Stephen W Schaffer

Summary

Affiliation: University of South Alabama
Country: USA

Publications

  1. ncbi Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
  2. ncbi Quality and safety issues related to traditional animal medicine: role of taurine
    Kyoko Takahashi
    The Museum of Osaka University, Toyonaka, Osaka, Japan
    J Biomed Sci 17:S44. 2010
  3. ncbi Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    J Biomed Sci 17:S32. 2010
  4. ncbi Physiological roles of taurine in heart and muscle
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S2. 2010
  5. ncbi Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis
    S W Schaffer
    Department of Pharmacology, School of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Heart Circ Physiol 278:H1948-54. 2000
  6. ncbi Role of antioxidant activity of taurine in diabetes
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 87:91-9. 2009
  7. ncbi Proapoptotic and antiapoptotic effects of hyperglycemia: role of insulin signaling
    Craig Ricci
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 86:166-72. 2008
  8. ncbi Insulin withdrawal induces apoptosis via a free radical-mediated mechanism
    Craig Ricci
    University of South Alabama, College of Medicine, Department of Pharmacology, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 85:455-64. 2007
  9. ncbi Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis
    Craig Ricci
    Department of Pharmacolgy, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Cell Physiol 294:C413-22. 2008
  10. ncbi Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning
    Viktor Pastukh
    University of South Alabama, School of Medicine, Department of Pharmacology, Mobile, AL 36688, USA
    Mol Cell Biochem 269:59-67. 2005

Research Grants

  1. EFFECT OF DIABETES AND HYPERTENSION ON ISCHEMIC INJURY
    Stephen Schaffer; Fiscal Year: 2003

Collaborators

  • Junichi Azuma
  • Chian Ju Jong
  • Songwei Wu
  • Takashi Ito
  • David Schaffer
  • M V Cohen
  • Craig Ricci
  • Chian Ju Jong
  • Viktor Pastukh
  • Mahmood Mozaffari
  • Mahmood S Mozaffari
  • Kyoko Takahashi
  • T Krieg
  • Tadashi Saito
  • Rafik Abdelsayed
  • Mikhail Alexeyev
  • Champa Patel
  • Hereward Wimborne
  • Hairu Chen
  • Jun Yao Liu
  • Yuko Azuma
  • Kayoko Shimada
  • Masaya Kawase
  • Josh Leonard
  • Julio Turrens
  • Glenn Wilson
  • Viktoriya Solodushko
  • X-M Yang
  • J M Downey

