Research Topics
| C E SchmidtSummaryAffiliation: University of Texas Country: USA Publications
Research Grants
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Detail Information
Publications
Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineeringC E Schmidt
Department of Chemical Engineering, University of Texas at Austin, 78712, USA
Biomaterials 21:2215-31. 2000..However, with the recent advent of tissue engineering, the possibility of applying selective cell seeding to naturally derived bioprosthetics moves us closer to a living tissue replacement...- Neural tissue engineering: strategies for repair and regenerationChristine E Schmidt
Department of Biomedical Engineering The University of Texas at Austin, Austin, Texas 78712, USA
Annu Rev Biomed Eng 5:293-347. 2003..This article reviews the nervous system physiology, the factors that are critical for nerve repair, and the current approaches that are being explored to aid peripheral nerve regeneration and spinal cord repair... - Biocompatibility implications of polypyrrole synthesis techniquesJohn M Fonner
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas, 1 University Station, MC C0800, Austin, TX 78712, USA
Biomed Mater 3:034124. 2008..The results of these studies should provide practical insight to researchers working with conducting polymers, and particularly PPy, on the relationships between synthesis parameters, polymeric properties and biological compatibility... - Photopatterned collagen-hyaluronic acid interpenetrating polymer network hydrogelsShalu Suri
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
Acta Biomater 5:2385-97. 2009..With the ability to fine-tune the scaffold properties by performing structural modifications and to create patterned scaffolds, these hydrogels can be employed as potential candidates for regenerative medicine applications... - Carboxy-endcapped conductive polypyrrole: biomimetic conducting polymer for cell scaffolds and electrodesJoo-Woon Lee
Biomedical Engineering Department and Texas Materials Institute, The University of Texas at Austin, Austin, Texas 78712, USA. jwoonlee@ chungju.ac.kr
Langmuir 22:9816-9. 2006..Human umbilical vein endothelial cells (HUVECs) cultured on RGD-modified PPy-alpha-COOH demonstrated significantly higher adhesion and spreading than on the negative controls PPy-alpha-COOH and unmodified PPy... - Nerve growth factor-immobilized polypyrrole: bioactive electrically conducting polymer for enhanced neurite extensionNatalia Gomez
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712 1062, USA
J Biomed Mater Res A 81:135-49. 2007.... - Carboxylic acid-functionalized conductive polypyrrole as a bioactive platform for cell adhesionJoo Woon Lee
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
Biomacromolecules 7:1692-5. 2006..Thus, PPyCOOH could be useful in developing PPy composites that contain a variety of biological molecules as bioactive conducting platforms for specific biomedical purposes... - Vascular graft endothelialization: comparative analysis of canine and human endothelial cell migration on natural biomaterialsP Dixit
Department of Chemical Engineering, University of Texas at Austin, 26th and Speedway, MC C0400, Austin, Texas 78712-1062, USA
J Biomed Mater Res 56:545-55. 2001..This suggested that human in vivo graft re-endothelialization is likely not hindered by poor endothelial migration but is hindered by other cellular or graft properties... - Biomaterials functionalization using a novel peptide that selectively binds to a conducting polymerArchit B Sanghvi
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712-1084, USA
Nat Mater 4:496-502. 2005..This strategy can be extended to immobilize a variety of molecules to PPyCl for numerous applications. In addition, phage display can be applied to other polymers to develop bioactive materials without altering their bulk properties... - Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterialsA Kotwal
Department of Chemical Engineering, The University of Texas at Austin, 78712-1062, USA
Biomaterials 22:1055-64. 2001..These studies suggest that increased FN adsorption with immediate electrical stimulation may explain enhanced neurite extension on electrically stimulated PP... - Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applicationsJae Y Lee
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA
Biomaterials 30:4325-35. 2009.... - Neuroactive conducting scaffolds: nerve growth factor conjugation on active ester-functionalized polypyrroleJae Young Lee
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
J R Soc Interface 6:801-10. 2009..This novel scaffold, providing electroconductive and neurotrophic activities, has potential for neural applications, such as tissue engineering scaffolds and biosensors... - Hippocampal neurons respond uniquely to topographies of various sizes and shapesDavid Y Fozdar
Department of Mechanical Engineering, The University of Texas at Austin, 1 University Station, C2200, Austin, TX 78712, USA
Biofabrication 2:035005. 2010..The results suggest that incorporating microscale and sub-microscale topographies on biomaterial surfaces may enhance the biomaterials' ability to modulate nerve development and regeneration... - Immobilized nerve growth factor and microtopography have distinct effects on polarization versus axon elongation in hippocampal cells in cultureNatalia Gomez
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712 1062, USA
Biomaterials 28:271-84. 2007..These results could be potentially applied for the design of biomaterials in applications were axon growth is critical... - Characterization of protein release from photocrosslinkable hyaluronic acid-polyethylene glycol hydrogel tissue engineering scaffoldsJennie B Leach
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
Biomaterials 26:125-35. 2005..These initial studies indicate that the naturally derived biopolymer HA can be employed to design novel photopolymerizable composites that are suitable for delivering stable proteins from scaffolding in tissue engineering applications... - Optimized acellular nerve graft is immunologically tolerated and supports regenerationTerry W Hudson
Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, USA
Tissue Eng 10:1641-51. 2004..In summary, the results imply that OA grafts are immunologically tolerated and that the removal of cellular material and preservation of the matrix are beneficial for promoting regeneration through an acellular nerve graft... - Genetic modification of alphaGal expression in xenogeneic endothelial cells yields a complex immunological responseJ A Fischbeck
Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
Tissue Eng 7:743-56. 2001..Furthermore, antibodies, as instigators in the complement response, and monocytes appear to recognize different cell surface epitopes... - Rapid endothelialization of PhotoFix natural biomaterial vascular graftsJohn Carnagey
Department of Chemical and Biomedical Engineering, The University of Texas at Austin, 26th and Speedway, Austin, TX 78712, USA
J Biomed Mater Res B Appl Biomater 65:171-9. 2003..Flow conditioning for 6 h enhanced in vitro cell retention by 24% and 40% on PhotoFix and PTFE grafts, respectively... - Engineering an improved acellular nerve graft via optimized chemical processingTerry W Hudson
Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA
Tissue Eng 10:1346-58. 2004..Also presented is an improved chemical decellularization protocol that preserves the internal structure of native nerve more than the predominant current protocol... - Photopatterned anisotropic swelling of dual-crosslinked hyaluronic acid hydrogelsScott A Zawko
Department of Chemical Engineering, The University of Texas at Austin, 1 University Station C0400, Austin, Texas 78712, USA
Acta Biomater 5:14-22. 2009..A biodegradable hydrogel with this unique swelling behavior yields a new, unexplored type of shape-changing TE scaffold... - Photocrosslinked hyaluronic acid hydrogels: natural, biodegradable tissue engineering scaffoldsJennie Baier Leach
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
Biotechnol Bioeng 82:578-89. 2003..Therefore, these novel GMHA hydrogels are suitable for modification with adhesive peptide sequences (e.g., RGD) and use in a variety of wound-healing applications... - Nanostructured scaffolds for neural applicationsStephanie K Seidlits
Department of Biomedical Engineering, 1 University Station, MC C0800 The University of Texas at Austin, Austin, TX 78712, USA
Nanomedicine (Lond) 3:183-99. 2008..Most importantly, this review focuses on the effects of incorporating nanoscale architectures into these materials on neuronal and glial cell growth and function... - Fabrication of three-dimensional scaffolds for heterogeneous tissue engineeringLi Hsin Han
Texas Materials Institute and Department of Mechanical Engineering, The University of Texas at Austin, C2200, Austin, TX 78712, USA
Biomed Microdevices 12:721-5. 2010..Cell-cultivation experiment was performed with the microporous scaffold, in which selective cell adhesion was observed... - Novel degradable co-polymers of polypyrrole support cell proliferation and enhance neurite out-growth with electrical stimulationHymavathi Durgam
Department of Biomedical Engineering, The University of Texas at Austin, 1 University Station, MC C0800, Austin, TX 78712, USA
J Biomater Sci Polym Ed 21:1265-82. 2010.... - Cell-laden hydrogel constructs of hyaluronic acid, collagen, and laminin for neural tissue engineeringShalu Suri
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA
Tissue Eng Part A 16:1703-16. 2010.... - Crystal templating dendritic pore networks and fibrillar microstructure into hydrogelsScott A Zawko
Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA
Acta Biomater 6:2415-21. 2010..The porous fibrillar HA scaffolds created by crystal templating may be applicable as regenerative patches for skin and other tissues... - Simple benchtop patterning of hydrogel grids for living cell microarraysScott A Zawko
Department of Chemical Engineering, The University of Texas at Austin, 1 University Station C0400, Austin, Texas 78712, USA
Lab Chip 10:379-83. 2010..This patterning technique addresses the need for a simple, inexpensive, benchtop method for micro-patterning glass slides and obtaining living cell microarrays... - Enhanced polarization of embryonic hippocampal neurons on micron scale electrospun fibersJae Young Lee
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA
J Biomed Mater Res A 92:1398-406. 2010..This information will be valuable in understanding the roles of subcellular features on neuron development and for the design of biomaterials for neural tissue interfacing... - Drug-binding hydrogels of hyaluronic acid functionalized with beta-cyclodextrinScott A Zawko
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA
J Biomed Mater Res A 87:1044-52. 2008..Drug-binding HA-betaCD hydrogels may be further engineered to create HA-based biomaterials with a built in drug delivery capability... - Polarization of hippocampal neurons with competitive surface stimuli: contact guidance cues are preferred over chemical ligandsNatalia Gomez
Department of Chemical Engineering, Institute of Neuroscience, The University of Texas at Austin, Austin, TX 78712 1062, USA
J R Soc Interface 4:223-33. 2007..This investigation contributes to the understanding of neuronal behaviour on artificial substrates, which is applicable to the creation of artificial environments for neural engineering applications... - Development of photocrosslinkable hyaluronic acid-polyethylene glycol-peptide composite hydrogels for soft tissue engineeringJennie B Leach
Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA
J Biomed Mater Res A 70:74-82. 2004..g., swelling ratio, enzymatic degradation rate). These composite hydrogels may prove to be a promising scaffolding biomaterial for a variety of soft tissue engineering applications...
Research Grants
- Micro-and nano-mechanical and chemical guidance of neuronsChristine Schmidt; Fiscal Year: 2007....
- Fabrication of Novel Biomimetic Polymers Using Combinatorial Peptide ScreeningChristine Schmidt; Fiscal Year: 2007....