GENE SCARBOROUGH

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Structure and function of the P-type ATPases
    G A Scarborough
    Department of Pharmacology, CB 7365 Mary Ellen Jones Building, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 11:517-22. 1999
  2. ncbi Crystallization, structure and dynamics of the proton-translocating P-type ATPase
    G A Scarborough
    Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, NC 27599, USA
    J Exp Biol 203:147-54. 2000
  3. ncbi The plasma membrane proton-translocating ATPase
    G A Scarborough
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cell Mol Life Sci 57:871-83. 2000
  4. ncbi Molecular mechanism of the P-type ATPases
    Gene A Scarborough
    J Bioenerg Biomembr 34:235-50. 2002
  5. ncbi Rethinking the P-type ATPase problem
    Gene A Scarborough
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Biochem Sci 28:581-4. 2003
  6. ncbi Domain movements of plasma membrane H(+)-ATPase: 3D structures of two states by electron cryo-microscopy
    Kyong Hi Rhee
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 21:3582-9. 2002
  7. ncbi Why we must move on from the E1E2 model for the reaction cycle of the P-type ATPases
    Gene A Scarborough
    Department of Pharmacology, Campus Box #7365, M. E. Jones Building, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Bioenerg Biomembr 35:193-201. 2003

Research Grants

  1. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 1980
  2. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 1991
  3. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANE
    GENE SCARBOROUGH; Fiscal Year: 1999
  4. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 2003

Collaborators

  • Kyong Hi Rhee
  • Kyong-Hi Rhee
  • Richard Henderson

Detail Information

Publications7

  1. ncbi Structure and function of the P-type ATPases
    G A Scarborough
    Department of Pharmacology, CB 7365 Mary Ellen Jones Building, University of North Carolina, Chapel Hill, NC 27599, USA
    Curr Opin Cell Biol 11:517-22. 1999
    ....
  2. ncbi Crystallization, structure and dynamics of the proton-translocating P-type ATPase
    G A Scarborough
    Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, NC 27599, USA
    J Exp Biol 203:147-54. 2000
    ..The forces that drive the sequence can also be clearly stipulated. However, an understanding of the molecular mechanism of ion transport catalyzed by the H(+) P-ATPase awaits an atomic resolution structure...
  3. ncbi The plasma membrane proton-translocating ATPase
    G A Scarborough
    Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, 27599, USA
    Cell Mol Life Sci 57:871-83. 2000
    ....
  4. ncbi Molecular mechanism of the P-type ATPases
    Gene A Scarborough
    J Bioenerg Biomembr 34:235-50. 2002
    ..Thus, although a few details await elucidation, a nearly complete understanding of the P-type ATPase reaction mechanism may be at hand...
  5. ncbi Rethinking the P-type ATPase problem
    Gene A Scarborough
    Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Biochem Sci 28:581-4. 2003
    ..Alternatives must be seriously considered...
  6. ncbi Domain movements of plasma membrane H(+)-ATPase: 3D structures of two states by electron cryo-microscopy
    Kyong Hi Rhee
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    EMBO J 21:3582-9. 2002
    ....
  7. ncbi Why we must move on from the E1E2 model for the reaction cycle of the P-type ATPases
    Gene A Scarborough
    Department of Pharmacology, Campus Box #7365, M. E. Jones Building, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Bioenerg Biomembr 35:193-201. 2003
    ..This new model will therefore serve us better as we seek to unravel the final details of the molecular mechanism of active ion transport catalyzed by these enzymes. It is thus time to move on from the traditional E1E2 model...

Research Grants23

  1. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 1980
    ..With respect to the glucose carrier we plan to a) develop a reliable assay for glucose carrier function in Neurospora plasma membrane vesicle and b) identify, isolate, and reconstitute the glucose carrier in a defined vesicle system. ..
  2. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 1991
    ....
  3. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANE
    GENE SCARBOROUGH; Fiscal Year: 1999
    ....
  4. ENERGY TRANSDUCTION IN NEUROSPORA PLASMA MEMBRANES
    GENE SCARBOROUGH; Fiscal Year: 2003
    ..We shall then proceed with structure determinations of these two important human membrane proteins. ..