Research Topics
| Fred SattlerSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trialFred R Sattler
Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Am J Clin Nutr 88:1313-21. 2008..HIV patients with wasting are at increased risk of opportunistic complications and fatality...- Testosterone and growth hormone improve body composition and muscle performance in older menFred R Sattler
Departments of Medicine, Division of Biokinesiology, Keck School of Medicine, University of Southern California, 1200 North State Street, Room 6442, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 94:1991-2001. 2009..Impairments in the pituitary-gonadal axis with aging are associated with loss of muscle mass and function and accumulation of upper body fat... - Metabolic effects of nandrolone decanoate and resistance training in men with HIVFred R Sattler
Departments of Medicine, Biokinesiology and Physical Therapy, and of Biometry, Keck School of Medicine of the University of Southern California, Los Angeles, California 90033, USA
Am J Physiol Endocrinol Metab 283:E1214-22. 2002..05). These metabolic effects were favorable (other than for HDL), but changes were generally transient (except for HDL in group 2), with measurements returning to baseline 2 mo after the interventions were completed... - Body habitus changes related to lipodystrophyFred Sattler
Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Clin Infect Dis 36:S84-90. 2003..Very limited evidence in persons infected with HIV has suggested that a supervised exercise program may be beneficial... - Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trialFred Sattler
Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
J Gerontol A Biol Sci Med Sci 66:122-9. 2011.... - A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatmentThomas W Storer
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 90:4474-82. 2005.... - Effects of androgen therapy on adipose tissue and metabolism in older menE Todd Schroeder
Department of Medicine and Division of Infectious Diseases, University of Southern California, Los Angeles, California 90033, USA
J Clin Endocrinol Metab 89:4863-72. 2004..Thus, therapy with an androgen that does not adversely affect lipids may be beneficial for some components of the metabolic syndrome in overweight older men with low testosterone levels... - Androgen therapy improves muscle mass and strength but not muscle quality: results from two studiesE Todd Schroeder
Division of Infectious Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Am J Physiol Endocrinol Metab 285:E16-24. 2003..001) for hamstrings, and 0.73 +/- 0.19 to 1.07 +/- 0.16 kg/cm2 (+55 +/- 36%; P < 0.001) for quadriceps. Thus androgen therapy alone did not improve muscle quality, but the addition of RT to nandrolone produced substantive improvements... - Effects of an oral androgen on muscle and metabolism in older, community-dwelling menE Todd Schroeder
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
Am J Physiol Endocrinol Metab 284:E120-8. 2003..001), and HDL-cholesterol decreased by -19 +/- 9 and -23 +/- 18 mg/dl in groups 2 and 3, respectively (P = 0.04 and P = 0.008). Thus oxymetholone improved LBM and maximal voluntary muscle strength and decreased fat mass in older men... - Treatment with oxandrolone and the durability of effects in older menE Todd Schroeder
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
J Appl Physiol 96:1055-62. 2004..Anabolic improvements were lost 12 wk after discontinuing oxandrolone, whereas improvements in fat mass were largely sustained... - Reliability of maximal voluntary muscle strength and power testing in older menE Todd Schroeder
University of Southern California, Departments of Medicine and Biokinesiology and Physical Therapy, 1540 East Alcazar St, CHP 155, Los Angeles, CA 90089, USA
J Gerontol A Biol Sci Med Sci 62:543-9. 2007..We hypothesized that performing these measures twice within 7-10 days would demonstrate a >5% increase due to learning and familiarization of the testing procedures... - Six-week improvements in muscle mass and strength during androgen therapy in older menE Todd Schroeder
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA 90089, USA
J Gerontol A Biol Sci Med Sci 60:1586-92. 2005..The purpose of our study was to assess the early effects of a potent anabolic androgen on muscle mass and strength, lower extremity power, and functional performance in older men... - B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patientsWilliam Stohl
Division of Rheumatology, Department of Medicine, Los Angeles County, Los Angeles, CA, USA
Clin Immunol 104:115-22. 2002..This raises the possibility that the combination of a BLyS protein antagonist with an agent that targets (helper) T cells may have salutary synergistic effects on autoantibody production in diseases such as systemic lupus erythematosus... - Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trialKathleen Mulligan
Department of Medicine, University of California, San Francisco, California 94110, USA
