for non-diabetic paediatric non-alcoholic steatohepatitisJ B Schwimmer
Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of California, San Diedo School of Medicine, CA 92103 8450, USA
Aliment Pharmacol Ther 21:871-9. 2005..Children with non-alcoholic steatohepatitis are insulin-resistant and metformin has been proposed as a potential therapy. However, paediatric safety and efficacy data are absent... - SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver diseaseJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics University of California, San Diego School of Medicine, San Diego, California 92103 8450, USA
Gastroenterology 138:1357-64, 1364.e1-2. 2010..The appropriate alanine aminotransferase (ALT) threshold value to use for diagnosis of chronic liver disease in children is unknown. We sought to develop gender-specific, biology-based, pediatric ALT thresholds... - Enteric-coated cysteamine for the treatment of paediatric non-alcoholic fatty liver diseaseR Dohil
Department of Pediatrics, University of California, Rady Children s Hospital, San Diego, USA
Aliment Pharmacol Ther 33:1036-44. 2011..Hepatic fat accumulation and oxidative stress contribute to its pathogenesis. Cysteamine bitartrate readily traverses cellular membranes and is a potent antioxidant... - Symptoms and quality of life in obese children and adolescents with non-alcoholic fatty liver diseaseK D Kistler
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
Aliment Pharmacol Ther 31:396-406. 2010..Data on the quality of life (QOL) of children with non-alcoholic fatty liver disease (NAFLD) are needed to estimate the true burden of illness in children with NAFLD... - Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver diseaseWinston Dunn
Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA 92103 8450, USA
Hepatology 47:1947-54. 2008..The current study supports the safety of one glass of wine per day for cardioprotection in patients at risk for both coronary heart disease and NAFLD... - Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver diseaseJeffrey B Schwimmer
Joint Program in Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Family and Preventive Medicine, Department of Pathology, The School of Medicine, University of California-San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA
J Pediatr 143:500-5. 2003..CONCLUSIONS: We identified significant predictors of liver pathology in children with NAFLD. Children being evaluated for NAFLD should be screened for insulin resistance, which is nearly universal and correlates with liver histology... - Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitisHeather M Patton
Division of Gastroenterology, University of California, San Diego, San Diego, California 92103, USA
Gastroenterology 135:1961-1971.e2. 2008..Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression... - Non-alcoholic fatty liver disease is associated with low bone mineral density in obese childrenP E Pardee
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, 92123, USA
Aliment Pharmacol Ther 35:248-54. 2012..Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. Liver disease can be a cause of low bone mineral density. Whether or not NAFLD influences bone health is not known... - Abnormal aminotransferase activity in women with polycystic ovary syndromeJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, San Diego, CA, USA
Fertil Steril 83:494-7. 2005..Women with elevated ALT had significantly higher body mass index, waist circumference, serum triglycerides, total cholesterol-to-HDL-cholesterol ratio, and degree of insulin resistance... - Nonalcoholic fatty liver disease in the pediatric populationJoel E Lavine
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego Medical Center and Children s Hospital, 200 W Arbor Drive, San Diego, CA 92103 8450, USA
Clin Liver Dis 8:549-58, viii-ix. 2004..Important differences between pediatric and adult fatty liver disease are highlighted... - Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future researchHeather M Patton
Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA, USA
J Pediatr Gastroenterol Nutr 43:413-27. 2006..A large, multicenter trial of vitamin E and metformin is underway as part of the NASH clinical research network... - Lumen and the liver--together again in NASHvilleJeffrey B Schwimmer
Department of Pediatrics, University of California, San Diego, USA
J Pediatr Gastroenterol Nutr 37:523-4. 2003 - Relaxation effects in the quantification of fat using gradient echo imagingMark Bydder
MR3 Research Building, University of California San Diego, San Diego, CA 92103 8226, USA
Magn Reson Imaging 26:347-59. 2008..At short echo times, the spectral broadening effects manifest as a short apparent T2 for the fat component... - Review article: epidemiology, pathogenesis and potential treatments of paediatric non-alcoholic fatty liver diseaseN J Barshop
Department of Pediatrics, University of California, San Diego, CA, USA
Aliment Pharmacol Ther 28:13-24. 2008..However, significant histological differences exist between adult and paediatric NAFLD to warrant caution in extrapolation of adult data... - Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver diseaseHeather M Patton
Departments of Medicine and Pediatrics, University of California, San Diego, San Diego, California, USA
Am J Gastroenterol 105:2093-102. 2010..We sought to determine whether MetS or its component features are associated with specific histological features or severity of NAFLD... - Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgeryPerrie E Pardee
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, and Rady Children s Hospital, San Diego, California CA 92103 8450, USA
Semin Pediatr Surg 18:144-51. 2009..Several clinical trials for NAFLD are in progress; however, clinical trials focusing on NASH are needed. Heightened physician awareness of NAFLD, NASH, and associated risk factors is important to identify and treat affected children... - Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantificationGavin Hamilton
Department of Radiology, University of California, San Diego, San Diego, California 92103 8226, USA
J Magn Reson Imaging 30:145-52. 2009..To compare PRESS and STEAM MR spectroscopy for assessment of liver fat in human subjects... - Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver diseaseManal F Abdelmalek
