Research Topics
| EDWARD M contact SCHWARZSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Anti-TNF-alpha therapy as a clinical intervention for periprosthetic osteolysisE M Schwarz
Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Res 2:165-8. 2000..Here we review recent studies implicating tumor necrosis factor (TNF)-alpha in periprosthetic osteolysis and the rationale for clinical studies of anti-TNF therapy and other interventions for periprosthetic loosening...- TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral bloodQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA
Arthritis Res Ther 10:R37. 2008..The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors (OCPs) from bone marrow... - Increased lymphangiogenesis in joints of mice with inflammatory arthritisQian Zhang
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Res Ther 9:R118. 2007..The lymphatic system may play an important role in the pathogenesis of inflammatory arthritis... - CD16 (FcRgammaIII) as a potential marker of osteoclast precursors in psoriatic arthritisYahui Grace Chiu
Allergy Immunology and Rheumatology Unit, University of Rochester Medical School, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Res Ther 12:R14. 2010..Our previous studies showed an elevated frequency of OC precursors (OCP) in PsA patients. Here, we examined if OC arise from CD16-positive monocytes in PsA... - Bone implant interface, osteolysis and potential therapiesE M Schwarz
The Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester Medical Center, Rochester, NY 14642, USA
J Musculoskelet Neuronal Interact 4:390-2. 2004 - Autoimmunity and boneEdward M Schwarz
Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
Ann N Y Acad Sci 1068:275-83. 2006..Thus, systemic factors produced by autoimmunity have a dramatic impact on active myelopoiesis and bone homeostasis... - Clinical development of anti-RANKL therapyEdward M Schwarz
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Res Ther 9:S7. 2007.... - CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg miceJie Li
Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Res Ther 13:R138. 2011.... - Altered bone remodeling in psoriatic arthritisKofi A Mensah
Department of Orthopaedics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
Curr Rheumatol Rep 10:311-7. 2008..It also discusses the effects of tumor necrosis factor inhibition on bone resorption and new bone formation in PsA... - Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytesMichael Ulrich-Vinther
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 46:2095-104. 2002..To evaluate the effects of ultraviolet (UV) light as an adjuvant for recombinant adeno-associated virus (rAAV) transduction in human articular chondrocytes... - The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritisEdward M Schwarz
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Adv Exp Med Biol 658:1-10. 2010.... - Use of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: a 1-year clinical pilot of etanercept vs. placeboEdward M Schwarz
The Center for Musculoskeletal Research, Box 665, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Orthop Res 21:1049-55. 2003..Using the data from this pilot we provide a model power calculation for such a trial... - Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiationWillis Huang
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Arthritis Res Ther 5:R49-59. 2003.... - Dynamic exercises in patients with rheumatoid arthritisA P Anandarajah
Allergy, Immunology and Rheumatology Unit, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Ann Rheum Dis 63:1359-61. 2004 - RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysisC T Ritchlin
The Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester 14642, USA
J Musculoskelet Neuronal Interact 4:276-84. 2004..Herein, we provide a review of the role of RANK, RANKL and OPG in erosive arthritis and periprosthetic osteolysis and discuss the potential of anti-RANKL therapy for these conditions... - The effect of etanercept on osteoclast precursor frequency and enhancing bone marrow oedema in patients with psoriatic arthritisA P Anandarajah
Department of Allergy, Immunology and Rheumatology, University of Rochester, New York, USA
Ann Rheum Dis 67:296-301. 2008..To better understand this association, the effect of etanercept on OCPF and BMO was analysed in PsA patients with erosive arthritis... - Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysisX Zhang
Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York, USA
J Bone Miner Res 16:660-70. 2001..These results provide direct evidence that COX-2 is an important mediator of wear debris-induced osteolysis and suggests that COX-2 inhibitors are potential therapeutic agents for the prevention of wear debris-induced osteolysis... - Efficacy of etanercept for wear debris-induced osteolysisL M Childs
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
J Bone Miner Res 16:338-47. 2001.... - Effect of anti-tumor necrosis factor-alpha gene therapy on wear debris-induced osteolysisL M Childs
