Research Topics
Genomes and GenesSpecies | Kenneth A SchenkmanSummaryAffiliation: University of Washington Country: USA Publications
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Detail Information
Publications
Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivoDavid J Marcinek
Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195 7115, USA
Am J Physiol Heart Circ Physiol 285:H1900-8. 2003..Therefore, we reject a regulatory role for oxygen in cellular respiration and conclude that oxygen acts as a simple substrate for respiration under physiological conditions...- Optical spectroscopy demonstrates elevated intracellular oxygenation in an endotoxic model of sepsis in the perfused heartKenneth A Schenkman
Departments of Pediatrics, University of Washington, Seattle, Washington, USA
Shock 27:695-700. 2007..Cellular dysfunction seen in sepsis may be caused by compromised oxygen use rather than insufficient oxygen delivery. Optical spectroscopy has the potential to noninvasively monitor patients and their responses to therapy... - Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenationKenneth A Schenkman
Anesthesia and Critical Care 9 G1, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
Am J Physiol Heart Circ Physiol 285:H1819-25. 2003..These results suggest that caution should be used in extrapolating intracellular oxygen dynamics from buffer-perfused to blood-perfused hearts... - Mitochondrial function in vivo: spectroscopy provides window on cellular energeticsCatherine E Amara
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
Methods 46:312-8. 2008.... - Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractilityJ Chiaka Ejike
Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
Am J Physiol Heart Circ Physiol 288:H2062-7. 2005.... - Mitochondrial coupling in vivo in mouse skeletal muscleDavid J Marcinek
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
Am J Physiol Cell Physiol 286:C457-63. 2004.... - Simultaneous optical spectroscopic measurement of hemoglobin and myoglobin saturations and cytochrome aa3 oxidation in vivoLorilee S L Arakaki
Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA
Appl Spectrosc 64:973-9. 2010.... - Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport modelDaniel A Beard
Department of Bioengineering, University of Washington, Box 352255, Seattle, WA 98195, USA
Am J Physiol Heart Circ Physiol 285:H1826-36. 2003..It is incorrect to assume that the usual buffer-perfused Langendorff heart preparation is adequately oxygenated for flows in the range of < or =10 ml. min-1. ml tissue-1... - Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscleDavid J Marcinek
Department of Radiology, University of Washington Medical Center, Seattle, WA 98195, USA
J Physiol 569:467-73. 2005..These results demonstrate reduced mitochondrial coupling in aged skeletal muscle that alters cellular metabolism and energetics... - Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectraDavid J Marcinek
Department of Radiology, University of Washington Medical Center, Seattle, Washington 98195, USA
Appl Spectrosc 61:665-9. 2007..This advance will facilitate comparison of the metabolic properties between individual muscles and provides a fully noninvasive approach to measuring local respiration that can be adapted for clinical use... - Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathyShane E Kruse
Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, WA 98195, USA
Cell Metab 7:312-20. 2008..Nonetheless, total oxygen consumption and muscle ATP and phosphocreatine concentrations measured in vivo were within normal parameters... - Direct optical measurement of intraoperative myocardial oxygenation during congenital heart surgeryGordon A Cohen
Department of Surgery, University of Washington, Seattle, Washington, USA
ASAIO J 57:314-7. 2011..34). This study demonstrates for the first time that myocyte cellular oxygenation can be measured intraoperatively during cardiac surgery. Measurement of cellular oxygenation may be useful for improving myocardial preservation techniques... - Continuous measurement of oxygen consumption by pancreatic isletsIan R Sweet
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
Diabetes Technol Ther 4:661-72. 2002..The system has particular application to the field of human islet transplantation, where assessment and the study of islet viability have been hampered by a lack of experimental methods... - An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heartSebastian K G Maier
Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 99:4073-8. 2002.... - Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill childrenJoan S Roberts
Division of Pediatric Critical Care Medicine, Children's Hospital and Regional Medical Center and University of Washington, Seattle, WA, USA
Crit Care Med 34:2217-23. 2006.... - Cerebral oxygenation in neonatal and pediatric patients during veno-arterial extracorporeal life supportJaneth C Ejike
Loma Linda University School of Medicine, Loma Linda, CA, USA
Pediatr Crit Care Med 7:154-8. 2006..Near infrared spectroscopy measurement may offer an important adjunct for neurologic monitoring of ECLS patients...