Research Topics
Genomes and Genes
| Minoru SatohSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseasesYoshioki Yamasaki
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, PO Box 100221, Gainesville, Florida 32610, USA
Arthritis Res Ther 8:R111. 2006..4% of SLE and other diseases). Other autoantibodies found in SLE were rare in this subset, suggesting that patients with anti-RPA may form a unique clinical and immunological subset...- Autoantibodies that stabilize U1snRNP are a significant component of human autoantibodies to snRNP and delay proteolysis of sm antigens in vitroMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
J Rheumatol 31:2382-9. 2004..The biological significance of stabilizing antibodies was investigated by titering anti-U1-C/U1-A compared to stabilizing antibodies, and by examining the effects of stabilizing antibodies on antigen processing... - Induction of lupus autoantibodies by adjuvantsMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P O Box 100221, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
J Autoimmun 21:1-9. 2003..The potential to induce autoimmunity may complicate the use of oil adjuvants in human and veterinary vaccines... - Clinical implication of autoantibodies in patients with systemic rheumatic diseasesMinoru Satoh
University of Florida, Division of Rheumatology and Clinical Immunology, Department of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, PO Box 100221, Gainesville, FL 32610 0221, USA
Expert Rev Clin Immunol 3:721-38. 2007..Clinical approaches in differential diagnosis of antinuclear antibodies and the significance of antinuclear antibodies in healthy individuals are also discussed... - X-linked immunodeficient mice spontaneously produce lupus-related anti-RNA helicase A autoantibodies, but are resistant to pristane-induced lupusMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
Int Immunol 15:1117-24. 2003..The spontaneous production of anti-RHA by xid mice and its suppression by pristane treatment at the level of autoantibody induction supports the idea that lupus autoantibodies may be generated through a variety of mechanisms... - B cell proliferation, somatic hypermutation, class switch recombination, and autoantibody production in ectopic lymphoid tissue in murine lupusDina C Nacionales
Center for Autoimmune Disease, University of Florida, Gainesville, 32610, USA
J Immunol 182:4226-36. 2009.... - Type I interferon production by tertiary lymphoid tissue developing in response to 2,6,10,14-tetramethyl-pentadecane (pristane)Dina C Nacionales
Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
Am J Pathol 168:1227-40. 2006..In view of the increased IFN-I production in systemic lupus erythematosus, these studies suggest that IFN-I from ectopic lymphoid tissue could play a role in the pathogenesis of experimental lupus in mice... - Pristane-induced autoimmunity in germ-free miceAkiei Mizutani
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610-0221, USA
Clin Immunol 114:110-8. 2005..Although microbial stimulation acts synergistically with pristane, these results clearly indicate that pristane does not act merely by increasing exposure to microbial products such as LPS... - Type I interferon modulates monocyte recruitment and maturation in chronic inflammationPui Y Lee
Center for Autoimmune Disease, University of Florida, Gainesville, 32610 0221, USA
Am J Pathol 175:2023-33. 2009..Continuous monocyte recruitment and the lack of terminal differentiation induced by IFN-I may help sustain the chronic inflammatory response... - Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritisPrasanthi Kakumanu
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida 32610 0221, USA
J Rheumatol 36:2682-90. 2009..We investigated the citrulline dependence of anti-CCP and its significance in the arthritis of SLE... - Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristaneTolga T Barker
Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
Lab Invest 91:1540-50. 2011..028). Pristane-induced alveolar hemorrhage is a useful model to study the pathogenesis and develop new therapy for this underappreciated and often life-threatening complication of SLE... - Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosusYi Li
Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0221, USA
Arthritis Res Ther 12:R90. 2010..The aim of this study was to identify a surrogate marker for IFN-I activity in clinical samples for monitoring disease activity and response to therapy... - Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical studyMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL, 32610 USA
Arthritis Res Ther 13:R73. 2011..Here the clinical association of anti-topo I was reevaluated in unselected patients seen in a rheumatology clinic setting... - TLR7-dependent and FcgammaR-independent production of type I interferon in experimental mouse lupusPui Y Lee
Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