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Bone Joint Surg Am 83:1789-97. 2001..It acts by binding to tumor necrosis factor-alpha and preventing signaling through the membrane-bound tumor necrosis factor receptors... - Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2Q Zhang
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 52:2708-18. 2005.... - A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesisW Huang
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Calcif Tissue Int 73:584-93. 2003..These studies demonstrate a rapid screening approach for identifying the potential collective effects of multiple factors on osteoclastic bone resorption... - Degradative pathways in tissues of the temporomandibular joint. Use of in vitro and in vivo models to characterize matrix metalloproteinase and cytokine activityJ E Puzas
Department of Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Cells Tissues Organs 169:248-56. 2001..Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFbeta and IL-1 stimulate and PGE(2) inhibits its activity... - Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cellsH Ito
The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
Gene Ther 11:34-41. 2004..These results demonstrate that LAGT combined with rAAV is a promising procedure to facilitate gene induction in HuMSCs for human gene therapy... - BMP signaling stimulates chondrocyte maturation and the expression of Indian hedgehogC D Grimsrud
Department of Orthopaedics, School of Medicine and Dentistry, University of Rochester Medical Center, NY 14642, USA
J Orthop Res 19:18-25. 2001.... - Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint componentsP F Pollice
Department of Orthopaedics, University of Rochester Medical Center, New York 14642, USA
J Bone Joint Surg Am 83:1057-61. 2001..This effect could increase implant longevity and decrease the need for revision arthroplasty... - Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantationChao Xie
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Bone Joint Surg Am 90:9-13. 2008..Our current approach overcomes this encumbrance and enables examination of gene function in a time-dependent and repair-tissue-specific manner... - Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunityDan Li
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
J Orthop Res 26:96-105. 2008..05). Collectively, these studies demonstrate the first quantitative model of implant-associated OM that defines the kinetics of microbial growth, osteolysis, and humoral immunity following infection... - MRI and quantification of draining lymph node function in inflammatory arthritisSteven T Proulx
The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
Ann N Y Acad Sci 1117:106-23. 2007..63, P = 0.01) between LNcap and synovial volume. TNF-Tg mice with a lower LNcap display an accelerated progression of arthritis. These results indicate a protective function of enhanced lymphatic drainage in inflammatory arthritis... - Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunaeTzong Jen Sheu
Department of Orthopedics, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Bone Miner Res 17:915-22. 2002..The clone 5 peptide shows a high homology to glypican 4 (GPC4), a proteoglycan attachment receptor found in a number of cell types... - Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossificationLee A Kaback
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Cell Physiol 214:173-82. 2008.... - Recent advances in gene delivery for structural bone allograftsHani A Awad
Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
Tissue Eng 13:1973-85. 2007..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications... - Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineeringChao Xie
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Tissue Eng 13:435-45. 2007..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering... - Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiationDo Y Soung
Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
J Bone Miner Res 22:1260-70. 2007..We found that Runx3 is essential for mediating the early stage of endochondral ossification through cooperation with other Runx family members... - NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1Teruhito Yamashita
Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 282:18245-53. 2007..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption... - Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repairXinping Zhang
The Center for Musculoskeletal Research, University of Rochester Medical Center, New York 14642, USA
J Clin Invest 109:1405-15. 2002..These results provide a model whereby COX-2 regulates the induction of cbfa1 and osterix to mediate normal skeletal repair... - Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factorYu Feng Dong
Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Cell Physiol 208:77-86. 2006.... - Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expressionZhenqiang Yao
Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 281:11846-55. 2006..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease... - Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific mannerYu Feng Dong
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
Mol Endocrinol 21:2805-20. 2007..Together, our findings show that Twist1 may be an important regulator of chondrocyte progression toward terminal maturation in response to TGF-beta and canonical Wnt signaling... - Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritisGuoyong Yin
Center for Cardiovascular Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Mol Ther 5:547-54. 2002..These data suggest a novel mechanism by which endostatin inhibits angiogenesis, and demonstrates the potential utility of anti-angiogenic gene therapy for treatment of inflammatory arthritis... - Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytesDhruv B Pateder
Department of Orthopaedic Surgery, University of Rochester School of Medicine, Rochester, New York 14642, USA
Radiat Res 157:62-8. 2002.... - What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?Rocky S Tuan
Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA
J Am Acad Orthop Surg 16:S42-8. 2008.... - Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteinsRuolin Guo
Department of Pathology and Laboratory Medicine, and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 283:23084-92. 2008..Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteoblasts could help to treat inflammation-induced osteoporosis... - Quantification of massive allograft healing with dynamic contrast enhanced-MRI and cone beam-CT: a pilot studyNicole Ehrhart
Department of Clinical Sciences, Colorado State University, Fort Collins, CO, USA
Clin Orthop Relat Res 466:1897-904. 2008.... - Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CTRyosuke Tsutsumi
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642 0001, USA
J Orthop Res 26:1340-6. 2008..001)... - In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesisLisa M Childs
Department of Microbiology and Immunology, University of Rochester Medical Center, New York 14642, USA
J Bone Miner Res 17:192-9. 2002..These studies indicate that osteoclast depletion via RANK blockade is an effective method to prevent and reverse wear debris-induced osteolysis without jeopardizing osteogenesis... - Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumorsChristopher R Good
Department of Orthopaedics, University of Rochester School of Medicine, Rochester, New York 14642, USA
J Surg Oncol 79:174-9. 2002..Further study is necessary to determine in which specific tumors RANK-L is the cytokine responsible for increased osteoclastic activity, and to develop possible therapeutic use of RANK-L antagonists such as osteoprotegerin (OPG)... - Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanismZhenqiang Yao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Biol Chem 283:9917-24. 2008..TNF could induce c-Fos expression in OCPs at sites of inflammation in bone to promote this autocrine mechanism and thus amplify bone loss... - Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene deliveryPatrick Basile
Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York 14642, USA
Mol Ther 16:466-73. 2008..Collectively, our data demonstrate the feasibility and efficacy of therapeutic tendon allograft processing as a novel paradigm in tissue engineering in order to address difficult clinical problems such as tendon adhesions... - Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomographySteven T Proulx
Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Rheum 56:4024-37. 2007.... - Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysisJ Jeffrey Goater
Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester Medical Center, NY 14642, USA
J Orthop Res 20:169-73. 2002..This increased osteoclastogenesis was completely inhibited by the FLS-OPG, as osteoclast numbers in the calvaria of these animals were similar to that seen in the SHAM controls... - Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblastsHiroyuki Kaneki
Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
J Biol Chem 281:4326-33. 2006..We propose that one of the mechanisms by which TNF inhibits bone formation in inflammatory bone disorders is by promoting Runx2 proteasomal degradation through up-regulation of Smurf1 and Smurf2 expression... - Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiationTian Fang Li
Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Bone Miner Res 21:4-16. 2006..Smad2 or Smad3 overexpression and BMP blockade abrogate accelerated maturation in Smad3-/- chondrocytes. BMP signaling is increased in TGF-beta deficiency and is required for accelerated chondrocyte maturation... - Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathwayTian Fang Li
Department of Orthopaedics, The Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA
Exp Cell Res 299:128-36. 2004..Overall, our results demonstrate that PTHrP downregulates Runx2 expression primarily through the PKA signaling pathway... - Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivoCristin M Ferguson
