Research Topics
| Mohammad SaleemSummaryAffiliation: University of Wisconsin Country: USA Publications
Research Grants
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Detail Information
Publications
Lupeol triterpene, a novel diet-based microtubule targeting agent: disrupts survivin/cFLIP activation in prostate cancer cellsMohammad Saleem
School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, MSC 4385, Madison, WI 53719, USA
Biochem Biophys Res Commun 388:576-82. 2009..We suggest that Lupeol alone or as an adjuvant to other microtubule agents could be developed as a potential agent for the treatment of human CaP...- Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpeneMohammad Saleem
School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 53719, USA
Cancer Lett 285:109-15. 2009..This mini review provides detailed account of preclinical studies conducted to determine the utility of Lupeol as a therapeutic and chemopreventive agent for the treatment of inflammation and cancer... - Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activatorBilal Bin Hafeez
Department of Dermatology, University of Wisconsin, 1300 University Avenue, Medical Science Center, B 25, Madison, WI 53706, USA
Clin Cancer Res 15:452-9. 2009..Because Notch1 was found to be overexpressed in prostate cancer (PCa) cells and human PCa tissue, we therefore tested our hypothesis that overexpression of Notch1 in PCa promotes tumor invasion... - Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signalingMohammad Saleem
Department of Dermatology, University of Wisconsin, 1300 University Avenue, MSC 25B, Madison, WI 53706, USA
Carcinogenesis 30:808-17. 2009..We suggest that Lupeol could be developed as an agent for chemoprevention as well as chemotherapy of human CaP... - Lupeol inhibits growth of highly aggressive human metastatic melanoma cells in vitro and in vivo by inducing apoptosisMohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
Clin Cancer Res 14:2119-27. 2008..In this study, the effect of lupeol, a diet-based triterpene, was determined on the growth and tumorigenicity of human melanoma cells in vitro and in vivo... - A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signalingBilal Bin Hafeez
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
Cancer Res 68:8564-72. 2008..Analysis of tumors from delphinidin-treated mice showed significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA. Taken together, our data suggest that delphinidin could be developed as an agent against human PCa... - Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaBImtiyaz Murtaza
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
Int J Cancer 125:2465-73. 2009..These data provide evidence that fisetin could provide a biological rationale for treatment of pancreatic cancer or as an adjuvant with conventional therapeutic regimens... - Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivoVaqar Mustafa Adhami
Department of Dermatology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Clin Cancer Res 13:1611-9. 2007.... - Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallateNaghma Khan
Department of Dermatology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Cancer Res 66:2500-5. 2006..This review discusses the modulations of important signaling events by EGCG and their implications in cancer management... - Tea beverage in chemoprevention and chemotherapy of prostate cancerImtiaz A Siddiqui
Department of Dermatology, University of Wisconsin, Medical Sciences Center, Room B 25 1300 University Avenue, Madison, Wisconsin 53706, USA
Acta Pharmacol Sin 28:1392-408. 2007..In this review we address the issue of possible use of tea, especially green tea, for the prevention as well as treatment of PCa... - Suppression of cFLIP by lupeol, a dietary triterpene, is sufficient to overcome resistance to TRAIL-mediated apoptosis in chemoresistant human pancreatic cancer cellsImtiyaz Murtaza
Department of Dermatology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Cancer Res 69:1156-65. 2009..We suggest that lupeol, alone or as an adjuvant to current therapies, could be useful for the management of human PaC... - Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemopreventionJeremy J Johnson
Division of Pharmacy Practice, University of Wisconsin School of Pharmacy, 1031 Rennebohm Hall, Madison, WI 53705, USA
Cancer Prev Res (Phila) 3:1112-23. 2010..We suggest that carnosol may be developed or chemically modified through more rigorous structure-activity relationship studies for a new class of investigational agents-a dual AR/ER modulator... - S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9Mohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
Proc Natl Acad Sci U S A 103:14825-30. 2006..We suggest that S100A4 could be used as a biomarker for CaP progression and a novel therapeutic or chemopreventive target for human CaP treatment... - Specific targeting of Wnt/?-catenin signaling in human melanoma cells by a dietary triterpene lupeolRohinton S Tarapore
Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA
Carcinogenesis 31:1844-53. 2010..We suggest that lupeol alone or as an adjuvant to current therapies could be developed as an agent for the management of human melanomas harboring constitutive Wnt/?-catenin signaling... - A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft modelMohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
Cancer Res 65:11203-13. 2005..Because early clinical prostate cancer growth is an androgen-dependent response, the results of the present study suggest that Lupeol may have a potential to be an effective agent against prostate cancer... - A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1Mohammad Saleem
Department of Dermatology, Laboratory of Medicine, University of Wisconsin, 1300 University Avenue, Medical Sciences Center, B 25, Madison, Wisconsin 53706, USA
Cancer Epidemiol Biomarkers Prev 15:217-27. 2006..Here, we establish the clinical significance of matriptase and its inhibitor, hepatocyte growth factor activator inhibitor-1 (HAI-1), during the progression of human prostate cancer (CaP)... - Beneficial effects of tea and its polyphenols against prostate cancerImtiaz A Siddiqui
Department of Dermatology, University of Wisconsin, Medical Sciences Center, Madison, WI 53706, USA
Mol Nutr Food Res 50:130-43. 2006..In this review we attempt to summarize the experimental as well as the epidemiological basis for the possible role of tea and its polyphenols for chemoprevention and chemotherapy of CaP... - Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathwayMohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
Carcinogenesis 26:1956-64. 2005..Lupeol could be a potential agent against pancreatic cancer, however, further in-depth in vivo studies are warranted... - Tea beverage in chemoprevention of prostate cancer: a mini-reviewMohammad Saleem
Department of Dermatology, University of Wisconsin, 1300 Medical Science Center, Madison, WI 53706, USA
Nutr Cancer 47:13-23. 2003..This article attempts to address the issue of the possible use of tea, especially green tea, for the chemoprevention of prostate cancer... - Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 miceMohammad Saleem
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
Oncogene 23:5203-14. 2004..We suggest that Lupeol is an attractive antitumor-promoting agent that must be evaluated in tumor models other than skin carcinogenesis...
Research Grants
- Lupeol, A Novel Fuit and Vegetable Based Triterpene for Prostate CancerMOHAMMAD BHAT; Fiscal Year: 2007..We believe that this application will be extremely valuable in providing a novel fruit and vegetable based agent for chemoprevention and possibly for treating prostate cancer ..