J Exp Med 205:2995-3006. 2008..Collectively, the data demonstrate that TMPD-stimulated IFN-I production requires TLR7/MyD88 signaling and is independent of autoantibody-mediated uptake of ribonucleoproteins by FcgammaRs... - Induction of lupus-related specific autoantibodies by non-specific inflammation caused by an intraperitoneal injection of n-hexadecane in BALB/c miceYoshiki Kuroda
Division of Rheumatology and Clinical Immunology, Department of Medicine, ARB-R2-156, 1600 SW Archer Road, Box 100221, Gainesville, FL 32610-0221, USA
Toxicology 218:186-96. 2006..These previously unrecognized immunological effects of n-hexadecane may have implications in monitoring human exposure to hydrocarbons and in the pathogenesis of autoimmune diseases... - Autoantibodies to RNA helicase A: a new serologic marker of early lupusYoshioki Yamasaki
University of Florida, Gainesville, FL 32610, USA
Arthritis Rheum 56:596-604. 2007..To investigate the clinical and immunologic significance of autoantibodies to RNA helicase A (RHA) in patients with systemic rheumatic diseases... - IL-1? modulates neutrophil recruitment in chronic inflammation induced by hydrocarbon oilPui Y Lee
Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
J Immunol 186:1747-54. 2011..Taken together, our findings uncover an IL-1?-dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation... - Deficiency of the type I interferon receptor protects mice from experimental lupusDina C Nacionales
University of Florida College of Medicine, Gainesville, Florida, USA
Arthritis Rheum 56:3770-83. 2007..The objective of this study was to examine the role of IFN-I signaling in the pathogenesis of murine lupus induced by 2,6,10,14-tetramethylpentadecane (TMPD)... - Effect of an exogenous trigger on the pathogenesis of lupus in (NZB x NZW)F1 miceHideo Yoshida
Department of Medicine, University of Florida, Gainesville, FL 32610-0221, USA
Arthritis Rheum 46:2235-44. 2002..CONCLUSION: These data lead us to propose that environmental influences exacerbate autoimmune manifestations in genetically lupus-susceptible mice through their stimulatory effects on proinflammatory cytokines, such as IL-12... - In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigenKindra M Kelly Scumpia
University of Florida College of Medicine, Gainesville, FL 32610 0221, USA
Arthritis Rheum 56:3379-86. 2007..This study was undertaken to examine whether U1 RNA possesses adjuvant activity in vivo... - Formation of GW/P bodies as marker for microRNA-mediated regulation of innate immune signaling in THP-1 cellsKaleb M Pauley
Department of Oral Biology, University of Florida, Gainesville, FL 32610 0424, USA
Immunol Cell Biol 88:205-12. 2010..These data show that the increase in size and number of GWB may serve as a biomarker for miRNA-mediated gene regulation, and miR-146a has a significant role in the regulation of LPS-induced cytokine production in THP-1 cells... - Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patientsKaleb M Pauley
Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
Arthritis Res Ther 10:R101. 2008..In this study, the expression of selected microRNAs is examined in rheumatoid arthritis... - Autoimmune targeting of key components of RNA interferenceAndrew Jakymiw
Department of Oral Biology, University of Florida, 1600 S, W, Archer Road, Gainesville, FL 32610, USA
Arthritis Res Ther 8:R87. 2006..Together, these results demonstrate an autoimmune response to components of the RNAi pathway which could potentially implicate the involvement of an innate anti-viral response in the pathogenesis of autoantibody production... - A novel type I IFN-producing cell subset in murine lupusPui Y Lee
Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610 0221, USA
J Immunol 180:5101-8. 2008..Therefore, immature monocytes rather than DCs appear to be the primary source of IFN-I in this model of IFN-I-dependent lupus... - Autoimmunity induced by adjuvant hydrocarbon oil components of vaccineYoshiki Kuroda
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, ARB-R2-156, 1600 SW Archer Road, P.O. Box 100221 Gainesville, FL 32610-0221, USA
Biomed Pharmacother 58:325-37. 2004..Nevertheless, the potential of adjuvant hydrocarbon oils to induce autoimmunity has implications in the use of oil adjuvants in human and veterinary vaccines as well as basic research... - Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodiesMalgorzata E Krzyszczak
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
Clin Rheumatol 30:1333-9. 2011..04). The production of SSc-related autoantibodies is gender and race dependent, and this can be highly relevant in understanding their clinical significance... - Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosusErinn S Kellner
Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610 0221, USA
J Neuroimmunol 223:13-9. 2010..Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE... - Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupusYi Li
Division of Rheumatology and Clinical Immunology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0221, USA
Arthritis Res Ther 11:R6. 2009..The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients... - Distinctive patterns of autoimmune response induced by different types of mineral oilYoshiki Kuroda