Division of Gastroenterology, Duke University, Durham, NC 27710, USA
Hepatology 51:1961-71. 2010..These results identify a readily modifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD... - Television viewing and hypertension in obese childrenPerrie E Pardee
Department of Pediatrics, School of Medicine, University of California, Rady Children s Hospital and Health Center, San Diego 92103 845, USA
Am J Prev Med 33:439-43. 2007..However, the association between TV viewing and hypertension in children is unknown. This study aimed to identify whether TV watching is associated with hypertension in obese children... - The obesity epidemic and nonalcoholic fatty liver disease in childrenWinston Dunn
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego Medical Center, 200 West Arbor Drive, San Diego, CA 92103, USA
Curr Gastroenterol Rep 10:67-72. 2008..Such studies are imperative to address fundamental questions regarding cause and cure... - Histopathology of pediatric nonalcoholic fatty liver diseaseJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California-San Diego School of Medicine, San Diego, CA 92103-8450, USA
Hepatology 42:641-9. 2005..NASH subtypes should be considered when interpreting liver biopsies and planning studies of the pathophysiology, genetics, natural history, or response to treatment in pediatric NAFLD... - Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research networkKristin David
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92103, USA
Hepatology 49:1904-12. 2009..Conclusion: Adults with NAFLD have a significant decrement in QOL. Treatment of NAFLD should incorporate strategies to improve QOL, especially physical health... - Advances in pediatric nonalcoholic fatty liver diseaseRohit Loomba
Division of Gastroenterology, Department of Medicine, University of California at San Diego and Rady Children s Hospital, San Diego, CA, USA
Hepatology 50:1282-93. 2009..CONCLUSION: Public health awareness and intervention are needed to promote healthy diet, exercise, and lifestyle modifications to prevent and reduce the burden of disease in the community... - Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver diseaseAmy G Shah
Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
Clin Gastroenterol Hepatol 7:1104-12. 2009..We compared the performance of the FIB4 index (based on age, aspartate aminotransferase [AST] and alanine aminotransferase [ALT] levels, and platelet counts) with 6 other non-invasive markers of fibrosis in patients with NAFLD... - Adenovirus 36 and obesity in children and adolescentsCharles Gabbert
University of California, San Diego, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, School of Medicine, and Department of Gastroenterology, Rady Children s Hospital San Diego, 200 West Arbor Dr, San Diego, CA 92103 8450, USA
Pediatrics 126:721-6. 2010..The primary aim of this study was to assess the relationship between adenovirus 36 (AD36)-specific antibodies and obesity in children... - Hepatic, cardiovascular, and endocrine outcomes of the histological subphenotypes of nonalcoholic fatty liver diseaseEitan Rubinstein
Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, Rady Children s Hospital, San Diego, California 92103 8450, USA
Semin Liver Dis 28:380-5. 2008.... - Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort studyWinston Dunn
Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California, USA
Am J Gastroenterol 103:2263-71. 2008..The current study compared the survival of subjects with and without suspected NAFLD in a population-based cohort, and placed the finding in the context of previously published case series... - Managing overweight in older children and adolescentsJeffrey B Schwimmer
Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Diego, 200 West Arbor Drive, San Diego, California 92103-8450, USA
Pediatr Ann 33:39-44. 2004..Many overweight and obese children and adolescents can achieve weight loss of 0.5 kg per week even over long periods. For some severely obese children, pharmacotherapy or surgery may be necessary... - Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 TTakeshi Yokoo
Department of Radiology, University of California, San Diego Medical Center, University of California at San Diego, MR3 Laboratory, 408 Dickinson St, San Diego, CA 92103 8226, USA
Radiology 251:67-76. 2009.... - Prevalence and outcome of allergic colitis in healthy infants with rectal bleeding: a prospective cohort studyStavra A Xanthakos
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Ohio 45229-3039, USA
J Pediatr Gastroenterol Nutr 41:16-22. 2005..CONCLUSION: A significant proportion of infants with rectal bleeding may not have allergic colitis and may undergo unnecessary, expensive formula or maternal diet changes that may discourage breast-feeding... - Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosisFiona Hughes Cassidy
Department of Radiology, University of California at San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA
Radiographics 29:231-60. 2009.... - Clinical Research Network launches TONIC trial for treatment of nonalcoholic fatty liver disease in childrenJoel E Lavine
J Pediatr Gastroenterol Nutr 42:129-30. 2006 - Musculoskeletal pain in obese children and adolescentsSteven D Stovitz
Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
Acta Paediatr 97:489-93. 2008..To determine whether bodyweight is associated with musculoskeletal pain within a population of obese children and adolescents... - Fast break on the fat brake: mechanism of peroxisome proliferator-activated receptor-delta regulation of lipid accumulation in hepatocytesDanielle B Andrews
Hepatology 48:355-7. 2008 - Pediatric obesity: the unique issues in Latino-American male youthSteven D Stovitz
Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
Am J Prev Med 34:153-60. 2008.... - Health-related quality of life in pediatric patients with irritable bowel syndrome: a comparative analysisJames W Varni
Department of Landscape Architecture and Urban Planning, College of Architecture, Texas A and M University, College Station, Texas 77843 3137, USA
J Dev Behav Pediatr 27:451-8. 2006..These findings suggest the need for targeted interventions to address these dimensions of impaired HRQOL...
Research Grants
- Adipose and Fatty Liver in the Metabolic SyndromeJeffrey Schwimmer; Fiscal Year: 2006..abstract_text> ..