Nancy Schwartz

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Proteoglycans in brain development
    Nancy B Schwartz
    Department of Pediatrics, Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Glycoconj J 21:329-41. 2004
  2. ncbi APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region
    Edward W Pirok
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:35606-16. 2005
  3. ncbi Sulfate activation and transport in mammals: system components and mechanisms
    N B Schwartz
    Department of Pediatrics, University of Chicago Hospitals, IL 60637, USA
    Chem Biol Interact 109:143-51. 1998
  4. ncbi Biosynthesis and regulation of expression of proteoglycans
    N Schwartz
    Departments of Pediatrics and Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    Front Biosci 5:D649-55. 2000
  5. ncbi Got sulfate? Luring axons this way and that
    Nancy B Schwartz
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    Chem Biol 14:119-20. 2007
  6. ncbi Aggrecan regulates telencephalic neuronal aggregation in culture
    Miriam S Domowicz
    Departments of Pediatrics and Biochemistry and Molecular Biology, Committee on Developmental Biology, The University of Chicago, 5841 S Maryland Avenue, MC 5058, Chicago, IL 60637, USA
    Brain Res Dev Brain Res 143:207-16. 2003
  7. ncbi Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis
    Miriam S Domowicz
    Department of Pediatrics, The University of Chicago, Chicago, Illinois, USA
    Dev Dyn 226:42-50. 2003
  8. ncbi Aggrecan is expressed by embryonic brain glia and regulates astrocyte development
    Miriam S Domowicz
    Department of Pediatrics, 5841 S Maryland Ave, MC 5058, The University of Chicago, Chicago, IL 60637, USA
    Dev Biol 315:114-24. 2008
  9. ncbi Glial migratory streams in the developing hindbrain: a slice culture approach
    Leslie A King
    Department of Pediatrics, 5841 S Maryland Avenue, MC 5058, The University of Chicago, Chicago, IL 60637, USA
    J Neurosci Methods 177:30-43. 2009
  10. ncbi Aggrecan modulation of growth plate morphogenesis
    Miriam S Domowicz
    Departments of Pediatrics and Biochemistry and Molecular Biology, Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Biol 329:242-57. 2009

Research Grants

  1. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy B Schwartz; Fiscal Year: 2010
  2. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2006
  3. GRADUATE TRAINING IN GROWTH AND DEVELOPMENT
    Nancy Schwartz; Fiscal Year: 2007
  4. THE UNIVERSITY OF CHICAGO PREP
    Nancy Schwartz; Fiscal Year: 2007
  5. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2007
  6. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2000
  7. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 1993