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, Florida 32610-0221, USA
Toxicol Sci 78:222-8. 2004..Induction of autoantibodies by mineral oils considered nontoxic also may have pathogenetic implications in human autoimmune diseases... - Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositisYoshioki Yamasaki
University of Florida, Gainesville, USA
Arthritis Rheum 54:2004-9. 2006..Although anti-PL-7, similar to anti-Jo-1, is associated with PM/DM with ILD, muscle involvement in the patients with anti-PL-7 appeared to be milder than that in the anti-Jo-1 subset... - The role of GW/P-bodies in RNA processing and silencingAndrew Jakymiw
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
J Cell Sci 120:1317-23. 2007..Here, we propose a working model for GW body assembly in terms of its relationship to RNA interference. In this process, one or more heteromeric protein complexes accumulate in successive steps into larger ribonucleoprotein structures... - Detection of the argonaute protein Ago2 and microRNAs in the RNA induced silencing complex (RISC) using a monoclonal antibodyKeigo Ikeda
Department of Oral Biology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610-0424, USA
J Immunol Methods 317:38-44. 2006..Since Ago2 protein is the effector protein of RNAi, anti-Ago2 monoclonal antibody may be useful in capturing functional miRNAs... - Nucleolar staining cannot be used as a screening test for the scleroderma marker anti-RNA polymerase I/III antibodiesYoshioki Yamasaki
University of Florida, Gainesville, FL 32610-0221, USA
Arthritis Rheum 54:3051-6. 2006..CONCLUSION: Although some sera positive for anti-RNAP I/III antibodies clearly stain nucleoli, nucleolar staining is inconsistent and cannot be used to screen for anti-RNAP I/III antibodies... - Role of non-protein amino acid L-canavanine in autoimmunityJun Akaogi
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610-0221, USA
Autoimmun Rev 5:429-35. 2006..Alfalfa/L-canavanine-induced lupus will be an interesting model of autoimmunity induced by the modification of self-proteins at the translational level... - Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencingSongqing Li
Departments of Oral Biology and Anatomy and Cell Biology, University of Florida, Gainesville, FL 32610, USA
J Cell Sci 121:4134-44. 2008..Our data demonstrated that GW182 and, probably, TNGW1 acted as a repressor in Ago2-mediated translational silencing. Furthermore, TNGW1 might contribute to diversity in the formation and function of GW and/or P bodies... - "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60Kindra M Kelly
University of Florida, Gainesville, USA
Arthritis Rheum 54:1557-67. 2006.... - Ecotropic murine leukemia viruses and exogenous mouse mammary tumor viruses are not essential for pristane-induced lupusJun Akaogi
University of Florida, Gainesville, FL, USA
Arthritis Rheum 48:2990-2. 2003 - Colocalization of antigen-specific B and T cells within ectopic lymphoid tissue following immunization with exogenous antigenJason S Weinstein
Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, University of Florida, Gainesville, FL 32610, USA
J Immunol 181:3259-67. 2008..This has implications for understanding the strong association of humoral autoimmunity with lymphoid neogenesis, which may be associated with deficient censoring of autoreactive cells... - Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 miceChaim O Jacob
Department of Medicine, University of Southern California School of Medicine, Los Angeles, CA 90089, USA
J Immunol 171:1564-71. 2003..Furthermore, these results also question the apparent equation of the effect of Stat deficiency with loss of secretion or response to particular cytokines... - Lack of chromatin and nuclear fragmentation in vivo impairs the production of lupus anti-nuclear antibodiesLorenza Frisoni
Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19140, USA
J Immunol 179:7959-66. 2007..Thus, our work in vivo strongly suggests that apoptotic molecular steps during cell death generate nuclear autoantigens to sustain the specific autoimmune response in systemic lupus erythematosus... - Autoantibodies to survival of motor neuron complex in patients with polymyositis: immunoprecipitation of D, E, F, and G proteins without other components of small nuclear ribonucleoproteinsMinoru Satoh
University of Florida, Gainesville, FL, USA
Arthritis Rheum 63:1972-8. 2011..The purpose of this study was to examine the target antigens and clinical manifestations associated with this specificity... - Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupusNicola Calvani
Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, Florida, USA
Kidney Int 64:897-905. 2003..We investigated the role of IL-12 for lupus-like disease induced by pristane. IL-12p35-deficient (-/-) and control (+/+) BALB/c mice were treated with pristane or phosphate-buffered saline (PBS)... - Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosusHaoyang Zhuang
Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL 32610, USA
Clin Immunol 117:238-50. 2005.... - Small interfering RNA-mediated silencing induces target-dependent assembly of GW/P bodiesShangli Lian
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
Mol Biol Cell 18:3375-87. 2007..We propose that RNAi is a key regulatory mechanism for the assembly of GWB, and in some cases, GWB may serve as markers for RNAi in mammalian cells... - Induction of autoimmunity by pristane and other naturally occurring hydrocarbonsWestley H Reeves
Division of Rheumatology and Clinical Immunology, and Laboratory Medicine, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, United States
Trends Immunol 30:455-64. 2009..This model is well suited for examining links between dysregulated IFN-I production and the pathogenesis of human SLE, which like TMPD-lupus, is associated with high levels of IFN-I... - miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITYMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, Florida 32610, USA
J Biol Chem 284:34590-9. 2009..Thus our studies demonstrated that miR-146a is critical for the in vitro monocytic cell-based endotoxin tolerance... - Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 productionJun Akaogi
University of Florida, P O Box 100221, Gainesville, FL 32610 0221, USA
J Leukoc Biol 76:227-36. 2004..PGE(2) can modulate inflammatory reactions via the EP2/4 receptor through its regulation of TNF-alpha and IL-6. Modification of EP signaling may be a new therapeutic strategy in inflammatory/autoimmune diseases... - Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signalingMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
J Immunol 186:1723-34. 2011..Our studies have thus demonstrated that miR-146a plays a crucial role for in vitro monocytic cell-based endotoxin-induced cross-tolerance... - Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9pHaoyang Zhuang
University of Florida, Gainesville, USA
Arthritis Rheum 54:1573-9. 2006..The data support the idea that abnormal regulation of type I IFN production is involved in the pathogenesis of SLE... - Patients with pulmonary tuberculosis are frequently positive for anti-cyclic citrullinated peptide antibodies, but their sera also react with unmodified arginine-containing peptidePrasanthi Kakumanu
Division of Rheumatology and Clinical Immunology, University of Florida, PO Box 100221, Gainesville, FL 32610 0221, USA
Arthritis Rheum 58:1576-81. 2008.... - Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse modelChristian Grimstein
Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
J Transl Med 9:21. 2011..In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA)... - MicroRNA in TLR signaling and endotoxin toleranceMd A Nahid
Department of Oral Biology, University of Florida, Gainesville, FL, USA
Cell Mol Immunol 8:388-403. 2011..Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases... - Effective use of autoantibody tests in the diagnosis of systemic autoimmune diseaseRobert Lyons
Division of Rheumatology and Clinical Immunology, University of Florida, P. O. Box 100221, Gainesville, FL 32610-0221, USA
Ann N Y Acad Sci 1050:217-28. 2005.... - Diagnostic accuracy for lupus and other systemic autoimmune diseases in the community settingSonali Narain
Division of Rheumatology and Clinical Immunology and Center for Autoimmune Disease, Program in Epidemiology and Public Health, and Department of Biostatistics, University of Florida, Gainesville, USA
Arch Intern Med 164:2435-41. 2004..Since misdiagnosis of systemic autoimmune diseases can have serious consequences, we evaluated community physicians' accuracy in diagnosing autoimmune diseases and the consequences of misdiagnosis... - Atypical clinical presentation of a subset of patients with anti-RNA polymerase III--non-scleroderma cases associated with dominant RNA polymerase I reactivity and nucleolar stainingAngela Ceribelli
Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610 0424, USA
Arthritis Res Ther 13:R119. 2011..The clinical presentation of anti-RNAP III positive patients, onset of Raynaud's phenomenon (RP) and SSc in unselected patients in a rheumatology clinic were evaluated... - Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmonMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL 32610 0221, USA
Fish Shellfish Immunol 30:1080-6. 2011..Evaluation for polyclonal hypergamamglobulinemia and autoimmunity should be included as an important trait when vaccine efficacy and safety are evaluated in future... - Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritisChristian Grimstein
Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
J Gene Med 12:35-44. 2010..In order to develop a new treatment option, the present study employs a gene therapy-based combination therapy using doxycycline and human alpha-1 antitrypsin (hAAT)... - Induction of cytoplasmic rods and rings structures by inhibition of the CTP and GTP synthetic pathway in mammalian cellsWendy C Carcamo
Department of Oral Biology, University of Florida, Gainesville, Florida, United States of America