J Clin Endocrinol Metab 92:563-70. 2007..Reduced energy intake is a primary factor in HIV-associated wasting. Megestrol acetate (MA) stimulates appetite and weight gain. However, much of the weight gained is fat, possibly as a result of MA-induced hypogonadism... - Cardiopulmonary responses to eccentric and concentric resistance exercise in older adultsAlberto F Vallejo
University of Southern California, Biokinesiolgy, Los Angeles, CA, USA
Age Ageing 35:291-7. 2006..In older ambulatory persons, exercise strategies that are expected to generate beneficial muscle adaptations with low cardiopulmonary demands are needed... - Satellite cell numbers in young and older men 24 hours after eccentric exerciseHans C Dreyer
Department of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, USA
Muscle Nerve 33:242-53. 2006..These data suggest that age-related changes in satellite cell recruitment may contribute to muscle regeneration deficits among the elderly... - Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal womenChristina M Dieli-Conwright
Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, University of Southern California, Los Angeles, CA 90033, USA
Med Sci Sports Exerc 42:422-9. 2010..Specifically, it is unknown if HRT enhances estrogen receptor (ER) transcriptional activation in skeletal muscle at rest and after resistance exercise... - Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trialE Todd Schroeder
Division of Biokinesiology, University of Southern California, Los Angeles, CA 90033, USA
Clin Trials 4:560-71. 2007..This report describes the challenges of conducting a complex clinical investigation assessing the effects of anabolic hormones on body composition, physical function, and metabolism during aging... - Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for TuberculosisAlejandro Sanchez
Division of Infectious Diseases, Department of Medicine, The Keck School of Medicine and the School of Pharmacy of the University of Southern California, IRD Building, Room 432, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
Tuberc Res Treat 2011:346295. 2011..CRP levels declined by ?50% at each interval visit. Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation... - Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virusPaul M Beringer
Department of Pharmacy, University of Southern California, Los Angeles, California 90033, USA
Pharmacotherapy 30:1004-10. 2010.... - Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapyMichael P Dube
Department of Medicine, Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Clin Infect Dis 35:475-81. 2002..A trend toward insulin resistance appeared late in the study following weight gain, particularly of trunk fat, but without loss of limb fat... - Pathogenesis and treatment of lipodystrophy: what clinicians need to knowFred R Sattler
Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA
Top HIV Med 16:127-33. 2008..Sattler, MD, at an International AIDS Society--USA Continuing Medical Education course in Washington, DC, in May 2008. The original presentation is available as a Webcast at www.iasusa.org... - Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal womenChristina M Dieli-Conwright
Division of Biokinesiology and Physical Therapy, Clinical Exercise Research Center, University of Southern California, Los Angeles, California, USA
J Appl Physiol 107:1381-8. 2009..Furthermore, postmenopausal women using HRT experienced a greater myogenic response to maximal eccentric exercise... - Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapyErika M Young
Department of Medicine and Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202-2879, USA
Cardiovasc Toxicol 4:179-86. 2004..This improvement occurred independent of development of insulin resistance, which occurred only with indinavir... - Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signalingSatoshi Fujita
Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 0460, USA
Diabetes 56:1615-22. 2007..05). In conclusion, a bout of aerobic exercise restores the anabolic response of muscle proteins to insulin by improving endothelial function and Akt/mTOR signaling in older subjects... - Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trialKathleen Mulligan
Division of Endocrinology, San Francisco General Hospital, 1001 Potrero Avenue, Rm 3501K, San Francisco, CA 94110, USA
Arch Intern Med 165:578-85. 2005..Although studies have examined a variety of anabolic therapies in HIV-infected men, the safety and efficacy of such treatments in women have not been adequately studied...
Research Grants
- HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGINGFred Sattler; Fiscal Year: 2005..The results should also provide valuable information for future testing of new, novel treatment strategies, which are more tolerable and convenient than parenteral therapies for age associated sarcopenia. ..
- UNIVERSITY OF SOUTHERN CALIFORNIA CLINICAL TRIALS UNITFred Sattler; Fiscal Year: 2007..g. East LA) that will often be applicable for the care of patients in developing countries. ADMINISTRATIVE COMPONENT: ..