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 665, Rochester, NY 14642, USA
J Orthop Res 22:687-96. 2004..The findings confirm a critical role for TGF-beta during skeletal development. A more complete understanding of the role of TGF-beta and its down-stream signals will lead to improved understanding and treatment of cartilage diseases... - RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritisPing Li
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA
J Bone Miner Res 19:207-13. 2004..RANK signaling is not required for the TNFalpha-stimulated increase in CD11b(hi) osteoclast precursors but is essential for mature osteoclast formation... - CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoterAndreia M Ionescu
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
J Cell Physiol 198:428-40. 2004.... - Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic micePing Li
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 50:265-76. 2004..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo... - Use of zoledronate to treat osteoblastic versus osteolytic lesions in a severe-combined-immunodeficient mouse modelYu-Po Lee
Department of Orthopaedic Surgery, David Geffen School of Medicine, Los Angeles, California 90095, USA
Cancer Res 62:5564-70. 2002..Hence, bisphosphonates may not be ideal agents to prevent the formation of osteoblastic lesions associated with prostate cancer metastases to bone... - Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytesM Hicham Drissi
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
J Cell Biochem 90:1287-98. 2003..Factors or signals that alter either of these transcription factors regulate the rate of chondrocyte differentiation... - A phage display technique identifies a novel regulator of cell differentiationTzong Jen Sheu
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 278:438-43. 2003..We hypothesize that binding to TRAP may be one mechanism by which the full osteoblast phenotype is expressed during the process of bone remodeling... - Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5Xuefeng Li
Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Endocrinology 144:2514-23. 2003..These findings demonstrate that RA induces the expression of BMP-signaling molecules and enhances BMP effects in chondrocytes... - ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal developmentDonghui Zhang
Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
J Bone Miner Res 18:1593-604. 2003..The findings suggest that BMP signaling modulates the Ihh/PTHrP signaling pathway that regulates the rate of chondrocyte differentiation... - The TNF-alpha transgenic mouse model of inflammatory arthritisPing Li
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Springer Semin Immunopathol 25:19-33. 2003.... - ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturationAndreia M Ionescu
Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Exp Cell Res 288:198-207. 2003..Thus, ATF-2 regulates chondrocyte maturation as a direct target of TGF-beta signaling while CREB regulates differentiation by targeting genes independent of the individual signaling effects of TGF-beta or BMP-2... - PGE2 inhibits chondrocyte differentiation through PKA and PKC signalingTian-Fang Li
Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Exp Cell Res 300:159-69. 2004..These observations demonstrate potent prostaglandin regulatory effects on chondrocyte maturation and show a role for both PKA and PKC signaling in PGE2 regulatory events... - Adeno-associated virus-mediated osteoprotegerin gene transfer protects against particulate polyethylene-induced osteolysis in a murine modelShang-You Yang
Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Arthritis Rheum 46:2514-23. 2002..Data suggest that gene transfer using rAAV-OPG may be a feasible and effective therapeutic candidate to treat or prevent wear debris-associated osteolysis and aseptic loosening... - Gene therapy with human osteoprotegerin decreases callus remodeling with limited effects on biomechanical propertiesMichael Ulrich-Vinther
Department of Orthopaedics, Aarhus University Hospital, Noerrebrogade, DK 8000 Aarhus C, Denmark
Bone 37:751-8. 2005..039). The experiment demonstrates that AAV-OPG gene therapy decreases the fracture remodeling, but this does not influence the structural strength of healing fractures... - Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapyHiromu Ito
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
Nat Med 11:291-7. 2005..In conclusion, we find that RANKL and VEGF are necessary and sufficient for efficient autograft remodeling and can be transferred using rAAV to revitalize structural allografts... - Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesionsBrian T Feeley
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76 134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
Bone 38:154-66. 2006..The role of BMPs in the formation of prostate cancer metastases to bone remains unknown. We hypothesized that BMPs influence the development and progression of osteolytic prostate cancer lesions... - Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesisYongjun Wang