Collaborators

Detail Information

Publications12

  1. ncbi Proteoglycans in brain development
    Nancy B Schwartz
    Department of Pediatrics, Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Glycoconj J 21:329-41. 2004
    ..Taken together our results suggest a function for aggrecan in the specification of a sub-set of glia precursors that might give rise to astrocytes in vivo...
  2. ncbi APBP-1, a DNA/RNA-binding protein, interacts with the chick aggrecan regulatory region
    Edward W Pirok
    Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 280:35606-16. 2005
    ..Functional analyses by transient transfections and Northern blot analyses suggest APBP-1 has the capacity to repress aggrecan expression, indicating that this factor may be important regulator of aggrecan gene expression...
  3. ncbi Sulfate activation and transport in mammals: system components and mechanisms
    N B Schwartz
    Department of Pediatrics, University of Chicago Hospitals, IL 60637, USA
    Chem Biol Interact 109:143-51. 1998
    ..The mechanism by which PAPS reaches its sites of utilization in the Golgi lumen has also been elucidated: The PAPS translocase is a 230-kDa integral Golgi membrane protein which functions as an antiport...
  4. ncbi Biosynthesis and regulation of expression of proteoglycans
    N Schwartz
    Departments of Pediatrics and Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
    Front Biosci 5:D649-55. 2000
    ..Elucidation of cell- and developmental-specific control elements which regulate the expression of these complex macromolecular families are only beginning...
  5. ncbi Got sulfate? Luring axons this way and that
    Nancy B Schwartz
    Department of Pediatrics, The University of Chicago, Chicago, IL 60637, USA
    Chem Biol 14:119-20. 2007
    ..In this issue of Chemistry & Biology, Shipp and Hsieh-Wilson describe microarrays to probe these complex modifications...
  6. ncbi Aggrecan regulates telencephalic neuronal aggregation in culture
    Miriam S Domowicz
    Departments of Pediatrics and Biochemistry and Molecular Biology, Committee on Developmental Biology, The University of Chicago, 5841 S Maryland Avenue, MC 5058, Chicago, IL 60637, USA
    Brain Res Dev Brain Res 143:207-16. 2003
    ..These studies suggest a function for aggrecan as a diffusible signal in CNS histomorphogenesis...
  7. ncbi Developmental expression of the HNK-1 carbohydrate epitope on aggrecan during chondrogenesis
    Miriam S Domowicz
    Department of Pediatrics, The University of Chicago, Chicago, Illinois, USA
    Dev Dyn 226:42-50. 2003
    ....
  8. ncbi Aggrecan is expressed by embryonic brain glia and regulates astrocyte development
    Miriam S Domowicz
    Department of Pediatrics, 5841 S Maryland Ave, MC 5058, The University of Chicago, Chicago, IL 60637, USA
    Dev Biol 315:114-24. 2008
    ..Taken together, these results indicate a major role for aggrecan in the control of glial cell maturation during brain development...
  9. ncbi Glial migratory streams in the developing hindbrain: a slice culture approach
    Leslie A King
    Department of Pediatrics, 5841 S Maryland Avenue, MC 5058, The University of Chicago, Chicago, IL 60637, USA
    J Neurosci Methods 177:30-43. 2009
    ..This slice culture system is thus an innovative and robust tool for examining glial cell migration and the extracellular molecular and signaling pathways which regulate glial differentiation...
  10. ncbi Aggrecan modulation of growth plate morphogenesis
    Miriam S Domowicz
    Departments of Pediatrics and Biochemistry and Molecular Biology, Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Biol 329:242-57. 2009
    ....
  11. ncbi Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
    Mauricio Cortes
    Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA
    Development 136:1697-706. 2009
    ..Overall, this study demonstrates an important function for CSPGs in modulating Ihh signaling in the developing growth plate, and highlights the importance of carbohydrate sulfation in regulating growth factor signaling...
  12. ncbi Chondrodysplasias due to proteoglycan defects
    Nancy B Schwartz
    Department of Pediatrics, University of Chicago, MC 5058, 5826 S. Maryland Ave, Chicago, IL 60637, USA
    Glycobiology 12:57R-68R. 2002
    ....

Research Grants30

  1. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy B Schwartz; Fiscal Year: 2010
    ....
  2. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2006
    ..These studies have the long-term goal of providing a model of how this critically important pathway is regulated and then to correlate defects in the overall pathway with abnormal growth and development. ..
  3. GRADUATE TRAINING IN GROWTH AND DEVELOPMENT
    Nancy Schwartz; Fiscal Year: 2007
    ..Based on the past record of this training program, the future trainees will continue to pursue careers in academic medicine and/or research. ..
  4. THE UNIVERSITY OF CHICAGO PREP
    Nancy Schwartz; Fiscal Year: 2007
    ..All of these elements represent definable and readily accessible goals. The ultimate sucess will be the matriculation of Scholars into a PhD or MD/PhD program and their continued success as biomedical scientists. ..
  5. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2007
    ..These studies have the long-term goal of providing a model of how this critically important pathway is regulated and then to correlate defects in the overall pathway with abnormal growth and development. ..
  6. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 2000
    ....
  7. PROTEOGLYCAN SYNTHESIS IN MUTANT MOUSE SYSTEMS
    Nancy Schwartz; Fiscal Year: 1993
    ....