Detail Information

Publications18

  1. ncbi Effect of beta-alanine treatment on mitochondrial taurine level and 5-taurinomethyluridine content
    Chian Ju Jong
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S25. 2010
    ..The present study examines the effect of taurine deficiency on the first step of mitochondrial protein synthesis regulation by taurine, namely, the formation of taurinomethyluridine containing tRNA...
  2. ncbi Quality and safety issues related to traditional animal medicine: role of taurine
    Kyoko Takahashi
    The Museum of Osaka University, Toyonaka, Osaka, Japan
    J Biomed Sci 17:S44. 2010
    ..Bovis, we felt that several issues needed to be addressed: 1) the source of the C. Bovis materials and quality control; 2) the role of taurine in the efficacy of C. Bovis...
  3. ncbi Differential effects of taurine treatment and taurine deficiency on the outcome of renal ischemia reperfusion injury
    Mahmood S Mozaffari
    Department of Oral Biology, Medical College of Georgia School of Dentistry, Augusta, Georgia 30912, USA
    J Biomed Sci 17:S32. 2010
    ..Collectively, the results indicate that body taurine status is a major determinant of renal IR injury...
  4. ncbi Physiological roles of taurine in heart and muscle
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Biomed Sci 17:S2. 2010
    ..The mechanism of this action has not been studied. Taurine is a chemically simple compound, but it has profound effects on cells. This has led to the suggestion that taurine is an essential or semi-essential nutrient for many mammals...
  5. ncbi Cardioprotective effect of chronic hyperglycemia: effect on hypoxia-induced apoptosis and necrosis
    S W Schaffer
    Department of Pharmacology, School of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Heart Circ Physiol 278:H1948-54. 2000
    ....
  6. ncbi Role of antioxidant activity of taurine in diabetes
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 87:91-9. 2009
    ..The importance of this and other actions of taurine in diabetes is discussed...
  7. ncbi Proapoptotic and antiapoptotic effects of hyperglycemia: role of insulin signaling
    Craig Ricci
    Department of Pharmacology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 86:166-72. 2008
    ..In the absence of insulin, however, the natural activity of high glucose is unmasked. As a result, Akt signaling is increased and the cell is rendered resistant to cell death...
  8. ncbi Insulin withdrawal induces apoptosis via a free radical-mediated mechanism
    Craig Ricci
    University of South Alabama, College of Medicine, Department of Pharmacology, Mobile, AL 36688, USA
    Can J Physiol Pharmacol 85:455-64. 2007
    ..Collectively, these data demonstrate that insulin deficiency leads to apoptosis and suggest a role for oxidative mitochondrial DNA damage in this cascade...
  9. ncbi Mitochondrial DNA damage triggers mitochondrial-superoxide generation and apoptosis
    Craig Ricci
    Department of Pharmacolgy, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Cell Physiol 294:C413-22. 2008
    ..This novel mechanism may play an important pathological role...
  10. ncbi Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning
    Viktor Pastukh
    University of South Alabama, School of Medicine, Department of Pharmacology, Mobile, AL 36688, USA
    Mol Cell Biochem 269:59-67. 2005
    ..Since inhibition of PI 3-kinase with Wortmannin also prevents osmotic-mediated cardioprotection, we conclude that hyperosmotic-mediated activation of the PI 3-kinase/Akt pathway contributes to osmotic preconditioning...
  11. ncbi Beneficial effect of taurine depletion on osmotic sodium and calcium loading during chemical hypoxia
    Stephen W Schaffer
    Department of Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama 36688, USA
    Am J Physiol Cell Physiol 282:C1113-20. 2002
    ..Taurine deficiency also reduced the degree of hypoxia-induced calcium overload. Thus the observed resistance against hypoxia-induced necrosis and apoptosis is probably related to an improvement in sodium and calcium handling...
  12. ncbi Effect of taurine on protein kinase C isoforms: role in taurine's actions?
    Takashi Ito
    Department of Pharmacology, University of South Alabama, College of Medicine, USA
    Adv Exp Med Biol 643:3-11. 2009
    ..In conclusion, the cytoprotective and pro-growth actions of taurine appears to be mediated in part by the activation of PKCepsilon...
  13. ncbi Effect of hypernatremia on injury caused by energy deficiency: role of T-type Ca2+ channel
    Viktor Pastukh
    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, Alabama, USA
    Am J Physiol Cell Physiol 299:C289-97. 2010
    ..Thus hypernatremia appears to protect the cell against metabolic inhibition by promoting the downregulation of the T-type calcium channel and stimulating cytoprotective protein kinase pathways...
  14. ncbi Effect of ischemia, calcium depletion and repletion, acidosis and hypoxia on cellular taurine content
    S W Schaffer
    Department of Pharmacology, University of South Alabama School of Medicine, Mobile, Alabama, USA
    Amino Acids 23:395-400. 2002
    ..The data suggest that taurine efflux is regulated by [Na(+)](i) and cellular osmolality, but not by cellular pH...
  15. ncbi Role of mitochondrial permeability transition in taurine deficiency-induced apoptosis
    Chian Ju Jong
    University of South Alabama, College of Medicine, Department of Pharmacology, Mobile, Alabama, USA
    Exp Clin Cardiol 16:125-8. 2011
    ....
  16. ncbi Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprotection
    T Krieg
    Department of Physiology, University of South Alabama, College of Medicine, Mobile, Alabama, USA
    Amino Acids 26:263-6. 2004
    ....
  17. ncbi Effects of chronic glipizide treatment on the NIDD heart
    S W Schaffer
    Department of Pharmacology, College of Medicine, University of South Alabama, Mobile
    Horm Metab Res 25:348-52. 1993
    ..Since these changes occur in the absence of changes in glucose tolerance or insulin levels, the heart appears to be very sensitive to the direct effects of the sulfonylureas...
  18. ncbi Defective response to cAMP-dependent protein kinase in non-insulin-dependent diabetic heart
    S W Schaffer
    Department of Pharmacology, School of Medicine, University of South Alabama, Mobile 36688
    Am J Physiol 261:E369-76. 1991
    ..The likelihood that these abnormalities contribute to alterations in calcium homeostasis and myocardial contractile function is discussed...

Research Grants4

  1. EFFECT OF DIABETES AND HYPERTENSION ON ISCHEMIC INJURY
    Stephen Schaffer; Fiscal Year: 2003
    ..Cell culture studies will be complimented by studies using an isolated heart model to test the hypothesis that hypertensive diabetic hearts will be more susceptible to an ischemic insole because of elevated levels of angiotensin. ..