Center for Musculoskeletal Research, Department of Orthopeadics, University of Rochester, Rochester, New York 14642, USA
J Bone Miner Res 20:1624-36. 2005..Runx1 induces mesenchymal stem cell commitment to the early stages of chondrogenesis... - Biological effects of rAAV-caAlk2 coating on structural allograft healingMette Koefoed
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Mol Ther 12:212-8. 2005..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation... - The effects of RANK blockade and osteoclast depletion in a model of pure osteoblastic prostate cancer metastasis in bonePeter G Whang
Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Center for Health Sciences 76-134, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
J Orthop Res 23:1475-83. 2005..These results indicate that in vivo RANK blockade may not be effective for the prevention of osteoblastic metastasis but may potentially represent a novel therapy that limits the growth of established metastatic CaP lesions in bone... - Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-betaYufeng Dong
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Cell Biochem 95:1057-68. 2005..Moreover, this pathway is modulated by members of the TGF-beta family and demonstrates the highly integrated nature of signals controlling endochondral ossification... - Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particlesXiaochao Wei
Center for Musculoskeletal Research University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA
J Bone Miner Res 20:1136-48. 2005..Thus, the synovial fibroblast is important mediator of osteolysis and target for therapeutic strategies... - Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in boneAndrew H Gordon
Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
Cancer Res 65:3209-17. 2005..These findings imply that NF-kappaB and its associated genes may be relevant therapeutic targets in osteolytic tumor burden... - Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particlesEmily E Carmody
University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 46:1298-308. 2002..CONCLUSION: This study demonstrates that gene delivery of vIL-10 inhibits 3 processes critically involved in periprosthetic osteolysis: 1) wear debris-induced proinflammatory cytokine production, 2) osteoclastogenesis, and 3) osteolysis... - Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytesMichael J Zuscik
Center for Muscluskeletal Research, School of Medicine and Dentistry, University of Rochester, NY 14642, USA
J Orthop Res 20:811-8. 2002.... - Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysisMichael Ulrich-Vinther
Department of Orthopedics, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642, USA
J Bone Joint Surg Am 84:1405-12. 2002..This study investigated whether gene therapy using a recombinant adeno-associated viral vector that expresses OPG can inhibit wear debris-induced osteolysis... - Effects of receptor activator of NFkappaB (RANK) signaling blockade on fracture healingLisa M Flick
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Orthop Res 21:676-84. 2003..Together, these data imply that osteoclast depletion via inhibition of RANK signaling is a viable option for the treatment of pathological bone loss since no adverse effects on fracture healing are observed when therapy is discontinued...
Research Grants
- PTH Effects of Craniofacial AllograftsEDWARD M contact SCHWARZ; Fiscal Year: 2010..Here we propose to formally demonstrate that PTH has these effects and could be used as an adjuvant therapy during craniomaxillofacial reconstructive surgery. ..
- B cells and draining lymph node function in arthritic flairEdward Schwarz; Fiscal Year: 2009..Here we propose to test this theory in mouse models and RA patients. ..
- PTH Effects of Craniofacial AllograftsEdward Schwarz; Fiscal Year: 2009..Here we propose to formally demonstrate that PTH has these effects and could be used as an adjuvant therapy during craniomaxillofacial reconstructive surgery. ..
- Revitalizing Allografts for Craniofacial ReconstructionEdward Schwarz; Fiscal Year: 2007....
- PACAP Overexpression and Voiding FunctionEdward Schwarz; Fiscal Year: 2004..If successful, the mice will be distributed to interested labs to assist with the rigorous characterization of the models as they relate to the neurochemical organization of voiding function. ..
- Mouse Models for Interstitial CystitisEdward Schwarz; Fiscal Year: 2004..Finally, we will attempt to generate a transgenic mouse model of IC by targeting the expression of a secreted form of mouse protamine-1 (sMP1) to the transitional epithelium and evaluate these animals in our system. ..
- GENE THERAPY FOR ARTHRITIS IN THE TNFA-TRANSGENIC MOUSEEdward Schwarz; Fiscal Year: 2002..abstract_text> ..
- B cells and draining lymph node function in arthritic flairEdward M Schwarz; Fiscal Year: 2010..Here we propose to test this theory in mouse models and RA patients. ..