PLoS ONE 6:e29690. 2011..In the present study, the formation of these conserved structures in mammalian cells and functions linked to these structures were examined... - MicroRNAs in systemic rheumatic diseasesAngela Ceribelli
Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, Florida 32610 0424, USA
Arthritis Res Ther 13:229. 2011..The ultimate goal is the identification of a miRNA target or targets that could be manipulated through specific therapies, aiming at activation or inhibition of specific miRNAs responsible for the development of disease... - MicroRNAs in rheumatoid arthritisAngela Ceribelli
Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL 32610 0424, USA
FEBS Lett 585:3667-74. 2011..In fact, the expression of some microRNAs, such as miR-146a, is upregulated in different cell types and tissues in RA patients. MicroRNAs in RA could also be considered as possible future targets for new therapeutic approaches... - Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseasesMinoru Satoh
Division of Rheumatology and Clinical Immunology, Department of Medicine, and Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA
Mod Rheumatol 19:219-28. 2009..Clinicians should be able to use autoantibody tests more efficiently and effectively with a basic knowledge on the significance of and potential problems in autoantibody tests... - Requirement of Rac1 in the development of cardiac hypertrophyMinoru Satoh
Cardiovascular and Hematology Divisions, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:7432-7. 2006..These results indicate that Rac1 is critical for the hypertrophic response in the heart and suggest that therapies which target myocardial Rac1 may be beneficial in the treatment of cardiac hypertrophy... - The major murine systemic lupus erythematosus susceptibility locus Sle1 results in abnormal functions of both B and T cellsEric S Sobel
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville 32610, USA
J Immunol 169:2694-700. 2002.... - Disruption of GW bodies impairs mammalian RNA interferenceAndrew Jakymiw
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
Nat Cell Biol 7:1267-74. 2005..Our data support a model in which GW182 and/or the microenvironment of the cytoplasmic GWBs contribute to the RNA-induced silencing complex and to RNA silencing... - Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndromeSanil J Manavalan
Weill Medical College of Cornell University, New York, New York 10021, USA
Arthritis Rheum 50:187-98. 2004..g., due to genomic deletion) has functional significance. We examined this question in relation to a known 21.6-kb insertion/deletion-related polymorphism (IDRP) in the human BV locus... - Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritisJun Qi Yang
Department of Internal Medicine, Autoimmunity and Tolerance Laboratory, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Immunol 171:2142-53. 2003..These findings suggest that CD1d may play an immunoregulatory role in the development of lupus in the pristane-induced model... - [Immunologic tests: Anti Ki/PA28gamma antibody]Tetsuroh Okano
Department of Immunology, School of Allied Health Science, Kitasato University
Nippon Rinsho 63:519-22. 2005 - [Immunologic tests: Anti SS-A/Ro, anti SS-B/La antibody]Tetsuroh Okano
Department of Immunology, School of Allied Health Science, Kitasato University
Nippon Rinsho 63:495-8. 2005 - Differential anti-Golgi complex autoantibody production following murine lactate dehydrogenase-elevating virus infectionKazuhisa Nozawa
Institute for Environment and Gender Specific Medicine, Juntendo University Graduate School of Medicine, Chiba, Japan
Immunopharmacol Immunotoxicol 30:13-25. 2008..Future comparative characterizations in the immune processing of Golgi complex autoantigens using these viral strains may be useful in obtaining specific insights in the specific anti-Golgi complex autoimmune responses... - Olmesartan ameliorates renovascular injury and oxidative stress in Zucker obese rats enhanced by dietary proteinTamehachi Namikoshi
Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan
Am J Hypertens 20:1085-91. 2007..This study investigated whether dietary protein intake enhances renal and vascular injuries by oxidative stress, and assessed effects of olmesartan, an angiotensin II type 1 receptor blocker, in this model... - Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritisYoshisuke Haruna
Kawasaki Medical School, Matsushima, Kurashiki, Japan
Arthritis Rheum 56:1827-35. 2007..To investigate the effect of statins on vascular dysfunction in rat adjuvant-induced arthritis (AIA)... - Intravenous cyclophosphamide therapy in a case with refractory thrombotic microangiopathic hemolytic anemia and SLEJun Akaogi
Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, Kanagawa, 216 8511, Japan
Clin Rheumatol 23:541-3. 2004..Immunosuppressive therapy at an early stage of the disease may be beneficial in refractory cases of TMHA with autoimmune features...
Research Grants
- Role of arginine deficiency in pathogenesis of lupusMinoru Satoh; Fiscal Year: 2004..abstract_text> ..